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25 Possible Causes for Immunoglobulin G Increased, Splenomegaly, Virus Associated Hemophagocytic Syndrome

  • Sickle Cell Disease

    In two mouse SCD models, Berkeley and SAD, inhibition of red blood cell dehydration and sickling was achieved with correction of hematological parameters, splenomegaly, and[ncbi.nlm.nih.gov] Sickle RBCs have increased immunoglobulin G (IgG) on the cell surface.[emedicine.medscape.com] […] index of suspicion is therefore required for the diagnosis of such cases in a nonendemic area like Delhi specifically in patients who presented with unexplained anemia and splenomegaly[doi.org]

  • Infectious Mononucleosis

    Clinical estimates of splenomegaly are fallible.[ncbi.nlm.nih.gov] Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[emedicine.medscape.com] In adolescent and adult patients presenting with sore throat, the presence of posterior cervical, inguinal or axillary adenopathy, palatine petechiae, splenomegaly, or atypical[ncbi.nlm.nih.gov]

  • Hodgkin Lymphoma

    The presenting feature common in all cases was superficial lymphadenopathy followed by hepatomegaly in 17 (20%) cases and splenomegaly in 16 (19%).[ncbi.nlm.nih.gov] Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com] Abdomen: Abdominal enlargement may be noted with splenomegaly or hepatomegaly.[symptoma.com]

  • Infectious Mononucleosis Hepatitis

    Although complications are rare, IM is associated with atraumatic splenic rupture due to splenomegaly and multiple malignancies (e.g., Hodgkin's lymphoma, Burkitt lymphoma[amboss.com] Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[emedicine.medscape.com] Abdominal ultrasound may be required to assess for splenomegaly.[patient.info]

  • Autoimmune Hepatitis

    Physical exam was remarkable for digital clubbing, splenomegaly and orthodeoxia.[ncbi.nlm.nih.gov] Virus-, drug- and lymphoma-associated hemophagocytic syndrome (HPS) was ruled out. Therefore, the patient was diagnosed with autoimmune-associated HPS (AAHS).[ncbi.nlm.nih.gov] It is characterized by inflammatory liver histology, elevated transaminase level, circulating nonorgan-specific autoantibodies, and increased level of immunoglobulin G in[ncbi.nlm.nih.gov]

  • Chronic Active Hepatitis B

    Clinical signs include liver tenderness, hepatomegaly, and splenomegaly. Acute HBV infection typically lasts two to four months.[aafp.org] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov] Laboratory testing should show evidence of abnormal liver chemistry tests, increased total immunoglobulin G (IgG) or gamma-globulin levels and autoantibodies.[clinicaladvisor.com]

  • Chronic Active Hepatitis

    Signs of chronic liver disease usually develop and include the following: (a) Splenomegaly (spleen enlargement).[armymedical.tpub.com] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov] Laboratory testing should show evidence of abnormal liver chemistry tests, increased total immunoglobulin G (IgG) or gamma-globulin levels and autoantibodies.[clinicaladvisor.com]

  • Lupus Nephritis

    The abdomen was remarkable for splenomegaly and lower extremities for erythema nodosum. No peripheral lymphadenopathy was detected.[ncbi.nlm.nih.gov] However, she suffered Epstein- Barr virus (EBV)-associated hemophagocytic syndrome (HPS) twice, and in each case she was treated with anticancer drugs and achieved a complete[ncbi.nlm.nih.gov]

  • Hepatosplenomegaly

    Splenomegaly associated with portal hypertension results in platelet sequestration and thrombocytopenia. 2.[quizlet.com] T-cell lymphoma and the virus-associated hemophagocytic syndrome. Am J Clin Pathol. 1991; 97 :189–194. [ PubMed ] 16.[ncbi.nlm.nih.gov] Relapses of thrombocytopenia with increases of platelet-associated immunoglobulin G and hepatosplenomegaly have been observed approximately every 2 months, and two relapses[ncbi.nlm.nih.gov]

  • Hepatitis A

    Signs include hepatomegaly, lymphadenopathy and splenomegaly, though these findings vary from individual to individual, depending on general health status and age group.[symptoma.com] hemophagocytic syndrome [3].[ncbi.nlm.nih.gov] […] serum immunoglobulin G levels, presence of other diseases with autoimmune features Systemic lupus erythematosus Systemic autoimmune disease is predominant; abdominal pain[web.archive.org]

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