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27 Possible Causes for Immunoglobulin G Increased, Virus Associated Hemophagocytic Syndrome

  • Sickle Cell Disease

    Sickle RBCs have increased immunoglobulin G (IgG) on the cell surface.[emedicine.medscape.com]

  • Infectious Mononucleosis

    Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[emedicine.medscape.com] Epstein-Barr virus-associated hemophagocytic syndrome and fatal infectious mononucleosis. Am J Hematol. 1996 Oct. 53(2):111-5. [Medline].[emedicine.medscape.com] Epstein-Barr virus-induced infectious mononucleosis after two separate episodes of virus-associated hemophagocytic syndrome. Intern Med. 2009. 48(13):1169-73. [Medline].[emedicine.medscape.com]

  • Chronic Active Hepatitis B

    Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov] Laboratory testing should show evidence of abnormal liver chemistry tests, increased total immunoglobulin G (IgG) or gamma-globulin levels and autoantibodies.[clinicaladvisor.com] To our knowledge this is the first report of a hemophagocytic syndrome in that setting.[ncbi.nlm.nih.gov]

  • Chronic Active Hepatitis

    Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov] Laboratory testing should show evidence of abnormal liver chemistry tests, increased total immunoglobulin G (IgG) or gamma-globulin levels and autoantibodies.[clinicaladvisor.com] Frequently, immune serum markers are present; they include autoantibodies against liver-specific and non–liver-specific antigens and increased immunoglobulin G (IgG) levels[emedicine.medscape.com]

  • Lupus Nephritis

    However, she suffered Epstein- Barr virus (EBV)-associated hemophagocytic syndrome (HPS) twice, and in each case she was treated with anticancer drugs and achieved a complete[ncbi.nlm.nih.gov]

  • Infectious Mononucleosis Hepatitis

    Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[emedicine.medscape.com] Commonly, patients and physicians equate increased EBV immunoglobulin G (IgG) VCA antibody titers with chronic infectious mononucleosis or CFS because more than 90% of the[emedicine.medscape.com] Epstein-Barr virus-associated hemophagocytic syndrome and fatal infectious mononucleosis. Am J Hematol. 1996 Oct. 53(2):111-5. [Medline].[emedicine.medscape.com]

  • Autoimmune Hepatitis

    Virus-, drug- and lymphoma-associated hemophagocytic syndrome (HPS) was ruled out. Therefore, the patient was diagnosed with autoimmune-associated HPS (AAHS).[ncbi.nlm.nih.gov] It is characterized by inflammatory liver histology, elevated transaminase level, circulating nonorgan-specific autoantibodies, and increased level of immunoglobulin G in[ncbi.nlm.nih.gov] Elevated serum immunoglobulin G (IgG) was detected, and tests for platelet-associated IgG and anti-nuclear antibody were positive.[ncbi.nlm.nih.gov]

  • Hodgkin Lymphoma

    Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com]

  • Influenza Pneumonia

    Virus-associated hemophagocytic syndrome (VAHS) refers to hemophagocytic lymphohistiocytosis due to viral infection.[emcrit.org] Diagnosis of seasonal influenza was established by seroconvertion, i.e. a four-fold increase of immunoglobulin G in the complement fixation test (Barcelona) or the haemagglutination[erj.ersjournals.com] Virus-associated hemophagocytic syndrome as a major contributor to death in patients with 2009 influenza A (H1N1) infection. Crit Care. 2011 Mar 2. 15(2):R80. [Medline].[medscape.com]

  • Lymphadenitis

    We describe a fatal case of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome with human herpesvirus-6B (HHV-6B)-associated lymphadenitis and virus-associated[ncbi.nlm.nih.gov] G (IgG) and IgA, and normal/increased serum levels of IgM.[ncbi.nlm.nih.gov] hemophagocytic syndrome triggered by an over-the-counter medication to treat respiratory and influenza-like symptoms.[ncbi.nlm.nih.gov]

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