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Interleukin-2
The second patient was treated with denileukin diftitox, an immunotoxin fusion protein that targets the IL-2 receptor.[ncbi.nlm.nih.gov]
Abstract Despite its apparent failure in cancer therapy, IL-2 still remains fundamental in the activation of antitumor immunity.[ncbi.nlm.nih.gov]
Other approaches to IL2R targeted treatment of cancer have been the use of ligand-toxin fusion proteins and immunotoxins.[ard.bmj.com]
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Toxic Effect
Abstract Immunotoxins are chimeric proteins consisting of a toxin coupled to an antibody.[ncbi.nlm.nih.gov]
CONCLUSIONS: This study identified osteoporosis in patients who received long-term therapy with etretinate but not isotretinoin.[ncbi.nlm.nih.gov]
Indications for the use of antimicrobial therapy must be strictly followed, because banal, frequent infections are not indication for antimicrobial therapy.[ncbi.nlm.nih.gov]
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Diffuse Intrinsic Pontine Glioma
There are a few current clinical trials of brainstem CED in treating DIPG patients using targeted macromolecules such as antibodies and immunotoxins.[ncbi.nlm.nih.gov]
Since DIPG occurs in the brainstem, a vital region of the brain, there are no surgical options for providing relief to patients, and chemotherapy as well as radiation therapy[ncbi.nlm.nih.gov]
KEYWORDS: Brainstem tumor; Cell culture; Kinase inhibitor; Neurosphere; Signal transduction; Targeted therapy[ncbi.nlm.nih.gov]
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Childhood Acute Lymphoblastic Leukemia
Moxetumomab pasudotox is a recombinant anti-CD22 immunotoxin.[ncbi.nlm.nih.gov]
[…] and relapse treatment and highlighted recent and promising innovative therapies with an overview of the most promising ongoing clinical trials.[ncbi.nlm.nih.gov]
No intrathecal chemotherapy was administered, and radiation therapy was not necessary.[ncbi.nlm.nih.gov]
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Methotrexate
Combination therapies can overcome the efficacy limitations while not increasing treatment-associated morbidity.[ncbi.nlm.nih.gov]
The researchers concluded that the addition of Temodar to radiation therapy improves survival compared to radiation therapy alone as initial therapy for glioblastoma multiforme[news.cancerconnect.com]
KEYWORDS: drug reaction; inflammatory disorders; pharmacology; psoriasis; systemic; therapy[ncbi.nlm.nih.gov]
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Cladribine
HCL-specific trials are listed on Cancer.gov: a phase II trial of cladribine followed 4 weeks later by 8 weekly doses of rituximab, and phase I-II trials of recombinant immunotoxins[clinicaltrials.gov]
No drug therapy has been validated.[ncbi.nlm.nih.gov]
In a few reported cases of AIHA arising in patients with WM after cladribine therapy, there was a latency of 24 to 60 months between therapy and the onset of AIHA, three of[ncbi.nlm.nih.gov]
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Malignant Glioma
Such clinical evolution of a malignant glioma after a single round of immunotoxin infusion is rather unusual.[ncbi.nlm.nih.gov]
Because GI perforation is a life-threatening yet treatable complication, neurooncologists must have a low threshold to consider it in patients on antiangiogenic drug therapy[ncbi.nlm.nih.gov]
KEYWORDS: 1-C13 pyruvate DNP MRS; Aerobic glycolysis; Malignant glioma; Metabolic reprogramming; Metabolic therapy; Warburg effect[ncbi.nlm.nih.gov]
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Paclitaxel
The researchers combined nab-paclitaxel with an experimental immunotoxin called RG7787, with good results.[asbestos.com]
This bioresponsive prodrug strategy demonstrates potent chemotherapeutic efficiency in vivo and may be utilized in clinical cancer therapy.[ncbi.nlm.nih.gov]
Such dynamic fabrications of the nanoparticulate therapy stimulate cellular interaction with frontier area for future research in tumor targeting potential.[ncbi.nlm.nih.gov]
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Hairy Cell Leukemia
The authors conducted a literature review of the MEDLINE database for articles in English concerning immunotoxins, BRAF inhibitors and BCR pathway inhibitors via PubMed.[ncbi.nlm.nih.gov]
When combined to a PA, rituximab yields a 100 % response rate, even beyond frontline therapy.[ncbi.nlm.nih.gov]
Targeted immunotoxins remain an interesting area of study.[ncbi.nlm.nih.gov]
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Perhexiline
Immunotoxin enhancement by the Ca2 antagonist perhexiline was also inhibited by plasma.[ncbi.nlm.nih.gov]
Abstract Two patients developed cirrhosis of the liver following therapy with perhexiline maleate.[ncbi.nlm.nih.gov]
Forty consecutive patients with either unstable angina pectoris or non-Q-wave myocardial infarction with persistent angina pectoris, despite maximal pharmacological therapy[ncbi.nlm.nih.gov]