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101 Possible Causes for immunotoxin, therapy

  • Interleukin-2

    The second patient was treated with denileukin diftitox, an immunotoxin fusion protein that targets the IL-2 receptor.[ncbi.nlm.nih.gov] Abstract Despite its apparent failure in cancer therapy, IL-2 still remains fundamental in the activation of antitumor immunity.[ncbi.nlm.nih.gov] Other approaches to IL2R targeted treatment of cancer have been the use of ligand-toxin fusion proteins and immunotoxins.[ard.bmj.com]

  • Toxic Effect

    Abstract Immunotoxins are chimeric proteins consisting of a toxin coupled to an antibody.[ncbi.nlm.nih.gov] CONCLUSIONS: This study identified osteoporosis in patients who received long-term therapy with etretinate but not isotretinoin.[ncbi.nlm.nih.gov] Indications for the use of antimicrobial therapy must be strictly followed, because banal, frequent infections are not indication for antimicrobial therapy.[ncbi.nlm.nih.gov]

  • Diffuse Intrinsic Pontine Glioma

    There are a few current clinical trials of brainstem CED in treating DIPG patients using targeted macromolecules such as antibodies and immunotoxins.[ncbi.nlm.nih.gov] Since DIPG occurs in the brainstem, a vital region of the brain, there are no surgical options for providing relief to patients, and chemotherapy as well as radiation therapy[ncbi.nlm.nih.gov] KEYWORDS: Brainstem tumor; Cell culture; Kinase inhibitor; Neurosphere; Signal transduction; Targeted therapy[ncbi.nlm.nih.gov]

  • Childhood Acute Lymphoblastic Leukemia

    Moxetumomab pasudotox is a recombinant anti-CD22 immunotoxin.[ncbi.nlm.nih.gov] […] and relapse treatment and highlighted recent and promising innovative therapies with an overview of the most promising ongoing clinical trials.[ncbi.nlm.nih.gov] No intrathecal chemotherapy was administered, and radiation therapy was not necessary.[ncbi.nlm.nih.gov]

  • Methotrexate

    Combination therapies can overcome the efficacy limitations while not increasing treatment-associated morbidity.[ncbi.nlm.nih.gov] The researchers concluded that the addition of Temodar to radiation therapy improves survival compared to radiation therapy alone as initial therapy for glioblastoma multiforme[news.cancerconnect.com] KEYWORDS: drug reaction; inflammatory disorders; pharmacology; psoriasis; systemic; therapy[ncbi.nlm.nih.gov]

  • Cladribine

    HCL-specific trials are listed on Cancer.gov: a phase II trial of cladribine followed 4 weeks later by 8 weekly doses of rituximab, and phase I-II trials of recombinant immunotoxins[clinicaltrials.gov] No drug therapy has been validated.[ncbi.nlm.nih.gov] In a few reported cases of AIHA arising in patients with WM after cladribine therapy, there was a latency of 24 to 60 months between therapy and the onset of AIHA, three of[ncbi.nlm.nih.gov]

  • Malignant Glioma

    Such clinical evolution of a malignant glioma after a single round of immunotoxin infusion is rather unusual.[ncbi.nlm.nih.gov] Because GI perforation is a life-threatening yet treatable complication, neurooncologists must have a low threshold to consider it in patients on antiangiogenic drug therapy[ncbi.nlm.nih.gov] KEYWORDS: 1-C13 pyruvate DNP MRS; Aerobic glycolysis; Malignant glioma; Metabolic reprogramming; Metabolic therapy; Warburg effect[ncbi.nlm.nih.gov]

  • Paclitaxel

    The researchers combined nab-paclitaxel with an experimental immunotoxin called RG7787, with good results.[asbestos.com] This bioresponsive prodrug strategy demonstrates potent chemotherapeutic efficiency in vivo and may be utilized in clinical cancer therapy.[ncbi.nlm.nih.gov] Such dynamic fabrications of the nanoparticulate therapy stimulate cellular interaction with frontier area for future research in tumor targeting potential.[ncbi.nlm.nih.gov]

  • Hairy Cell Leukemia

    The authors conducted a literature review of the MEDLINE database for articles in English concerning immunotoxins, BRAF inhibitors and BCR pathway inhibitors via PubMed.[ncbi.nlm.nih.gov] When combined to a PA, rituximab yields a 100 % response rate, even beyond frontline therapy.[ncbi.nlm.nih.gov] Targeted immunotoxins remain an interesting area of study.[ncbi.nlm.nih.gov]

  • Perhexiline

    Immunotoxin enhancement by the Ca2 antagonist perhexiline was also inhibited by plasma.[ncbi.nlm.nih.gov] Abstract Two patients developed cirrhosis of the liver following therapy with perhexiline maleate.[ncbi.nlm.nih.gov] Forty consecutive patients with either unstable angina pectoris or non-Q-wave myocardial infarction with persistent angina pectoris, despite maximal pharmacological therapy[ncbi.nlm.nih.gov]

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