Impaired Exercise Tolerance: Causes & Reasons

Possible Causes for Impaired Exercise Tolerance

The impairment of exercise tolerance indicated by NYHA classification was markedly improved by PD for both groups. [ncbi.nlm.nih.gov]

Numerous mechanisms unrelated to hemodynamic dysfunction may underlie impaired exercise tolerance in patients with chronic heart failure. [doi.org]

[…] as tolerated and, for Pts with impaired renal function or psychogenic polydipsia, fluid restriction. 2. drug therapy with multiple agents–diuretics, ACE inhibitors, digoxin [medical-dictionary.thefreedictionary.com]

Anemia

[…] include fatigue, pallor, tachycardia, poor exercise tolerance, and suboptimal work performance. 14 Depleted blood reserves during delivery may increase the need for blood [bloodjournal.org]

Low cobalamin is associated with an increased fetal risk of low lean mass and excess adiposity, increased insulin resistance, and impaired neurodevelopment. 13 Maternal risks [bloodjournal.org]

Eisenmenger Syndrome

Impaired exercise tolerance, decreased arterial oxygen saturation, iron deficiency, pre-tricuspid shunts, arrhythmias, increased brain natriuretic peptide, echocardiographic [heart.bmj.com]

Patients with pre-tricuspid shunts were older, had higher BNP concentrations and lower exercise tolerance compared to patients with post-tricuspid shunts. [ncbi.nlm.nih.gov]

tolerance, impaired oxygen transport capacity due to “relative anemia”, and may increase the risk of cerebrovascular events.29,30 Venesection should only be offered to patients [dovepress.com]

Heart Failure

Numerous mechanisms unrelated to hemodynamic dysfunction may underlie impaired exercise tolerance in patients with chronic heart failure. [doi.org]

[…] of life, including dyspnoea, fatigue, poor exercise tolerance and fluid retention. [radcliffecardiology.com]

Coupled with the pathological changes of heart failure and associated symptoms is a reduction in exercise tolerance due to impaired skeletal muscle function. [dx.doi.org]

Chronic Obstructive Pulmonary Disease

It has not helped us understand why some patients with severe FEV1 impairment have better exercise tolerance compared with others with similar FEV1 values. [ncbi.nlm.nih.gov]

Pharmacological therapy is aimed at relieving symptoms; improving exercise tolerance and quality of life; slowing decline and even improving lung function; or preventing or [doi.org]

Pharmacological therapy is aimed at relieving symptoms, improving exercise tolerance and quality of life, slowing decline and even improving lung function, or preventing and [doi.org]

Obesity

[…] counselling; educational package Broom w3 531 with hypertension, impaired glucose tolerance, or dyslipidaemia, 1 year follow-up (UK) 46 37.1 101 Orlistat 120 mg three times [ncbi.nlm.nih.gov]

A, the nutrition professional will focus on a dietary regimen tailored to the patient with impaired glucose tolerance or emerging type 2 diabetes. [dx.doi.org]

[…] counselling XENDOS w16 3305 patients (21% with impaired glucose tolerance), 4 year follow-up (Sweden) 43 37.3 111 Orlistat 120 mg three times daily (n=1650); placebo (n=1655 [ncbi.nlm.nih.gov]

Coronary Atherosclerosis

New York Heart Association class II-IV), and prediabetes (patients had impaired glucose tolerance and impaired fasting glucose with a balanced profile of obesity and cardiovascular [doi.org]

[…] glucose tolerance and impaired fasting glucose—that is, prediabetes. 36 Comparability of trial and patient population characteristics Conceptual heterogeneity between drug [doi.org]

[…] disease risk factors across exercise and drug trials). [doi.org]

Neurocirculatory Asthenia

Google Scholar — Functional capacity and exercise tolerance in patients with impaired cardiovascular function, p. 201 in Clinical Cardiopulmonary Physiology. [link.springer.com]

Chronic Fatigue Syndrome

Subjective reports of PEM and prolonged recovery are supported by objective evidence, including failure to normally reproduce exercise test results (2-day CPET) and impaired [nap.edu]

Summary PEM is a worsening of a patient’s symptoms and function after exposure to physical or cognitive stressors that were normally tolerated before disease onset. [nap.edu]

Pulmonary Hypertension

DOI: https://doi.org/10.3399/bjgp12X658467 INTRODUCTION Dyspnoea on exertion, impaired exercise tolerance, and fatigue are most often due to common cardiac and pulmonary diseases [bjgp.org]

[…] capacity, reduce exercise tolerance, 87 induce iron deficiency, 24 and increase the risk of stroke. 88 If phlebotomy is performed, iron status should be monitored closely [doi.org]

Bosentan improves exercise tolerance and oxygen saturation in some patients with impaired hemodynamics after Fontan surgery. 406 A single dose of sildenafil improves V̇O 2 [doi.org]

Chronic Constrictive Pericarditis

She then developed insidious progressive impairment in her exercise tolerance. [radcliffecardiology.com]

Aortic Valve Insufficiency

In addition, physicians may have a lower threshold for referring a patient for AVR after a treadmill test in which the patient had impaired exercise tolerance, presumed symptoms [content.onlinejacc.org]

Fabry Disease

Diastolic dysfunction is probably the commonest cause of exertional dyspnoea and reduced exercise tolerance in patients and may be present before the development of overt [doi.org]

Diastolic dysfunction is common and results in impaired ventricular filling due to increased ventricular stiffness and impaired relaxation (Fig. 2 f). [doi.org]

Ischemic Cardiomyopathy

The cardinal manifestations of HF are dyspnea and fatigue, which may limit exercise tolerance, and fluid retention, which may lead to pulmonary congestion and peripheral edema [doi.org]

Definition of HF Heart failure is a complex clinical syndrome that can result from any structural or functional cardiac disorder that impairs the ability of the ventricle [doi.org]

Both abnormalities can impair the functional capacity and quality of life of affected individuals, but they do not necessarily dominate the clinical picture at the same time [doi.org]

Chronic Myeloid Leukemia

More frequently, however, an in-depth medical history reveals a deterioration of well-being, impaired exercise tolerance, loss of appetite, feeling of fullness in the abdomen [ncbi.nlm.nih.gov]

Glycogen Storage Disease Type 13

In fact, unlike GSDV where oral administration of glucose immediately prior to exercise can improve exercise tolerance, in Tarui disease it exacerbates exercise intolerance [ojrd.biomedcentral.com]

Formal cycle ergometry studies confirmed the mild impairment of glycogenolysis: there was no change in lactate during dynamic, submaximal exercise and IV glucose administration [ncbi.nlm.nih.gov]

[…] leading to an ‘ out-of-wind phenomenon’ by impairing fatty acid oxidation [ 18 ]. [ojrd.biomedcentral.com]

Phosphoglycerate Kinase 1 Deficiency

[…] leading to an ‘ out-of-wind phenomenon’ by impairing fatty acid oxidation [ 18 ]. [ojrd.biomedcentral.com]

Muscle Phosphorylase Kinase Deficiency

Formal cycle ergometry studies confirmed the mild impairment of glycogenolysis: there was no change in lactate during dynamic, submaximal exercise and IV glucose administration [ncbi.nlm.nih.gov]

[…] improved exercise tolerance, but less than in McArdle patients (72). [ncbi.nlm.nih.gov]

Barth Syndrome

[…] extraction/utilization, exercise tolerance and quality of life in these individuals. [clinicaltrials.gov]

The investigators have recently found severe exercise intolerance in adolescents with BTHS that was mediated by impaired skeletal muscle oxygen extraction and utilization. [clinicaltrials.gov]

Previous evidence from other mitochondrial pathologies demonstrated that chronic aerobic exercise training enhanced mitochondrial biogenesis, improved skeletal muscle oxygen [clinicaltrials.gov]

Hereditary Myopathy with Lactic Acidosis due to ISCU Deficiency

[…] leading to an ‘ out-of-wind phenomenon’ by impairing fatty acid oxidation [ 18 ]. [ojrd.biomedcentral.com]

Hereditary ATTR Amyloidosis

Orthostatic hypotension is a troublesome symptom that can present with non-specific symptoms of fatigue, reduced exercise tolerance and vague dizziness. [content.iospress.com]

The severity of cardiovascular autonomic impairment is unrelated to the severity of the peripheral neuropathy. [content.iospress.com]

Myoadenylate Deaminase Deficiency

[…] for progressive cycle ergometry exercise. [ncbi.nlm.nih.gov]

One conceivable consequence of AMPD deficiency would be an impairment of the PNC with a resultant attenuation of TCAi anaplerosis ( Sabina et al. 1980 ; Flanagan et al. 1986 [ncbi.nlm.nih.gov]

[…] perspective, the main finding in this study is that patients with less than 1 % residual AMPD activity were not markedly different from subjects with normal AMPD activity in their tolerance [ncbi.nlm.nih.gov]

Anemia of Chronic Disease

[…] progression; Increased cardiovascular morbidity and mortality ; Reduced exercise tolerance, angina, and worsening of heart failure (where this already exists); Poorer organ [myvmc.com]

Chronic Kidney Disease Patients with chronic kidney disease that have coexisting anaemia experience: Reduced quality of life; Cognitive impairment; Sleep disturbance; Disease [myvmc.com]

Hypoglycemia

A 71-year-old woman previously diagnosed with reactive hypoglycemia was transferred to our emergency unit because of loss of consciousness. Her plasma glucose level was 27 mg/dL, and continuous glucose monitoring (CGM) revealed postprandial asymptomatic hypoglycemia. A hypervascular tumor was identified via[…] [ncbi.nlm.nih.gov]

Morbid Obesity

Morbid obesity is associated with liver pathology, most commonly non-alcoholic steatohepatitis (NASH) leading to cirrhosis. However, the morbid obesity impedes qualification for organ transplantation. We present a case report of a 56-year-old woman who underwent bariatric procedure followed by liver transplantation[…] [ncbi.nlm.nih.gov]

Iron Deficiency Anemia

Abstract Our aim was to evaluate the cut-off value and efficiency of using reticulocyte hemoglobin content as a marker to diagnose iron deficiency anemia in Chinese adults. 140 adults who needed bone marrow aspiration for diagnosis at the hematology department of the Peking Union Medical College Hospital were[…] [ncbi.nlm.nih.gov]

Bronchial Asthma

Asthma is a relatively common condition that is characterized by at least partially reversible inflammation of the airways and reversible airway obstruction due to airway hyperreactivity. It can be acute, subacute or chronic. Asthma is one of the most common chronic diseases in the world. According to the 2014 Global[…] [radiopaedia.org]

Angina Pectoris

There are three different types of angina pectoris. These include: Stable Angina In stable angina, episodes of chest discomfort are usually predictable. They can occur during exertion (such as running to catch a bus) or during mental or emotional stress. Normally, the chest discomfort is relieved with rest, use of[…] [nitromist.com]

Cardiomyopathy

Cardiomyopathy is a complicated disease of the heart muscle that compromises the muscle's "contractility" for efficiently delivering blood to the body. There are a number of possible causes, ranging from bacterial and viral infections to metabolic disorders, drugs and toxins, and connective tissue disorders,[…] [aopa.org]

Acute Coronary Syndrome

Please note : this guideline has exceeded its review date and is currently under review by specialists. Exercise caution in the use of the clinical guideline. N.B. Some of the recommendations in this guideline are currently under review and may change. Introduction Chest pain is one of the most common presentations[…] [handbook.ggcmedicines.org.uk]