Impaired Exercise Tolerance: Causes & Reasons

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Possible Causes for Impaired Exercise Tolerance

Congestive Heart Failure

The impairment of exercise tolerance indicated by NYHA classification was markedly improved by PD for both groups. [ncbi.nlm.nih.gov]

Numerous mechanisms unrelated to hemodynamic dysfunction may underlie impaired exercise tolerance in patients with chronic heart failure. [doi.org]

Coupled with the pathological changes of heart failure and associated symptoms is a reduction in exercise tolerance due to impaired skeletal muscle function. [dx.doi.org]

Heart Failure

Numerous mechanisms unrelated to hemodynamic dysfunction may underlie impaired exercise tolerance in patients with chronic heart failure. [doi.org]

[…] of life, including dyspnoea, fatigue, poor exercise tolerance and fluid retention. [radcliffecardiology.com]

Coupled with the pathological changes of heart failure and associated symptoms is a reduction in exercise tolerance due to impaired skeletal muscle function. [dx.doi.org]

Chronic Obstructive Pulmonary Disease

It has not helped us understand why some patients with severe FEV1 impairment have better exercise tolerance compared with others with similar FEV1 values. [ncbi.nlm.nih.gov]

Pharmacological therapy is aimed at relieving symptoms; improving exercise tolerance and quality of life; slowing decline and even improving lung function; or preventing or [doi.org]

Pharmacological therapy is aimed at relieving symptoms, improving exercise tolerance and quality of life, slowing decline and even improving lung function, or preventing and [doi.org]

Anemia

[…] include fatigue, pallor, tachycardia, poor exercise tolerance, and suboptimal work performance. 14 Depleted blood reserves during delivery may increase the need for blood [bloodjournal.org]

Low cobalamin is associated with an increased fetal risk of low lean mass and excess adiposity, increased insulin resistance, and impaired neurodevelopment. 13 Maternal risks [bloodjournal.org]

Obesity

[…] counselling; educational package Broom w3 531 with hypertension, impaired glucose tolerance, or dyslipidaemia, 1 year follow-up (UK) 46 37.1 101 Orlistat 120 mg three times [ncbi.nlm.nih.gov]

[…] program (with or without adjunctive drug therapy) and who present with obesity-related comorbid conditions, such as hypertension, impaired glucose tolerance, diabetes mellitus [annals.org]

Among persons with a BMI >30 who already have impaired glucose tolerance and are at risk for developing type II diabetes mellitus, adopting lifestyle changes that decrease [library.med.utah.edu]

Chronic Constrictive Pericarditis

She then developed insidious progressive impairment in her exercise tolerance. [radcliffecardiology.com]

Neurocirculatory Asthenia

Google Scholar — Functional capacity and exercise tolerance in patients with impaired cardiovascular function, p. 201 in Clinical Cardiopulmonary Physiology. [link.springer.com]

Pulmonary Hypertension

DOI: https://doi.org/10.3399/bjgp12X658467 INTRODUCTION Dyspnoea on exertion, impaired exercise tolerance, and fatigue are most often due to common cardiac and pulmonary diseases [bjgp.org]

Bosentan improves exercise tolerance and oxygen saturation in some patients with impaired hemodynamics after Fontan surgery. 406 A single dose of sildenafil improves V̇O 2 [doi.org]

[…] by exercise. [doi.org]

Coronary Atherosclerosis

New York Heart Association class II-IV), and prediabetes (patients had impaired glucose tolerance and impaired fasting glucose with a balanced profile of obesity and cardiovascular [doi.org]

[…] glucose tolerance and impaired fasting glucose—that is, prediabetes. 36 Comparability of trial and patient population characteristics Conceptual heterogeneity between drug [doi.org]

[…] disease risk factors across exercise and drug trials). [doi.org]

Aortic Valve Insufficiency

In addition, physicians may have a lower threshold for referring a patient for AVR after a treadmill test in which the patient had impaired exercise tolerance, presumed symptoms [content.onlinejacc.org]

Chronic Fatigue Syndrome

Subjective reports of PEM and prolonged recovery are supported by objective evidence, including failure to normally reproduce exercise test results (2-day CPET) and impaired [nap.edu]

Summary PEM is a worsening of a patient’s symptoms and function after exposure to physical or cognitive stressors that were normally tolerated before disease onset. [nap.edu]

Eisenmenger Syndrome

Patients with pre-tricuspid shunts were older, had higher BNP concentrations and lower exercise tolerance compared to patients with post-tricuspid shunts. [ncbi.nlm.nih.gov]

tolerance, impaired oxygen transport capacity due to “relative anemia”, and may increase the risk of cerebrovascular events. 29, 30 Venesection should only be offered to [dovepress.com]

Right ventricular (RV) function was impaired in patients with atrial septal defects, with larger right ventricles, impaired systolic function and adaptation. [ncbi.nlm.nih.gov]

Ischemic Cardiomyopathy

The cardinal manifestations of HF are dyspnea and fatigue, which may limit exercise tolerance, and fluid retention, which may lead to pulmonary congestion and peripheral edema [circ.ahajournals.org]

Definition of HF Heart failure is a complex clinical syndrome that can result from any structural or functional cardiac disorder that impairs the ability of the ventricle [circ.ahajournals.org]

Both abnormalities can impair the functional capacity and quality of life of affected individuals, but they do not necessarily dominate the clinical picture at the same time [circ.ahajournals.org]

Chronic Myeloid Leukemia

More frequently, however, an in-depth medical history reveals a deterioration of well-being, impaired exercise tolerance, loss of appetite, feeling of fullness in the abdomen [ncbi.nlm.nih.gov]

Glycogen Storage Disease Type 13

Formal cycle ergometry studies confirmed the mild impairment of glycogenolysis: there was no change in lactate during dynamic, submaximal exercise and IV glucose administration [ncbi.nlm.nih.gov]

In fact, unlike GSDV where oral administration of glucose immediately prior to exercise can improve exercise tolerance, in Tarui disease it exacerbates exercise intolerance [ojrd.biomedcentral.com]

[…] improved exercise tolerance, but less than in McArdle patients (72). [ncbi.nlm.nih.gov]

Barth Syndrome

[…] extraction/utilization, exercise tolerance and quality of life in these individuals. [clinicaltrials.gov]

The investigators have recently found severe exercise intolerance in adolescents with BTHS that was mediated by impaired skeletal muscle oxygen extraction and utilization. [clinicaltrials.gov]

Previous evidence from other mitochondrial pathologies demonstrated that chronic aerobic exercise training enhanced mitochondrial biogenesis, improved skeletal muscle oxygen [clinicaltrials.gov]

Phosphoglycerate Kinase 1 Deficiency

[…] leading to an ‘ out-of-wind phenomenon’ by impairing fatty acid oxidation [ 18 ]. [ojrd.biomedcentral.com]

Muscle Phosphorylase Kinase Deficiency

Formal cycle ergometry studies confirmed the mild impairment of glycogenolysis: there was no change in lactate during dynamic, submaximal exercise and IV glucose administration [ncbi.nlm.nih.gov]

[…] improved exercise tolerance, but less than in McArdle patients (72). [ncbi.nlm.nih.gov]

Hereditary Myopathy with Lactic Acidosis due to ISCU Deficiency

[…] leading to an ‘ out-of-wind phenomenon’ by impairing fatty acid oxidation [ 18 ]. [ojrd.biomedcentral.com]

Hereditary ATTR Amyloidosis

Orthostatic hypotension is a troublesome symptom that can present with non-specific symptoms of fatigue, reduced exercise tolerance and vague dizziness. [content.iospress.com]

The severity of cardiovascular autonomic impairment is unrelated to the severity of the peripheral neuropathy. [content.iospress.com]

Myoadenylate Deaminase Deficiency

[…] for progressive cycle ergometry exercise. [ncbi.nlm.nih.gov]

One conceivable consequence of AMPD deficiency would be an impairment of the PNC with a resultant attenuation of TCAi anaplerosis ( Sabina et al. 1980 ; Flanagan et al. 1986 [ncbi.nlm.nih.gov]

[…] perspective, the main finding in this study is that patients with less than 1 % residual AMPD activity were not markedly different from subjects with normal AMPD activity in their tolerance [ncbi.nlm.nih.gov]

Anemia of Chronic Disease

[…] progression; Increased cardiovascular morbidity and mortality ; Reduced exercise tolerance, angina, and worsening of heart failure (where this already exists); Poorer organ [myvmc.com]

Chronic Kidney Disease Patients with chronic kidney disease that have coexisting anaemia experience: Reduced quality of life; Cognitive impairment; Sleep disturbance; Disease [myvmc.com]

Congenital Disorder of Glycosylation Type 1T

Glucose tolerance is slightly impaired, and the “second wind” phenomenon occurs very rarely in GSD type VII. [link.springer.com]

Vigorous exercise should be avoided for every patient in each group of defects due to a risk of acute renal failure secondary to rhabdomyolysis (myoglobinuria) and of gout [link.springer.com]

Hypoglycemia

A 71-year-old woman previously diagnosed with reactive hypoglycemia was transferred to our emergency unit because of loss of consciousness. Her plasma glucose level was 27 mg/dL, and continuous glucose monitoring (CGM) revealed postprandial asymptomatic hypoglycemia. A hypervascular tumor was identified via[…] [ncbi.nlm.nih.gov]

Morbid Obesity

Morbid obesity is associated with liver pathology, most commonly non-alcoholic steatohepatitis (NASH) leading to cirrhosis. However, the morbid obesity impedes qualification for organ transplantation. We present a case report of a 56-year-old woman who underwent bariatric procedure followed by liver transplantation[…] [ncbi.nlm.nih.gov]

Iron Deficiency Anemia

Abstract Ankaferd Blood Stopper (ABS) comprises a mixture of plants and stops bleeding via forming a protein network by erythroid aggregation. Bleeding causes reduction of iron levels in body. It has been indicated that ABS contains significant amount of iron. Thus, we investigated the biological activity of[…] [ncbi.nlm.nih.gov]

Bronchial Asthma

History A detailed assessment of the medical history should address the following: Whether symptoms are attributable to asthma Whether findings support the likelihood of asthma (eg, family history) Asthma severity Identification of possible precipitating factors Family history may be pertinent for asthma, allergy,[…] [emedicine.medscape.com]

Angina Pectoris

You may have heard the term “angina pectoris” or “stable angina” in your doctor’s office, but what is it, and what could it mean for you? It’s important to understand the basics. Angina pectoris is the medical term for chest pain or discomfort due to coronary heart disease. It occurs when the heart muscle[…] [heart.org]

Cardiomyopathy

ESC Heart Fail. 2018 Feb;5(1):197-200. doi: 10.1002/ehf2.12242. Epub 2018 Jan 13. Author information 1 Echocardiography Laboratory, Division of Pediatric Cardiology and Arrhythmology, Department of Pediatric Cardiology and Cardiac Surgery, Bambino Gesù Children Hospital-IRCSS, Rome, Italy. 2 Division of Cardiac[…] [ncbi.nlm.nih.gov]

Acute Coronary Syndrome

Please note : this guideline has exceeded its review date and is currently under review by specialists. Exercise caution in the use of the clinical guideline. N.B. Some of the recommendations in this guideline are currently under review and may change. Introduction Chest pain is one of the most common presentations[…] [handbook.ggcmedicines.org.uk]