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84 Possible Causes for Impaired Exercise Tolerance, Iron Increased

  • Aplastic Anemia

    We studied 4 adult AA patients who had transfusion-induced iron overload and showed hematological improvement after ICT with oral deferasirox.[ncbi.nlm.nih.gov] Stainable iron is usually increased; however, the presence of increased ringed sideroblasts suggests a diagnosis of MDS.[cancertherapyadvisor.com] Adequate iron chelation can decrease serum ferritin levels and may improve hepatic T2*, cardiac T2*, and LVEF levels.[ncbi.nlm.nih.gov]

  • Iron Deficiency Anemia

    This is because your need for iron increases during these times of growth and development.[web.archive.org] Increased demand: Iron deficiency can occur during rapid periods of growth.[irondisorders.org] […] to increase the iron in your body.[nhlbi.nih.gov]

  • Cystic Fibrosis

    The current management of this condition includes the use of regular red blood cell transfusions and iron chelation therapy.[ncbi.nlm.nih.gov] The development of an effective therapy to increase hemoglobin levels in homozygous β-thalassemia, without the use of red blood cell transfusions, could allow normal growth[ncbi.nlm.nih.gov] […] and development while decreasing or eliminating transfusional iron overload, which is the leading life-threatening factor in patients with this disease.[ 134 ] Butyrate analogs[ncbi.nlm.nih.gov]

  • Acute Myelocytic Leukemia

    An iron stain usually shows increased iron stores and may show ring sideroblasts (Figure 2, B [inset]).[archivesofpathology.org] The potential for neurotoxicity has aroused concern about the use of high-dose cytarabine in elderly patients who, ironically, have a higher likelihood of having drug-resistant[doi.org] […] in the patients who received high-dose cytarabine in our trial 45 ; the risk of neurotoxicity was less than 1 percent if none or one of these factors was present, but it increased[doi.org]

  • Viral Hepatitis

    Viral hepatitis is liver inflammation due to a viral infection. It may present in acute form as a recent infection with relatively rapid onset, or in chronic form. The most common causes of viral hepatitis are the five unrelated hepatotropic viruses hepatitis A, B, C, D, and E. Other viruses can also cause liver[…][en.wikipedia.org]

  • Acute Myeloid Leukemia with Myelodysplasia-related Changes

    Mitochondrial pathology in MDS is suggested by abnormal mitochondrial iron accumulation, increased apoptosis, and a high frequency of acquired mitochondrial DNA mutations[ncbi.nlm.nih.gov]

  • Acute Lymphoblastic Leukemia

    Acute lymphocytic leukemia (ALL), otherwise referred to as acute lymphoblastic leukemia or acute lymphoid leukemia, is a hematopoietic malignancy that involves the overproduction of cancerous white blood cells in the bone marrow. Acute lymphoblastic leukemia is a type of malignancy that most commonly affects children.[…][symptoma.com]

  • Anemia

    Often athletes who are concerned about being iron deficient or think that increased iron levels can increase performance will jump immediately to iron supplements.[trainingpeaks.com] Increased hepcidin levels long before active disease, indicating altered iron metabolism, may be a marker for developing disease among TB-exposed individuals.[ncbi.nlm.nih.gov] The erythrocytes are hypochromic and microcytic and the iron binding capacity is increased. 280 Iron deficiency anemias 280.0 Iron deficiency anemia secondary to blood loss[icd9data.com]

  • Hemochromatosis-related Cardiomyopathy

    There is a linear correlation between alcohol intake and serum iron indices and increased iron absorption in alcoholics.[patient.info] […] by gene mutations involving iron metabolism, leading to increase iron uptake in the gastrointestinal tract.[wikiecho.org] Iron injections in mice increase skeletal muscle iron content, induce oxidative stress and reduce exercise performance. Experimental physiology, 94(6), 720-730.[en.wikibooks.org]

  • Anemia of Chronic Disease

    […] progression; Increased cardiovascular morbidity and mortality ; Reduced exercise tolerance, angina, and worsening of heart failure (where this already exists); Poorer organ[myvmc.com] The TIBC is high in IDA (which makes sense – there’s little iron around, so the capacity for binding iron increases).[pathologystudent.com] The most characteristic feature is the increase of non-heme iron storage.[symptoma.com]

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