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12 Possible Causes for Impaired Exercise Tolerance, Iron Increased, Reticulocyte Count Decreased

  • Iron Deficiency Anemia

    Normal 0.5-1.5% Hypoprolifearative: Decreased reticulocytes Bone marrow unable to produce requisite number of RBC's Lack of essential substance (iron, B12, folate) or invasion[meddean.luc.edu] This is because your need for iron increases during these times of growth and development.[web.archive.org] Increased demand: Iron deficiency can occur during rapid periods of growth.[irondisorders.org]

  • Aplastic Anemia

    For example, for a person with anemia, an inappropriately low reticulocyte count often indicates decrease in red blood cell production in the bone marrow .[labtestsonline.org] We studied 4 adult AA patients who had transfusion-induced iron overload and showed hematological improvement after ICT with oral deferasirox.[ncbi.nlm.nih.gov] Stainable iron is usually increased; however, the presence of increased ringed sideroblasts suggests a diagnosis of MDS.[cancertherapyadvisor.com]

  • Acute Myelocytic Leukemia

    An iron stain usually shows increased iron stores and may show ring sideroblasts (Figure 2, B [inset]).[archivesofpathology.org] The potential for neurotoxicity has aroused concern about the use of high-dose cytarabine in elderly patients who, ironically, have a higher likelihood of having drug-resistant[doi.org] […] in the patients who received high-dose cytarabine in our trial 45 ; the risk of neurotoxicity was less than 1 percent if none or one of these factors was present, but it increased[doi.org]

  • Acute Myeloid Leukemia with Myelodysplasia-related Changes

    Mitochondrial pathology in MDS is suggested by abnormal mitochondrial iron accumulation, increased apoptosis, and a high frequency of acquired mitochondrial DNA mutations[ncbi.nlm.nih.gov]

  • Anemia

    For example, for a person with anemia, an inappropriately low reticulocyte count often indicates decrease in red blood cell production in the bone marrow.[labtestsonline.org] […] include fatigue, pallor, tachycardia, poor exercise tolerance, and suboptimal work performance. 14 Depleted blood reserves during delivery may increase the need for blood[bloodjournal.org] Often athletes who are concerned about being iron deficient or think that increased iron levels can increase performance will jump immediately to iron supplements.[trainingpeaks.com]

  • Myelodysplasia

    Red blood cells contain iron, so if you have a lot of blood transfusions, the level of iron in your body will increase.[macmillan.org.uk] Patients with significant, refractory, or chronic anemia eventually develop iron overload due to transfusions and/or increased iron absorption from the gut.[merckmanuals.com] (iron laden mitochondria visible as perinuclear granules with Prussian iron stain), megaloblastoid nuclear maturation, nuclear budding abnormalities (polypoid outlines, internuclear[pathologyoutlines.com]

  • Primary Myelofibrosis

    , and polychromatophilia and very elevated reticulocyte counts can occur. 263,264 The antiglobulin (Coombs) test usually is negative, but red cell autoantibodies can develop[patient-help.com] […] for the increase in hemoglobin levels.[ncbi.nlm.nih.gov] […] growth of the supporting fibrous tissue network leading to formation of abnormal cells and decreased numbers of cells. lack of iron making RBC formation difficult spread[news-medical.net]

  • Myeloproliferative Disease

    […] mean normal predicted value. 9.  Increased RBC count and Hgb levels (except when iron deficient)  Elevated RBC mass  Panmyelosis in the bone marrow  Low EPO level  Positive[slideshare.net] ., iron deficiency or bleeding).[medindia.net] In this situation, the patient is iron deficient from chronic blood loss, effectively performing auto-phlebotomy.[clinlabnavigator.com]

  • Anemia of Chronic Disease

    […] in hemoglobin; usually not severe MCV usually normal, but may be slightly decreased Reticulocyte count not appropriately increased for anemia RBCs usually normocytic & normochromic[quizlet.com] […] progression; Increased cardiovascular morbidity and mortality ; Reduced exercise tolerance, angina, and worsening of heart failure (where this already exists); Poorer organ[myvmc.com] The TIBC is high in IDA (which makes sense – there’s little iron around, so the capacity for binding iron increases).[pathologystudent.com]

  • Severe Aplastic Anemia

    In SAA patients, complete blood count and reticulocyte count usually reveal pancytopenia and decreased levels of reticulocytes; lymphopenia is rare.[symptoma.com] Stainable iron is usually increased; however, the presence of increased ringed sideroblasts suggests a diagnosis of MDS.[cancertherapyadvisor.com] For example, for a person with anemia, an inappropriately low reticulocyte count often indicates decrease in red blood cell production in the bone marrow .[labtestsonline.org]

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