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10 Possible Causes for Impaired Exercise Tolerance, Leukopenia, Peripheral T Cells Decreased

  • Aplastic Anemia

    Symptoms result from anemia, thrombocytopenia (petechiae, bleeding), or leukopenia (infections).[merckmanuals.com] MATERIALS AND METHODS: A total of 41 patients with AA and 46 patients with hypo-MDS were collected, and the proportions of peripheral blood T lymphocyte subsets, CD3 - CD16[ncbi.nlm.nih.gov] The regimen has a low incidence of bone marrow suppression, and the incidences of anemia, leukopenia, neutropenia and thrombocytopenia exceeding grade 3 are less than 5%.[ncbi.nlm.nih.gov]

  • Follicular Lymphoma

    […] develops any systemic symptoms.Another set of symptoms which may occur in the later stages of the condition are those depicting dysfunction of the bone marrow such as anemia, leukopenia[symptoma.com] In this context, it may be a potentially important observation that the fraction of circulating Tregs, the most important cell population to maintain peripheral tolerance,[doi.org] Symptoms related to bone marrow dysfunction, such as anemia, leukopenia, or thrombocytopenia, are rare at presentation but can also be observed in the later stages of the[emedicine.com]

  • Severe Aplastic Anemia

    Symptoms result from anemia, thrombocytopenia (petechiae, bleeding), or leukopenia (infections).[msdmanuals.com] Results showed that the percentage of CD4 effector T cells in peripheral blood and bone marrow lymphocytes was decreased in SAA patients.[ncbi.nlm.nih.gov] […] cell count (anemia) can cause: Fatigue Pallor (paleness) Rapid heart rate Shortness of breath with exercise Weakness Lightheadedness upon standing Low white cell count (leukopenia[mountsinai.org]

  • Systemic Lupus Erythematosus

    Drugs causing leukopenia Some drugs may lead to leukopenia.[news-medical.net] exercise tolerance are nonspecific.[journals.lww.com] Decreased T cell precursor frequencies to Epstein–Barr virus glycoprotein Gp110 in peripheral blood correlate with disease activity and severity in patients with rheumatoid[ncbi.nlm.nih.gov]

  • Graves Disease

    Side effects of MMI occur in up to 28% of children. 72 The most common side effects are mild, such as transient elevations of liver enzymes, mild and transient leukopenia,[pediatrics.aappublications.org] Notably, HLA-DR14, a known risk factor for GD in Japanese individuals and the decreased regulatory T-cell numbers that were seen in the pediatric case, may affect the early[ncbi.nlm.nih.gov] Central and peripheral tolerance and Th1 cells appeared to be associated with the pathogenesis of GD in 22qDS.[ncbi.nlm.nih.gov]

  • Chronic Phase of Chronic Myeloid Leukemia

    […] hematologic adverse effects were observed in imatinib resistant or imatinib intolerant patients with CML, e.g. thrombocytopenia (48%), anemia (22%), neutropenia (49%), and leukopenia[intechopen.com] The proportion of natural killer cells and cytotoxic T cells in peripheral lymphocytes increased after switching to dasatinib.[ncbi.nlm.nih.gov] In contrast, the proportion of regulatory T cells decreased during treatment. The safety profile of dasatinib was consistent with previous studies.[ncbi.nlm.nih.gov]

  • Lupus Erythematosus

    Hematologic evaluation typically reveals anemia, leukopenia, and thrombocytopenia. Urinalysis typically reveals proteinuria, hematuria, and casts.[epilepsy.com] exercise tolerance are nonspecific.[journals.lww.com] Apoptosis rate increased in parallel to the drop-down of elevated CD5 CD19 cells. Peripheral T-cell subsets remained stable under low-dose MTX.[ncbi.nlm.nih.gov]

  • Multiple Sclerosis

    In the fingolimod group, leukopenia was presumably related to lymphocyte sequestration, which is attributable to the mode of action of fingolimod.[nejm.org] This article reviews the literature related to MS and physical exercise. Physical exercise depends on patients' physiological tolerance and response to exercise.[ncbi.nlm.nih.gov] Immunologic changes included a marked decrease in proliferation of interferon γ–producing myelin-reactive CD4 T cells in peripheral blood and decreased titers of myelin-specific[oadoi.org]

  • Septic Shock

    Predisposing factors include Leukopenia (especially that associated with cancer or treatment with cytotoxic drugs) Invasive devices (including endotracheal tubes, vascular[merckmanuals.com] Brain injury can lead to stroke and thought impairment. Heart and lung damage can lead to significant disabilities that may include reduced exercise tolerance.[emedicinehealth.com] The patient presented a remarkable cell activation profile and diminished percentage of peripheral blood T regulatory cells.[ncbi.nlm.nih.gov]

  • Multidrug-resistant Tuberculosis

    Other nephrotoxic drugs, such as NSAIDs, should be avoided in this situation where possible. 11.5 Haematological Several drugs cause anaemia, leukopenia and thrombocytopenia[erj.ersjournals.com] […] induction from CD25 peripheral blood T cells by IL-4 ( 53 ).[iai.asm.org] The production of tumour necrosis factor-alpha is decreased in peripheral blood mononuclear cells from multidrug-resistant tuberculosis patients following stimulation with[iai.asm.org]

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