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21 Possible Causes for Impaired Exercise Tolerance, Massive Splenomegaly, Pancytopenia

  • Primary Myelofibrosis

    She also underwent splenectomy when she was 13 years old, due to massive splenomegaly, anemia and various infection disease episodes.[ncbi.nlm.nih.gov] This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[aoporphan.com] Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm characterized by progressive anemia, massive splenomegaly, leukoerythroblastosis, extramedullary hematopoiesis[ncbi.nlm.nih.gov]

  • Myeloproliferative Disease

    Splenomegaly, sometimes massive, is a characteristic finding. Symptoms include the following: Splenic pain. Early satiety. Anemia. Bone pain. Fatigue. Fever.[northshore.org] Four years later, at the age of 16, her brother was diagnosed as having acute myelofibrosis, and some months afterwards he died from fulminant pneumonia coincidently with pancytopenia[ncbi.nlm.nih.gov] ( D61.82 ) pancytopenia (due to) (with) congenital (pure) red cell aplasia ( D61.01 ) pancytopenia (due to) (with) hairy cell leukemia ( C91.4- ) pancytopenia (due to) (with[icd10data.com]

  • Chronic Lymphocytic Leukemia

    splenomegaly and occasionally lymphadenopathy; prognosis is often poor.[medical-dictionary.thefreedictionary.com] Brentuximab vedotin had a transient effect, but the patient died of sepsis due to residual PTCL and pancytopenia.[ncbi.nlm.nih.gov] The symptoms of this infection range from a silent infection to fever, enlargement of the liver and spleen, weight loss, and pancytopenia.[ncbi.nlm.nih.gov]

  • Chronic Myeloid Leukemia

    Here, we report a case of aCMLin a 5-month baby who presented with massive splenomegaly. The diagnosis was in accordance with the WHO criteria established in 2008.[ncbi.nlm.nih.gov] We present a case of 29-year-old white male farmer, with chronic myeloid leukemia treated with imatinib who developed significant pancytopenia, leading to discontinuation[ncbi.nlm.nih.gov] Chronic myeloid leukemia (CML) is a chronic myeloproliferative disorder that usually presents with high white blood cell counts and massive splenomegaly.[ncbi.nlm.nih.gov]

  • Mantle Cell Lymphoma

    Splenomegaly is often massive, while aberrant WBC count may be seen, either as markedly high leukocytosis or pancytopenia.[symptoma.com] Splenomegaly is often massive, while aberrant WBC count may be seen, either as markedly high leukocytosis or pancytopenia.[symptoma.com] The clinical presentation involves generalized lymphadenopathy, splenomegaly that is often massive and systemic symptoms, primarily because the vast majority of patients are[symptoma.com]

  • Philadelphia Chromosome Positive Chronic Myeloid Leukemia

    […] included thrombocytopenia (n 8), diarrhea (n 3), alanine aminotransferase elevation (n 3), aspartate aminotransferase elevation (n 2), dyspnea (n 2), neutropenia (n 2), pancytopenia[bloodjournal.org]

  • Chronic Phase of Chronic Myeloid Leukemia

    Shima H 1, 2 , Kiyokawa N 3 , Miharu M 3 , Tanizawa A 4 , Kurosawa H 5 , Watanabe A 6 , Ito M 7 , Tono C 8 , Yuza Y 9 , Muramatsu H 10 , Hotta N 11 , Okada M 12 , Hamamoto K 13 , Kajiwara R 14 , Saito AM 2 , Horibe K 2 , Mizutani S 15 , Adachi S 16 , Ishii E 17 , Shimada H 1 . Author information 1 Department of Pediatrics,[…][ncbi.nlm.nih.gov]

  • Myelodysplasia

    splenomegaly (day 5) and a history of such events, and one to pneumonia without neutropenia (week 20).[doi.org] A 41-year-old patient manifested pancytopenia with macrocytosis following pesticide exposure. She was later found to have myelodysplasia with trisomy 15.[ncbi.nlm.nih.gov] Hudspeth and John Lazarchick, Pancytopenia with myelodysplasia due to copper deficiency, Pediatric Blood & Cancer, 51, 5, (693-695), (2008). George J.[doi.org]

  • Familial Myelofibrosis

    Massive splenomegaly 22 cm may predict TRM and relapse (Bacigalupo et al, 2010 ).[onlinelibrary.wiley.com] The illness presented with pallor, haemorrhagic symptoms, and hepatosplenomegaly, and the blood picture was that of pancytopenia and leucoerythroblastosis.[ncbi.nlm.nih.gov] Pancytopenia and leukoerythroblastosis require further clarification and should prompt a bone marrow biopsy.[symptoma.com]

  • Amyloidosis

    The deaths in the placebo group were due to ischemic stroke, amyloid cardiomyopathy, bowel perforation, sepsis, and pancytopenia in one patient each.[doi.org]

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