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511 Possible Causes for Impaired Exercise Tolerance, Mutation in the Hereditary Hemochromatosis Gene

  • Congestive Heart Failure

    The impairment of exercise tolerance indicated by NYHA classification was markedly improved by PD for both groups.[ncbi.nlm.nih.gov] The actuarial survival rates of persons who are homozygous for the mutation of the hemochromatosis gene C282Y have been reported to be 95%, 93%, and 66%, at 5, 10, and 20[doi.org] Numerous mechanisms unrelated to hemodynamic dysfunction may underlie impaired exercise tolerance in patients with chronic heart failure.[doi.org]

  • Heart Failure

    Numerous mechanisms unrelated to hemodynamic dysfunction may underlie impaired exercise tolerance in patients with chronic heart failure.[doi.org] The actuarial survival rates of persons who are homozygous for the mutation of the hemochromatosis gene C282Y have been reported to be 95%, 93%, and 66%, at 5, 10, and 20[doi.org] […] of life, including dyspnoea, fatigue, poor exercise tolerance and fluid retention.[radcliffecardiology.com]

  • Hemochromatosis-related Cardiomyopathy

    Classic hereditary hemochromatosis is caused by mutations of the HFE gene.[rarediseases.org] Gene assay is diagnostic of hereditary hemochromatosis caused by HFE gene mutations.[merckmanuals.com] […] similar to classic hereditary hemochromatosis.[karger.com]

  • Restrictive Cardiomyopathy

    Cardiac Hemochromatosis Hereditary hemochromatosis (HH) is caused by increased absorption of dietary iron, which accumulates in various organs, leading to their dysfunction[circres.ahajournals.org] Several mutations in genes involving iron absorption and metabolism can cause HH and influence clinical manifestations, severity of disease, and response to therapy.[circres.ahajournals.org]

  • Anemia

    […] include fatigue, pallor, tachycardia, poor exercise tolerance, and suboptimal work performance. 14 Depleted blood reserves during delivery may increase the need for blood[bloodjournal.org] Low cobalamin is associated with an increased fetal risk of low lean mass and excess adiposity, increased insulin resistance, and impaired neurodevelopment. 13 Maternal risks[bloodjournal.org]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Anemia of Chronic Disease

    […] progression; Increased cardiovascular morbidity and mortality ; Reduced exercise tolerance, angina, and worsening of heart failure (where this already exists); Poorer organ[myvmc.com] Peripheral blood DNA from the patients was genotyped for the C282Y and H63D HFE gene mutations associated with hereditary hemochromatosis using TaqMan technology and an ABI[haematologica.org] Chronic Kidney Disease Patients with chronic kidney disease that have coexisting anaemia experience: Reduced quality of life; Cognitive impairment; Sleep disturbance; Disease[myvmc.com]

  • Obesity

    […] counselling; educational package Broom w3 531 with hypertension, impaired glucose tolerance, or dyslipidaemia, 1 year follow-up (UK) 46 37.1 101 Orlistat 120 mg three times[ncbi.nlm.nih.gov] A, the nutrition professional will focus on a dietary regimen tailored to the patient with impaired glucose tolerance or emerging type 2 diabetes.[cmaj.ca] […] counselling XENDOS w16 3305 patients (21% with impaired glucose tolerance), 4 year follow-up (Sweden) 43 37.3 111 Orlistat 120 mg three times daily (n 1650); placebo (n 1655[ncbi.nlm.nih.gov]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Hypoglycemia

    An 84-year-old Japanese woman with metastatic insulinoma suffered from frequent hypoglycemic events. Continuous glucose monitoring (CGM) confirmed severe and frequent symptomatic/asymptomatic hypoglycemia. After the initiation of everolimus treatment, the hypoglycemic events were rapidly eliminated. CGM revealed[…][ncbi.nlm.nih.gov]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Chronic Obstructive Pulmonary Disease

    It has not helped us understand why some patients with severe FEV1 impairment have better exercise tolerance compared with others with similar FEV1 values.[ncbi.nlm.nih.gov] Pharmacological therapy is aimed at relieving symptoms; improving exercise tolerance and quality of life; slowing decline and even improving lung function; or preventing or[doi.org] Pharmacological therapy is aimed at relieving symptoms, improving exercise tolerance and quality of life, slowing decline and even improving lung function, or preventing and[doi.org]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Iron Deficiency Anemia

    SHERSTEN KILLIP, M.D., M.P.H., JOHN M. BENNETT, M.D., M.P.H., and MARA D. CHAMBERS, M.D., University of Kentucky, Lexington, Kentucky Am Fam Physician. 2007 Mar 1;75(5):671-678. Patient information: See a related handouts on this topic at . The prevalence of iron deficiency anemia is 2 percent in adult men, 9 to 12 percent[…][aafp.org]

    Missing: Mutation in the Hereditary Hemochromatosis Gene

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