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842 Possible Causes for Impaired Exercise Tolerance, Mutation in the Hereditary Hemochromatosis Gene, Nocturnal Paroxysmal Dyspnea

  • Congestive Heart Failure

    Features due to left heart failure: Dyspnea, orthopnea and paroxysmal nocturnal dyspnea: These symptoms develop due to congestion of the lungs.[symptoma.com] The impairment of exercise tolerance indicated by NYHA classification was markedly improved by PD for both groups.[ncbi.nlm.nih.gov] The actuarial survival rates of persons who are homozygous for the mutation of the hemochromatosis gene C282Y have been reported to be 95%, 93%, and 66%, at 5, 10, and 20[doi.org]

  • Heart Failure

    Major criteria: · Paroxysmal nocturnal dyspnea · Neck vein distention · Rales · Radiographic cardiomegaly (increasing heart size on chest radiography) · Acute pulmonary edema[web.archive.org] Numerous mechanisms unrelated to hemodynamic dysfunction may underlie impaired exercise tolerance in patients with chronic heart failure.[doi.org] The actuarial survival rates of persons who are homozygous for the mutation of the hemochromatosis gene C282Y have been reported to be 95%, 93%, and 66%, at 5, 10, and 20[doi.org]

  • Cardiomyopathy

    Symptoms: Patients with cardiomyopathy will typically present with dyspnea, orthopnea, paroxysmal nocturnal dyspnea, bilateral edema, and fatigue.[symptoma.com] These symptoms of heart failure most commonly include dyspnea , orthopnea , paroxysmal nocturnal dyspnea , and fluid retention. How Is Postpartum Cardiomyopathy Treated?[verywellhealth.com] nocturnal dyspnea, and edema.[aafp.org]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Coronary Atherosclerosis

    New York Heart Association class II-IV), and prediabetes (patients had impaired glucose tolerance and impaired fasting glucose with a balanced profile of obesity and cardiovascular[doi.org] […] glucose tolerance and impaired fasting glucose—that is, prediabetes. 36 Comparability of trial and patient population characteristics Conceptual heterogeneity between drug[doi.org] […] disease risk factors across exercise and drug trials).[doi.org]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Aortic Valve Stenosis

    Other symptoms associated with AS are related to cardiac failure, such as paroxysmal nocturnal dyspnea, orthopnea, and dyspnea on exertion.[symptoma.com] The patient also presented dyspnea on minimal exertion, orthopnea, paroxysmal nocturnal dyspnea and edema of lower limbs. The patient denied fever.[web.archive.org] The clinical picture consists of the SAD triad: syncope upon physical exertion, angina and dyspnea.[symptoma.com]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Ischemic Cardiomyopathy

    Pulmonary congestion reduces when the patient is in erect position, it results in improvement in symptoms. [1],[2],[5] Paroxysmal nocturnal dyspnea Paroxysmal nocturnal dyspnea[explainmedicine.com] The cardinal manifestations of HF are dyspnea and fatigue, which may limit exercise tolerance, and fluid retention, which may lead to pulmonary congestion and peripheral edema[doi.org] nocturnal dyspnea) Chest pain or pressure may be present along with the above symptoms Fatigue and weakness are commonly associated with cardiomyopathy Dizziness and lightheadedness[dovemed.com]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Aortic Valve Insufficiency

    As the disease progresses, orthopnea and paroxysmal nocturnal dyspnea start to occur. Angina is predominantly nocturnal in these patients.[symptoma.com] In addition, physicians may have a lower threshold for referring a patient for AVR after a treadmill test in which the patient had impaired exercise tolerance, presumed symptoms[content.onlinejacc.org] Symptoms of aortic insufficiency are similar to those of heart failure and include the following: Dyspnea on exertion Orthopnea Paroxysmal nocturnal dyspnea Palpitations Angina[en.wikipedia.org]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Dilated Cardiomyopathy

    The following are the symptoms with which a patient may present: fatigue, orthopnea, dyspnea on exertion, paroxysmal nocturnal dyspnea, increasing edema, weight gain, or an[symptoma.com] At presentation she had dyspnea at rest, orthopnea and paroxysmal nocturnal dyspnea.[doi.org] nocturnal dyspnea) and/or reduced cardiac output (fatigue, shortness of breath, dyspnea, on exertion); arrhythmia and/or conduction system disease (CSD), including syncope[nature.com]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Mitral Valve Insufficiency

    Patients may be asymptomatic or may have manifestations like fatigue caused by reduced cardiac output, tachypnea or dyspnea, orthopnea, paroxysmal nocturnal dyspnea and hemoptysis[symptoma.com] nocturnal dyspnea), as well as symptoms of cardiogenic shock (i.e., shortness of breath at rest).[en.wikipedia.org] When the legs are elevated at night, the fluid redistributes centrally, causing pulmonary edema and resulting in orthopnea (dyspnea while lying flat) or paroxysmal nocturnal[healio.com]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Primary Cardiomyopathy

    nocturnal dyspnea, and edema.[aafp.org] […] atrial fibrillation (Paf)発作性心房細動 paroxysmal nocturnal dyspnea発作性夜間呼吸困難 paroxysmal supraventricular tachycardia(PSVT)発作性上室性頻拍 paroxysmal ventricular tachycardia (PVT)発作性心室頻拍[tokyo-med.ac.jp] Symptoms of heart failure may include shortness of breath, fatigue, cough, orthopnea, paroxysmal nocturnal dyspnea, and edema.[aafp.org]

    Missing: Mutation in the Hereditary Hemochromatosis Gene