Danon Disease
[…] clusters of autophagic vacuoles, indicative of autolysosomes.[ncbi.nlm.nih.gov]
However, the first muscle biopsy with large cytoplasmic vacuoles confused the diagnosis and led to the second biopsy that allowed for the final diagnosis.[ncbi.nlm.nih.gov]
Two patients underwent heart transplantation; histology of explanted hearts demonstrated severe interstitial fibrosis, hypertrophic cardiomyocytes with cytoplasmic vacuoles[ncbi.nlm.nih.gov]
Rhabdomyoma of the Myocardium
. - Purkinje cell tumour ( Foamy myocardial transformation) - Hamartoma (no cytoplasmic vacuolation). Pinterest -(drsampurna)[histopathology-india.net]
However, the cytoplasmic vacuoles tend to be central, with myofibrils at the periphery.[cttr.org]
September 2012 AWG Rating : Modality : Photomicrograph Description : High-power-field protomicrograph of a cardiac rhabdomyoma in a different patient, showing the enlarged and vacuolated[ipccc.net]
Anemia
As demyelination and vacuolation increase, axons degenerate. Gliosis may be present in older lesions.[web.archive.org]
[…] include fatigue, pallor, tachycardia, poor exercise tolerance, and suboptimal work performance. 14 Depleted blood reserves during delivery may increase the need for blood[bloodjournal.org]
Microscopic: Multifocal vacuolated and demyelinated lesions exist in the white matter of the posterior and lateral columns.[web.archive.org]
Barth Syndrome
Membrane-bound vacuoles were seen in neutrophil bone marrow cells. Intramuscular fat droplets were increased in type I skeletal muscle fibres.[ncbi.nlm.nih.gov]
[…] extraction/utilization, exercise tolerance and quality of life in these individuals.[clinicaltrials.gov]
L. (2008) Cardiolipin mediates cross-talk between mitochondria and the vacuole. Mol. Biol. Cell 19, 5047 – 5058. 5. Zhou, J., Zhong, Q., Li, G., and Greenberg, M.[asbmb.org]
Acute Myeloid Leukemia with Myelodysplasia-related Changes
vacuoles, and periodic acid-Schiff positivity Dysgranulopoiesis: neutrophils with hypogranular cytoplasm, hyposegmented or bizarrely segmented nuclei Dysmegakaryocytopoiesis[symptoma.com]
[…] include the following: Medium- to large-sized erythroblasts with round nuclei, fine chromatin, one or more nucleoli, deeply basophilic cytoplasm, and occasional coalescent vacuoles[northshore.org]
The following features may be observed: Dyserythropoiesis: megablastosis, karyorrhexis and nuclear irregularity, fragmentation or multinucleation, ring sideroblasts, cytoplasmic[symptoma.com]
Heart Failure
RESULTS: The patient was found to have extensive vacuolization caused by giant ring mitochondria on endomyocardial biopsy.[ncbi.nlm.nih.gov]
Numerous mechanisms unrelated to hemodynamic dysfunction may underlie impaired exercise tolerance in patients with chronic heart failure.[doi.org]
[…] of life, including dyspnoea, fatigue, poor exercise tolerance and fluid retention.[radcliffecardiology.com]
Iron Deficiency Anemia
The IDA isolates had significantly higher expression of vacuolating cytotoxin gene vacA than non-IDA isolates, consistent with the results of VacA protein assays.[ncbi.nlm.nih.gov]
Chronic Fatigue Syndrome
Histological and electron-microscopic studies revealed vacuolated cells with distorted nuclei and various cytoplasmic inclusions suggestive of incomplete viral expression.[ncbi.nlm.nih.gov]
Subjective reports of PEM and prolonged recovery are supported by objective evidence, including failure to normally reproduce exercise test results (2-day CPET) and impaired[nap.edu]
Summary PEM is a worsening of a patient’s symptoms and function after exposure to physical or cognitive stressors that were normally tolerated before disease onset.[nap.edu]
Cardiomyopathy
The mechanism of myocardial injury is related to degeneration and atrophy of myocardial cells, with loss of myofibrils and cytoplasmic vacuolization.[emedicine.medscape.com]
Triglyceride-containing cytoplasmic droplets Diabetes Hypertriglyceridemia Muscle pathology Lipid storage Type 1 & 2 fibers, or More in Type 1 May be predominantly subsarcolemmal Autophagic vacuoles[neuromuscular.wustl.edu]
Myelodysplasia
, megaloblastoid nuclear maturation, nuclear budding abnormalities (polypoid outlines, internuclear bridging, nuclear fragments, multinuclearity, nuclear hyperlobation), cytoplasmic[pathologyoutlines.com]
[…] include HIV, autoimmune and congenital Non-neoplastic disorders may simulate myelodysplasia Vitamin/micronutrient deficiencies B12/folate Copper Ring sideroblasts present Cytoplasmic[surgpathcriteria.stanford.edu]
[…] percursors and karyorrhexis Erythroid nuclear budding Erythroid nuclear strings or internuclear bridging (also seen in congenital dyserythropoietic anemias) PAS (globular in vacuoles[wiki.clinicalflow.com]