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107 Possible Causes for Impaired Exercise Tolerance, Vacuolization

  • Danon Disease

    […] clusters of autophagic vacuoles, indicative of autolysosomes.[] However, the first muscle biopsy with large cytoplasmic vacuoles confused the diagnosis and led to the second biopsy that allowed for the final diagnosis.[] Two patients underwent heart transplantation; histology of explanted hearts demonstrated severe interstitial fibrosis, hypertrophic cardiomyocytes with cytoplasmic vacuoles[]

  • Rhabdomyoma of the Myocardium

    . - Purkinje cell tumour ( Foamy myocardial transformation) - Hamartoma (no cytoplasmic vacuolation). Pinterest -(drsampurna)[] However, the cytoplasmic vacuoles tend to be central, with myofibrils at the periphery.[] September 2012 AWG Rating : Modality : Photomicrograph Description : High-power-field protomicrograph of a cardiac rhabdomyoma in a different patient, showing the enlarged and vacuolated[]

  • Anemia

    As demyelination and vacuolation increase, axons degenerate. Gliosis may be present in older lesions.[] […] include fatigue, pallor, tachycardia, poor exercise tolerance, and suboptimal work performance. 14 Depleted blood reserves during delivery may increase the need for blood[] Microscopic: Multifocal vacuolated and demyelinated lesions exist in the white matter of the posterior and lateral columns.[]

  • Barth Syndrome

    Membrane-bound vacuoles were seen in neutrophil bone marrow cells. Intramuscular fat droplets were increased in type I skeletal muscle fibres.[] […] extraction/utilization, exercise tolerance and quality of life in these individuals.[] L. (2008) Cardiolipin mediates cross-talk between mitochondria and the vacuole. Mol. Biol. Cell 19, 5047 – 5058. 5. Zhou, J., Zhong, Q., Li, G., and Greenberg, M.[]

  • Acute Myeloid Leukemia with Myelodysplasia-related Changes

    vacuoles, and periodic acid-Schiff positivity Dysgranulopoiesis: neutrophils with hypogranular cytoplasm, hyposegmented or bizarrely segmented nuclei Dysmegakaryocytopoiesis[] […] include the following: Medium- to large-sized erythroblasts with round nuclei, fine chromatin, one or more nucleoli, deeply basophilic cytoplasm, and occasional coalescent vacuoles[] The following features may be observed: Dyserythropoiesis: megablastosis, karyorrhexis and nuclear irregularity, fragmentation or multinucleation, ring sideroblasts, cytoplasmic[]

  • Heart Failure

    RESULTS: The patient was found to have extensive vacuolization caused by giant ring mitochondria on endomyocardial biopsy.[] Numerous mechanisms unrelated to hemodynamic dysfunction may underlie impaired exercise tolerance in patients with chronic heart failure.[] […] of life, including dyspnoea, fatigue, poor exercise tolerance and fluid retention.[]

  • Iron Deficiency Anemia

    The IDA isolates had significantly higher expression of vacuolating cytotoxin gene vacA than non-IDA isolates, consistent with the results of VacA protein assays.[]

  • Chronic Fatigue Syndrome

    Histological and electron-microscopic studies revealed vacuolated cells with distorted nuclei and various cytoplasmic inclusions suggestive of incomplete viral expression.[] Subjective reports of PEM and prolonged recovery are supported by objective evidence, including failure to normally reproduce exercise test results (2-day CPET) and impaired[] Summary PEM is a worsening of a patient’s symptoms and function after exposure to physical or cognitive stressors that were normally tolerated before disease onset.[]

  • Cardiomyopathy

    The mechanism of myocardial injury is related to degeneration and atrophy of myocardial cells, with loss of myofibrils and cytoplasmic vacuolization.[] Triglyceride-containing cytoplasmic droplets Diabetes Hypertriglyceridemia Muscle pathology Lipid storage Type 1 & 2 fibers, or More in Type 1 May be predominantly subsarcolemmal Autophagic vacuoles[]

  • Myelodysplasia

    , megaloblastoid nuclear maturation, nuclear budding abnormalities (polypoid outlines, internuclear bridging, nuclear fragments, multinuclearity, nuclear hyperlobation), cytoplasmic[] […] include HIV, autoimmune and congenital Non-neoplastic disorders may simulate myelodysplasia Vitamin/micronutrient deficiencies B12/folate Copper Ring sideroblasts present Cytoplasmic[] […] percursors and karyorrhexis Erythroid nuclear budding Erythroid nuclear strings or internuclear bridging (also seen in congenital dyserythropoietic anemias) PAS (globular in vacuoles[]

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