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50 Possible Causes for Impaired Lipolysis

  • Cold Exposure

    Lack of PEMT did not impair the capacity for thermogenesis in skeletal muscle or brown adipose tissue.[ncbi.nlm.nih.gov] Plasma catecholamines were not altered by Pemt genotype, and stimulation of lipolysis was intact in brown and white adipose tissue of Pemt(-/-) mice.[ncbi.nlm.nih.gov]

  • Obesity

    When more calories become available, particularly from fat, these hormonal changes may impair the individual's ability to respond by increasing fat oxidation.[doi.org] […] plasma IGF-1 levels, increased plasma cortisol and a relative reduction in plasma insulin concentrations ( Torun and Chew 1999 ) are consistent with an inhibitory effect on lipolysis[doi.org]

  • Polycystic Ovary Syndrome

    […] hyperinsulinemia with impaired suppression in lipolysis and lipid oxidation, and lower IS.[ncbi.nlm.nih.gov] Impaired adipocyte lipolysis in nonobese women with the polycystic ovary syndrome: a possible link to insulin resistance? J Clin Endocrinol Metab 1997;82:1147–53.[doi.org] Endocr Rev. 18 : 774 – 800. 16, Wahrenberg H. 1997 Impaired adipocyte lipolysis in nonobese women with the polycystic ovary syndrome: a possible link to insulin resistance[doi.org]

  • Diabetes Mellitus

    An inability to suppress lipolysis in adipose tissue increases plasma levels of free fatty acids that may impair insulin -stimulated glucose transport and muscle glycogen[merck.com]

  • Stroke

    They also stimulate inflammation by releasing cytokines and may play a role in the pathophysiology of dyslipidemia, hypertension, impaired thrombolysis, and renal damage.[doi.org] […] insulin resistance, inflammation, diabetes, and other metabolic and cardiovascular derangements. 337 Visceral adipocytes provoke insulin resistance by promoting extensive lipolysis[doi.org]

  • Hypothyroidism

    In addition, there is a marked impairment in sympathetic-mediated lipolysis in white adipose tissue ( 126 ).[ncbi.nlm.nih.gov] […] catecholamine-stimulated lipolysis in mice.[ncbi.nlm.nih.gov] J Biol Chem 278:38913–38920 [ PubMed ] [ Google Scholar ] Ying H, Araki O, Furuya F, Kato Y, Cheng SY 2007 Impaired adipogenesis caused by a mutated thyroid hormone α1 receptor[ncbi.nlm.nih.gov]

  • Liver Cirrhosis

    A previous study found that impaired re-esterification rather than accelerated lipolysis elevates FFA in LC patients[ 36 ].[dx.doi.org]

  • Meigs Syndrome

    First, insulin normally suppresses lipolysis in adipocytes, so impaired insulin signaling increases lipolysis, resulting in increased FFA levels.[dmm.biologists.org]

  • Diabetic Ketoacidosis

    Pathophysiology Alcohol diminishes hepatic gluconeogenesis and leads to decreased insulin secretion, increased lipolysis, impaired fatty acid oxidation, and subsequent ketogenesis[msdmanuals.com] Increased lipolysis, with ketone body (ß-hydroxybutyrate Pinkey JH, Bingley PJ, Sawtell PA, Dunger DB, Gale EA.[web.archive.org] Increased lipolysis, with ketone body (β-hydroxybutyrate [β-OHB] and acetoacetate) production causes ketonemia and metabolic acidosis.[doi.org]

  • Glucagonoma

    Elevated blood glucose, in turn, impairs further glucagon secretion by means of a negative feedback mechanism.[symptoma.com] Glucagon mediates an increase in hepatic glycogenolysis, gluconeogenesis and lipolysis and thus augments blood sugar levels.[symptoma.com]

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