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5 Possible Causes for Impaired Platelet Aggregation and Spreading

  • Bleeding Disorder due to CalDAG-GEFI Deficiency

    Disease Ontology : 12 An inherited blood coagulation disease characterized by autosomal recessive inheritance of mucocutaneous bleeding, prolonged and severe epistaxis, hematomas and bleeding after tooth extraction that has material basis in homozygous mutation in the RASGRP2 gene on chromosome 11q13. MalaCards[…][malacards.org]

  • Severe Autosomal Recessive Macrothrombocytopenia

    platelet aggregation to physiological agonists but not to ristocetin, normal clot retraction, reduced fibrinogen binding and expression of activated αIIbβ3 upon stimulation[moh-it.pure.elsevier.com] , normal platelet adhesion to immobilized fibrinogen but reduced platelet spreading and tyrosine phosphorylation, indicating defective αIIbβ 3-mediated outside-in signaling[moh-it.pure.elsevier.com] Results: The characteristics of our families are moderate macrothrombocytopenia and defective platelet function associated with a mild reduction of surface αIIbβ 3, impaired[moh-it.pure.elsevier.com]

  • Von Willebrand Disease Type 2B

    This dysregulated signaling impairs platelet aggregation, platelet secretion, and platelet spreading.[ncbi.nlm.nih.gov] […] to platelets (Figure 1 B).[ncbi.nlm.nih.gov] Their current work suggests a third mechanism for type 2B bleeding; thrombocytopathy as a result of dysregulated platelet signaling is a consequence of variant vWF binding[ncbi.nlm.nih.gov]

  • Von Willebrand Disease Type 2A

    This dysregulated signaling impairs platelet aggregation, platelet secretion, and platelet spreading.[jci.org] […] to platelets (Figure 1 B).[jci.org] Their current work suggests a third mechanism for type 2B bleeding; thrombocytopathy as a result of dysregulated platelet signaling is a consequence of variant vWF binding[jci.org]

  • Autosomal Dominant Thrombocytopenia 5

    Other numerous platelet abnormalities have been reported in FPD/AML including impaired platelet aggregation, decreased platelet spreading, decreased activation of alphaIIb-beta3[link.springer.com]

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