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8 Possible Causes for Impaired Platelet Aggregation and Spreading, Increased Bleeding Tendency due to Platelet Dysfunction

  • Platelet-Type Bleeding Disorder 18

    tendency due to platelet dysfunction.[malacards.org] […] disorder, platelet-type 18 (BDPLT18) [MIM:615888]: A disorder characterized by increased bleeding tendency due to platelet dysfunction.[genecards.org] Bleeding disorder, platelet-type 18 (BDPLT18) [MIM:615888]: A disorder characterized by increased bleeding tendency due to platelet dysfunction.[creative-diagnostics.com]

  • Platelet-Type Bleeding Disorder 19

    platelet aggregation to physiological agonists but not to ristocetin, normal clot retraction, reduced fibrinogen binding and expression of activated αIIbβ3 upon stimulation[moh-it.pure.elsevier.com] due to platelet dysfunction.[malacards.org] […] disorder, platelet-type 19 (BDPLT19) [MIM:616176]: A disorder characterized by increased bleeding tendency due to platelet dysfunction.[genecards.org]

  • Microcytic Anemia

    bleeding tendency due to platelet dysfunction; and acquired lack of folic acid and iron.[ncbi.nlm.nih.gov] […] number of etiologic factors have been implicated, including decreased production of erythropoietin; decreased erythrocyte life span secondary to uremia and splenomegaly; increased[ncbi.nlm.nih.gov]

    Missing: Impaired Platelet Aggregation and Spreading
  • Normocytic Normochromic Anemia

    No reticulocyte response occurs, red blood cell survival is decreased and there is an associated increased bleeding tendency due to uraemia-induced platelet dysfunction.[patient.info]

    Missing: Impaired Platelet Aggregation and Spreading
  • Von Willebrand Disease Type 2B

    This dysregulated signaling impairs platelet aggregation, platelet secretion, and platelet spreading.[ncbi.nlm.nih.gov] […] to platelets (Figure 1 B).[ncbi.nlm.nih.gov] Their current work suggests a third mechanism for type 2B bleeding; thrombocytopathy as a result of dysregulated platelet signaling is a consequence of variant vWF binding[ncbi.nlm.nih.gov]

    Missing: Increased Bleeding Tendency due to Platelet Dysfunction
  • Von Willebrand Disease Type 2A

    This dysregulated signaling impairs platelet aggregation, platelet secretion, and platelet spreading.[jci.org] […] to platelets (Figure 1 B).[jci.org] Their current work suggests a third mechanism for type 2B bleeding; thrombocytopathy as a result of dysregulated platelet signaling is a consequence of variant vWF binding[jci.org]

    Missing: Increased Bleeding Tendency due to Platelet Dysfunction
  • Normochromic Anemia

    No reticulocyte response occurs, red blood cell survival is decreased and there is an associated increased bleeding tendency due to uraemia-induced platelet dysfunction.[patient.info]

    Missing: Impaired Platelet Aggregation and Spreading
  • Autosomal Dominant Thrombocytopenia 5

    Other numerous platelet abnormalities have been reported in FPD/AML including impaired platelet aggregation, decreased platelet spreading, decreased activation of alphaIIb-beta3[link.springer.com]

    Missing: Increased Bleeding Tendency due to Platelet Dysfunction

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