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944 Possible Causes for IN, nucleus, of, protein, sequestration

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  • Idiopathic Neutropenia

    The mature neutrophil has a segmented nucleus (it is often called a 'seg' or 'poly'), while the immature neutrophil has a band-shape nucleus (it is called a band).[medicinenet.com] The Severe Chronic Neutropenia International Registry Idiopathic Neutropenia The term ‘idiopathic neutropenia’ describes various types of neutropenia that may occur at any[depts.washington.edu] The kinetics of PMN disappearance from peripheral blood and the pattern of sequestration overlapped that induced by the injection of pre-formed soluble IC.[ncbi.nlm.nih.gov] The levels of the high mobility group box 1 protein (HMGB1), representing a TLR4 ligand, were significantly increased in patient LTBMC supernatants compared to controls.[ncbi.nlm.nih.gov] This molecule, which is needed for peptide synthesis, can – in vitro at least – be translocated from the nucleus to the membrane during apoptosis, suggesting how the autoantibodies[arthritis-research.biomedcentral.com]

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  • Influenza

    A challenge faced by these viruses is the trafficking of viral components into and out of the nucleus through the nuclear membrane.[ncbi.nlm.nih.gov] […] highly complex structure ever solved); the definition of the virus encoded enzymes required for RNA replication; the ordered assembly of the capsid shell and the protein sequestration[horizonpress.com] Like hemagglutinin and neuraminidase, the M2 protein is an integral membrane protein of the influenza A virus 4 , 5 .[dx.doi.org] This will require education, persuasion, and social support to ensure that medical and non-medical needs are met, with the latter being central to the success of sequestration[doi.org] Consequently, changes in ( e s e )/ T modulate droplet nucleus production, and, if droplet nucleus abundance is important for airborne IVT, should also affect observed rates[doi.org]

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  • Adult Idiopathic Neutropenia

    The mature neutrophil has a segmented nucleus (it is often called a 'seg' or 'poly'), while the immature neutrophil has a band-shape nucleus (it is called a band).[medicinenet.com] Risk idiopathic neutropenia adults of serious infections. Rheumatoid arthritis. By ukneutropeniasupportgroup. Indications and usage. Idiopathic neutropenia.[friends-acronym.ga] […] patients is probably the result of a combination of at least three factors, reduced neutrophil production in bone marrow, enhanced neutrophil extravasation, and increased sequestration[ingentaconnect.com] These results suggest that cytokine polymorphisms associated with control of gene expression and protein levels were not associated with occurrence of CINA and were not responsible[ncbi.nlm.nih.gov] WBCs are used up at a faster rate by: SEQUESTRATION AND MARGINATION OF WBCS.[medical-dictionary.thefreedictionary.com]

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  • Anemia of Chronic Disease

    -ringed sideroblasts -Fe accumulates in mitochondria surrounding nucleus of erythroblast b/c lack of protoporphyrin to make heme. Fe stains blue in Prussian blue stain.[brainscape.com] Abstract This study describes the frequency and the type of anemia seen in patients with nonimmune chronic idiopathic neutropenia of adults (NI-CINA).[ncbi.nlm.nih.gov] It may also be the central mediator of iron sequestration during infections and inflammatory states and the mediator of anemia of chronic disease.[ncbi.nlm.nih.gov] Acute-phase proteins, such as hepcidin, as well as pro- and anti-inflammatory cytokines affect iron acquisition and release pathways of monocytes and macrophages thereby leading[ncbi.nlm.nih.gov] In ACD total body iron stores are normal, though serum iron is typically low secondary to iron sequestration by macrophages, and often iron supplementation is not an effective[ncbi.nlm.nih.gov]

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  • Osteoporosis

    As the concentration of β-catenin reaches a critical level, β-catenin travels to the nucleus, where it activates the transcription of Wnt target genes.[emedicine.medscape.com] Pathogenic variants may result in various consequences, sometimes cumulative: decrease or abolition of the catalytic activity; inability to form homodimers; sequestration[web.archive.org] A similar increase in risk was observed for animal protein, but no association was found for consumption of vegetable protein.[doi.org] protein.[doi.org] In the elderly, low protein intakes are often observed in patients with hip fracture.[doi.org]

    Missing: IN of
  • Progeria

    In certain premature-ageing syndromes, the architecture of the cell nucleus is abnormal.[doi.org] In macroautophagy there is a sequestration of complete portions of the cytosol (often including phagocytosed material or organelles) into a double membrane vesicle known as[benbest.com] […] information 1 Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. [email protected] Abstract A clinical trial of a protein[ncbi.nlm.nih.gov] This concept led to the hypothesis that protein farnesyltransferase inhibitors (FTIs) might ameliorate the disease phenotypes of progeria in mouse models.[ncbi.nlm.nih.gov] Reduction of these proteins may contribute over time to development of vasculopathy in the ascending aorta in progeria syndrome.[ncbi.nlm.nih.gov]

    Missing: IN of
  • Paroxysmal Nocturnal Hemoglobinuria

    Pedro, Logroño, Spain. 25 Cancer Research Centre (IBMCC, USAL-CSIC), Institute for Biomedical Research of Salamanca (IBSAL) and Department of Medicine and Cytometry Service (NUCLEUS[ncbi.nlm.nih.gov] Abstract Chronic idiopathic neutropenia (CIN) is an acquired disorder of granulopoiesis characterized by increased apoptosis of the bone marrow (BM) granulocytic progenitor[ncbi.nlm.nih.gov] The efficient sequestration of hemoglobin by the red blood cell membrane and the presence of multiple hemoglobin clearance mechanisms suggest a critical need to prevent the[ncbi.nlm.nih.gov] […] genetics Membrane Proteins/immunology* Mutation Substances CD59 Antigens Membrane Proteins phosphatidylinositol glycan-class A protein CD59 protein, human Supplementary concept[ncbi.nlm.nih.gov] Administration of Hemoglobin Solutions Clinical Review Clinician's Corner April 6, 2005 JAMA. 2005;293(13):1653-1662. doi:10.1001/jama.293.13.1653 Context The efficient sequestration[jama.ama-assn.org]

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  • Cerebral Malaria

    In this issue of the JCI, Gallego-Delgado and colleagues present evidence that implicates angiotensin receptors and the relocation of β-catenin to the endothelial cell nucleus[ncbi.nlm.nih.gov] Within cases of histologically defined cerebral malaria, which includes phenotypes termed "sequestration only" (CM1) and "sequestration with extravascular pathology" (CM2)[ncbi.nlm.nih.gov] Although many functions have been ascribed to HRPII, the function of this protein remains ambiguous.[openscholarship.wustl.edu] […] malaria-infected erythrocytes causes endothelial cell apoptosis and have linked these events to the translocation of β-catenin from the intercellular junctions to the cell nucleus[jci.org] RESULTS: Five children with clinically defined CM during life had other causes of death identified at autopsy, no MR, and scanty intracerebral sequestration.[ncbi.nlm.nih.gov]

    Missing: IN of
  • Dentatorubral-Pallidoluysian Atrophy

    Abstract We examined the cerebellar dentate nucleus (CDN) in 16 patients with hereditary dentatorubral-pallidoluysian atrophy (DRPLA), one of the neurodegenerative diseases[ncbi.nlm.nih.gov] CREB‐binding protein sequestration by expanded polyglutamine. Hum Mol Genet 2000 ; 9 : 2197 –202.[doi.org] Emerging data indicate that huntingtin and atrophin-1 may have distinct protein interactions.[ncbi.nlm.nih.gov] Key words Dentatorubral-pallidoluysian atrophy Cerebellar dentate nucleus neuron Skein-like inclusion Polyglutamine Immunohistochemistry This is a preview of subscription[doi.org] The DRPLA gene is translated into protein in the brain.[ncbi.nlm.nih.gov]

    Missing: IN of
  • Congenital Neutropenia

    Idiopathic neutropenia is usually a relatively mild condition autoimmune neutropenia is most common in infants and young children.[contact.org.uk] WBCs are used up at a faster rate by: SEQUESTRATION AND MARGINATION OF WBCS.[medical-dictionary.thefreedictionary.com] […] or 3) destabilization of the protein resulting in induction of the unfolded protein response.[ncbi.nlm.nih.gov] […] codon (protein synthesis is initiated at the codon ATG) of neutrophil elastase (ELANE) result in the production of N-terminally truncated elastase, which mislocates to the nucleus[ncbi.nlm.nih.gov] […] codon (protein synthesis is initiated at the codon ATG) of neutrophil elastase ( ELANE ) result in the production of N-terminally truncated elastase, which mislocates to the nucleus[bloodjournal.org]

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