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3,839 Possible Causes for IN, sequestering, vacuole

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  • Parasite

    The limiting membrane of vacuoles containing Toxoplasma gondii and Plasmodium apicomplexan parasites lies at the host-parasite interface.[ncbi.nlm.nih.gov] We demonstrate that Toxoplasma sequesters a broad range of Rab vesicles into the PV.[ncbi.nlm.nih.gov] […] parasites utilize pore-forming proteins that disrupt host cell membranes to either traverse host cells while migrating through tissues or egress from the parasite-containing vacuole[ncbi.nlm.nih.gov]

    Missing: IN
  • Drug Hypersensitivity

    […] confer resistance to chloroquine (CQ) and related antimalarials by enabling the protein to transport these drugs away from their targets within the parasite's digestive vacuole[ncbi.nlm.nih.gov] In the second scenario, we show that although amantadine also sequesters within the DV, the parasite's hypersensitivity to this drug arises from the PfCRTCQR-mediated transport[ncbi.nlm.nih.gov]

    Missing: IN
  • Amyotrophic Lateral Sclerosis

    Cytoplasmic vacuoles were found in the remaining anterior horn motor neurons of the lumbar spinal cord.[ncbi.nlm.nih.gov] Functional characterization of the p.Ala204Glyfs* 6 demonstrated that the mutant protein alters HSPB1 dynamic equilibrium, sequestering the wild-type protein in a stable dimer[ncbi.nlm.nih.gov] Moreover, the repeat-containing RNA could be toxic, eventually by sequestering RNA-binding proteins in the nucleus.[medicalxpress.com]

    Missing: IN
  • Oculopharyngeal Muscular Dystrophy

    In contrast, patients with distal myopathy with rimmed vacuoles revealed many rimmed vacuoles, on average in 20% of the fibers, and their oculopharyngeal muscles were spared[ncbi.nlm.nih.gov] This study demonstrates that a large number of nuclear proteins are sequestered in OPMD INIs, which may compromise cellular function.[ncbi.nlm.nih.gov] Skeletal muscle fibers nuclei from OPMD patients contain insoluble polyalanine expanded PABPN1 (expPABPN1) nuclear aggregates that sequester different cellular components.[ncbi.nlm.nih.gov]

    Missing: IN
  • Lafora Disease

    Electron microscopy reveals fine pale-staining filaments, fine dark-staining granules, and dark-rimmed vacuoles within these non-membrane-bound inclusions.[ncbi.nlm.nih.gov] The aggregrated glycogen sequesters glycogen synthase but not other glycogen metabolizing enzymes.[ncbi.nlm.nih.gov] 10x); Highest in infants Rarely normal in adults (5%) EMG: Irritative myopathy Myopathy Fibrillations Complex repetitive discharges Myotonic discharges Muscle pathology Vacuoles[neuromuscular.wustl.edu]

    Missing: IN
  • Pelizaeus-Merzbacher Disease

    Surprisingly, promoting autophagy with rapamycin decreases the degradation of nascent PLP suggesting autophagic vacuoles serve as a cellular storage compartment.[ncbi.nlm.nih.gov] These vacuoles appear to develop between myelin lamellae. Oligodendroglial cells and axons are preserved.[neuropathology-web.org] We suggest that there are multiple subcellular fates of PLP/DM20 when overexpressed: the vast majority being degraded by the proteasome, a proportion sequestered into autophagic[ncbi.nlm.nih.gov]

    Missing: IN
  • Sandhoff's Disease

    Histologic and ultra-structural evaluation revealed typical storage vacuoles.[ncbi.nlm.nih.gov] Treatment of pulmonary surfactant dysfunction using cholesterol-sequestering cyclodextrins Info Publication number EP2900246A4 EP2900246A4 EP20120885828 EP12885828A EP2900246A4[google.com] The microscopic studies may reveal the following: Neurons showing ballooned cytoplasmic vacuoles Periodic Acid-Schiff (PAS) staining of tissues helps in diagnosing and differentiating[dovemed.com]

    Missing: IN
  • Subcutaneous Injection

    Light microscopy of a biopsy specimen from the edge of the ulcer showed optically clear vacuoles in the dermis, together with a mixed cellular infiltrate.[ncbi.nlm.nih.gov] In 58%, SPIOs were sequestered in macrophages. SPIOs were not seen within the areas of nodes containing metastases, but was seen surrounding the metastases.[ncbi.nlm.nih.gov] Scanning electron microscopic studies revealed amorphous spherules within the vacuoles, and energy-dispersive spectroscopy established the presence of silicon in these spherules[ncbi.nlm.nih.gov]

    Missing: IN
  • Vitamin E Deficiency

    Muscle biopsy revealed inflammatory infiltrates and rimmed vacuoles, similar to those found in inclusion-body myositis.[ncbi.nlm.nih.gov] Surprisingly, the ligand is sequestered deep in the hydrophobic core of the protein, implicating a large structural rearrangement for the entry and release of alpha-T.[ncbi.nlm.nih.gov] Histologically (M. gastrocnemius) we saw the described typical but not specific changes (neurogenic atrophy, phosphatase-positive vacuoles with myelin bodies, cores).[thieme-connect.com]

    Missing: IN
  • Liposarcoma

    […] lesions occurred in the tongue of a 30-year-old man and in the triceps of a 67-year-old woman and were characterized by bland, epithelioid cells with striking intracytoplasmic vacuolization[ncbi.nlm.nih.gov] For sequestering analysis of angiogenesis factor in vivo, we performed immuno-fluorescence (IF) staining on tumor tissue.[ncbi.nlm.nih.gov] Lipoblasts are often present; these are cells with an abundant clear multi- vacuolated cytoplasm and an eccentric darkly staining nucleus that is indented by the vacuoles.[en.wikipedia.org]

    Missing: IN

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