Inappropriate Laughter: Causes & Reasons

Possible Causes for Inappropriate Laughter

Angelman syndrome is characterized by mental retardation, seizures, ataxia, inappropriate laughter, lack of speech, a particular facial appearance, and generally a chromosome [ncbi.nlm.nih.gov]

laughter and happy disposition. [ncbi.nlm.nih.gov]

Given the patient's relatively mild developmental impairment, without clinical evidence of seizures, gait disturbance or inappropriate laughter, the diagnosis of AS was not [ncbi.nlm.nih.gov]

Pick Disease of The Brain

laughter 0000748 Irritability Irritable 0000737 Language impairment 0002463 Neuronal loss in central nervous system Loss of brain cells 0002529 Perseveration 0030223 Personality [rarediseases.info.nih.gov]

0000006 Disinhibition 0000734 Echolalia Echoing another person's speech 0010529 Emotional blunting 0030213 Frontotemporal dementia 0002145 Gliosis 0002171 Hyperorality 0000710 Inappropriate [rarediseases.info.nih.gov]

Schizophrenia

laughter or crying Oversleeping or insomnia; forgetful, unable to concentrate Odd or irrational statements; strange use of words or way of speaking While these warning signs [helpguide.org]

[…] social withdrawal Hostility or suspiciousness, extreme reaction to criticism Deterioration of personal hygiene Flat, expressionless gaze Inability to cry or express joy or inappropriate [helpguide.org]

Temporal Lobe Epilepsy

Homepage Rare diseases Search Search for a rare disease Familial mesial temporal lobe epilepsy with febrile seizures Disease definition A rare, genetic, familial partial epilepsy disease characterized by simple partial seizures, complex partial seizures and/or secondarily generalized seizures, originating from the inner[…] [orpha.net]

Hallucinogen

This is often referred to as “skittling,” “robotripping,” or “dexing,” the DEA Inappropriate laughter, feelings of floating, altered sense of touch and hearing, hallucinations [solutions-recovery.com]

Disorganized Schizophrenia

Symptoms of / Reasons for Hebephrenic Schizophrenia Inappropriate laughter Delusions Lack of motivation Bizarre emotional responses [gomentor.com]

[…] or inappropriate laughter, and incoherent thought and speech. [britannica.com]

Inappropriate laughter - laughing at situations that aren't funny Delusions - believing something that is not true Lack of motivation and inability to be a productive member [gomentor.com]

Frontotemporal Dementia

Frontotemporal dementia is a term encompassing a group of dementias associated with progressive atrophy of the temporal lobe, frontal lobe, or both. Principal symptoms include behavioral disinhibition and personality changes, as well as deficits in language, both in speech production and word comprehension. The[…] [symptoma.com]

Lysergic Acid Diethylamide Poisoning

Ergot alkaloids are constituents of various fungi, but especially from the ergot fungus (Claviceps purpurea (Fr.) Tul.). In the 20th century the poisoning of grain with ergot lead to mass extinction and a higher infant mortality. In addition to the deposits in the ergot fungus, they are still synthesized in other[…] [en.naturalproducts.wiki]

Temporal Lobe Disorder

Published Journal Article We tested for differences in temporal lobe volume in bipolar disorder and the relationship between these volumes and psychotropic medication use.125 subjects with bipolar disorder and 87 comparison subjects with no psychiatric illness completed clinical interviews and 1.5T MRI brain scans.[…] [scholars.duke.edu]

Primary Amebic Meningoencephalitis

Am Fam Physician. 2016 Apr 15;93(8):644. to the editor : When seeing patients with headache and fever, particularly in warmer months, physicians in the United States should consider the diagnosis of primary amebic meningoencephalitis (PAM). Careful history, special laboratory testing, and special treatment may be[…] [aafp.org]

Psilocybine

Psilocybin is an indole alkaloid derived from the monoamine alkaloid tryptamine, which, in turn, is derived from the amino acid tryptophan.4 After ingestion, psilocybin is metabolized to the active compound psilocin, which is also present in psilocybin mushrooms, but in smaller amounts. 5 Psilocin is pharmacologically similar[…] [sites.google.com]

Anaesthetic Induction Agent

Abstract Etomidate (Hypnomidate; Ethnor (Janssen)) in propylene glycol was used for induction of anaesthesia in 25 patients requiring cardiac surgery, and the effects on pulse and blood pressure were measured. It is concluded that etomidate is a suitable induction agent for open-heart surgery. [ncbi.nlm.nih.gov]

Phenol Sulfotransferase Deficiency

Signs of sensitivity to phenols and salicylates can include: Red cheeks or ears after eating Hyperactivity Inappropriate laughter Irritability Impatience Aggression Lack of [epidemicanswers.org]

Monosomy 2pter-p24

Moreover patients show severe mental retardation, inappropriate laughter, happy disposition, ataxic gait, jerky movements, spasticity, lack of speech [30]. [ncbi.nlm.nih.gov]

Autosomal Dominant Mental Retardation Type 1

Hyperactivity Hyperactive behavior Inappropriate laughter Short stature Decreased body height, Height less than 3rd percentile, Small stature, Stature below 3rd percentile [rarediseases.oscar.ncsu.edu]

Uniparental Disomy

They may have seizures and often have inappropriate outbursts of laughter. [healthlibrary.uchospitals.edu]

Petit Fryns Syndrome

AS presents with severe mental retardation, absent speech, periods of inappropriate laughter, microcephaly, macrostomia, maxillary hypoplasia, prognathia and neurological [nature.com]

Adenylosuccinate Lyase Deficiency

Always she used to remain happy and cheerful with frequent excessive, inappropriate laughter. [pediatricneurosciences.com]

laughter), aggressive behavior, temper tantrums, impulsivity, hyperactivity, short attention span, and hypersensitivity to noise and lights. [rarediseases.info.nih.gov]

Behavioral abnormalities, including hyperactivity, self and hetero-aggressiveness, inappropriate laughter were frequently reported, particularly in type I. [ojrd.biomedcentral.com]

Christianson Syndrome

laughter 0000748 Microcephaly Abnormally small skull Decreased circumference of cranium Decreased size of skull Reduced head circumference Small head circumference [ more [rarediseases.info.nih.gov]

[…] in infancy 0008872 Gait ataxia Inability to coordinate movements when walking 0002066 Gastroesophageal reflux Acid reflux Acid reflux disease Heartburn [ more ] 0002020 Inappropriate [rarediseases.info.nih.gov]

Classic Progressive Supranuclear Palsy Syndrome

Ups and downs, “roller coaster” emotions In PSP emotional lability, or pseudobulbar affect, may occur and is characterized by sudden or inappropriate laughter or inconsolable [movementdisorders.ufhealth.org]

Macrocephaly - Intellectual Disability - Autism

laughter Aggressive behavior Impulsivity Hyperactivity Short attention span Poor eye contact Brain tumor (astrocytoma) Benign adrenal gland tumor (adrenal adenoma) Abnormality [undiagnosed.hms.harvard.edu]

MR, absent speech, microcephaly, seizures, puppetlike ataxic movements, inappropriate laughter, and facial dysmorphisms characterize AS. [misc.medscape.com]

Developmental regression Intellectual disability Autism spectrum disorder Absent speech Overeating (polyphagia) Sleep disturbance Self-mutilation and injurious behavior Pica Inappropriate [undiagnosed.hms.harvard.edu]

Colobomatous Microphthalmia - Rhizomelic Dysplasia Syndrome

laughter - MR, speech delay - AD inheritance - bilateral coronal craniosynostosis (tall shortened head) - developmental delay and MR - syndactyly - brachycephaly - maxillary [quizlet.com]

[…] prominent forehead, midfacial hypoplasia - maternal 15q11-13 microdeletion - "happy puppet", jerky and ataxic - hypotonia - midface hypopasia - prognathism - seizures - inappropriate [quizlet.com]

Disproportionate Short Stature - Ptosis - Valvular Heart Lesions

laughter) Hyperexcitability, short attention span Fascination with water Treatment Prognosis : Life expectancy is typically normal. [amboss.com]

[…] movements of the limbs Truncal hypotonia, limb hypertonia, hyperreflexia Difficulty sleeping Intellectual disability Characteristic happy demeanor with frequent laughing (inappropriate [amboss.com]

Acute Rheumatic Endocarditis

laughter If your child has a fever, they might require immediate care. [healthline.com]

[…] fever sweating vomiting a flat, slightly raised, ragged rash jerky, uncontrollable movements of the hands, feet, and face a decrease in attention span outbursts of crying or inappropriate [healthline.com]

Severe Neonatal-Onset Encephalopathy with Microcephaly

laughter mapped to chromosome 15q11 and ascribed to deletion, uniparental disomy, and mutations of either the imprinting centre or the UBE3A gene. 8 Considering that RTT [jmg.bmj.com]

[…] pattern in circulating white blood cells of healthy female carriers. 6 7 Angelman syndrome (AS) is an epileptic encephalopathy with microcephaly, absent speech, ataxia, and inappropriate [jmg.bmj.com]

Paranoid Schizophrenia

Disorganized Schizophrenia – child-like and repetitive behaviors, inappropriate laughter, and incoherent speech. [disability-benefits-help.org]

laughter or crying Oversleeping or insomnia; forgetful, unable to concentrate Odd or irrational statements; strange use of words or way of speaking While these warning signs [helpguide.org]

Short Stature and Facio-Auriculo-Thoracic Malformations

laughter Adducted thumb Neuronal loss in central nervous system Urinary incontinence X-linked dominant inheritance Epileptic encephalopathy Intellectual disability, profound [mendelian.co]

[…] lentis Anteverted nares Muscular hypotonia Abnormality of lower limb joint Broad femoral metaphyses Osteochondroma Camptodactyly of toe Increased serum lactate Tetraparesis Inappropriate [mendelian.co]

GNAO1 Encephalopathy

ORPHA:52503 Adenylosuccinase Deficiency Happy demeanor, Hyperactivity, Inability to walk, Aggressive behavior, Inappropriate laughter, Ga... [mousephenotype.org]

laughter OMIM:615074 Inherited Creutzfeldt-Jakob Disease Abnormal pyramidal sign, Spastic dysarthria, Bradykinesia, Progressive cerebellar ataxia, Gait at... [mousephenotype.org]

laughter, Broad-based gait ORPHA:411515 Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome Reduced proportion of CD4-negative, CD8-negative, alpha-beta [mousephenotype.org]

Prader-Willi Syndrome

They may have seizures and often have inappropriate outbursts of laughter. [urmc.rochester.edu]

Autosomal Dominant Mental Retardation Type 3

MR, absent speech, microcephaly, seizures, puppetlike ataxic movements, inappropriate laughter, and facial dysmorphisms characterize AS. [emedicine.medscape.com]