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29 Possible Causes for Incidence of Hepatocellular Carcinoma Increased, Scleral Icterus

  • Liver Cirrhosis

    El-Serag HB, Davila JA, Petersen NJ, McGlynn KA (2003) The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update.[doi.org] In the presented case, the authors describe an obese middle-aged man that presented to the emergency department for persistent oedema, scleral icterus and fatigue.[ncbi.nlm.nih.gov] A compelling clinical picture required, in the absence of other explanations, the presence of at least 4 of the following: spider nevi, scleral icterus, palmar erythema, ascites[dx.doi.org]

  • Hepatocellular Carcinoma

    The incidence of hepatocellular carcinoma increased with serum HBV DNA level at study entry in a dose-response relationship ranging from 108 per 100,000 person-years for an[ncbi.nlm.nih.gov] The incidence of hepatocellular carcinoma (HCC) is increasing in western countries.[ncbi.nlm.nih.gov] There was an increasing trend of cumulative hepatocellular carcinoma incidence with increasing serum HBV DNA level at study entry examination for all participants.[doi.org]

  • Cholestasis

    Hepatocellular carcinoma, once a relatively uncommon tumor, has been increasing in incidence since the 1990s because of its association with hepatitis C–induced cirrhosis.[clevelandclinicmeded.com] Her physical exam was remarkable for jaundice and scleral icterus without any stigmata of liver disease.[ncbi.nlm.nih.gov] It results in jaundice, which can be detected by scleral icterus at a concentration as low as 2 mg/dL, and by dark urine.[emedicine.medscape.com]

  • Hemochromatosis

    Approximately 6 percent of patients with hereditary hemochromatosis and cirrhosis develop hepatocellular carcinoma; this represents a 20-fold increased lifetime risk over[aafp.org] C 14, 20 AASLD and IDI vary* Hereditary hemochromatosis is associated with malignancies, particularly hepatocellular carcinoma.[aafp.org] […] the general population and a 4 percent annual incidence rate. 3 The mechanism for increased risk is the effect of excess iron in promoting oxidative DNA damage and free radical[aafp.org]

  • Macronodular Cirrhosis

    Pearls and Other Issues Hepatocellular Carcinoma HCC is the most common primary cancer in the liver, and its incidence is increasing [33].[ncbi.nlm.nih.gov] icterus BREATH: Fetor hepaticus (musty odor of breath and urine found in cirrhosis with hepatic failure) CHEST: Possible gynecomastia in men ABDOMEN: Tender hepatomegaly[encyclopedia.lubopitko-bg.com] […] cirrhosis), needle tracks (viral hepatitis) EYES : Kayser-Fleischer rings (corneal copper deposition seen in Wilson’s disease; best diagnosed with slit lamp examination), scleral[encyclopedia.lubopitko-bg.com]

  • Viral Hepatitis

    PURPOSE: Liver cancer (hepatocellular carcinoma (HCC)) incidence and mortality rates are increasing in the United States.[ncbi.nlm.nih.gov] Physical exam Assessment of the patient may yield remarkable findings such as jaundice, scleral icterus, and an enlarged and tender liver.[symptoma.com] Icteric Phase During this phase clinical signs of jaundice and scleral icterus will appear and some right upper quadrant tenderness may develop due to enlargement of the liver[pathwaymedicine.org]

  • Secondary Sclerosing Cholangitis

    Hepatocellular carcinoma, once a relatively uncommon tumor, has been increasing in incidence since the 1990s because of its association with hepatitis C–induced cirrhosis.[clevelandclinicmeded.com] A 55-year-old morbidly obese male presented electively with a 2-week history of low back pain and scleral icterus for 2 days.[karger.com] In this setting, the estimated incidence of the development of hepatocellular carcinoma is 1% to 4% per year. 34 Cirrhosis from causes other than hepatitis C, particularly[clevelandclinicmeded.com]

  • Alcoholic Hepatitis

    […] maignant neoplasia (hepatocellular carcinoma).[meddean.luc.edu] Physical Exam: VS: T 98.9 HR 104 RR 19 BP 117/67 O2 99% RA Gen: Well-appearing obese female in no acute distress HEENT: PERRL, marked scleral icterus, sublingual icterus,[ddxof.com] icterus, skin and sublingual jaundice).[clinicaladvisor.com]

  • Primary Sclerosing Cholangitis

    Hepatocellular carcinoma, once a relatively uncommon tumor, has been increasing in incidence since the 1990s because of its association with hepatitis C–induced cirrhosis.[clevelandclinicmeded.com] In this setting, the estimated incidence of the development of hepatocellular carcinoma is 1% to 4% per year. 34 Cirrhosis from causes other than hepatitis C, particularly[clevelandclinicmeded.com]

  • Hepatitis B

    This type of infection dramatically increases the incidence of hepatocellular carcinoma (HCC; liver cancer).[en.wikipedia.org] It usually presents as a subclinical, mild illness, with only up to 30% of people developing scleral icterus, nausea, vomiting, and right‐upper quadrant tenderness ( Bodihar[doi.org] For example, in Japan, where the incidence of hepatocellular carcinoma has been increasing despite a decrease in the prevalence of HBsAg, HCV is now considered the major risk[ncbi.nlm.nih.gov]

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