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26 Possible Causes for Incidence of Hepatocellular Carcinoma Increased, Testicular Atrophy

  • Hemochromatosis

    Approximately 6 percent of patients with hereditary hemochromatosis and cirrhosis develop hepatocellular carcinoma; this represents a 20-fold increased lifetime risk over[aafp.org] Testicular atrophy, sometimes caused by excessive iron deposition in the testes, is a risk factor for testicular cancer.[ncbi.nlm.nih.gov] Men: Impotence, loss of libido, gynecomastia, testicular atrophy. Women: Amenorrhea and loss of libido.[pathwaymedicine.org]

  • Liver Cirrhosis

    El-Serag HB, Davila JA, Petersen NJ, McGlynn KA (2003) The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update.[dx.doi.org] atrophy (shrinking) and impotence in males or amenorrhoea (no periods) in women cognitive problems such as memory loss, confusion or concentration difficulties.[betterhealth.vic.gov.au] El-Serag HB (2012) Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology 142 : 1264–1273. [ PMC free article ] [ PubMed ] [ Google Scholar ] 2.[ncbi.nlm.nih.gov]

  • Hepatitis

    El-Serag HB, Davila JA, Petersen NJ, McGlynn KA: The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update.[doi.org] The incidences of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma are also rising, and HCC is now the leading cause of obesity-related cancer deaths in[doi.org] These persons are at increased risk for chronic liver disease, including cirrhosis and hepatocellular carcinoma, and they are the major reservoir of ongoing HBV transmission[cdc.gov]

  • Toxic Liver Disease

    […] of hepatocellular carcinoma, and death.[aafp.org] atrophy Temporal wasting Hypertrophic osteoarthropathy Dupuytren contracture Fetor hepaticus ARVs and Hepatotoxicity Many ARVs may cause liver damage, particularly in patients[hiv.va.gov] The daily consumption of more than four drinks of alcohol (48 g) increases the risk of cirrhosis, as well as death from other causes. 10, 11 Alcohol abuse and hepatitis C[aafp.org]

  • Hepatitis B

    For example, in Japan, where the incidence of hepatocellular carcinoma has been increasing despite a decrease in the prevalence of HBsAg, HCV is now considered the major risk[ncbi.nlm.nih.gov] When cirrhosis develops one may find peripheral edema, ascites, icterus, caput medusa, variceal bleeding, testicular atrophy and gynaecomastia.[symptoma.com] July 2, 2010 CDC Reports Increasing Incidence of Liver Cancer, Mostly Due to Chronic Hepatitis B and C June 15, 2010 Sex Hormone Receptor May Explain Higher Risk of Hepatocellular[hivandhepatitis.com]

  • Chronic Hepatitis C

    Rising incidence of hepatocellular carcinoma. N Engl J Med 1999; 340: 745–750 PubMed CrossRef Google Scholar 30. Wong JB, Bennett WG, Koff RS, et al.[doi.org] As this population ages, studies project that the incidence of cirrhosis, decompensated cirrhosis, and hepatocellular carcinoma (HCC) will markedly increase over the next[doi.org] The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update. Ann Intern Med. 2003 Nov 18. 139(10):817-23. [Medline].[emedicine.com]

  • Drug-induced Cholestatic Hepatitis

    Hepatocellular carcinoma, once a relatively uncommon tumor, has been increasing in incidence since the 1990s because of its association with hepatitis C–induced cirrhosis.[clevelandclinicmeded.com] In this setting, the estimated incidence of the development of hepatocellular carcinoma is 1% to 4% per year. 34 Cirrhosis from causes other than hepatitis C, particularly[clevelandclinicmeded.com]

  • Chronic Hepatitis

    In the REVEAL study of a cohort of individuals infected with hepatitis B, 2 high viral load was shown to be associated with an increased incidence of hepatocellular carcinoma[ascopost.com] Breast swelling (gynaecomastia), testicular atrophy, loss of libido and amenorrhoea due to endocrine dysfunction. Confusion and drowsiness (encephalopathy).[patient.info] El-Serag HB, Davila JA, Petersen NJ, McGlynn KA: The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update.[doi.org]

  • Chronic Persistent Hepatitis

    El-Serag HB, Davila JA, Petersen NJ, McGlynn KA: The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update.[doi.org] Breast swelling (gynaecomastia), testicular atrophy, loss of libido and amenorrhoea due to endocrine dysfunction. Confusion and drowsiness (encephalopathy).[patient.info] The incidences of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma are also rising, and HCC is now the leading cause of obesity-related cancer deaths in[doi.org]

  • Hepatitis C

    Rising incidence of hepatocellular carcinoma. N Engl J Med 1999; 340: 745–750 PubMed CrossRef Google Scholar 30. Wong JB, Bennett WG, Koff RS, et al.[doi.org] As this population ages, studies project that the incidence of cirrhosis, decompensated cirrhosis, and hepatocellular carcinoma (HCC) will markedly increase over the next[doi.org] The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update. Ann Intern Med. 2003 Nov 18. 139(10):817-23. [Medline].[emedicine.medscape.com]

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