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134 Possible Causes for Incomplete Myelination

  • Pelizaeus-Merzbacher Disease

    Magnetic resonance imaging revealed incomplete myelination of cerebral white matter, which resembled that of Pelizaeus-Merzbacher disease.[ncbi.nlm.nih.gov] Although PMD is a rare monogenic disease, hundreds of mutations in the X-linked myelin gene proteolipid protein 1 (PLP1) have been identified in humans.[ncbi.nlm.nih.gov] Attempts to identify a common pathogenic process underlying PMD have been complicated by an incomplete understanding of PLP1 dysfunction and limited access to primary human[ncbi.nlm.nih.gov]

  • Minamata Disease

    Abnormaly thin or poorly formed myelin sheaths were noticed. Incomplete myelination and abnormal myelination varied in size and shape appeared as fetal anomaly.[ncbi.nlm.nih.gov] There were so many unmyelinated and poorly myelinated nerve fibers that myelinated fibers scattered irregularly in small numbers or in groups of peculiar features in the intraneural[ncbi.nlm.nih.gov]

  • Adult Polyglucosan Body Disease

    Postmortem examinations in two cases showed moderate cerebral and spinal atrophy, ill-defined areas of incomplete myelin loss in white matter and small necrotic foci in the[ncbi.nlm.nih.gov]

  • Fraser Syndrome

    It was revealed also an incomplete myelination of the brain. Genetic test revealed the mutations c.[5752dup];[8544 1G T] p.[ijponline.biomedcentral.com]

  • Onion

    In the auditory system, incompletely myelinated cochlear nerve fibers in the infant and in patients with multiple sclerosis show delays of the auditory evoked potential latencies[ncbi.nlm.nih.gov] This process can become so severe that the myelinated fiber loses its myelin and ultimately degenerates; however, many fibers remain viable and thinly myelinated.[ncbi.nlm.nih.gov]

  • X-linked Intellectual Disability Type Kroes

    myelination associated with progressive ...[citeulike.org] We describe a patient with slowly progressive spastic paraparesis, segmental dystonia, intellectual disability, behavioral problems, and evidence of permanent, incomplete[citeulike.org]

  • Sialidosis Type 2

    An occasional vesicle showed incomplete myelin-like bodies (Figure 2).[annsaudimed.net]

  • Mucolipidosis Type 1

    An occasional vesicle showed incomplete myelin-like bodies (Figure 2).[annsaudimed.net]

  • Neonatal Hypotonia

    Neonatal and Infantile Hypotonia The clinical distinction between upper and lower motor neuron disorders in infants is blurred because incomplete myelinization of the developing[physiotherapy-treatment.com] myelination). 4 Table 3 Evaluation for central and peripheral causes of hypotonia Our patient's electrolytes and liver enzymes were normal.[n.neurology.org] […] being interpreted as fibrillations), normal smaller motor unit action potentials (which may appear myopathic), and slower conduction velocities (due to newborn nerves having incomplete[n.neurology.org]

  • Globoid Cell Leukodystrophy

    myelinated before 18 months of age.[ajnr.org] […] brain involvement can be determined with MR imaging if the cerebellar signal abnormalities and pyramidal tract involvement are detected in the developing brain, which is incompletely[ajnr.org]

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