Increased Glycogen Content: Causes & Reasons

Possible Causes for Increased Glycogen Content

Biochemical analysis of fresh-frozen muscle tissue disclosed increased glycogen content and a complete lack of phosphofructokinase (PFK) activity. [ncbi.nlm.nih.gov]

Muscle histology showed PAS-positive vacuoles, and electronmicroscopy revealed massive subsarcolemmal and intermyofibrillar accumulation of glycogen. [ncbi.nlm.nih.gov]

Fetal Nicotine Spectrum Disorder

Speculation: Diminished glycogen content of the fetal lung in the latter part of gestation may reflect increasing utilization for phosphatidyl choline synthesis. [nature.com]

The glycogen content of tissues treated with cortisol was significantly reduced compared to the controls, 2.42 ± 0.97 (SD) mg/g wet lung versus 3.81 ± 1.05 (SD) mg/g ( P < [nature.com]

Treatment with cortisol resulted in significantly enhanced incorporation of the 14 C label into glycogen and phosphatidl choline (Tables 3 and 4). [nature.com]

Orotic Aciduria Type 2

The content of glycogen in the muscles… CONTINUE READING Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv [semanticscholar.org]

[…] did not increase production of lactate. [semanticscholar.org]

[…] similar to the one described by McArdle have found that lactate is formed from added glucose 1-phosphate at a rate comparable to that of controls, but addition of muscle glycogen [semanticscholar.org]

Glycogen Storage Disease Type 3

It revealed increased glycogen content and deficency of amylo-1-6 glucosidase activity in the erythrocytes, that confirms the diagnosis of glycogenosis type III. [indianpediatrics.net]

Liver biopsy revealed an increase in the glycogen content (6 percent of wet weight). [usmle.biochemistryformedics.com]

The glycogen content is markedly increased in GSD III (as high as 3 to 5 times the normal levels), and the accumulated glycogen appears structurally abnormal (shorter outer [nature.com]

Glycogen Depletion

IN CONCLUSION: after successfully managed marathon running in patients with IDDM, insulin sensitivity was not increased in spite of low glycogen content and enhanced glycogen [ncbi.nlm.nih.gov]

Increased dietary protein and calorie content relieved her symptoms, restored liver glycogen but had no effect on the development of the cirrhosis over the next 12 months. [ncbi.nlm.nih.gov]

In endurance athletes, high muscle glycogen content can increase the time to fatigue during exertion. [musclesound.com]

Glycogen Storage Disease Type 0

Liver biopsy revealed an increase in the glycogen content (6 percent of wet weight). [usmle.biochemistryformedics.com]

The increase in glycogen content results from an inability to degrade glycogen beyond the limit dextrin of phosphorylase. [usmle.biochemistryformedics.com]

Differentiating patients with GSD type III from those with GSD type I solely on the basis of physical findings is not easy, but the hepatomegaly, increased liver glycogen [usmle.biochemistryformedics.com]

McArdle Disease

Niezen-Koning, O.P. van Diggelen and F.J. van Spronsen, Muscular glycogen storage diseases without increased glycogen content on histopathological examination, Molecular Genetics [doi.org]

A muscle biopsy at the age of 42 years revealed increased glycogen content and deficiency of the debrancher enzyme, confirming the diagnosis of GSD IIIa. [nature.com]

A diagnosis of GSD III was made based on increased glycogen content, altered ratio of glucose-1-phosphate/glucose, evidence of debrancher enzyme deficiency in liver and/or [nature.com]

Glycogen Storage Disease Type 13

[…] exercise Inability to exercise [ more ] 0003546 Increased muscle glycogen content 0009051 Myalgia Muscle ache Muscle pain [ more ] 0003326 Showing of 6 | Last updated: 5/ [rarediseases.info.nih.gov]

Increased Phosphorylase kinase activity: Normal Hypoglycemia: Neonatal Skeletal Muscle Glycogen content & metabolism, Quantitative Trait Locus (SMGMQTL) ● Protein kinase [neuromuscular.wustl.edu]

[…] creatine phosphokinase Increased serum CK Increased serum creatine kinase Increased serum creatine phosphokinase [ more ] 0003236 Exercise intolerance Decreased ability to [rarediseases.info.nih.gov]

Liver Phosphorylase Kinase Deficiency

Liver biopsy revealed an increase in the glycogen content (6 percent of wet weight). [usmle.biochemistryformedics.com]

Despite the decrease in hepatic glycogen content, the glycemic response to glucagon (0.03 mg/kg; 1 mg maximum) is variable and may even be normal because some glycogen can [clinicaladvisor.com]

The increase in glycogen content results from an inability to degrade glycogen beyond the limit dextrin of phosphorylase. [usmle.biochemistryformedics.com]

Glycogen Storage Disease Type 7

Showing of 18 | 80%-99% of people have these symptoms Anemia Low number of red blood cells or hemoglobin 0001903 Increased muscle glycogen content 0009051 Myotonia 0002486 [rarediseases.info.nih.gov]

Transient Infantile Hypertriglyceridemia and Hepatosteatosis

Fatigue Postnatal growth retardation Ranula Increased hepatic glycogen content Hepatic steatosis Abnormality of lipid metabolism Cholestasis Macrovesicular hepatic steatosis [mendelian.co]

Accelerated atherosclerosis Acute hepatic steatosis Increased VLDL cholesterol concentration Need help with a diagnosis? [mendelian.co]

[…] serum ferritin Hemophagocytosis Abnormal natural killer cell physiology Milia Xanthelasma Eruptive xanthomas Aortic atherosclerosis Increased HDL cholesterol concentration [mendelian.co]

Glycogen Storage Disease Type 6

[…] hepatic glycogen content 0006568 Percent of people who have these symptoms is not available through HPO Autosomal recessive inheritance 0000007 Failure to thrive in infancy [rarediseases.info.nih.gov]

Liver glycogen content may also be increased as much as 4-fold, although muscle glycogen remains normal in structure and quantity. [humpath.com]

The glycogen content is markedly increased in GSD III (as high as 3 to 5 times the normal levels), and the accumulated glycogen appears structurally abnormal (shorter outer [nature.com]

Myopathy with Giant Abnormal Mitochondria

The most prominent ultrastructural findings are evidence of increased glycogen, usually present in vescicles or in mitochondria, and changes in number, size and structure [karger.com]

Glycogen Storage Disease

All patients showed a striking increase of erythrocytes glycogen content. No AGL activity was detected in peripheral leukocytes. [ncbi.nlm.nih.gov]

A muscle biopsy at the age of 42 years revealed increased glycogen content and deficiency of the debrancher enzyme, confirming the diagnosis of GSD IIIa. [nature.com]

Exercise intolerance 0003546 Increased muscle glycogen content 0009051 Myalgia Muscle ache Muscle pain [ more ] 0003326 Showing of 6 | Last updated: 12/1/2018 Glycogen storage [rarediseases.info.nih.gov]

Mitochondrial Myopathy with Reversible Cytochrome C Oxidase Deficiency

[…] staining with oxidative enzyme reaction, increased glycogen content, and increased number of lipid droplets. [dokumen.tips]

[…] syn- drome, morphological studies showed accumulation of mitochondria in many fibers, which appeared ragged red upon modified Gomori trichrome staining; they also showed increased [dokumen.tips]

Syndromic Microphthalmia Type 10

[…] muscle glycogen content Increased muscle lipid content Muscle fiber hypertrophy Low-set ears Downslanted palpebral fissures Cerebellar atrophy Congenital onset Macrotia Cerebellar [mendelian.co]

[…] corpus callosum Kyphoscoliosis High forehead Severe lactic acidosis Malar flattening Decreased plasma carnitine Spinal rigidity Cytochrome C oxidase-negative muscle fibers Increased [mendelian.co]

Glycogen Storage Disease Type 1

Treatment of mice with S4048 resulted in an ~60% reduction in blood glucose, increased hepatic glycogen and triacylglycerol (triglyceride) content, and a markedly enhanced [ncbi.nlm.nih.gov]

At baseline, GSD1 patients exhibited significantly lower rates of EGP (0.53 +/- 0.04 vs. 1.74 +/- 0.03 mg.kg(-1).min(-1); P < 0.01) but an increased intrahepatic glycogen [ncbi.nlm.nih.gov]

Despite the decrease in hepatic glycogen content, the glycemic response to glucagon (0.03 mg/kg; 1 mg maximum) is variable and may even be normal because some glycogen can [clinicaladvisor.com]

Postural Orthostatic Tachycardia Syndrome

[…] muscle glycogen and lipid content Exercise intolerance Chronic fatigue Cold and Heat intolerance Excessive sweating (hyperhidrosis) Inflamed and irritated skin (eczema) Cognitive [undiagnosed.hms.harvard.edu]

[…] feeling off balance (vertigo) Difficulty walking Unusual manner of walking (scissor gait, gait disturbance, gait ataxia) Weakness of foot and ankle (foot dorsiflexor weakness) Increased [undiagnosed.hms.harvard.edu]

Fanconi-Bickel Syndrome

[…] is attenuated by an increase in glycogen release that occurs with increasing glycogen content [ 34 ]. [bioscirep.org]

As the density of fat is low and that of glycogen high, the increased density points to a predominant increase of glycogen content [36]. [slideheaven.com]

The liver size and glycogen (a glucose storage molecule) content were reduced when the patients were placed on an antiketogenic (high carbohydrate) diet. [encyclopedia.com]

Acquired Amyloid Myopathy

This was confirmed by a biochemical analysis of the muscle tissue, showing a significant increase in glycogen content. [hopkinsarthritis.org]

The histopathologic findings were indicative of abnormal glycogen accumulation. [hopkinsarthritis.org]

Pompe Disease

If performed, increased glycogen contents and buildup of autophagic vacuoles may be observed. Normal muscle biopsies don't exclude GSD2. [symptoma.com]

Muscle GAA activity and glycogen content After 4 months of rhGAA treatment, GAA activity increased 2- to 3-fold over baseline pretreatment levels in both patients 1 and 2, [nature.com]

Vaginal Candidiasis

The high levels of reproductive hormones and an increase in the vaginal environment’s glycogen content create a favorable environment for Candida species, providing an abundant [emedicine.medscape.com]

It is believed that higher estrogen levels and higher glycogen content in vaginal secretions during pregnancy increase a woman’s risk of developing VVC. 4 As VVC is so common [cfp.ca]

Pregnancy The associated high concentration of reproductive hormones especially oestrogen in pregnancy increases the glycogen content in the vaginal epithelial cells, which [medcraveonline.com]

Glycogen Storage Disease Type 9

Staining with periodic acid Schiff (PAS) showed greatly increased glycogen content in the myocardium (Fig. 3C) and, to a lesser extent, in skeletal muscle (Fig. 3E). [nature.com]

Despite the decrease in hepatic glycogen content, the glycemic response to glucagon (0.03 mg/kg; 1 mg maximum) is variable and may even be normal because some glycogen can [clinicaladvisor.com]

content, liver disease, growth retardation, hypotonia, abnormal lipid profile, and increased lactate and uric acid. [doi.org]

Insulin Resistance

It also increased glucose uptake, glycogen content and glycogen synthase (GS) activation in HG-induced insulin resistant HepG2 cells. [ncbi.nlm.nih.gov]

Additionally, our study confirms previous work demonstrating that consuming low carbohydrate content in meals after exercise prevents the restoration of muscle glycogen concentration [doi.org]

[…] the next morning and significantly increased insulin sensitivity the next day. [doi.org]

Amelogenesis Imperfecta Type 1G with Nephrocalcinosis

[…] hepatic glycogen content Flushing Hypoglycemic seizures Hypoglycemic coma Nonketotic hypoglycemia Follicular hyperplasia Enlarged tonsils Round ear Myelitis Parakeratosis [mendelian.co]

Hyperhidrosis Recurrent hypoglycemia Hypoglycemia Generalized seizures Gynecomastia Truncal obesity Large for gestational age Seborrheic dermatitis Hypoketotic hypoglycemia Increased [mendelian.co]

Vaginitis

They may also raise the sugar content (and the pH) of the vagina and increase the risk of yeast infection. [emedicinehealth.com]

The reduction of endogenous estrogen causes thinning of the epithelium and a diminished glycogen content. [emedicine.com]

Keratitis Bullosa

[…] muscle glycogen content Hyperuricemia Scoliosis Frontal bossing Leukopenia Juvenile onset Difficulty walking Abnormality of the nervous system Hyperlordosis Hypertrophic [mendelian.co]

Abnormality of the skull Gangrene Hearing impairment Myelitis Abnormality of the ulna Raynaud phenomenon Abnormality of femur morphology Abnormality of tibia morphology Increased [mendelian.co]

Vulvitis

The high levels of reproductive hormones and an increase in the glycogen content in the vaginal environment create a favorable environment for Candida species. [www1.cgmh.org.tw]

The reduction of endogenous estrogen causes thinning of the epithelium and a diminished glycogen content. [www1.cgmh.org.tw]

Glycogen is necessary for rapid multiplication and maintenance of lactobacilli. [www1.cgmh.org.tw]

Fingerprint Body Myopathy

OMIM:144250 Mitochondrial Myopathy With Reversible Cytochrome C Oxidase Deficiency Increased muscle glycogen content, Macroglossia, Ragged-red muscle fibers, Increased muscle [mousephenotype.org]

OMIM:616834 Mitochondrial Myopathy, Infantile, Transient Failure to thrive, Increased muscle glycogen content, Macroglossia, Ragged-red muscle fibers, Inc... [mousephenotype.org]

[…] muscle glycogen content, EMG: myopathic abnormalities, Weakness of facial musc... [mousephenotype.org]

Diabetic Hypoglycemia

Experimental studies and in humans have shown that after one or more episodes of hypoglycemia, increased glycogen content in the brain[38,39]. [wjgnet.com]