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227 Possible Causes for Increased IL-18

  • Common Cold

    Increases the production of cytokines (for example, IL‐1, IL‐2, IL‐6, IL‐10, IL‐12, IL‐18, TNF‐α, interferon‐α) ( Gill 1998 ; Meydani 2000 ).[doi.org]

  • Upper Respiratory Infection

    Increases the production of cytokines (for example, IL‐1, IL‐2, IL‐6, IL‐10, IL‐12, IL‐18, TNF‐α, interferon‐α) ( Gill 1998 ; Meydani 2000 ).[doi.org]

  • Hypersensitivity

    IL-18 and IL-1β were also increased after the NLRP6 gene was silenced. Pathological score suggested low inflammation of colonic mucous rather than terminal ileum.[ncbi.nlm.nih.gov] Pepsin digest of wheat gliadin fraction increases production of IL-1β via TLR4/MyD88/TRIF/MAPK/NF-kappaB signaling pathway and an NLRP3 inflammasome activation .[dx.doi.org] […] over 18 years in the general adult population in West Sweden , Respiratory Medicine , 108 , 5 , (685) , (2014) .[doi.org]

  • Acne Vulgaris

    Recently, Tochio et al. 18 reported that LPO in comedones may result in an increase in IL-1α expression via nuclear factor-kappa B and may also be involved in the progression[ncbi.nlm.nih.gov] When sebum oxidation occurs, LPO forms in the comedones and can increase the levels of cytokines and chemokines involved in cutaneous inflammation 17.[ncbi.nlm.nih.gov]

  • Malnutrition

    IL-18 knockout mice became obese through overeating and resistant to insulin through increased gluconeogenesis in the liver [ 65 ].[dx.doi.org] Consequently, intracerebrally administered IL-18 inhibited food intake.[dx.doi.org] Recently, the cytokine IL-18, which usually drives TH1 responses in synergy with IL-12, has been linked to obesity.[dx.doi.org]

  • Food Allergy

    Pepsin digest of wheat gliadin fraction increases production of IL-1β via TLR4/MyD88/TRIF/MAPK/NF-kappaB signaling pathway and an NLRP3 inflammasome activation.[dx.doi.org] Gastroenterology 135, 194–204 (2008). 18. Palova-Jelinkova, L. et al.[dx.doi.org]

  • Periodontitis

    […] inflammation in periodontal tissues, with higher levels of inflammatory mediators such as interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α). 17, 18 Periodontal[doi.org] […] functioning, neutrophil activity, and cytokine biology. 15 Both type 1 and type 2 diabetes are associated with elevated levels of systemic markers of inflammation. 16 Diabetes increases[doi.org]

  • Hay Fever

    Zuercher and Annick Mercenier, Increased IL-5 and IL-13 cytokine level in ex vivo stimulated whole blood cells from grass pollen allergic donors correlate with seasonal exposure[doi.org] , Results in Immunology, 1, 1, (18), (2011).[doi.org]

  • Osteoarthritis

    IL-18 affects chondrocytes and synovial cells by increasing the levels of several inflammatory compounds [ 5 ].[doi.org] -1β 10 mM Inhibition of iNOS, COX-2 and IL-6 expression [ 18 ] Human chondrocytes 5-20 mM Increased synthesis of GAG and HA due to acceleration of facilitated glucose uptake[doi.org] The cytokines involved may be inflammatory interleukins (IL-1 β, IL-6, IL-15, IL-17, and IL-18) and tumour necrosis factor-alpha (TNF- α ) or anti-inflammatory interleukins[doi.org]

  • Allergic Rhinitis

    Zuercher and Annick Mercenier, Increased IL-5 and IL-13 cytokine level in ex vivo stimulated whole blood cells from grass pollen allergic donors correlate with seasonal exposure[doi.org] , Results in Immunology, 1, 1, (18), (2011).[doi.org]

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