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251 Possible Causes for Increased Risk of Hepatocellular Carcinoma

  • Alpha-1 Antitrypsin Deficiency

    Complications cirrhosis with increased risk of hepatocellular carcinoma 19 A1AT deficiency carriers are at 70-100% increased risk of lung cancer 20 The differential will depend[radiopaedia.org] Other management strategies include avoidance of smoking and of other risk factors for cirrhosis.[radiopaedia.org]

  • Hemochromatosis

    Generation of free radicals by iron particles may damage hepatocyte DNA, increasing risk of hepatocellular carcinoma.[pathwaymedicine.org] hepatocellular carcinoma.[ncbi.nlm.nih.gov] Excessive iron deposition and damage in the liver is also associated with increased risk for hepatocellular carcinoma.[lecturio.com]

  • Hepatocellular Carcinoma

    Risk of Liver Cirrhosis and Cancer, while Carbohydrates May Be Protective 8-7-2009 Metabolic Syndrome Is Associated with Increased Risk of Hepatocellular Carcinoma in Chronic[hivandhepatitis.com] […] the Risk of Liver Fibrosis and Hepatocellular Carcinoma in People with Chronic Hepatitis C 7/04/08 Incidence of and Risk Factors for Hepatocellular Carcinoma in Hepatitis[hivandhepatitis.com] Carcinoma Rates Vary Widely Across Sex and Racial/Ethnic Groups 7/25/08 Two Studies Look at Promising Therapies for Liver Cancer 7/25/08 Insulin Resistance and Diabetes Increase[hivandhepatitis.com]

  • Alcohol Abuse

    Liver cancer : Heavy alcohol consumption is associated with approximately 2-fold increased risks of two types of liver cancer ( hepatocellular carcinoma and intrahepatic cholangiocarcinoma[cancer.gov] […] cell carcinoma.[niaaa.nih.gov] In addition, people who inherit a deficiency in an enzyme that metabolizes alcohol have been found to have substantially increased risks of esophageal squamous cell carcinoma[cancer.gov]

  • Metabolic Syndrome

    Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma. Gastroenterology. 2004 Feb;126 (2):460-8. [ Links ] 11. Gard M, Wright J.[dx.doi.org] Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma. Gastroenterology. 2004; 126 (2):460–468. [ PubMed ] [ Google Scholar ] 11.[ncbi.nlm.nih.gov]

  • Food Poisoning

    Cancer Studies performed in Asia and Africa have shown that chronic consumption of aflatoxins in food increases the risk of developing hepatocellular carcinoma.[doi.org]

  • Insulin Resistance

    Because increased insulin resistance is a risk factor for development of hepatocellular carcinoma and reduced long-term survival, insulin resistance is a therapeutic target[ncbi.nlm.nih.gov]

  • Chronic Alcoholism

    Coexisting iron accumulation or chronic hepatitis C increases risk of hepatocellular carcinoma.[merckmanuals.com]

  • Obesity

    NAFL can proceed to non-alcoholic steatohepatitis (NASH), to liver failure, and even cirrhosis, with an increased risk for development of hepatocellular carcinoma.[library.med.utah.edu] A BMI of 30 or more markedly increases the risk for osteoarthritis of the knees.[library.med.utah.edu] (Choudhury and Sanyal, 2004) Osteoarthritis Increased weight will increase the stress on weight-bearing joints, particularly lower extremities, leading to osteoarthritis.[library.med.utah.edu]

  • Cholelithiasis

    The incidence of ICC is relatively low but increasing worldwide [ 4, 5 ]. The risk factors for ICC are complex.[bmccancer.biomedcentral.com] ICC, the second most frequent liver neoplasm following hepatocellular carcinoma, is highly malignant and shows extremely poor prognosis [ 3 ].[bmccancer.biomedcentral.com]

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