Increased Susceptibility to Infections: Causes & Reasons

Possible Causes for Increased Susceptibility to Infections

Neither increased susceptibility to infections nor agammaglobulinemia have been described as a manifestation of terminal 14q32.33 deletion. [ncbi.nlm.nih.gov]

An increased susceptibility to infection is the clinical hallmark of the disorder. [clinicaladvisor.com]

The clinical picture was dominated by severe episodes of recurrent upper respiratory tract infections. [ncbi.nlm.nih.gov]

Common Variable Immunodeficiency

The patient had a history of increased susceptibility to infections and autoimmune phenomena. [ncbi.nlm.nih.gov]

susceptibility to infections. [ncbi.nlm.nih.gov]

CVID is a disorder characterized by low levels of antibodies (serum immunoglobulins) and increased susceptibility to infections. [sciencedaily.com]

Selective IgA Immunodeficiency

susceptibility to infection. [hamad.qa]

Patients with hyper-IgM experience recurrent sinopulmonary infections but also have an increased susceptibility to opportunistic infections, severe neutropenia, and complications [acphospitalist.org]

Immunol. (1998) [ Pubmed ] Neutrophil dysfunction and increased susceptibility to infection. Ottonello, L., Dapino, P., Pastorino, G., Dallegri, F., Sacchetti, C. Eur. [wikigenes.org]

Severe Combined Immunodeficiency

This disorder affects children and results in increased susceptibility to infections. One possible treatment is a bone marrow transplant. [study.com]

Common signs and symptoms include an increased susceptibility to infections including ear infections; pneumonia or bronchitis; oral thrush; and diarrhea. [rarediseases.info.nih.gov]

The children lack their natural defense against infection, so it's not hard to understand that the leading sign or symptom of SCID is increased susceptibility to infection [study.com]

Hyper-IgE Syndrome

Common features are severe eczema, increased susceptibility to infections and markedly raised levels of immunoglobulin E (IgE). [piduk.org]

Other features depending on the underlying gene defect can be increased susceptibility to cutaneous viral infections and severe manifestations of allergy. [pediatriconcall.com]

Chronic Granulomatous Disease

In both syndromes, the clinical manifestations include an increased susceptibility to infections and a number of non-infectious, inflammatory conditions including systemic [ncbi.nlm.nih.gov]

susceptibility to infections. [ncbi.nlm.nih.gov]

Chronic granulomatous disease is a rare primary immunodeficiency disorder, which leads to increased susceptibility to recurrent infections and severe inflammatory manifestations [ncbi.nlm.nih.gov]

Lethal Ataxia with Deafness and Optic Atrophy

susceptibility to infections / recurrent infections - Intellectual deficit / mental / psychomotor retardation / learning disability - Nerve conduction abnormality - Optic [csbg.cnb.csic.es]

Levels of uric acid in blood were normal in all these four affected males, and none of them presented with increased susceptibility to infections. [doi.org]

Frequent infections Frequent, severe infections Increased frequency of infection infections, recurrent Predisposition to infections Susceptibility to infection [ more ] 0002719 [rarediseases.info.nih.gov]

DiGeorge Syndrome

susceptibility to infections. [icd9data.com]

Digeorge syndrome Digeorges syndrome Clinical Information A congenital anomaly characterized by immunodeficiency, abnormal facies, congenital heart disease, hypocalcemia, and increased [icd9data.com]

Ataxia-Telangiectasia Syndrome

The increased susceptibility to infections in people with ataxia-telangiectasia results from malfunction of B cells and T cells (lymphocytes), which help the body defend itself [msdmanuals.com]

To characterize the immunodeficiency in ataxia-telangiectasia (A-T) and to determine whether the immunodeficiency is progressive and associated with increased susceptibility [ncbi.nlm.nih.gov]

Topic Resources Ataxia-telangiectasia is a hereditary disorder characterized by incoordination, dilated capillaries, and an immunodeficiency that causes increased susceptibility [msdmanuals.com]

Adrenal Cushing Syndrome

An increased susceptibility to infection may also lead to sepsis. Hyperglycemia and hypertension are a common association as it was there in this case. [ijem.in]

Increased susceptibility to infections. Affected children tend to be obese but grow slowly so are short for their age. How does Cushing's syndrome progress? [patient.info]

susceptibility to some infections including pneumonia and TB. [nadf.us]

Shwachman Syndrome

Affected individuals with neutropenia may also have additional abnormalities believed to result from an increased susceptibility to infections. [rarediseases.org]

Because neutropenia may result in an increased susceptibility to bacterial infections, physicians may closely monitor affected individuals, recommend preventive measures, [rarediseases.org]

Primary Antibody Deficiency Disorder

susceptibility to infections. [ncbi.nlm.nih.gov]

susceptibility to infection and inflammatory dysregulation of PAD.7 Bronchiectasis occurred more frequently in Black/African-American patients (75%) compared to other BMC [ncbi.nlm.nih.gov]

Clinical Working Definition a Criteria 1 Common variable immunodeficiency disorders (CVID) Patients with at least one of the following: • Increased susceptibility to infection [ncbi.nlm.nih.gov]

Primary Immune Deficiency Disorder

Because one of the most important functions of the normal immune system is to protect us against infection, patients with PI commonly have an increased susceptibility to infection [primaryimmune.org]

Abstract: Patients with primary immunodeficiency diseases most often are recognized because of their increased susceptibility to infection (chronic or recurrent infections [asmscience.org]

The most common symptom of PIDD is an increased susceptibility to infection. [symptoma.com]

Papillon Lefevre Disease

The disease is characterized by palmoplantar hyperkeratosis, loss of deciduous and permanent teeth and increased susceptibility to infections. [ncbi.nlm.nih.gov]

About 20% patients with Papillon-Lefevre syndrome have an increased susceptibility to infections due to some dysfunction of the immune system.[5,12,13] Most common are recurrent [ncbi.nlm.nih.gov]

susceptibility to recurrent pyogenic infection of skin.[4] Case Report A 15 year old boy presented with persistent thickening and scaling of skin of palms and soles, which [ncbi.nlm.nih.gov]

Complement Factor D Deficiency

[…] by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway. [malacards.org]

Properdin deficiency is also associated with increased susceptibility to infection with Neisseria organisms. [clinicaladvisor.com]

Disorders of the complement cascade may or may not result in increased susceptibility to infections. [antimicrobe.org]

Complement Deficiency Syndrome

C3 27 Bacterial infections, SLE-like syndrome C4 26 SLE-like syndrome, encapsulated bacterial infections C1-INH 2-10:100,000 Angioedema MBL 2-7% UK population Increased susceptibility [sinobiological.com]

There are more than 150 PID diseases, and PID leads to increased susceptibility to infection. Most of the PIDs present with only B-cell defects (Fig 1). [pedsinreview.aappublications.org]

Complement deficiency or dysfunction may increase susceptibility to infection and seems to be related to certain autoimmune disorders. [doctor-clinic.org]

Immunodeficiency due to Ficolin 3 Deficiency

Recurrent lower respiratory tract infections MedGen UID: 756211 •Concept ID: C3163798 • Disease or Syndrome An increased susceptibility to lower respiratory tract infections [ncbi.nlm.nih.gov]

Recurrent Staphylococcus aureus infections MedGen UID: 392925 •Concept ID: C2673462 • Finding Increased susceptibility to Staphylococcus aureus infections, as manifested by [ncbi.nlm.nih.gov]

Some patients may show increased susceptibility to infection in the perinatal or neonatal period, whereas others may show autoimmune features as adults. [ncbi.nlm.nih.gov]

Properdin Deficiency

Deficiency of properdin is a rare X-linked condition characterized by increased susceptibility to infection with Neisseria meningitidis associated with a high mortality rate [ncbi.nlm.nih.gov]

Most individuals have had either an increased susceptibility to infection, rheumatic disorders, or angioedema. [ommbid.mhmedical.com]

[…] in complement leads to increased susceptibility to infection? [quizlet.com]

Complement 3 Deficiency

susceptibility to infections. [quizlet.com]

Among the possible complications are the following: Deficiencies of the terminal complement components increases susceptibility to infections by Neisseria. [en.wikipedia.org]

This may lead to an increased susceptibility to infection and a balance must often be struck between controlling immune complex disease and increasing propensity to infection [patient.info]

Female with more than three X Chromosomes

Immunoglobulin anomalies and an increased susceptibility to infection have also been reported. Cardiovascular malformations may also be present. [orpha.net]

Autosomal Agammaglobulinemia

An increased susceptibility to infection is the clinical hallmark of the disorder. [dermatologyadvisor.com]

Primary immunodeficiency diseases are inherited disorders of the immune system that result in an increased susceptibility to infection and an increased morbidity and mortality [mhmedical.com]

susceptibility to infection. [hamad.qa]

Severe Congenital Neutropenia

Severe persistent neutropenia results in an increased susceptibility to frequent bacterial infections. [ncbi.nlm.nih.gov]

Bacterial infections, recurrent Frequent bacterial infections Increased susceptibility to bacterial infections Recurrent major bacterial infections [ more ] 0002718 Thrombocytosis [rarediseases.info.nih.gov]

susceptibility to infections. [en.wikipedia.org]

Chédiak-Higashi Syndrome

susceptibility to infections, and progressive neuropathy. [genome.jp]

The Chediak-Higashi syndrome (CHS) is a rare form of partial albinism which includes increased susceptibility to infections, a hemorrhagic tendency and peripheral polyneuropathies [deepblue.lib.umich.edu]

Patients exhibit partial oculocutaneous albinism, increased susceptibility to infections and the presence of giant granules in leukocytes. [scielo.br]

Combined Immunodeficiency due to CD3-Gamma Deficiency

Combined Immunodeficiency Diseases Genetic defects in T-cell function lead to an increased susceptibility to infections or to other clinical problems that are more serious [musculoskeletalkey.com]

Recently a new syndrome has been described, designated "Mendelian Susceptibility to Mycobacterial Infection"(MIM 209950) in which patients present increased susceptibility [jped.com.br]

Disorders of complement system Complement abnormalities also lead to increased susceptibility to infections. [microbiologybook.org]

Lymphopenic Agammaglobulinemia - Short-Limbed Dwarfism Syndrome

Primary immunodeficiency diseases are inherited disorders of the immune system that result in an increased susceptibility to infection and an increased morbidity and mortality [mhmedical.com]

SELECTIVE IMMUNOGLOBULIN DEFICIENCIES  Reported in 1% of all patients with recurrent infection  Isolated Ig A deficiency reported in 0.2% of normal population  Increased [slideshare.net]

Symptoms include oculocutaneous (eye-related) albinism, and increased susceptibility to pyogenic infections (Fundenberg, 1980). [web2.uwindsor.ca]

Progressive Retinal Dystrophy due to Retinol Transport Defect

Additionally, retinol deficiency may result in dry skin, increased susceptibility to infection and acne (PubMed:23189188). {ECO:0000269 PubMed:23189188}. [genecards.org]

Additionally, retinol deficiency may result in dry skin, increased susceptibility to infection and acne (PubMed:23189188). [uniprot.org]

Sanjad-Sakati Syndrome

susceptibility to infection. [unboundmedicine.com]

Increased susceptibility to infections with recurrent respiratory infections. Reported ocular anomalies (progressive corneal opacity, tortuous retinal vessels). [accessanesthesiology.mhmedical.com]

[…] hyperphosphatemia, seizures, severe intrauterine and postnatal growth failure, dwarfism, mental retardation, dysmorphic features including retromicrognathia and abnormal dentition and increased [unboundmedicine.com]

Immunodeficiency

susceptibility to infection. [primaryimmune.org]

As with the components of the complement system, several studies have suggested an association between MBL deficiency and increased susceptibility to infection and development [tandfonline.com]

Kabuki Syndrome

In particular, most KS patients show increased susceptibility to infections and have reduced serum immunoglobulin levels, while some suffer also from autoimmune manifestations [ncbi.nlm.nih.gov]

Increased susceptibility to infections, join laxity, heart, dental and ophthalmological anomalies are common. Hypoglycaemia is more common in KS2 than in KS1. [ncbi.nlm.nih.gov]

susceptibility to infection (2) cleft palate is a feature that is sometimes observed in patients with Kabuki syndrome (3) Kabuki Syndrome support group Reference: Matsumoto [gpnotebook.com]

Iatrogenic Cushing Syndrome

Increased susceptibility to infections. Liver swelling with increased liver enzymes ALP, ALKP. Calcinosis Cutis a condition of calcium deposits in the skin. [secondchanceaihadogs.com]

An increased susceptibility to infection may also lead to sepsis. Hyperglycemia and hypertension are a common association as it was there in this case. [ijem.in]

[…] urination Visual problems caused by glaucoma or cataracts Increased susceptibility to infections Thin, fragile skin that bruises easily and heals slowly Pinkish streaks that [labtestsonline.org]