Increased Susceptibility to Infections: Causes & Reasons

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Possible Causes for Increased Susceptibility to Infections

Lethal Ataxia with Deafness and Optic Atrophy

susceptibility to infections / recurrent infections - Intellectual deficit / mental / psychomotor retardation / learning disability - Nerve conduction abnormality - Optic [csbg.cnb.csic.es]

Levels of uric acid in blood were normal in all these four affected males, and none of them presented with increased susceptibility to infections. [doi.org]

Frequent infections Frequent, severe infections Increased frequency of infection infections, recurrent Predisposition to infections Susceptibility to infection [ more ] 0002719 [rarediseases.info.nih.gov]

Adrenal Cushing Syndrome

An increased susceptibility to infection may also lead to sepsis. Hyperglycemia and hypertension are a common association as it was there in this case. [ijem.in]

Increased susceptibility to infections. Affected children tend to be obese but grow slowly so are short for their age. How does Cushing's syndrome progress? [patient.info]

susceptibility to some infections including pneumonia and TB. [nadf.us]

Shwachman Syndrome

Affected individuals with neutropenia may also have additional abnormalities believed to result from an increased susceptibility to infections. [rarediseases.org]

These may include increased tooth decay (dental caries), mouth ulcers, and/or disease of the tissues that surround and support the teeth (periodontal disease). [rarediseases.org]

Primary Immune Deficiency Disorder

The most common symptom of PIDD is an increased susceptibility to infection. [symptoma.com]

Abstract: Patients with primary immunodeficiency diseases most often are recognized because of their increased susceptibility to infection (chronic or recurrent infections [asmscience.org]

susceptibility to infection. [lls.org]

Papillon Lefevre Disease

Other symptoms of PLS may include pyogenic skin infections, nail dystrophy, hyperhidrosis, increased susceptibility to infection, and ectopic cranial calcifications (Laass [genedx.com]

The disease is characterized by palmoplantar hyperkeratosis, loss of deciduous and permanent teeth and increased susceptibility to infections. [ncbi.nlm.nih.gov]

The exact mechanism of the increased susceptibility to infections is also unknown, but some investigators have demonstrated a dysfunction in neutrophil motility and bactericidal [jiaomr.in]

Complement Factor D Deficiency

[…] by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway. [malacards.org]

Properdin deficiency is also associated with increased susceptibility to infection with Neisseria organisms. [clinicaladvisor.com]

Disorders of the complement cascade may or may not result in increased susceptibility to infections. [antimicrobe.org]

Complement Deficiency Syndrome

C3 27 Bacterial infections, SLE-like syndrome C4 26 SLE-like syndrome, encapsulated bacterial infections C1-INH 2-10:100,000 Angioedema MBL 2-7% UK population Increased susceptibility [sinobiological.com]

There are more than 150 PID diseases, and PID leads to increased susceptibility to infection. Most of the PIDs present with only B-cell defects (Fig 1). [pedsinreview.aappublications.org]

Complement deficiency or dysfunction may increase susceptibility to infection and seems to be related to certain autoimmune disorders. [doctor-clinic.org]

Properdin Deficiency

Deficiency of properdin is a rare X-linked condition characterized by increased susceptibility to infection with Neisseria meningitidis associated with a high mortality rate [ncbi.nlm.nih.gov]

Most individuals have had either an increased susceptibility to infection, rheumatic disorders, or angioedema. [ommbid.mhmedical.com]

[…] in complement leads to increased susceptibility to infection? [quizlet.com]

Immunodeficiency due to Ficolin 3 Deficiency

Some patients may show increased susceptibility to infection in the perinatal or neonatal period, whereas others may show autoimmune features as adults. [diseaseinfosearch.org]

Decreased MBL levels may be associated with increased susceptibility to infections when the adaptive immune system is immature (in early childhood) 12 or has been suppressed [labcorp.com]

Such deficiency is associated with increased susceptibility to infections and greater disease severity and in aggressive antibiotic treatment can be required in high risk [alphalabs.co.uk]

Complement 3 Deficiency

susceptibility to infections. [quizlet.com]

Among the possible complications are the following: Deficiencies of the terminal complement components increases susceptibility to infections by Neisseria. [en.wikipedia.org]

This may lead to an increased susceptibility to infection and a balance must often be struck between controlling immune complex disease and increasing propensity to infection [patient.info]

Agammaglobulinemia

Neither increased susceptibility to infections nor agammaglobulinemia have been described as a manifestation of terminal 14q32.33 deletion. [ncbi.nlm.nih.gov]

An increased susceptibility to infection is the clinical hallmark of the disorder. [clinicaladvisor.com]

The clinical picture was dominated by severe episodes of recurrent upper respiratory tract infections. [ncbi.nlm.nih.gov]

Autosomal Agammaglobulinemia

An increased susceptibility to infection is the clinical hallmark of the disorder. [dermatologyadvisor.com]

Primary immunodeficiency diseases are inherited disorders of the immune system that result in an increased susceptibility to infection and an increased morbidity and mortality [mhmedical.com]

susceptibility to infection. [hamad.qa]

Female with more than three X Chromosomes

Immunoglobulin anomalies and an increased susceptibility to infection have also been reported. Cardiovascular malformations may also be present. [orpha.net]

Combined Immunodeficiency due to CD3-Gamma Deficiency

Combined Immunodeficiency Diseases Genetic defects in T-cell function lead to an increased susceptibility to infections or to other clinical problems that are more serious [musculoskeletalkey.com]

Recently a new syndrome has been described, designated "Mendelian Susceptibility to Mycobacterial Infection"(MIM 209950) in which patients present increased susceptibility [jped.com.br]

Disorders of complement system Complement abnormalities also lead to increased susceptibility to infections. [microbiologybook.org]

Chédiak-Higashi Syndrome

The Chediak-Higashi syndrome (CHS) is a rare form of partial albinism which includes increased susceptibility to infections, a hemorrhagic tendency and peripheral polyneuropathies [deepblue.lib.umich.edu]

susceptibility to infection [ 2, 3 ]. [link.springer.com]

Patients exhibit partial oculocutaneous albinism, increased susceptibility to infections and the presence of giant granules in leukocytes. [scielo.br]

Iatrogenic Cushing Syndrome

Increased susceptibility to infections. Liver swelling with increased liver enzymes ALP, ALKP. Calcinosis Cutis a condition of calcium deposits in the skin. [secondchanceaihadogs.com]

An increased susceptibility to infection may also lead to sepsis. Hyperglycemia and hypertension are a common association as it was there in this case. [ijem.in]

[…] urination Visual problems caused by glaucoma or cataracts Increased susceptibility to infections Thin, fragile skin that bruises easily and heals slowly Pinkish streaks that [labtestsonline.org]

Kabuki Syndrome

In particular, most KS patients show increased susceptibility to infections and have reduced serum immunoglobulin levels, while some suffer also from autoimmune manifestations [ncbi.nlm.nih.gov]

Increased susceptibility to infections, join laxity, heart, dental and ophthalmological anomalies are common. Hypoglycaemia is more common in KS2 than in KS1. [ncbi.nlm.nih.gov]

Due to this increased susceptibility to infection, children with KS should have immunologic evaluations at the time of diagnosis in order to reduce preventable morbidity and [ncbi.nlm.nih.gov]

Progressive Retinal Dystrophy due to Retinol Transport Defect

Additionally, retinol deficiency may result in dry skin, increased susceptibility to infection and acne (PubMed:23189188). {ECO:0000269 PubMed:23189188}. [genecards.org]

Additionally, retinol deficiency may result in dry skin, increased susceptibility to infection and acne (PubMed:23189188). [uniprot.org]

Lymphopenic Agammaglobulinemia - Short-Limbed Dwarfism Syndrome

Primary immunodeficiency diseases are inherited disorders of the immune system that result in an increased susceptibility to infection and an increased morbidity and mortality [mhmedical.com]

SELECTIVE IMMUNOGLOBULIN DEFICIENCIES  Reported in 1% of all patients with recurrent infection  Isolated Ig A deficiency reported in 0.2% of normal population  Increased [slideshare.net]

Symptoms include oculocutaneous (eye-related) albinism, and increased susceptibility to pyogenic infections (Fundenberg, 1980). [web2.uwindsor.ca]

Common Variable Immunodeficiency

susceptibility to infections. [ncbi.nlm.nih.gov]

The patient had a history of increased susceptibility to infections and autoimmune phenomena. [ncbi.nlm.nih.gov]

Areas covered: The affected patients are characterized by increased susceptibility to infections and low levels of serum immunoglobulin. [ncbi.nlm.nih.gov]

Sanjad-Sakati Syndrome

susceptibility to infection. [unboundmedicine.com]

Increased susceptibility to infections with recurrent respiratory infections. Reported ocular anomalies (progressive corneal opacity, tortuous retinal vessels). [accessanesthesiology.mhmedical.com]

[…] hyperphosphatemia, seizures, severe intrauterine and postnatal growth failure, dwarfism, mental retardation, dysmorphic features including retromicrognathia and abnormal dentition and increased [unboundmedicine.com]

Immunodeficiency

Because one of the most important functions of the normal immune system is to protect us against infection, patients with PI commonly have an increased susceptibility to infection [primaryimmune.org]

susceptibility to infection. [primaryimmune.org]

As with the components of the complement system, several studies have suggested an association between MBL deficiency and increased susceptibility to infection and development [tandfonline.com]

Hemolytic Anemia due to Glycolytic Enzyme Deficiency

Other clinical signs can be observed, in particular, diaphragm paralysis that requires assisted ventilation, cardiomyopathy and an increased susceptibility to infections. [medicbind.com]

susceptibility to infections, cardiomyopathy, and death usually during early childhood. [ommbid.mhmedical.com]

susceptibility to infection, and muscle weakness that can affect breathing and heart function.The anemia in this condition begins in infancy. [icdlist.com]

Wiskott-Aldrich Syndrome

Wiskott-Aldrich syndrome (WAS) is an X-linked recessive disorder characterized by thrombocytopenia, small platelets, eczema, increased susceptibility to infection, and immunodeficiency [ncbi.nlm.nih.gov]

However, with respect to the major symptoms of WAS, none of these three patients showed either thrombocytopenia or increased susceptibility to infection, but one patient showed [ncbi.nlm.nih.gov]

Affecting males almost exclusively, it manifests as persistent atopic dermatitis, increased susceptibility to infections, and thrombocytopenic purpura, ecchymoses, petechiae [youtube.com]

Selective IgA Immunodeficiency

susceptibility to infection. [hamad.qa]

Patients with hyper-IgM experience recurrent sinopulmonary infections but also have an increased susceptibility to opportunistic infections, severe neutropenia, and complications [acphospitalist.org]

Immunol. (1998) [ Pubmed ] Neutrophil dysfunction and increased susceptibility to infection. Ottonello, L., Dapino, P., Pastorino, G., Dallegri, F., Sacchetti, C. Eur. [wikigenes.org]

Aflatoxicosis

Chronic toxicity in those birds is characterized by loss of weight, decline in feed efficiency, drop in egg production and increased susceptibility to infections. [ncbi.nlm.nih.gov]

Cyclopiazonic acid (CPA) has additive toxicity with aflatoxin and T-2 toxin (1,2) Affected Systems/Organs Immune system (increases susceptibility to infection). [barnhealth.com]

Myeloperoxidase Deficiency

Abstract Myeloperoxidase (MPO) deficiency is a common inherited disorder linked to increased susceptibility to infection and malignancy. [ncbi.nlm.nih.gov]

Abstract A patient with a refractory anaemia preceding acute myeloblastic leukaemia had an increased susceptibility to infection due to Staphylococcus aureus. 36% of neutrophils [ncbi.nlm.nih.gov]

We conclude that a combination of MPO-deficiency and gestational toxemia may indicate increased susceptibility to severe candida infections. [ncbi.nlm.nih.gov]

Severe Combined Immunodeficiency

This disorder affects children and results in increased susceptibility to infections. One possible treatment is a bone marrow transplant. [study.com]

Primary immunodeficiencies (PIDs) represent a large group of disorders with an increased susceptibility to infections. [ncbi.nlm.nih.gov]

The children lack their natural defense against infection, so it's not hard to understand that the leading sign or symptom of SCID is increased susceptibility to infection [study.com]

Familial Nasal Polyposis

susceptibility to infections. [en.wikipedia.org]

[…] in the nose or throat), slow wound healing, eye problems such as glaucoma or cataracts, weakened immune system (immunodeficiency) which causes an increased susceptibility [en.wikipedia.org]

[…] to infections and adrenal insufficiency. [en.wikipedia.org]

Radiation Sickness Syndrome

Radioactive elements such as uranium and barium, release excess energy in the form of particles or waves. Alpha particles, beta particles, and gamma rays are types of radioactive emissions that can cause damage by interacting with the atoms that make up living cells. All types of radiation can cause damage to the[…] [msdmanuals.com]