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198 Possible Causes for Increased Susceptibility to Infections, Recurrent Otitis Media, Recurrent Sinusitis

  • Primary Immune Deficiency Disorder

    The most common symptom of PIDD is an increased susceptibility to infection.[] Scarred tympanic membranes or chronic perforation due to recurrent otitis media is commonly seen in patients with antibody deficiencies.[] Signs of PIDD in children may include An autoimmune disease such as Type 1 diabetes, rheumatoid arthritis or lupus Recurrent ear infections, sinusitis, bronchitis, meningitis[]

  • Hypogammaglobulinemia

    susceptibility to pyogenic infections.[] Over 98% of patients present with recurrent bronchitis, sinusitis, otitis and pneumonia, and chronic pulmonary damage is the major complication.[] Case description: A 41-year-old female with TS, hypothyroidism, and recurrent otitis media as a child presents with severe vitamin deficiencies including: iron, vitamin B12[]

  • Congenital Neutropenia

    Congenital neutropenia is characterized by a decrease in the absolute number of circulating neutrophils and an increased susceptibility to infections.[] , osteopenia, osteoporosis, childhood leukemia, childhood MDS, recurrent fever, recurrent sinusitis and recurrent gingivitis.[] Herein, we describe two siblings with SCN born from consanguineous parents who were referred for complaints of recurrent cutaneous infections, gingivitis, purulent otitis[]

  • HIV Infection

    Fig 3. eSF enhance HIV infection more potently than DCs in a manner involving both trans -infection and increased susceptibility of T cells to HIV infection.[] They may present with recurrent infections of the respiratory tract, including otitis media, tonsillitis, sinusitis, pharyngitis, and bronchitis.[] HIV infection increases susceptibility to smoking-induced emphysema. Chest. 2000;117(5 suppl 1):285S. 33. Kirk GD, Merlo C, O'Driscoll P, et al.[]

  • Congenital Acquired Immune Deficiency Syndrome

    KEY TERMS Agammaglobulinemia —The lack of gamma globulins in the blood, associated with an increased susceptibility to infection.[] Symptoms: Recurrent respiratory infections. Persistent bacterial infections - sinusitis, otitis and bronchitis.[] Antibody immunodeficiencies are marked by hypo- or dysgammaglobulinemia, recurrent bacterial otitis media, and sinopulmonary infections.[]

  • Primary Ciliary Dyskinesia

    Asthma is associated with increased susceptibility to infection. Minerva Med (2015) 106:1–7. PubMed Abstract Google Scholar 44.[] sinusitis, and often an agenesis of the frontal sinuses.[] Seven cases were complicated with recurrent otitis media and 15 cases were complicated with infertility.[]

  • HIV-2 Infection

    Susceptibility to infection does not need to increase with age to reproduce higher HIV-2 prevalence amongst older individuals.[] […] of IL-2-producing CD4 T-cells is found to decline ( 42 ), which in turn relates to the reduced renewal capacity and increased susceptibility of these populations of cells[] However, infection has remained prevalent amongst older adults (12% amongst over 45 years) [4], susceptibility of women is believed to increase with age [23] and it has been[]

  • Common Variable Immunodeficiency

    susceptibility to infections.[] sinusitis and bronchitis.[] Antibody immunodeficiencies are marked by hypo- or dysgammaglobulinemia, recurrent bacterial otitis media, and sinopulmonary infections.[]

  • Shwachman Syndrome

    Affected individuals with neutropenia may also have additional abnormalities believed to result from an increased susceptibility to infections.[] Recurrent bacterial, viral, and fungal infections, particularly, otitis, sinusitis, pneumonia, septicemia, osteomyelitis, and cutaneous infections are common.[] otitis media, mastoiditis, and two episodes of pneumonia.[]

  • Gastroesophageal Reflux Disease

    Conclusions Severe hypochlorhydria generated by PPI use leads to bacterial colonisation and increased susceptibility to enteric bacterial infection.[] […] and chronic sinusitis.[] otitis media.[]

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