Indifference to Pain: Causes & Reasons

Possible Causes for Indifference to Pain

Channelopathy-Associated Congenital Insensitivity to Pain

There is no support group for congenital insensitivity/indifference to pain. [contact.org.uk]

[…] to pain congenital pain indifference indifference to pain, congenital, autosomal recessive pain insensitivity, congenital SOURCE: Emory University - Department of Human Genetics [thinkgenetic.com]

[…] channelopathy-associated insensitivity to pain CIP congenital analgesia congenital indifference to pain congenital pain indifference indifference to pain, congenital, autosomal [ghr.nlm.nih.gov]

Lesch-Nyhan Syndrome

Kapasi AY, Trasi SS, Khopkar US, Wadhwa SL (1992) Congenital indifference to pain. Indian J Dermatol Venereol Leprol 58: 273-276. [heraldopenaccess.us]

Phencyclidine Intoxication

Rhabdomyolysis can occur with phencyclidine hydrochloride (PCP) intoxication. However, to our knowledge acute renal failure with phencyclidine-induced rhabdomyolysis has not been reported previously. Therefore, we describe two patients with this condition. The modern treatment of phencyclidine intoxication, namely[…] [ncbi.nlm.nih.gov]

Autosomal Dominant Hereditary Sensory and Autonomic Neuropathy

' and 'congenital indifference to pain'. [indianjpain.org]

[…] to Pain, Congenital, Autosomal Recessive Asymbolia For Pain Congenital Analgesia, Autosomal Recessive Insensitivity To Pain, Channelopathy-Associated Neuropathy, Hereditary [ukgtn.nhs.uk]

This results in feeding difficulties, excessive sweating, absence of tears, indifference to pain, reduced corneal sensitivity, emotional lability and red blotching of the [medical-dictionary.thefreedictionary.com]

Familial Dysautonomia

Deep tendon reflexes are often diminished or absent and there is a general indifference to pain and temperature. [disorders.eyes.arizona.edu]

Striking features are indifference to pain and diminished lacrimation, which predispose to corneal ulceration, and poor vasomotor control, which predisposes to hypertension [jamanetwork.com]

Neuropathic Arthropathy

Some of the offenders include diabetic neuropathy, tabes dorsalis, syringomyelia, and congenital indifference to pain. [ncbi.nlm.nih.gov]

A case of a variant of congenital indifference to pain, in which the patient initially developed lower extremity neurogenic arthropathy ultimately requiring bilateral above-the-knee [ncbi.nlm.nih.gov]

Indifference to pain means that the patient can perceive the stimulus, but lacks an appropriate response: they do not flinch or withdraw when exposed to pain. [en.wikipedia.org]

Lytic Bone Lesion

[…] to Pain, Congenital, Autosomal Recessive Asymbolia For Pain Congenital Analgesia, Autosomal Recessive Insensitivity To Pain, Channelopathy-Associated Neuropathy, Hereditary [ukgtn.nhs.uk]

Some sensory syndromes in children: indifference to pain and sensory neuropathy. J. Neurol. Neurosurg. Psychiat. 22 :267–276. Google Scholar Special report 1978. [link.springer.com]

A.: Some sensory syndromes in children: indifference to pain and sensory neuropathy. J. Neurol. Neurosurg. Psychiat. 22: 267-276, 1959. 17. Ogryzlo, M. [genome.jp]

Congenital Autosomal Dominant Indifference to Pain

Magee KR, Schneider SF, Rosenzweig N: Congenital indifference to pain. J Nerv Ment Dis 1961;132:249–259. Schneider SF: A psychological basis for indifference to pain. [karger.com]

More Symptoms of Indifference to pain, congenital, autosomal recessive » • • • Back to: « Indifference to pain Genetics of Indifference to pain, congenital, autosomal recessive [familydiagnosis.com]

There is no support group for congenital insensitivity/indifference to pain. [contact.org.uk]

Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids

[…] album of pain and desperation. [nokorra.bandcamp.com]

Bandcamp New & Notable Feb 28, 2019 go to album Indifferent Rivers Romance End by Wreck and Reference Wreck and Reference expand on their metal base to deliver a masterfully-wrought [nokorra.bandcamp.com]

Hereditary Sensory and Autonomic Neuropathy Type 1C

' and 'congenital indifference to pain'. [indianjpain.org]

Indifference to pain syndrome in a twelve-year-old boy (case report). Tehran Univ Med J 2007; 65 (4) :87-91. [journals.sbmu.ac.ir]

We only considered patients with HSANs II, IV, and V, or related variants associated with profound pain hyposensitivity (or “pain indifference”). [anesthesiology.pubs.asahq.org]

Fatal Infantile Lactic Acidosis with Methylmalonic Aciduria

Rivers Romance End by Wreck and Reference Wreck and Reference expand on their metal base to deliver a masterfully-wrought album of pain and desperation. [nokorra.bandcamp.com]

WRAITH by Teeth Of The Sea Tempering dystopian electronics with Morricone-esque set pieces, the UK psych soothsayers' latest album is also their most dynamic. go to album Indifferent [nokorra.bandcamp.com]

Autosomal Recessive Distal Osteolysis Syndrome

Congenital insensitivity to pain Congenital insensitivity (indifference) to pain is a rare syndrome inherited as an autosomal recessive trait. [clinicalgate.com]

A.: Some sensory syndromes in children: indifference to pain and sensory neuropathy. J. Neurol. Neurosurg. Psychiat. 22: 267-276, 1959. 17. Ogryzlo, M. [genome.jp]

Unlike the situation in congenital indifference to pain (OMIM 147430,243000), in neurogenic acro-osteolysis the perception not only of pain but also of temperature and touch [rrnursingschool.biz]

Generalized Epilepsy with Febrile Seizures plus Type 7

[…] disorder not specified Generalized epilepsy with febrile seizures plus Severe myoclonic epilepsy in infancy Congenital Indifference to Pain Inherited Erythromelalgia Familial [snpedia.com]

[…] disorder; INDIFFERENCE TO PAIN, CONGENITAL; early infantile epileptic encephalopathy 6; generalized epilepsy with febrile seizures plus 7 AD, AR 74 GABRD 137163 Epilepsy, [centogene.com]

ClinVar Risk rs73969684(G;G) rs73969684(T;T) Alt rs73969684(G;G) rs73969684(T;T) Reference Rs73969684(C;C) Significance Other Disease Small fiber neuropathy Paroxysmal extreme pain [snpedia.com]

Generalized Epilepsy with Febrile Seizures plus Type 3

[…] disorder not specified Generalized epilepsy with febrile seizures plus Severe myoclonic epilepsy in infancy Congenital Indifference to Pain Inherited Erythromelalgia Familial [snpedia.com]

[…] disorder; INDIFFERENCE TO PAIN, CONGENITAL; early infantile epileptic encephalopathy 6; generalized epilepsy with febrile seizures plus 7 AD, AR 75 Treatment of generalized [centogene.com]

ClinVar Risk rs73969684(G;G) rs73969684(T;T) Alt rs73969684(G;G) rs73969684(T;T) Reference Rs73969684(C;C) Significance Other Disease Small fiber neuropathy Paroxysmal extreme pain [snpedia.com]

Autism Spectrum Disorder

Hyper- or hyporeactivity to sensory input or unusual interests in sensory aspects of the environment (e.g., apparent indifference to pain/temperature, adverse response to [researchautism.net]

[…] to pain/temperature, excessive smelling/touching of objects, fascination with lights and movement, being overwhelmed with loud noises, etc), and others. [psychiatry.org]

[…] to pain or temperature Doesn't engage in imitative or make-believe play Fixates on an object or activity with abnormal intensity or focus Has specific food preferences, such [mayoclinic.org]

Hereditary Sensory Neuropathy Type 1F

We only considered patients with HSANs II, IV, and V, or related variants associated with profound pain hyposensitivity (or “pain indifference”). [anesthesiology.pubs.asahq.org]

Other features include reduced or absent tears, depressed deep tendon reflexes, absent corneal reflex, postural hypotension and relative indifference to pain. [en.wikipedia.org]

Familial Episodic Pain Syndrome Type 1

[…] and autonomic neuropathy type IID; blue filled circles, indifference to pain; black open circles, febrile convulsion; black filled circles, Dravet syndrome. [thejournalofheadacheandpain.springeropen.com]

TO PAIN, CONGENITAL (AUTOSOMAL RECESSIVE); PAROXYSMAL EXTREME PAIN DISORDER SCN9A Full Sequencing UP TO 6 WEEKS Gene Sequencing SDHB - Paragangliomas and Pheochromocytoma [prontodiagnostics.com]

Paroxysmal Extreme Pain Disorder

[…] disorder not specified Generalized epilepsy with febrile seizures plus Severe myoclonic epilepsy in infancy Congenital Indifference to Pain Inherited Erythromelalgia Familial [snpedia.com]

[…] and autonomic neuropathy type IID; blue filled circles, indifference to pain; black open circles, febrile convulsion; black filled circles, Dravet syndrome. [link.springer.com]

ClinVar Risk rs73969684(G;G) rs73969684(T;T) Alt rs73969684(G;G) rs73969684(T;T) Reference Rs73969684(C;C) Significance Other Disease Small fiber neuropathy Paroxysmal extreme pain [snpedia.com]

Generalized Epilepsy with Febrile Seizures plus Type 2

[…] disorder not specified Generalized epilepsy with febrile seizures plus Severe myoclonic epilepsy in infancy Congenital Indifference to Pain Inherited Erythromelalgia Familial [snpedia.com]

[…] disorder; INDIFFERENCE TO PAIN, CONGENITAL; early infantile epileptic encephalopathy 6; generalized epilepsy with febrile seizures plus 7 AD, AR 75 Treatment of generalized [centogene.com]

ClinVar Risk rs73969684(G;G) rs73969684(T;T) Alt rs73969684(G;G) rs73969684(T;T) Reference Rs73969684(C;C) Significance Other Disease Small fiber neuropathy Paroxysmal extreme pain [snpedia.com]

Carnevale Krajewska Fischetto Syndrome

indifference, see congenital insensitivity to pain congenital plasminogen deficiency congenital poikiloderma, see Rothmund-Thomson syndrome congenital pontocerebellar hypoplasia [herenciageneticayenfermedad.blogspot.com]

[…] to pain, see congenital insensitivity to pain congenital insensitivity to pain, see hereditary sensory and autonomic neuropathy type V congenital insensitivity to pain congenital [herenciageneticayenfermedad.blogspot.com]

indifference, see congenital insensitivity to pain congenital plasminogen activator inhibitor type 1 deficiency, see complete plasminogen activator inhibitor 1 deficiency [mygenomics.com]

Coxitis Fugax

In accordance with this clinical case report, we would like to point out the necessity for the immediate diagnosis of indifferent hip pain by means of MRI, especially for [ncbi.nlm.nih.gov]

Boucher-Neuhäuser Syndrome

Multiple gene diagnostics: Gene panel indifference to pain (SCN9A, SCN11A) Gene panel small fiber neuropathy (SCN3A,SCN7A,SCN8A,SCN9A,SCN10A,SCN11A,SCN1B,SCN2B,SCN3B,SCN4B [gdnm.nl]

[…] to pain Congenital insensitivity to pain Cortical dysplasia D Dejerine-Sottas Disease Dopamine beta-hydroxylase deficiency Dyskinesia Dystonia Dystonia, dopamine responsive [gdnm.nl]

[…] hereditary, benign Choreoathetosis, hypothyroidism and neonatal respiratory distress Cognitive impairment with or without cerebellar ataxia Complex II deficiency Congenital indifference [gdnm.nl]

Generalized Epilepsy with Febrile Seizures Plus

[…] disorder not specified Generalized epilepsy with febrile seizures plus Severe myoclonic epilepsy in infancy Congenital Indifference to Pain Inherited Erythromelalgia Familial [snpedia.com]

[…] disorder; INDIFFERENCE TO PAIN, CONGENITAL; early infantile epileptic encephalopathy 6; generalized epilepsy with febrile seizures plus 7 AD, AR 75 Treatment of generalized [centogene.com]

[…] disorder; INDIFFERENCE TO PAIN, CONGENITAL; early infantile epileptic encephalopathy 6; generalized epilepsy with febrile seizures plus 7 AD, AR 77 Treatment of generalized [centogene.com]

Somatization Disorder

sexual indifference, erectile or ejaculatory dysfunction, irregular menses, excessive menstrual bleeding and/or vomiting throughout pregnancy) d) at least one pseudoneurological [ichd-3.org]

painful or unpleasurable coitus which were not explicitly asked for in this study in view of its sensitivity. 13, 22 Pertinent history of other symptoms not included in [ncbi.nlm.nih.gov]

( eg, nausea, bloating, vomiting other than during pregnancy, diarrhoea and/or intolerance of several different foods) c) at least one sexual symptom other than pain ( eg [ichd-3.org]

Familial Febrile Seizures Type 1

[…] disorder not specified Generalized epilepsy with febrile seizures plus Severe myoclonic epilepsy in infancy Congenital Indifference to Pain Inherited Erythromelalgia Familial [snpedia.com]

[…] disorder; INDIFFERENCE TO PAIN, CONGENITAL; early infantile epileptic encephalopathy 6; generalized epilepsy with febrile seizures plus 7 AD, AR 75 Treatment of generalized [centogene.com]

[…] disorder; INDIFFERENCE TO PAIN, CONGENITAL; early infantile epileptic encephalopathy 6; generalized epilepsy with febrile seizures plus 7 AD, AR 77 Treatment of generalized [centogene.com]

Intestinal Pseudo-Obstruction - Patent Ductus Arteriosus - Natal Teeth

項番疾患No 英語疾患名 2301 243000 Indifference to pain, congenital, autosomal recessive (CIP) (Insensitivity to pain, channelopathy-associated) (Congenital analgesia, autosomal recessive [syndromefinder.ncchd.go.jp]

[…] to Pain, Congenital, Autosomal Recessive; CIP OMIM:243050 Indolylacroyl Glycinuria with Mental Retardation OMIM:618339 Infantile Cataract, Skin Abnormalities, Glutamate Excess [informatics.jax.org]

[…] with Early-Onset Paget Disease with or without Frontotemporal Dementia 3; IBMPFD3 OMIM:147421 Inclusion Body Myositis OMIM:308300 Incontinentia Pigmenti; IP OMIM:243000 Indifference [informatics.jax.org]

Navajo Neurohepatopathy

Congenital indifference to pain (CIP, MIM #243000) is rare ( MPV17, the gene primarily involved in NNH. 1 Pain perception was normal in a sister with congenital liver disease [n.neurology.org]

Nocturnal Frontal Lobe Epilepsy

[…] disorder; INDIFFERENCE TO PAIN, CONGENITAL; early infantile epileptic encephalopathy 6; generalized epilepsy with febrile seizures plus 7 AD, AR 77 SLC2A1 138140 Dystonia [centogene.com]

[…] without cerebellar ataxia; early infantile epileptic encephalopathy 13; Seizures, benign familial infantile, 5 AD 41 SCN9A 603415 primary erythermalgia; Paroxysmal extreme pain [centogene.com]

Syphilitic Arthritis

Other causes include CPPD crystal deposition disease, recurrent intraarticular steroids, alcoholic neuropathy, amyloidosis, congenital indifference to pain, meningomyelocele [rheumaknowledgy.com]

Congenital Cataract-Ichthyosis Syndrome

Pain Insensitivity, Congenital A syndrome characterized by indifference to PAIN despite the ability to distinguish noxious from nonnoxious stimuli. [bioportfolio.com]

To Pain, Congenital, Autosomal Recessive 3 Infantile cerebellar-retinal degeneration 3 Infantile Gm1 Gangliosidosis 2 Infantile Hypophosphatasia 4 Infantile Liver Failure [preventiongenetics.com]

Myopathy with Early-Onset Paget Disease with or without Frontotemporal Dementia 2 2 Inclusion Body Myopathy with Early-Onset Paget Disease without Frontotemporal Dementia 3 1 Indifference [preventiongenetics.com]