Inflammatory Infiltrate: Causes & Reasons

Possible Causes for Inflammatory Infiltrate

Neuromyelitis Optica Spectrum Disorder with Anti-AQP4 Antibodies

The infiltration of inflammatory cells across the damaged blood–brain barrier and leptomeningeal blood barrier into the adjacent cortex could be the possible explanation of [dovepress.com]

(a) Axial FLAIR image shows an expansive infiltrative lesion in the pons with discrete extension to the right cerebellar hemisphere (arrow). [pubs.rsna.org]

NMOSD coexisting with Sjögren’s syndrome (SS) SS is a chronic systemic illness typically characterized by the dysfunction and inflammatory infiltration of the exocrine glands [dovepress.com]

Acute Interstitial Nephritis

Evidence of renal failure, abnormal urinalysis, and renal biopsy with inflammatory infiltrate in the interstitium confirmed a diagnosis of AIN. [ncbi.nlm.nih.gov]

Acute kidney injury occurred at 4-12 weeks after initiation of treatment, and harbored features of tubulo-interstitial nephritis (interstitial polymorphic inflammatory infiltrate [ncbi.nlm.nih.gov]

A kidney biopsy showed inflammatory infiltrate consistent with ATIN. [ncbi.nlm.nih.gov]

Cronkhite-Canada Syndrome

On histologic review, the main findings in the gastric mucosa were a prominent mucosal edema, a mixed inflammatory infiltrate rich in eosinophils, and architectural changes [ncbi.nlm.nih.gov]

infiltrate. [dermnetnz.org]

Histology showed cystically dilated glands and mixed inflammatory infiltrate comprising eosinophils and neutrophils. [cghjournal.org]

Interstitial Nephritis

Autoimmune interstitial nephritis evident by mixed inflammatory cell infiltrate with many plasma cells Incorrect. [ajkdblog.org]

Kidney biopsy showed acute tubular necrosis together with interstitial inflammatory infiltrate of mononuclear cells and interstitial fibrosis occupying 25% of the cortex. [ncbi.nlm.nih.gov]

Chronic inflammatory infiltrate and fibrosis are present in the renal interstitium. Atrophic tubules with chronic inflammatory infiltrate in interstitium. 45. [slideshare.net]

Eosinophilic Fasciitis

The biopsy showed fibrotic involvement of muscle and fascia, with a few inflammatory infiltrations of lymphocytes. [doi.org]

It can be precipitated by undue exertion and is characterized by eosinophilia and infiltration of skin and subcutaneous tissue by mixed inflammatory infiltrate including eosinophils [ncbi.nlm.nih.gov]

infiltrate containing eosinophils. [ncbi.nlm.nih.gov]

Hypersensitivity Myocarditis

The myocarditis in these patients was characterized by a patchy interstitial inflammatory infiltrate rich in eosinophils, focal myocytolysis, prominent perivascular infiltrates [ncbi.nlm.nih.gov]

Microscopic features: Myocardial inflammatory infiltrate associated with myocyte necrosis or degeneration. [histopathology-india.net]

The features of the injury and inflammatory infiltrate should be distinct from those of ischemic injury and toxic injuries such as catecholamine myocardial toxicity. [circ.ahajournals.org]

Lymphocytic Myocarditis

To investigate if LM changes coronary atherosclerotic plaque, we analyzed in autopsied hearts the inflammatory infiltrate and stability in coronary atherosclerotic lesions [ncbi.nlm.nih.gov]

Our patient received OKT3 therapy in a later phase of the disease, when inflammatory infiltrates were accompanied by extensive fibrosis and severe damage of cardiomyocytes [ncbi.nlm.nih.gov]

infiltrate, or degree of myocardial cell injury. [ncbi.nlm.nih.gov]

Oophoritis

The inflammatory infiltrate increased in intensity with follicular maturation and appeared to be destroying the theca interna. [ncbi.nlm.nih.gov]

[…] layer (H and E, ×200) Click here to view Figure 4: Theca interna with dense lymphoplasmacytic inflammatory infiltrate. [ijpmonline.org]

Both had enlarged cystic ovaries that on histological examination showed a perifollicular inflammatory infiltrate consisting of lymphocytes, plasma cells, and large numbers [ncbi.nlm.nih.gov]

Giant Cell Myocarditis

The diagnosis of GCM was made by endomyocardial biopsy (EMB), which revealed extensive fibrosis and inflammatory infiltration with multinucleated giant cells, as well as scattered [ncbi.nlm.nih.gov]

An inflammatory infiltrate with giant cells and myocardial necrosis is characteristic. [ncbi.nlm.nih.gov]

Cardiac recovery was rapid, complete (left ventricular ejection fraction rose to 55% from 10%), and was accompanied by the disappearance of the inflammatory infiltrates including [ncbi.nlm.nih.gov]

Sarcoid Myocarditis

Dallas criteria defined it as an inflammatory infiltrate of the myocardium with necrosis and /or degeneration of adjacent myocytes not typical of ischemic damage associated [ispub.com]

(iii) Prominent eosinophilia in the inflammatory cellular infiltrate present in Giant cell myocarditis. It is usually absent in cardiac sarcoidosis. [histopathology-india.net]

Numerous giant cells (arrows) can be identified within the inflammatory infiltrate (hematoxylin and eosin, x100) Multinucleated giant cells (long arrows) are seen adjacent [wikidoc.org]

Cutaneous Pseudolymphoma

The authors report on a 2-year-old boy with a lesion of molluscum contagiosum in which the inflammatory infiltrate that surrounded a cystlike structure containing molluscum [ncbi.nlm.nih.gov]

The inflammatory infiltrate is bandlike, nodular, or diffuse and is composed predominantly of lymphocytes with or without other inflammatory cells. [ncbi.nlm.nih.gov]

A mixed inflammatory infiltrate with germinal centers is indicative of lymphocytoma cutis. [img.medscape.com]

Fungal Myocarditis

Microscopic features: Myocardial inflammatory infiltrate associated with myocyte necrosis or degeneration. [histopathology-india.net]

Dallas criteria defined it as an inflammatory infiltrate of the myocardium with necrosis and /or degeneration of adjacent myocytes not typical of ischemic damage associated [ispub.com]

[…] in association with myocyte necrosis Borderline myocarditis: inflammatory infiltrates without evidence of myocyte necrosis Due to high interobserver variability, IHC is increasingly [pathologyoutlines.com]

Pemphigus Vegetans

There is also typically a dense inflammatory infiltrate in the dermis composed of eosinphils, lymphocytes, and occasionally neutrophils. [dermnet.com]

Dermis showed intense inflammatory infiltrate comprising of plasma cells and eosinophils [Figure - 2]. [e-ijd.org]

Microscopic findings include epidermal hyperplasia, focal acantholysis, and a dense mixed inflammatory infiltrate with intraepithelial and subepithelial eosinophilic microabscesses [insights.ovid.com]

Erythema Elevatum Diutinum

Histopathology of a recent erythematous plaque showed extensive dense inflammatory infiltrate in the upper dermis predominantly composed of neutrophils, extending around the [e-ijd.org]

infiltrate and the leucocytoclastic vasculitis. [ncbi.nlm.nih.gov]

The predominant cell type in the inflammatory infiltrate was polymorphonuclear leukocytes or a mixture of polymorphonuclear leukocytes and lymphocytes. [mayoclinic.pure.elsevier.com]

Hypertrophic Lichen Planus

infiltrate composed predominantly of T-cells. [fpnotebook.com]

Inflammatory infiltrate are sometimes present. [ijpmonline.org]

Pathological examination showed hydropic degeneration of the basal layer, pigmentary incontinence and moderate inflammatory lymphocytic infiltrate in the dermis. [scielo.br]

Eosinophilic Pustular Folliculitis

Results of histopathologic examination revealed subcorneal and intraepidermal pustules, and an inflammatory infiltrate consisting of lymphocytes and eosinophils mainly with [ncbi.nlm.nih.gov]

Histopathological examination showed a dense follicular inflammatory infiltrate with abundant eosinophils. [ncbi.nlm.nih.gov]

Histologically both of our patients showed a moderate mixed inflammatory infiltrate with numerous eosinophils centered around hair follicles. [ncbi.nlm.nih.gov]

Bacterial Myocarditis

Microscopic features: Myocardial inflammatory infiltrate associated with myocyte necrosis or degeneration. [histopathology-india.net]

Dallas criteria defined it as an inflammatory infiltrate of the myocardium with necrosis and /or degeneration of adjacent myocytes not typical of ischemic damage associated [ispub.com]

Acute viral myocarditis is usually associated with a lymphocytic inflammatory infiltrate. [pathwaymedicine.org]

Autoimmune Necrotizing Myopathy

infiltrate Inclusion body myositis : Similar inflammatory pattern Rimmed vacuoles may be difficult to find or not be "classic" Presence of occasional granular staining suggestive [pathologyoutlines.com]

Muscle biopsy is sensitive but not specific and reveals scattered necrotic regenerating fibers without inflammatory infiltrate. [shmabstracts.com]

Diagnostic methods Diagnosis is based on the clinical picture and on muscle biopsy showing minimal or no inflammatory infiltrates and marked muscle necrosis, unlike other [orpha.net]

Acquired Amyloid Myopathy

There is an inflammatory infiltrate around the muscle fibers (left panel). A necrotic fiber infiltrated by inflammatory cells is seen in the right panel. [hopkinsarthritis.org]

In a group of consecutive patients (n=22) with inflammatory infiltrates pairs of adhesion molecules were examined on infiltrating cells and vascular endothelial cells. [diva-portal.org]

[…] and mononuclear inflammatory infiltrates. [neuropathology-web.org]

Polymyositis

This study was aimed to research the effects of IL-15 on inducing inflammatory infiltration of macrophages in polymyositis (PM) through the NF-kB pathway, and whether IL-15 [ncbi.nlm.nih.gov]

The dispute The idiopathic inflammatory myopathies are a group of heterogeneous disorders characterised by acquired progressive muscle weakness and inflammatory infiltrates [doi.org]

Sweet Syndrome

[…] cutaneous lesions, abundant dermal neutrophilic inflammatory infiltrate evident on histopathologic examination, as well as an increase of inflammatory markers in the blood [jamanetwork.com]

Neutrophilic dermatoses comprise a wide spectrum of inflammatory diseases with overlapping features characterized histologically by the presence of an aseptic neutrophilic [ncbi.nlm.nih.gov]

Design Histopathologic, immunohistochemical, and cytogenetic studies of the inflammatory infiltrate in a case series of histiocytoid Sweet syndrome. [jamanetwork.com]

Perifolliculitis Capitis Abscedens

All rights reserved. per·i·fol·lic·u·li·tis (per'i-fŏ-lik'yū-lī'tis), The presence of an inflammatory infiltrate surrounding hair follicles; frequently occurs in conjunction [medical-dictionary.thefreedictionary.com]

Compare folliculitis. per·i·fol·lic·u·li·tis ( per'i-fŏ-lik'yū-lī'tis ) The presence of an inflammatory infiltrate surrounding hair follicles; frequently occurs in conjunction [medical-dictionary.thefreedictionary.com]

Diagnosis Granulomatous dermatitis with mixed inflammatory infiltrate. [ncbi.nlm.nih.gov]

Rhinoscleroma

T here is a dense mixed inflammatory infiltrate composed of abundant plasma cells and lymphocytes. [histopathology-india.net]

The first biopsy revealed the presence of chronic inflammatory infiltrate, with predominance of macrophages with foamy appearance. [scielo.sa.cr]

In the fibrotic stage, the characteristic Mikulicz cells are absent, fibrosis is extensive, and the inflammatory infiltrate contains lymphocytes and plasma cells. [histopathology-india.net]

Familial Keratoacanthoma

(blue-stained dermis) Bowen’s disease (in situ SCC) Hyperkeratosis Parakeratosis Atypical keratinocytes throughout epidermis Inflammatory infiltrate SCC Invasion of dermis [health.auckland.ac.nz]

Dermis shows a dense, chiefly mononuclear inflammatory infiltrate. A buttress of epidermis surrounded the crater. [idoj.in]

[…] squamous nests and islands, accompanied by marked inflammatory infiltrate with lichenoid features and eosinophils but no plasma cells May be deeply infiltrative, with microabscesses [pathologyoutlines.com]

Spinal Pachymeningitis

Dural biopsy demonstrated fibrosis and prominent CD4+ T-cells inflammatory infiltrate. [scienceopen.com]

Histology revealed a thickened dura with fibrosis and non-specific inflammatory infiltrate (Fig. 2). Microbiological test results were normal. [tidsskriftet.no]

The meningeal biopsy revealed markedly thickened fibro-connective dural tissue with infiltration of chronic inflammatory cells. [ruralneuropractice.com]

Plasma Cell Gingivitis

Figure 3b The inflammatory infiltrate is composed predominately of plasma cells (He × 400). [nature.com]

A second biopsy showed dense inflammatory cell infiltration, including mainly plasma cells, with no atypical cells. [jstage.jst.go.jp]

[…] here to view Figure 4: Tissue sections stained with hematoxylin and eosin viewed at 100× magnification showing stroma with inflammatory infiltrate of abundant plasma cell [jiaomr.in]

Necrobiosis Lipoidica Diabeticorum

Necrobiotic granuloma and inflammatory infiltrate: Full thickness of the dermis is involved with extension into the subcutis. [histopathology-india.net]

Broad horizontal arrangement of necrobiotic collagen with a surrounding inflammatory infiltrate of histiocytes and lymphocytes seen in necrobiosis lipoidica diabeticorum [mdedge.com]

A superficial and deep perivascular inflammatory infiltrate rich in plasma cells is typically present, and there may be vasculitis. External Links: [dermpedia.org]

Giant-Cell Granulomatous Hypophysitis

With respect to immunohistochemistry our results show histiocytes (CD68+) and an heterogeneous inflammatory infiltrate (CD45RO+ y CD20+). [revistaneurocirugia.com]

Pituitary dysfunction secondary to inflammatory infiltration is common. [edmcasereports.com]

A histological diagnosis of hypophysitis with a mixed inflammatory cell infiltrate was made. [edmcasereports.com]

Necrotizing Sialometaplasia

In all 3 cases, the biopsy specimen showed acinic necrosis surrounded by a dense polymorphous inflammatory infiltrate with atrophy of ductal cells but no squamous metaplasia [ncbi.nlm.nih.gov]

infiltrate, the endothelial cells, and stromal cells. [ncbi.nlm.nih.gov]

Inflammatory infiltrate was evident. On higher magnification sections showed bland epithelial islands. [journalgateway.com]

Epidermolysis Bullosa Pruriginosa

Histology revealed hyperkeratosis, acanthosis, subepidermal edema with dilated blood vessels and an inflammatory infiltrate in the dermis. [ijdvl.com]

infiltrates and late presentation are potential pitfalls in correctly diagnosing this subtype of hereditary EB. [wwww.unboundmedicine.com]

The clinical features of EB pruriginosa are becoming more widely recognized, but dermatologists, dermatopathologists, and histopathologists should be aware that inflammatory [ncbi.nlm.nih.gov]