Inflammatory Infiltrate: Causes & Reasons

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Possible Causes for Inflammatory Infiltrate

Acute Interstitial Nephritis

Acute kidney injury occurred at 4-12 weeks after initiation of treatment, and harbored features of tubulo-interstitial nephritis (interstitial polymorphic inflammatory infiltrate [ncbi.nlm.nih.gov]

A kidney biopsy showed inflammatory infiltrate consistent with ATIN. [ncbi.nlm.nih.gov]

Evidence of renal failure, abnormal urinalysis, and renal biopsy with inflammatory infiltrate in the interstitium confirmed a diagnosis of AIN. [ncbi.nlm.nih.gov]

Neuromyelitis Optica Spectrum Disorder with Anti-AQP4 Antibodies

Interstitial Nephritis

Chronic inflammatory infiltrate and fibrosis are present in the renal interstitium. Atrophic tubules with chronic inflammatory infiltrate in interstitium. 45. [slideshare.net]

Kidney biopsy showed acute tubular necrosis together with interstitial inflammatory infiltrate of mononuclear cells and interstitial fibrosis occupying 25% of the cortex. [ncbi.nlm.nih.gov]

The hallmark of AIN is an inflammatory infiltrate and oedema within the renal interstitium. [omicsonline.org]

Eosinophilic Fasciitis

The biopsy showed fibrotic involvement of muscle and fascia, with a few inflammatory infiltrations of lymphocytes. [doi.org]

It can be precipitated by undue exertion and is characterized by eosinophilia and infiltration of skin and subcutaneous tissue by mixed inflammatory infiltrate including eosinophils [ncbi.nlm.nih.gov]

infiltrate containing eosinophils. [ncbi.nlm.nih.gov]

Lymphocytic Myocarditis

To investigate if LM changes coronary atherosclerotic plaque, we analyzed in autopsied hearts the inflammatory infiltrate and stability in coronary atherosclerotic lesions [ncbi.nlm.nih.gov]

Our patient received OKT3 therapy in a later phase of the disease, when inflammatory infiltrates were accompanied by extensive fibrosis and severe damage of cardiomyocytes [ncbi.nlm.nih.gov]

infiltrate, or degree of myocardial cell injury. [ncbi.nlm.nih.gov]

Hypersensitivity Myocarditis

The myocarditis in these patients was characterized by a patchy interstitial inflammatory infiltrate rich in eosinophils, focal myocytolysis, prominent perivascular infiltrates [ncbi.nlm.nih.gov]

Microscopic features: Myocardial inflammatory infiltrate associated with myocyte necrosis or degeneration. [histopathology-india.net]

The features of the injury and inflammatory infiltrate should be distinct from those of ischemic injury and toxic injuries such as catecholamine myocardial toxicity. [circ.ahajournals.org]

Eosinophilic Angiocentric Fibrosis

One lacrimal gland biopsy showed a periductal inflammatory infiltrate, and 2 cases showed a storiform pattern of fibrosis. [ncbi.nlm.nih.gov]

It is characterized histologically by mixed inflammatory infiltrate predominated by eosinophils and concentric perivas-cular fibrosis. [yalepath.org]

Histological analysis of the resected tumour showed an inflammatory infiltrate with a predominance of eosinophils present in fibrous matrix and absence of eosinophilic vasculitis [ncbi.nlm.nih.gov]

Giant Cell Myocarditis

The diagnosis of GCM was made by endomyocardial biopsy (EMB), which revealed extensive fibrosis and inflammatory infiltration with multinucleated giant cells, as well as scattered [ncbi.nlm.nih.gov]

An inflammatory infiltrate with giant cells and myocardial necrosis is characteristic. [ncbi.nlm.nih.gov]

Cardiac recovery was rapid, complete (left ventricular ejection fraction rose to 55% from 10%), and was accompanied by the disappearance of the inflammatory infiltrates including [ncbi.nlm.nih.gov]

Oophoritis

The inflammatory infiltrate increased in intensity with follicular maturation and appeared to be destroying the theca interna. [ncbi.nlm.nih.gov]

[…] layer (H and E, ×200) Click here to view Figure 4: Theca interna with dense lymphoplasmacytic inflammatory infiltrate. [ijpmonline.org]

Both had enlarged cystic ovaries that on histological examination showed a perifollicular inflammatory infiltrate consisting of lymphocytes, plasma cells, and large numbers [ncbi.nlm.nih.gov]

Cronkhite-Canada Syndrome

On histologic review, the main findings in the gastric mucosa were a prominent mucosal edema, a mixed inflammatory infiltrate rich in eosinophils, and architectural changes [ncbi.nlm.nih.gov]

Histology showed cystically dilated glands and mixed inflammatory infiltrate comprising eosinophils and neutrophils. [cghjournal.org]

Duodenum: elongated, irregular and cystic crypts; lamina propria has mixed inflammatory infiltrate Colon: polypoid mucosa with cystically dilated glands and lamina propria [pathologyoutlines.com]

Cutaneous Pseudolymphoma

The authors report on a 2-year-old boy with a lesion of molluscum contagiosum in which the inflammatory infiltrate that surrounded a cystlike structure containing molluscum [ncbi.nlm.nih.gov]

The inflammatory infiltrate is bandlike, nodular, or diffuse and is composed predominantly of lymphocytes with or without other inflammatory cells. [ncbi.nlm.nih.gov]

A mixed inflammatory infiltrate with germinal centers is indicative of lymphocytoma cutis. [img.medscape.com]

Autoimmune Necrotizing Myopathy

Muscle biopsy is sensitive but not specific and reveals scattered necrotic regenerating fibers without inflammatory infiltrate. [shmabstracts.com]

infiltrate Inclusion body myositis : Similar inflammatory pattern Rimmed vacuoles may be difficult to find or not be "classic" Presence of occasional granular staining suggestive [pathologyoutlines.com]

Although immunosuppressive medication may be beneficial for IMNM, supporting an immune-mediated mechanism, inflammatory infiltrates generally are not found and little is known [ahcmedia.com]

Sweet Syndrome

infiltrate in the epidermis, dermis, and/or hypodermis and are often associated with systemic inflammatory and neoplastic disorders. [ncbi.nlm.nih.gov]

Design Histopathologic, immunohistochemical, and cytogenetic studies of the inflammatory infiltrate in a case series of histiocytoid Sweet syndrome. [jamanetwork.com]

[…] cutaneous lesions, abundant dermal neutrophilic inflammatory infiltrate evident on histopathologic examination, as well as an increase of inflammatory markers in the blood [jamanetwork.com]

Sarcoid Myocarditis

Dallas criteria defined it as an inflammatory infiltrate of the myocardium with necrosis and /or degeneration of adjacent myocytes not typical of ischemic damage associated [ispub.com]

(iii) Prominent eosinophilia in the inflammatory cellular infiltrate present in Giant cell myocarditis. It is usually absent in cardiac sarcoidosis. [histopathology-india.net]

Numerous giant cells (arrows) can be identified within the inflammatory infiltrate (hematoxylin and eosin, x100) Multinucleated giant cells (long arrows) are seen adjacent [wikidoc.org]

Eosinophilic Pustular Folliculitis

Results of histopathologic examination revealed subcorneal and intraepidermal pustules, and an inflammatory infiltrate consisting of lymphocytes and eosinophils mainly with [ncbi.nlm.nih.gov]

Histopathological examination showed a dense follicular inflammatory infiltrate with abundant eosinophils. [ncbi.nlm.nih.gov]

Histologically both of our patients showed a moderate mixed inflammatory infiltrate with numerous eosinophils centered around hair follicles. [ncbi.nlm.nih.gov]

Acute Sarcoidosis

[…] cell infiltrate (e.g., eosinophils, fibroblasts, plasma cells) Single or combined cytopenias (i.e., anemia, leukopenia, and/or thrombocytopenia) Non-Hodgkin lymphoma Infections [amboss.com]

[…] cell infiltrate Single or combined cytopenias Pneumoconiosis Exposure to mineral dust (e.g., silica) Often, patients are asymptomatic and the physical examination is unremarkable [amboss.com]

[…] tuberculosis or its DNA Hodgkin lymphoma History of infectious mononucleosis Pel-Ebstein fever Alcohol-induced pain Pruritus Non-caseating granulomas Reed-Sternberg cells Inflammatory [amboss.com]

Necrotizing Sialometaplasia

In all 3 cases, the biopsy specimen showed acinic necrosis surrounded by a dense polymorphous inflammatory infiltrate with atrophy of ductal cells but no squamous metaplasia [ncbi.nlm.nih.gov]

Inflammatory infiltrate was evident. On higher magnification sections showed bland epithelial islands. [journalgateway.com]

infiltrate, the endothelial cells, and stromal cells. [ncbi.nlm.nih.gov]

Hypertrophic Lichen Planus

infiltrate composed predominantly of T-cells. [fpnotebook.com]

Inflammatory infiltrate are sometimes present. [ijpmonline.org]

Pathological examination showed hydropic degeneration of the basal layer, pigmentary incontinence and moderate inflammatory lymphocytic infiltrate in the dermis. [scielo.br]

Plasma Cell Gingivitis

Figure 3b The inflammatory infiltrate is composed predominately of plasma cells (He × 400). [nature.com]

A second biopsy showed dense inflammatory cell infiltration, including mainly plasma cells, with no atypical cells. [jstage.jst.go.jp]

A mixed inflammatory infiltrate and blood vessels were also seen (Table/Fig 5). So, a diagnosis of plasma cell gingivitis was given. [jcdr.net]

IgG4-Related Aortitis

Thus a major consideration in classifying aortitis is to recognize the overall pattern of the inflammatory infiltrate. [uscapknowledgehub.org]

The biopsy showed an aortic adventitia which had largely been replaced by hyaline fibrous tissue composed of wide bands of collagen permeated by an inflammatory infiltrate [omicsonline.org]

Clusters of inflammatory infiltrates are present through the media and adventitia, consisting predominantly of lymphocytes and plasma cells. [em-consulte.com]

Fungal Myocarditis

Microscopic features: Myocardial inflammatory infiltrate associated with myocyte necrosis or degeneration. [histopathology-india.net]

Dallas criteria defined it as an inflammatory infiltrate of the myocardium with necrosis and /or degeneration of adjacent myocytes not typical of ischemic damage associated [ispub.com]

[…] in association with myocyte necrosis Borderline myocarditis: inflammatory infiltrates without evidence of myocyte necrosis Due to high interobserver variability, IHC is increasingly [pathologyoutlines.com]

Familial Keratoacanthoma

(blue-stained dermis) Bowen’s disease (in situ SCC) Hyperkeratosis Parakeratosis Atypical keratinocytes throughout epidermis Inflammatory infiltrate SCC Invasion of dermis [health.auckland.ac.nz]

Dermis shows a dense, chiefly mononuclear inflammatory infiltrate. A buttress of epidermis surrounded the crater. [idoj.in]

[…] squamous nests and islands, accompanied by marked inflammatory infiltrate with lichenoid features and eosinophils but no plasma cells May be deeply infiltrative, with microabscesses [pathologyoutlines.com]

Acquired Amyloid Myopathy

There is an inflammatory infiltrate around the muscle fibers (left panel). A necrotic fiber infiltrated by inflammatory cells is seen in the right panel. [hopkinsarthritis.org]

In a group of consecutive patients (n=22) with inflammatory infiltrates pairs of adhesion molecules were examined on infiltrating cells and vascular endothelial cells. [diva-portal.org]

[…] and mononuclear inflammatory infiltrates. [neuropathology-web.org]

Facial Granuloma

The inflammatory infiltrate surrounds the blood vessels, which show evidence of fibrin deposition. [plasticsurgerykey.com]

infiltrate involves the upper half of the dermis Neutrophils, plasma cells, eosinophils, lymphocytes and histiocytes Leukocytoclasia (karryorrhexis), extravasated red blood [pathologyoutlines.com]

There is sparing of a narrow grenz zone between the inflammatory infiltrate and the overlying epidermis. Figure 34-4 Granuloma faciale. [plasticsurgerykey.com]

Bacterial Myocarditis

Microscopic features: Myocardial inflammatory infiltrate associated with myocyte necrosis or degeneration. [histopathology-india.net]

Dallas criteria defined it as an inflammatory infiltrate of the myocardium with necrosis and /or degeneration of adjacent myocytes not typical of ischemic damage associated [ispub.com]

Acute viral myocarditis is usually associated with a lymphocytic inflammatory infiltrate. [pathwaymedicine.org]

Bullous Lichen Planus

The inflammatory cell infiltrations in upper dermis were mainly lymphocytes and eosinophil. [jemds.com]

Figure 2: Parakeratosis, hypergranulosis with basal cell degeneration forming cleft and moderate mononuclear inflammatory infiltrate in dermis (H and E, ×240) Click here to [idoj.in]

infiltrate (T cells and macrophages) that destroys the dermoepidermal junction Civatte bodies (apoptotic basal cells, PAS+) Artifactual cleft formation between epidermis [pathologyoutlines.com]

Epidermolysis Bullosa Pruriginosa

infiltrates and late presentation are potential pitfalls in correctly diagnosing this subtype of hereditary EB. [ncbi.nlm.nih.gov]

Histology revealed hyperkeratosis, acanthosis, subepidermal edema with dilated blood vessels and an inflammatory infiltrate in the dermis. [ijdvl.com]

RELEVANCE The clinical features of EB pruriginosa are becoming more widely recognized, but dermatologists, dermatopathologists, and histopathologists should be aware that inflammatory [wwww.unboundmedicine.com]

Pemphigus Vegetans

There is also typically a dense inflammatory infiltrate in the dermis composed of eosinphils, lymphocytes, and occasionally neutrophils. [dermnet.com]

Dermis showed intense inflammatory infiltrate comprising of plasma cells and eosinophils [Figure - 2]. [e-ijd.org]

Microscopic findings include epidermal hyperplasia, focal acantholysis, and a dense mixed inflammatory infiltrate with intraepithelial and subepithelial eosinophilic microabscesses [journals.lww.com]

IgG4-Related Mediastinitis

Histologic features were initially described in cases of autoimmune pancreatitis and include : (1) dense fibrosis with an associated mixed inflammatory infiltrate with IgG4 [humpath.com]

This group of entities is still poorly defined and is characterized by the common denominator of chronic inflammatory infiltrate admixed with abundant fibrosis. [books.google.es]

All nodules showed dense sclerosing fibrosis alternating with inflammatory infiltrates, predominantly composed of lymphocytes and plasma cells. [uscapknowledgehub.org]

Allergic Interstitial Nephritis

Chronic inflammatory infiltrate and fibrosis are present in the renal interstitium. Atrophic tubules with chronic inflammatory infiltrate in interstitium. 45. [slideshare.net]

ACUTE INTERSTITIAL NEPHRITIS Acute interstitial nephritis (AIN) refers to the presence of edema, inflammatory infiltration and tubular injury in the renal parenchyma. [tpis.upmc.com]

infiltrate ( T lymphocytes, monocytes ) Crystals on brightfield microscopy Therapy Discontinue drugs and administer IV fluids Prognosis Acute interstitial nephritis generally [amboss.com]