Possible Causes for insensitivity to pain Autonomic Neuropathy Abstract Congenital insensitivity (HSAN) to pain is a rare disorder, which affects the body's painprotective mechanism and predisposes the patient to increased risk and incidence [ncbi.nlm.nih.gov] HSAN type 4 (HSAN-4) and type 5 (HSAN-5) are characterized by insensitivity to pain and thermal sensation. [ncbi.nlm.nih.gov] […] to pain, hypotonia, and mental retardation. [ncbi.nlm.nih.gov] Hereditary Sensory Neuropathy Insensitivity to pain. [ncbi.nlm.nih.gov] Aasly, Two novel SCN9A mutations causing insensitivity to pain, Pain, 10.1016/j.pain.2009.02.016, 143, 1, (155-158), (2009). [doi.org] Clinical examination corrected the diagnosis by revealing insensitivity to pain in all four limbs, associated with spastic paraplegia. [ncbi.nlm.nih.gov] Channelopathy-Associated Congenital Insensitivity to Pain […] recessive pain insensitivity, congenital Dabby R. [ghr.nlm.nih.gov] Congenital insensitivity to pain with anhidrosis. [pediatricneurosciences.com] Symptoms Symptoms of Congenital insensitivity to pain with anhidrosis appear usually at birth or during infancy. [flipper.diff.org] Autosomal Dominant Hereditary Sensory and Autonomic Neuropathy Nagasako EM, Oaklander AL, Dworkin RH - Congenital insensitivity to pain: an update. Pain, 2003;101:213-219. [ Links ] 16. [scielo.br] 'Congenital insensitivity to pain' is a rare disorder. Traumatic injury and self-mutilation is an almost consistent feature in this disorder. [indianjpain.org] HSAN4 (congenital insensitivity to pain with anhidrosis) : patients have homozygous mutations in the NTRK1 gene 1. [radiopaedia.org] Familial Dysautonomia The diagnosis is based on clinical features: diminished lacrimation, insensitivity to pain, poor temperature control, abolished deep tendon reflexes, postural hypotension, [ncbi.nlm.nih.gov] Due to insensitivity to pain, various complications in familial dysautonomia were reported. [ncbi.nlm.nih.gov] […] to pain, inability to produce tears, poor growth, and labile blood pressure (episodic hypertension and postural hypotension). [snpedia.com] Neuropathic Arthropathy Profile of Ashlyn Blocker, 13, who has congenital insensitivity to pain. [en.wikipedia.org] […] to pain Peroneal muscular atrophy Two primary theories have been advanced: Neurotrauma: Loss of peripheral sensation and proprioception leads to repetitive microtrauma to [en.wikipedia.org] A congenital (present at birth) insensitivity to pain ? Leprosy ? A spinal cord injury ? [disabilitycasereview.com] Insect Bite Eventually, most people become immune and insensitive to the saliva after receiving a number of bites. [medicalnewstoday.com] The bite area may become redder with more pain and swelling. An itchy papule or wheal may develop and persist for several days. [medicalnewstoday.com] Vaginal Candidiasis The classical painful multiple vesicular or ulcerative lesions are absent in many infected persons. [web.archive.org] Diagnosis of HSV Infection The clinical diagnosis of genital herpes is both insensitive and nonspecific. [web.archive.org] Primary Erythromelalgia Loss of function mutations lead to congenital insensitivity to pain. [ncbi.nlm.nih.gov] Our findings demonstrate that mutations encoding for DIV of Nav1.7 can not only be linked to congenital insensitivity to pain or paroxysmal extreme pain disorder but can also [ncbi.nlm.nih.gov] […] mutations in congenital insensitivity to pain and erythromelalgia. [ PMID 26752484 ] Genotypic Analysis of SCN9A for Prediction of Postoperative Pain in Female Patients Undergoing [snpedia.com] Sexually Transmitted Disease The classical painful multiple vesicular or ulcerative lesions are absent in many infected persons. [cdc.gov] Diagnosis of HSV Infection The clinical diagnosis of genital herpes is both insensitive and nonspecific. [cdc.gov] Cold Exposure May be painful. Superficial Frostbite Skin appears white, mottled or gray. It feels hard or rubbery on the surface, but deeper tissue is still soft. [uiltexas.org] Skin is insensitive to touch. Deep Frostbite Management It is very important to note that refreezing newly thawed frostbitten tissue can cause extensive tissue damage. [uiltexas.org] Neuropathy Familial dysautonomia (FD)/Riley Day III AR 9q31 IKBKAP Congenital insensitivity to pain with anhidrosis (CIPA) IV AR 1q21-22 NTRK1 (TRKA) Congenital insensitivity to pain [ncbi.nlm.nih.gov] Cause Diabetic Neuropathy can cause insensitivity or a loss of ability to feel pain, heat, and cold. [foot.com] Congenital insensitivity to pain with anhidrosis: an NGF/TrkA-ralated disorder. [ncbi.nlm.nih.gov] Hyperuricemia It is likely that the traditional pain questions requiring pain episodes to last at least a month are insensitive in detecting hyperuricemia associated joint pain. [journals.plos.org] Regarding the current findings, it is important to realize that information about intermittent pain in our study was only available for the hand joints. [journals.plos.org] Dermatitis Mechano-responsive nociceptors have been shown in studies to respond to mostly pain, and mechano-insensitive receptors respond mostly to itch induced by histamine. [en.wikipedia.org] The different substances that elicit itch upon intracutaneous injection (injection within the skin) elicit only pain when injected subcutaneously (beneath the skin). [en.wikipedia.org] Itch is readily abolished in skin areas treated with nociceptor excitotoxin capsaicin, but remains unchanged in skin areas which were rendered touch-insensitive by pretreatment [en.wikipedia.org] Acroosteolysis […] to pain, e.g. leprosy juvenile chronic arthritis dermatomyositis vascular occlusion 5 reactive arthritis 6 pityriasis rubra pilaris (very rare skin condition) 8 pachydermoperiostosis [radiopaedia.org] […] to pain; injury such as frostbite, thermal or electrical burns, or snake bite; trauma; psoriasis; congenital abnormality such as with Hadju-Cheney; metabolic causes such [en.wikibooks.org] […] electricity trauma hyperparathyroidism epidermolysis bullosa porphyria drugs phenytoin (occurs in infants of epileptic mothers treated with phenytoin) 7 ergot poisoning/abuse insensitivity [radiopaedia.org] Hypogonadism […] to pain with anhidrosis) KIT (KIT Piebaldism, Gastrointestinal stromal tumor) STPK AMHR2 (Persistent Müllerian duct syndrome II) TGF beta receptors: Endoglin/Alk-1/SMAD4 [en.wikipedia.org] Jackson–Weiss syndrome) FGFR3 (Achondroplasia, Hypochondroplasia, Thanatophoric dysplasia, Muenke syndrome) INSR (Donohue syndrome Rabson–Mendenhall syndrome) NTRK1 (Congenital insensitivity [en.wikipedia.org] Diabetic Neuropathy Symptoms include: numbness tingling, burning, or prickling sharp pains or cramps extreme sensitivity to touch loss of balance or coordination insensitivity to pain or temperature [ohsu.edu] Symptoms include: Numbness Tingling, burning, or prickling Sharp pains or cramps Extreme sensitivity to touch Loss of balance or coordination Insensitivity to pain or temperature [columbianeurology.org] Atopic Dermatitis Mechano-responsive nociceptors have been shown in studies to respond to mostly pain, and mechano-insensitive receptors respond mostly to itch induced by histamine. [en.wikipedia.org] The different substances that elicit itch upon intracutaneous injection (injection within the skin) elicit only pain when injected subcutaneously (beneath the skin). [en.wikipedia.org] Itch is readily abolished in skin areas treated with nociceptor excitotoxin capsaicin, but remains unchanged in skin areas which were rendered touch-insensitive by pretreatment [en.wikipedia.org] Third Trimester Pregnancy insensitive to treatment. 6 Such responder analysis has been used to develop an OMT targeting strategy for patients with chronic low back pain. 7, 8 The PROMOTE study findings [jaoa.org] Responder analysis is now recommended in addition to reporting mean scores for back pain and related outcomes to avoid the skewing of trial results by patients who are clearly [jaoa.org] Aspirin-Induced Asthma […] to pain with anhidrosis ) KIT ( KIT Piebaldism, Gastrointestinal stromal tumor ) STPK AMHR2 ( Persistent Müllerian duct syndrome II ) TGF beta receptors : Endoglin / Alk- [ipfs.io] […] to pain with anhidrosis) KIT (KIT Piebaldism, Gastrointestinal stromal tumor) STPK AMHR2 (Persistent Müllerian duct syndrome II) TGF beta receptors: Endoglin/Alk-1/SMAD4 [en.wikipedia.org] […] syndrome ) FGFR3 ( Achondroplasia, Hypochondroplasia, Thanatophoric dysplasia, Muenke syndrome ) INSR ( Donohue syndrome Rabson–Mendenhall syndrome ) NTRK1 ( Congenital insensitivity [ipfs.io] Polyneuropathy Joints are particularly vulnerable to stress in people with polyneuropathy because they are often insensitive to pain. [powerofpain.org] Peripheral Neuropathy Certain types of hereditary neuropathies can affect the autonomic nerves, resulting in impaired sweating, postural hypotension, or insensitivity to pain. [ninds.nih.gov] It is thought to reduce chronic neuropathic pain by making nerves insensitive to pain messages. [doi.org] Painful or insensitive lower extremity. Therapy for Diabetes Mellitus. American Diabetes Association; 1998. Johnson CE, Takemoto JK. [emedicine.medscape.com] Osteoarthritis […] scores may also be an insensitive outcome measure. [dx.doi.org] […] scales may also be an insensitive outcome measure in this condition. 4 One limitation of our review is possible publication bias, in that by missing unpublished trials or [dx.doi.org] […] only one injection usually being given in clinical trials and at a lower dose (20 mg) than the 40 mg triamcinolone recommended by the American College of Rheumatologists. 3 Pain [dx.doi.org] Thrombocytopenia […] to pain with anhidrosis ) KIT ( KIT Piebaldism, Gastrointestinal stromal tumor ) STPK AMHR2 ( Persistent Müllerian duct syndrome II ) TGF beta receptors : Endoglin / Alk- [en.wikipedia.org] […] syndrome ) FGFR3 ( Achondroplasia, Hypochondroplasia, Thanatophoric dysplasia, Muenke syndrome ) INSR ( Donohue syndrome Rabson–Mendenhall syndrome ) NTRK1 ( Congenital insensitivity [en.wikipedia.org] Bruxism Several psychiatric reports confirmed the insensitivity to pain with possible affective and sensory abnormalities.47-50 For schizophrenia patients, behavioural pain activity [onlinelibrary.wiley.com] For example, schizophrenia could impair communication and social skills, while psychotropics may affect pain perception. [onlinelibrary.wiley.com] […] there is a debate regarding sensation threshold, pain threshold and pain tolerance.45, 46 Patients suffering from psychotic disorders may not be reliable in reporting the pain [onlinelibrary.wiley.com] Heterozygous Familial Hypercholesterolemia […] to pain with anhidrosis) KIT (KIT Piebaldism, Gastrointestinal stromal tumor) STPK AMHR2 (Persistent Müllerian duct syndrome II) TGF beta receptors: Endoglin/Alk-1/SMAD4 [en.wikipedia.org] Jackson–Weiss syndrome) FGFR3 (Achondroplasia, Hypochondroplasia, Thanatophoric dysplasia, Muenke syndrome) INSR (Donohue syndrome Rabson–Mendenhall syndrome) NTRK1 (Congenital insensitivity [en.wikipedia.org] Ileus Pain insensitivity in schizophrenia: trait or state marker?, J Psychiatr Pract, 2006, vol. 12 2 (pg. 90 - 102 ) 10. [academic.oup.com] Pain insensitivity in schizophrenia: a neglected phenomenon and some implications, Schizophr Bull, 1994, vol. 20 (pg. 235 - 248 ) 9. [academic.oup.com] insensitivity reported among schizophrenia patients may decrease awareness of somatic symptoms, such as those arising from severe constipation. 8, 9 Although constipation [academic.oup.com] Hemorrhoids Pain insensitive Prone to thrombosis if May prolapse outside vein ruptures anal canal (Thrombosed pile) (prolapsed hemorrhoid) 26. [slideshare.net] […] line Varicosities of veins Varicosities of veins draining draining inferior rectal artery superior rectal artery Lined by Lined by squamous epithelium columnar epithelium Painful [slideshare.net] Congenital Trigeminal Anesthesia Nagasako EM, Oaklander AL, Dworkin RH (2003) Congenital insensitivity to pain: an update. Pain 101: 213-219. [omicsonline.org] […] to pain with anhidrosis SYSTEMIC DISEASE Diabetes mellitus Vitamin A deficiency Multiple sclerosis CORNEAL DYSTROPHIES Lattice Granular IATROGENIC CAUSES Contact lens wear [aao.org] E (2014) Bispectral index monitoring in a patient with combination of congenital insensitivity to pain with anhidrosis (CIPA) and Shwachman–Diamond syndrome. [omicsonline.org] Pathological Fracture Congenital insensitivity to pain with anhidrosis (CIPA) is a rare hereditary sensory and autonomic neuropathy (HSAN) characterized by pain, self-mutilating behaviour, anhidrosis [ncbi.nlm.nih.gov]
