Insensitivity to Pain: Causes & Reasons

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Possible Causes for Insensitivity to Pain

Hereditary Sensory Neuropathy

Insensitivity to pain. [ncbi.nlm.nih.gov]

Aasly, Two novel SCN9A mutations causing insensitivity to pain, Pain, 10.1016/j.pain.2009.02.016, 143, 1, (155-158), (2009). [doi.org]

Anesthesia for patients with congenital insensitivity to pain and anhidrosis: A questionnaire study in Japan. [saudija.org]

Autosomal Dominant Hereditary Sensory and Autonomic Neuropathy

Nagasako EM, Oaklander AL, Dworkin RH - Congenital insensitivity to pain: an update. Pain, 2003;101:213-219. [ Links ] 16. [scielo.br]

Congenital insensitivity to pain: An update. Pain 2003;101:213-9. 2. Jonathan B, Padraig F, Webb D. [indianjpain.org]

HSAN4 (congenital insensitivity to pain with anhidrosis) : patients have homozygous mutations in the NTRK1 gene 1. [radiopaedia.org]

Channelopathy-Associated Congenital Insensitivity to Pain

Congenital insensitivity to pain with anhidrosis. [pediatricneurosciences.com]

[…] recessive pain insensitivity, congenital Dabby R. [ghr.nlm.nih.gov]

Symptoms Symptoms of Congenital insensitivity to pain with anhidrosis appear usually at birth or during infancy. [flipper.diff.org]

Familial Dysautonomia

The diagnosis is based on clinical features: diminished lacrimation, insensitivity to pain, poor temperature control, abolished deep tendon reflexes, postural hypotension, [ncbi.nlm.nih.gov]

Anatomic changes in congenital insensitivity to pain: absence of small primary sensory neurons in ganglia, roots and Lissauer's tract. [doi.org]

Due to insensitivity to pain, various complications in familial dysautonomia were reported. [ncbi.nlm.nih.gov]

Neuropathic Arthropathy

Profile of Ashlyn Blocker, 13, who has congenital insensitivity to pain. [en.wikipedia.org]

A congenital (present at birth) insensitivity to pain ? Leprosy ? A spinal cord injury ? [disabilitycasereview.com]

[…] to pain Peroneal muscular atrophy Two primary theories have been advanced: Neurotrauma: Loss of peripheral sensation and proprioception leads to repetitive microtrauma to [en.wikipedia.org]

Autonomic Neuropathy

Abstract Congenital insensitivity (HSAN) to pain is a rare disorder, which affects the body's painprotective mechanism and predisposes the patient to increased risk and incidence [ncbi.nlm.nih.gov]

HSAN type 4 (HSAN-4) and type 5 (HSAN-5) are characterized by insensitivity to pain and thermal sensation. [ncbi.nlm.nih.gov]

1型遺伝性感覚性自律神経性ニューロパチー 4型遺伝性感覚性自律神経性ニューロパチー Autosomal Dominant Neuropathy Hereditary Sensory Radicular Congenital Insensitivity to Pain with Anhidrosis Congenital Pain Insensitivity [lsd-project.jp]

Acroosteolysis

[…] to pain, e.g. leprosy, congenital insensitivity to pain juvenile chronic arthritis dermatomyositis vascular occlusion 5 reactive arthritis 6 pityriasis rubra pilaris (very [radiopaedia.org]

[…] to pain, e.g. leprosy juvenile chronic arthritis dermatomyositis vascular occlusion 5 reactive arthritis 6 pityriasis rubra pilaris (very rare skin condition) 8 pachydermoperiostosis [radiopaedia.org]

[…] to pain; injury such as frostbite, thermal or electrical burns, or snake bite; trauma; psoriasis; congenital abnormality such as with Hadju-Cheney; metabolic causes such [en.wikibooks.org]

Congenital Trigeminal Anesthesia

Nagasako EM, Oaklander AL, Dworkin RH (2003) Congenital insensitivity to pain: an update. Pain 101: 213-219. [omicsonline.org]

Congenital Insensitivity to Pain with Anhidrosis (CIPA) The exact prevalence of this rare condition is unknown. [hindawi.com]

[…] to pain with anhidrosis SYSTEMIC DISEASE Diabetes mellitus Vitamin A deficiency Multiple sclerosis CORNEAL DYSTROPHIES Lattice Granular IATROGENIC CAUSES Contact lens wear [aao.org]

Familial Broad Terminal Phalanges

[…] electricity trauma hyperparathyroidism epidermolysis bullosa porphyria drugs phenytoin (occurs in infants of epileptic mothers treated with phenytoin) 7 ergot poisoning/abuse insensitivity [radiopaedia.org]

Hereditary Sensory and Autonomic Neuropathy Type 7

Advanced Search Help Advanced search lets you search selected properties of the classification. You could search all properties or a selected subset only First, you need to provide keywords in the Search Text field then check the properties that you'd like to include in the search. The system will search for the[…] [icd.who.int]

Hereditary Sensory and Autonomic Neuropathy Type 1C

Congenital insensitivity to pain: An update. Pain 2003;101:213-9. 2. Jonathan B, Padraig F, Webb D. [indianjpain.org]

Congenital insensitivity ( HSAN ) to pain is a rare disorder, which affects the body's pain-protective mechanism and predisposes the patient to increased risk and incidence [ingentaconnect.com]

HSAN4 (congenital insensitivity to pain with anhidrosis) : patients have homozygous mutations in the NTRK1 gene 1. [radiopaedia.org]

2q37 Microdeletion Syndrome

Brief psychotic episode in a patient with chromosome 2q37 microdeletion syndrome Kevin Lally1, Nuraini Ibrahim1,2, Mary Kelly1,2, Gautam Gulati1 1Department of Psychiatry, University Hospital Limerick, Limerick, Ireland 2Psychiatry of Intellectual Disability, Daughters of Charity/Brothers of Charity, Limerick, Ireland[…] [casereports.bmj.com]

Autosomal Recessive Channelopathy-Associated Insensitivity to Pain

Homepage Rare diseases Search Search for a rare disease Congenital insensitivity to pain-anosmia-neuropathic arthropathy ORPHA:88642 Classification level: Disorder Synonym [orpha.net]

(s): SCN9A-related congenital insensitivity to pain Prevalence: <1 / 1 000 000 Inheritance: Autosomal dominant or Autosomal recessive Age of onset: - ICD-10: G60.8 OMIM: 243000 [orpha.net]

Navajo Neurohepatopathy

Karadimas, C. L., Vu, T. H., Holve, S. A., Chronopoulou, P., Quinzii, C., Johnsen, S. D., ... Hirano, M. (2006). Navajo neurohepatopathy is caused by a mutation in the MPV17 gene. American Journal of Human Genetics, 79 (3), 544-548. https://doi.org/10.1086/506913 Navajo neurohepatopathy is caused by a mutation in the MPV17[…] [jhu.pure.elsevier.com]

Congenital Autosomal Dominant Indifference to Pain

Symptoms Symptoms of Congenital insensitivity to pain with anhidrosis appear usually at birth or during infancy. [flipper.diff.org]

[…] recessive pain insensitivity, congenital Dabby R. [ghr.nlm.nih.gov]

Congenital insensitivity to pain and anhidrosis. [ijoonline.com]

Hereditary Sensory Neuropathy Type 1F

HSAN4 (congenital insensitivity to pain with anhidrosis) : patients have homozygous mutations in the NTRK1 gene 1. [radiopaedia.org]

Anesthesia for patients with congenital insensitivity to pain and anhidrosis: A questionnaire study in Japan. [saudija.org]

In 1963, Swanson first described two brothers with congenital insensitivity to pain, anhidrosis and mild mental retardation 3. [jpma.org.pk]

[…] to pain, congenital, with anhidrosis 256800 NUP62 19q13.33 Striatonigral degeneration, infantile 271930 NXF5 Xq22.1 Nuclear RNA export factor 5 300319 OCRL Xq25-q26 Dent [institutobernabeu.com]

[…] q35.3 Beckwith-Wiedemann syndrome 130650 Leukemia, acute myeloid 601626 Sotos syndrome 1 117550 NSUN2 5p15.31 Mental retardation, autosomal recessive 5 611091 NTRK1 1q23.1 Insensitivity [institutobernabeu.com]

Joubert Syndrome Type 18

Charcot-Marie-Tooth Disease Type 2A1

[…] to pain, congenital, 243000 SCN9A 160.5 0.98 0.96 Paroxysmal extreme pain disorder, 167400 SCN9A 160.5 0.98 0.96 Small fiber neuropathy, 133020 SCN9A 160.5 0.98 0.96 {Dravet [qgenomics.com]

[…] to pain, congenital, with anhidrosis, 256800 NTRK1 142.6 0.99 0.97 Medullary thyroid carcinoma, familial, 155240 PLEKHG5 98.6 0.96 0.91 Charcot-Marie-Tooth disease, recessive [qgenomics.com]

607734 NEFL 160 0.99 0.97 Charcot-Marie-Tooth disease, type 2E, 607684 NGF 286.7 1 1 Neuropathy, hereditary sensory and autonomic, type V, 608654 NTRK1 142.6 0.99 0.97 Insensitivity [qgenomics.com]

Familial Episodic Pain Syndrome Type 3

pain voltage-gated sodium channels Abbreviations CFA, complete Freund's adjuvant ; CIP, congenital insensitivity to pain ; CNS, central nervous system ; DRG, dorsal root ganglia [clinsci.org]

Congenital insensitivity to pain (CIP) Congenital insensitivity to pain (CIP) is a rare syndrome with various clinical expressions characterized by a dramatic impairment of [samobathi.com]

Symptoms vary, and may include insensitivity to pain, unstable blood pressure and body temperature, absence of overflow tears, frequent pneumonia, and poor growth. [familialdysautonomia.org]

Visceral Pain

Visceral structures are highly sensitive to distension (stretch), ischemia and inflammation, but relatively insensitive to other stimuli that normally evoke pain such as cutting [en.wikipedia.org]

Soon after the development of the operation of colostomy it was observed that the colon is insensitive to cutting, pricking or burning. [jamanetwork.com]

Visceral pain is pain that results from the activation of nociceptors of the thoracic, pelvic, or abdominal viscera (organs). [en.wikipedia.org]

Paroxysmal Extreme Pain Disorder

Abstract Background: Congenital insensitivity to pain (CIP) (OMIM 243000) is a rare autosomal-recessive disorder. [karger.com]

Loss of function mutations lead to congenital insensitivity to pain. [ncbi.nlm.nih.gov]

A different mutation in "SCN9A" causes congenital insensitivity to pain. [en.wikipedia.org]

Familial Episodic Pain Syndrome Type 2

[…] in lung cancer patients NGFB nerve growth factor (beta polypeptide) 1 115,828,537:115,880,857 neurotrophic growth factor congenital insensitivity to pain (Hereditary Sensory [painresearchforum.org]

Erythromelalgia Pain Insensitivity, Congenital Hereditary Sensory and Autonomic Neuropathies Chronic Pain Other: Observation Show Detailed Description Layout table for study [clinicaltrials.gov]

TO PAIN PAROXYSMAL EXTREME PAIN DISORDER GENERALIZED EPILEPSY WITH FEBRILE SEIZURES PLUS, TYPE 7 FAMILIAL FEBRILE CONVULSIONS, TYPE 3B Nav beta4 (N168/6) LONG QT SYNDROME [neuromab.ucdavis.edu]

Odonto-Onycho Dysplasia with Alopecia

VII (8), 121–124 (1971) Google Scholar Swanson, A G: Congenital insensitivity to pain with anhidrosis. A unique syndrome in two male sibships. Arch. [link.springer.com]

Congenital Disorder of Glycosylation Type 1G

see Congenital insensitivity to pain Congenital insensitivity to pain Congenital insensitivity to pain, see Hereditary sensory and autonomic neuropathy type V Congenital [medlineplus.gov]

[…] to pain, congenital, with anhidrosis (CIPA) Insensitivity to pain, congenital, with anhidrosis (CIPA) Isovaleric academia Jalili syndrome Joubert syndrome Joubert syndrome [zerlaboratories.com]

[…] to pain, see Congenital insensitivity to pain Char syndrome Charcot disease, see Amyotrophic lateral sclerosis Charcot-Marie-Tooth disease Charcot-Marie-Tooth hereditary [medlineplus.gov]

Primary Erythromelalgia

Loss of function mutations lead to congenital insensitivity to pain. [ncbi.nlm.nih.gov]

Our findings demonstrate that mutations encoding for DIV of Nav1.7 can not only be linked to congenital insensitivity to pain or paroxysmal extreme pain disorder but can also [ncbi.nlm.nih.gov]

[…] mutations in congenital insensitivity to pain and erythromelalgia. [ PMID 26752484 ] Genotypic Analysis of SCN9A for Prediction of Postoperative Pain in Female Patients Undergoing [snpedia.com]

Isolated Congenital Anosmia

pain). [malacards.org]

Congenital insensitivity to pain. Genetics Home Reference. November 2012; http://ghr.nlm.nih.gov/condition/congenital-insensitivity-to-pain. [rarediseases.info.nih.gov]

Anosmia is part of the clinical spectrum in various diseases, as seen in Kallmann syndrome, various ciliopathies and congenital insensitivity to pain. [ingentaconnect.com]

Carnevale Krajewska Fischetto Syndrome

see congenital insensitivity to pain congenital insensitivity to pain congenital insensitivity to pain, see hereditary sensory and autonomic neuropathy type V congenital [herenciageneticayenfermedad.blogspot.com]

see congenital insensitivity to pain congenital insensitivity to pain, see hereditary sensory and autonomic neuropathy type V congenital insensitivity to pain congenital [herenciageneticayenfermedad.blogspot.com]

[…] to pain, see congenital insensitivity to pain Char syndrome Charcot disease, see amyotrophic lateral sclerosis Charcot-Marie-Tooth disease Charcot-Marie-Tooth hereditary [herenciageneticayenfermedad.blogspot.com]

Uniparental Disomy

This UPD had been discovered fortuitously, when the child was investigated for a clinical diagnosis of congenital insensitivity to pain, an autosomal recessive disorder (Miura [oxfordmedicine.com]

Hereditary Neuropathy

Certain types of hereditary neuropathies can affect the autonomic nerves, resulting in impaired sweating, postural hypotension, or insensitivity to pain. [sharecare.com]

A few conditions result in problems with sweating or insensitivity to pain. [musculardystrophyuk.org]

The most common type is Charcot-Marie-Tooth disease – read more about this condition Symptoms vary and can include numbness, tingling, pain in the feet and hands, weakness [musculardystrophyuk.org]