Insensitivity to Pain: Causes & Reasons

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Possible Causes for Insensitivity to Pain

Hereditary Sensory Neuropathy

From Wikidata Jump to navigation Jump to search congenital disorder of nervous system Hereditary sensory and autonomic neuropathy (disorder) congenital insensitivity to pain [wikidata.org]

Anesthesia for patients with congenital insensitivity to pain and anhidrosis: A questionnaire study in Japan. [saudija.org]

Clinical examination corrected the diagnosis by revealing insensitivity to pain in all four limbs, associated with spastic paraplegia. [ncbi.nlm.nih.gov]

Autonomic Neuropathy

Abstract Congenital insensitivity (HSAN) to pain is a rare disorder, which affects the body's painprotective mechanism and predisposes the patient to increased risk and incidence [ncbi.nlm.nih.gov]

HSAN type 4 (HSAN-4) and type 5 (HSAN-5) are characterized by insensitivity to pain and thermal sensation. [ncbi.nlm.nih.gov]

1型遺伝性感覚性自律神経性ニューロパチー 4型遺伝性感覚性自律神経性ニューロパチー Autosomal Dominant Neuropathy Hereditary Sensory Radicular Congenital Insensitivity to Pain with Anhidrosis Congenital Pain Insensitivity [lsd-project.jp]

Autosomal Dominant Hereditary Sensory and Autonomic Neuropathy

Nagasako EM, Oaklander AL, Dworkin RH - Congenital insensitivity to pain: an update. Pain, 2003;101:213-219. [ Links ] 16. [scielo.br]

insensitivity or congenital insensitivity to pain, and an(a)esthesia. [anesthesiology.pubs.asahq.org]

Insensitivity with Anhidrosis, Congenital — Congenital Insensitivity to Pain with Anhidrosis — Hereditary Sensory Autonomic Neuropathy, Type 4 — HSAN 4 — Insensitivity to [mesh.kib.ki.se]

Channelopathy-Associated Congenital Insensitivity to Pain

Congenital insensitivity to pain with anhidrosis. [pediatricneurosciences.com]

[…] recessive pain insensitivity, congenital Dabby R. [ghr.nlm.nih.gov]

Congenital insensitivity to pain. [apicareonline.com]

Familial Dysautonomia

The diagnosis is based on clinical features: diminished lacrimation, insensitivity to pain, poor temperature control, abolished deep tendon reflexes, postural hypotension, [ncbi.nlm.nih.gov]

Anatomic changes in congenital insensitivity to pain: absence of small primary sensory neurons in ganglia, roots and Lissauer's tract. [doi.org]

Due to insensitivity to pain, various complications in familial dysautonomia were reported. [ncbi.nlm.nih.gov]

Neuropathic Arthropathy

Profile of Ashlyn Blocker, 13, who has congenital insensitivity to pain. [en.wikipedia.org]

A congenital (present at birth) insensitivity to pain ? Leprosy ? A spinal cord injury ? [disabilitycasereview.com]

[…] to pain Peroneal muscular atrophy Two primary theories have been advanced: Neurotrauma: Loss of peripheral sensation and proprioception leads to repetitive microtrauma to [en.wikipedia.org]

Acroosteolysis

[…] to pain, e.g. leprosy juvenile chronic arthritis dermatomyositis vascular occlusion 5 reactive arthritis 6 pityriasis rubra pilaris (very rare skin condition) 8 pachydermoperiostosis [radiopaedia.org]

[…] to pain; injury such as frostbite, thermal or electrical burns, or snake bite; trauma; psoriasis; congenital abnormality such as with Hadju-Cheney; metabolic causes such [en.wikibooks.org]

[…] electricity trauma hyperparathyroidism epidermolysis bullosa porphyria drugs phenytoin (occurs in infants of epileptic mothers treated with phenytoin) 7 ergot poisoning/abuse insensitivity [radiopaedia.org]

Primary Erythromelalgia

Loss of function mutations lead to congenital insensitivity to pain. [ncbi.nlm.nih.gov]

Our findings demonstrate that mutations encoding for DIV of Nav1.7 can not only be linked to congenital insensitivity to pain or paroxysmal extreme pain disorder but can also [ncbi.nlm.nih.gov]

[…] mutations in congenital insensitivity to pain and erythromelalgia. [ PMID 26752484 ] Genotypic Analysis of SCN9A for Prediction of Postoperative Pain in Female Patients Undergoing [snpedia.com]

Hyperdibasic Aminoaciduria Type 1

[…] to pain with anhidrosis, see congenital insensitivity to pain with anhidrosis hereditary interstitial pyelonephritis, see Alport syndrome Hereditary iron-loading anemia, [herenciageneticayenfermedad.blogspot.com]

[…] to pain with anhidrosis hereditary sensory and autonomic neuropathy type V hereditary sensory and autonomic neuropathy, type 4, see congenital insensitivity to pain with [herenciageneticayenfermedad.blogspot.com]

[…] to pain with anhidrosis HSAN5, see hereditary sensory and autonomic neuropathy type V HSANII, see hereditary sensory and autonomic neuropathy type II HSCR, see Hirschsprung [herenciageneticayenfermedad.blogspot.com]

Distal Hereditary Motor Neuropathy Type 5A

[…] to pain with anhidrosis. [explainmedicine.com]

Hereditary Sensory & Autonomic Neuropathies (HSAN) Hereditary Sensory & Autonomic Neuropathies (HSAN) type IV Clinically: Congenital insensitivity to pain Anhidrosis Recurrent [slideshare.net]

Other patients first recognise that they cannot distinguish warm and cold stimuli, and that they are insensitive to pain. [ojrd.biomedcentral.com]

Patterson Pseudoleprechaunism Syndrome

[…] to pain with anhidrosis ) KIT ( KIT Piebaldism, Gastrointestinal stromal tumor ) STPK AMHR2 ( Persistent Müllerian duct syndrome II ) TGF beta receptors : Endoglin / Alk- [ipfs.io]

[…] to pain with anhidrosis ) · KIT ( KIT Piebaldism, Gastrointestinal stromal tumor ) STPK AMHR2 ( Persistent Mullerian duct syndrome II ) TGF beta receptors : Endoglin / Alk [dictionary.sensagent.com]

[…] syndrome ) FGFR3 ( Achondroplasia, Hypochondroplasia, Thanatophoric dysplasia, Muenke syndrome ) INSR ( Donohue syndrome Rabson–Mendenhall syndrome ) NTRK1 ( Congenital insensitivity [ipfs.io]

Congenital Trigeminal Anesthesia

Nagasako EM, Oaklander AL, Dworkin RH (2003) Congenital insensitivity to pain: an update. Pain 101: 213-219. [omicsonline.org]

[…] to pain with anhidrosis SYSTEMIC DISEASE Diabetes mellitus Vitamin A deficiency Multiple sclerosis CORNEAL DYSTROPHIES Lattice Granular IATROGENIC CAUSES Contact lens wear [aao.org]

E (2014) Bispectral index monitoring in a patient with combination of congenital insensitivity to pain with anhidrosis (CIPA) and Shwachman–Diamond syndrome. [omicsonline.org]

Spondyloepimetaphyseal Dysplasia-Hypotrichosis Syndrome

insensitivity to pain. [radiologykey.com]

[…] to pain Congenital insensitivity to pain (CIP) is condition affecting pain sensation and olfaction. [kegg.jp]

[…] to Pain Syndrome Congenital Lipoid Adrenal Hyperplasia Congenital Merosin Deficient Muscular Dystrophy Congenital Muscular Dystrophy, Type 1C, with Neurologic Abnormalities [sequencing.com]

Acroosteolysis-Keloid-Like Lesions-Premature Aging Syndrome

Inherited Neuropathy

Certain types of hereditary neuropathies can affect the autonomic nerves, resulting in impaired sweating, postural hypotension, or insensitivity to pain. [ninds.nih.gov]

Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis. Nat. Genet. 1996; 13(4):485-8. [invitae.com]

The main complication is foot mutilation due to pain insensitivity, resulting in a high risk of infections and osteomyelitis. [merckmanuals.com]

Familial Broad Terminal Phalanges

[…] to pain, e.g. leprosy, congenital insensitivity to pain juvenile chronic arthritis dermatomyositis vascular occlusion 5 reactive arthritis 6 pityriasis rubra pilaris (very [radiopaedia.org]

Hereditary Sensory Neuropathy Type 1F

Anesthesia for patients with congenital insensitivity to pain and anhidrosis: A questionnaire study in Japan. [saudija.org]

In 1963, Swanson first described two brothers with congenital insensitivity to pain, anhidrosis and mild mental retardation 3. [jpma.org.pk]

insensitivity or congenital insensitivity to pain, and an(a)esthesia. [anesthesiology.pubs.asahq.org]

Hereditary Sensory and Autonomic Neuropathy Type 7

Hereditary Sensory and Autonomic Neuropathy Type 1C

Congenital insensitivity ( HSAN ) to pain is a rare disorder, which affects the body's pain-protective mechanism and predisposes the patient to increased risk and incidence [ingentaconnect.com]

Congenital insensitivity to pain: An update. Pain 2003;101:213-9. 2. Jonathan B, Padraig F, Webb D. [indianjpain.org]

Anesthesia for patients with congenital insensitivity to pain and anhidrosis: A questionnaire study in Japan. [saudija.org]

2q37 Microdeletion Syndrome

Navajo Neurohepatopathy

Karadimas, C. L., Vu, T. H., Holve, S. A., Chronopoulou, P., Quinzii, C., Johnsen, S. D., ... Hirano, M. (2006). Navajo neurohepatopathy is caused by a mutation in the MPV17 gene. American Journal of Human Genetics, 79 (3), 544-548. https://doi.org/10.1086/506913 Navajo neurohepatopathy is caused by a mutation in the MPV17[…] [jhu.pure.elsevier.com]

Congenital Autosomal Dominant Indifference to Pain

Congenital Congenital Indifference to Pain Congenital Analgesia Insensitivity, Congenital Pain Congenital Pain Insensitivity Congenital Pain Indifferences Insensitivity [bioportal.bioontology.org]

Congenital insensitivity to pain and anhidrosis: A case report from South India. [e-ijd.org]

Congenital insensitivity to pain. [apicareonline.com]

Bagatelle-Cassidy Syndrome

[…] to pain Congenital insensitivity to pain with anhidrosis Congenital intrauterine infection-like syndrome Congenital lactase deficiency Congenital laryngeal palsy Congenital [rarediseases.info.nih.gov]

Parastremmatic dwarfism PARC syndrome Paris-Trousseau thrombocytopenia Parkes Weber syndrome Parkinson disease type 9 Paroxysmal exertion-induced dyskinesia Paroxysmal extreme pain [rarediseases.info.nih.gov]

See Congenital generalized lipodystrophy Congenital generalized lipodystrophy type 4 Congenital heart block Congenital hydrocephalus Congenital hyperinsulinism Congenital insensitivity [rarediseases.info.nih.gov]

Familial Episodic Pain Syndrome Type 3

pain voltage-gated sodium channels Abbreviations CFA, complete Freund's adjuvant ; CIP, congenital insensitivity to pain ; CNS, central nervous system ; DRG, dorsal root ganglia [clinsci.org]

Congenital insensitivity to pain (CIP) Congenital insensitivity to pain (CIP) is a rare syndrome with various clinical expressions characterized by a dramatic impairment of [samobathi.com]

Symptoms vary, and may include insensitivity to pain, unstable blood pressure and body temperature, absence of overflow tears, frequent pneumonia, and poor growth. [familialdysautonomia.org]

Visceral Pain

Visceral structures are highly sensitive to distension (stretch), ischemia and inflammation, but relatively insensitive to other stimuli that normally evoke pain such as cutting [en.wikipedia.org]

Soon after the development of the operation of colostomy it was observed that the colon is insensitive to cutting, pricking or burning. [jamanetwork.com]

Visceral pain is pain that results from the activation of nociceptors of the thoracic, pelvic, or abdominal viscera (organs). [en.wikipedia.org]

Congenital Disorder of Glycosylation Type 1G

see Congenital insensitivity to pain Congenital insensitivity to pain Congenital insensitivity to pain, see Hereditary sensory and autonomic neuropathy type V Congenital [medlineplus.gov]

[…] to pain, congenital, with anhidrosis (CIPA) Insensitivity to pain, congenital, with anhidrosis (CIPA) Isovaleric academia Jalili syndrome Joubert syndrome Joubert syndrome [zerlaboratories.com]

[…] to pain, see Congenital insensitivity to pain Char syndrome Charcot disease, see Amyotrophic lateral sclerosis Charcot-Marie-Tooth disease Charcot-Marie-Tooth hereditary [medlineplus.gov]

Carnevale Krajewska Fischetto Syndrome

see congenital insensitivity to pain congenital insensitivity to pain congenital insensitivity to pain, see hereditary sensory and autonomic neuropathy type V congenital [herenciageneticayenfermedad.blogspot.com]

see congenital insensitivity to pain congenital insensitivity to pain, see hereditary sensory and autonomic neuropathy type V congenital insensitivity to pain congenital [herenciageneticayenfermedad.blogspot.com]

[…] to pain, see congenital insensitivity to pain Char syndrome Charcot disease, see amyotrophic lateral sclerosis Charcot-Marie-Tooth disease Charcot-Marie-Tooth hereditary [herenciageneticayenfermedad.blogspot.com]

Tollner-Horst-Manzke Syndrome

and Severe Mental Retardation Congenital Muscular Dystrophy plus Mental Retardation congenital muscular dystrophy with cataracts and intellectual disability Congenital Pain [rgd.mcw.edu]

Familial Episodic Pain Syndrome Type 2

[…] in lung cancer patients NGFB nerve growth factor (beta polypeptide) 1 115,828,537:115,880,857 neurotrophic growth factor congenital insensitivity to pain (Hereditary Sensory [painresearchforum.org]

Erythromelalgia Pain Insensitivity, Congenital Hereditary Sensory and Autonomic Neuropathies Chronic Pain Other: Observation Show Detailed Description Layout table for study [clinicaltrials.gov]

TO PAIN PAROXYSMAL EXTREME PAIN DISORDER GENERALIZED EPILEPSY WITH FEBRILE SEIZURES PLUS, TYPE 7 FAMILIAL FEBRILE CONVULSIONS, TYPE 3B Nav beta4 (N168/6) LONG QT SYNDROME [neuromab.ucdavis.edu]

Paroxysmal Extreme Pain Disorder

Loss of function mutations lead to congenital insensitivity to pain. [ncbi.nlm.nih.gov]

Abstract Background: Congenital insensitivity to pain (CIP) (OMIM 243000) is a rare autosomal-recessive disorder. [karger.com]

A different mutation in "SCN9A" causes congenital insensitivity to pain. [en.wikipedia.org]