Insensitivity to Pain: Causes & Reasons

Possible Causes for Insensitivity to Pain

Insensitivity to pain. [ncbi.nlm.nih.gov]

Aasly, Two novel SCN9A mutations causing insensitivity to pain, Pain, 10.1016/j.pain.2009.02.016, 143, 1, (155-158), (2009). [doi.org]

Anesthesia for patients with congenital insensitivity to pain and anhidrosis: A questionnaire study in Japan. [saudija.org]

Autosomal Dominant Hereditary Sensory and Autonomic Neuropathy

Nagasako EM, Oaklander AL, Dworkin RH - Congenital insensitivity to pain: an update. Pain, 2003;101:213-219. [ Links ] 16. [scielo.br]

Congenital insensitivity to pain: An update. Pain 2003;101:213-9. 2. Jonathan B, Padraig F, Webb D. [indianjpain.org]

HSAN4 (congenital insensitivity to pain with anhidrosis) : patients have homozygous mutations in the NTRK1 gene 1. [radiopaedia.org]

Channelopathy-Associated Congenital Insensitivity to Pain

[…] recessive pain insensitivity, congenital Dabby R. [ghr.nlm.nih.gov]

Other names for congenital insensitivity to pain include: asymbolia for pain channelopathy-associated insensitivity to pain CIP congenital analgesia congenital insensitivity [thinkgenetic.com]

Congenital insensitivity to pain with anhidrosis. [pediatricneurosciences.com]

Familial Dysautonomia

The diagnosis is based on clinical features: diminished lacrimation, insensitivity to pain, poor temperature control, abolished deep tendon reflexes, postural hypotension, [ncbi.nlm.nih.gov]

Anatomic changes in congenital insensitivity to pain: absence of small primary sensory neurons in ganglia, roots and Lissauer's tract. [doi.org]

[…] to pain with anhidrosis (CIPA), HSAN Type IV Congenital insensitivity to pain Dysautonomia Medical genetics of Ashkenazi Jews References [ edit ] ^ pediatriconcall.com Archived [en.wikipedia.org]

Autonomic Neuropathy

Abstract Congenital insensitivity (HSAN) to pain is a rare disorder, which affects the body's painprotective mechanism and predisposes the patient to increased risk and incidence [ncbi.nlm.nih.gov]

HSAN type 4 (HSAN-4) and type 5 (HSAN-5) are characterized by insensitivity to pain and thermal sensation. [ncbi.nlm.nih.gov]

1型遺伝性感覚性自律神経性ニューロパチー 4型遺伝性感覚性自律神経性ニューロパチー Autosomal Dominant Neuropathy Hereditary Sensory Radicular Congenital Insensitivity to Pain with Anhidrosis Congenital Pain Insensitivity [lsd-project.jp]

Neuropathic Arthropathy

Profile of Ashlyn Blocker, 13, who has congenital insensitivity to pain. [en.wikipedia.org]

* Alcoholic neuropathy * Cerebral palsy * Leprosy * Syphilis (tabes dorsalis), caused by the organism Treponema pallidum * Congenital insensitivity to pain * Spinal cord [uwmsk.org]

A congenital (present at birth) insensitivity to pain ? Leprosy ? A spinal cord injury ? [disabilitycasereview.com]

Congenital Trigeminal Anesthesia

Nagasako EM, Oaklander AL, Dworkin RH (2003) Congenital insensitivity to pain: an update. Pain 101: 213-219. [omicsonline.org]

[…] to pain with anhidrosis SYSTEMIC DISEASE Diabetes mellitus Vitamin A deficiency Multiple sclerosis CORNEAL DYSTROPHIES Lattice Granular IATROGENIC CAUSES Contact lens wear [aao.org]

E (2014) Bispectral index monitoring in a patient with combination of congenital insensitivity to pain with anhidrosis (CIPA) and Shwachman–Diamond syndrome. [omicsonline.org]

Acroosteolysis

[…] to pain, e.g. leprosy, congenital insensitivity to pain juvenile chronic arthritis dermatomyositis vascular occlusion 5 reactive arthritis 6 pityriasis rubra pilaris (very [radiopaedia.org]

[…] to pain, e.g. leprosy juvenile chronic arthritis dermatomyositis vascular occlusion 5 reactive arthritis 6 pityriasis rubra pilaris (very rare skin condition) 8 pachydermoperiostosis [radiopaedia.org]

[…] to pain; injury such as frostbite, thermal or electrical burns, or snake bite; trauma; psoriasis; congenital abnormality such as with Hadju-Cheney; metabolic causes such [en.wikibooks.org]

Hyperdibasic Aminoaciduria Type 1

[…] to pain with anhidrosis, see congenital insensitivity to pain with anhidrosis hereditary interstitial pyelonephritis, see Alport syndrome Hereditary iron-loading anemia, [herenciageneticayenfermedad.blogspot.com]

[…] to pain with anhidrosis hereditary sensory and autonomic neuropathy type V hereditary sensory and autonomic neuropathy, type 4, see congenital insensitivity to pain with [herenciageneticayenfermedad.blogspot.com]

[…] to pain with anhidrosis HSAN5, see hereditary sensory and autonomic neuropathy type V HSANII, see hereditary sensory and autonomic neuropathy type II HSCR, see Hirschsprung [herenciageneticayenfermedad.blogspot.com]

Primary Erythromelalgia

Loss of function mutations lead to congenital insensitivity to pain. [ncbi.nlm.nih.gov]

Our findings demonstrate that mutations encoding for DIV of Nav1.7 can not only be linked to congenital insensitivity to pain or paroxysmal extreme pain disorder but can also [ncbi.nlm.nih.gov]

[…] mutations in congenital insensitivity to pain and erythromelalgia. [ PMID 26752484 ] Genotypic Analysis of SCN9A for Prediction of Postoperative Pain in Female Patients Undergoing [snpedia.com]

Distal Hereditary Motor Neuropathy Type 5A

[…] to pain with anhidrosis. [explainmedicine.com]

Hereditary Sensory & Autonomic Neuropathies (HSAN) Hereditary Sensory & Autonomic Neuropathies (HSAN) type IV Clinically: Congenital insensitivity to pain Anhidrosis Recurrent [slideshare.net]

Other patients first recognise that they cannot distinguish warm and cold stimuli, and that they are insensitive to pain. [ojrd.biomedcentral.com]

Lytic Bone Lesion

Insensitivity with Anhidrosis, Congenital — Congenital Insensitivity to Pain with Anhidrosis — Hereditary Sensory Autonomic Neuropathy, Type 4 — HSAN 4 — Insensitivity to [mesh.kib.ki.se]

Congenital, Autosomal Recessive Asymbolia For Pain Congenital Analgesia, Autosomal Recessive Insensitivity To Pain, Channelopathy-Associated Neuropathy, Hereditary Sensory [ukgtn.nhs.uk]

[…] to pain. [orpha.net]

Familial Broad Terminal Phalanges

[…] electricity trauma hyperparathyroidism epidermolysis bullosa porphyria drugs phenytoin (occurs in infants of epileptic mothers treated with phenytoin) 7 ergot poisoning/abuse insensitivity [radiopaedia.org]

Hereditary Sensory Neuropathy Type 1F

HSAN4 (congenital insensitivity to pain with anhidrosis) : patients have homozygous mutations in the NTRK1 gene 1. [radiopaedia.org]

Signs and symptoms People with congenital insensitivity to pain with anhidrosis (CIPA) are insensitive to heat and pain. [nutritionhouse.com]

Anesthesia for patients with congenital insensitivity to pain and anhidrosis: A questionnaire study in Japan. [saudija.org]

Hereditary Sensory and Autonomic Neuropathy Type 7

Advanced Search Help Advanced search lets you search selected properties of the classification. You could search all properties or a selected subset only First, you need to provide keywords in the Search Text field then check the properties that you'd like to include in the search. The system will search for the[…] [icd.who.int]

Hereditary Sensory and Autonomic Neuropathy Type 1C

Congenital insensitivity to pain: An update. Pain 2003;101:213-9. 2. Jonathan B, Padraig F, Webb D. [indianjpain.org]

Congenital insensitivity ( HSAN ) to pain is a rare disorder, which affects the body's pain-protective mechanism and predisposes the patient to increased risk and incidence [ingentaconnect.com]

HSAN4 (congenital insensitivity to pain with anhidrosis) : patients have homozygous mutations in the NTRK1 gene 1. [radiopaedia.org]

2q37 Microdeletion Syndrome

Brief psychotic episode in a patient with chromosome 2q37 microdeletion syndrome Kevin Lally1, Nuraini Ibrahim1,2, Mary Kelly1,2, Gautam Gulati1 1Department of Psychiatry, University Hospital Limerick, Limerick, Ireland 2Psychiatry of Intellectual Disability, Daughters of Charity/Brothers of Charity, Limerick, Ireland[…] [casereports.bmj.com]

Autosomal Recessive Channelopathy-Associated Insensitivity to Pain

Homepage Rare diseases Search Search for a rare disease Congenital insensitivity to pain-anosmia-neuropathic arthropathy ORPHA:88642 Classification level: Disorder Synonym [orpha.net]

(s): SCN9A-related congenital insensitivity to pain Prevalence: <1 / 1 000 000 Inheritance: Autosomal dominant or Autosomal recessive Age of onset: - ICD-10: G60.8 OMIM: 243000 [orpha.net]

Navajo Neurohepatopathy

Navajo Neurohepatopathy: A Mitochondrial DNA Depletion Syndrome? نويسند‌گان: [ Kurenai Tanji ] - From the 1Department of Neurology and H. Houston Merritt Clinical Research Center for Muscular Dystrophy and Related Diseases, Columbia University, New York, NY; 2Department of Pathology, Columbia University, New[…] [scipers.com]

Congenital Autosomal Dominant Indifference to Pain

[…] recessive pain insensitivity, congenital Dabby R. [ghr.nlm.nih.gov]

Inheritance How is congenital insensitivity to pain inherited? [thinkgenetic.com]

So far all I have said is true for any sufferer of Congenital Insensitivity to Pain, however, there is a slight difference between this and Congenital Insensitivity to Pain [wassupdoc.wordpress.com]

Charcot-Marie-Tooth Disease Type 2A1

[…] to pain, congenital, 243000 SCN9A 160.5 0.98 0.96 Paroxysmal extreme pain disorder, 167400 SCN9A 160.5 0.98 0.96 Small fiber neuropathy, 133020 SCN9A 160.5 0.98 0.96 {Dravet [qgenomics.com]

[…] to pain, congenital, with anhidrosis, 256800 NTRK1 142.6 0.99 0.97 Medullary thyroid carcinoma, familial, 155240 PLEKHG5 98.6 0.96 0.91 Charcot-Marie-Tooth disease, recessive [qgenomics.com]

607734 NEFL 160 0.99 0.97 Charcot-Marie-Tooth disease, type 2E, 607684 NGF 286.7 1 1 Neuropathy, hereditary sensory and autonomic, type V, 608654 NTRK1 142.6 0.99 0.97 Insensitivity [qgenomics.com]

Familial Episodic Pain Syndrome Type 3

pain voltage-gated sodium channels Abbreviations CFA, complete Freund's adjuvant ; CIP, congenital insensitivity to pain ; CNS, central nervous system ; DRG, dorsal root ganglia [clinsci.org]

Congenital insensitivity to pain (CIP) Congenital insensitivity to pain (CIP) is a rare syndrome with various clinical expressions characterized by a dramatic impairment of [samobathi.com]

Symptoms vary, and may include insensitivity to pain, unstable blood pressure and body temperature, absence of overflow tears, frequent pneumonia, and poor growth. [familialdysautonomia.org]

Congenital Deafness with Total Albinism

@*CONCLUSION@#The compound heterozygous variants of the NTRK1 gene probably underlay the congenital insensitivity to pain with anhidrosis. [search.bvsalud.org]

Artículo en Chino | WPRIM | ID: wpr-879606 RESUMEN OBJECTIVE@#To explore the genetic variation of a Chinese family affected with congenital insensitivity to pain with anhidrosis [search.bvsalud.org]

Familial Episodic Pain Syndrome Type 2

[…] in lung cancer patients NGFB nerve growth factor (beta polypeptide) 1 115,828,537:115,880,857 neurotrophic growth factor congenital insensitivity to pain (Hereditary Sensory [painresearchforum.org]

Erythromelalgia Pain Insensitivity, Congenital Hereditary Sensory and Autonomic Neuropathies Chronic Pain Other: Observation Show Detailed Description Layout table for study [clinicaltrials.gov]

TO PAIN PAROXYSMAL EXTREME PAIN DISORDER GENERALIZED EPILEPSY WITH FEBRILE SEIZURES PLUS, TYPE 7 FAMILIAL FEBRILE CONVULSIONS, TYPE 3B Nav beta4 (N168/6) LONG QT SYNDROME [neuromab.ucdavis.edu]

Visceral Pain

Visceral structures are highly sensitive to distension (stretch), ischemia and inflammation, but relatively insensitive to other stimuli that normally evoke pain such as cutting [en.wikipedia.org]

Soon after the development of the operation of colostomy it was observed that the colon is insensitive to cutting, pricking or burning. [jamanetwork.com]

Visceral pain is pain that results from the activation of nociceptors of the thoracic, pelvic, or abdominal viscera (organs). [en.wikipedia.org]

Paroxysmal Extreme Pain Disorder

Abstract Background: Congenital insensitivity to pain (CIP) (OMIM 243000) is a rare autosomal-recessive disorder. [karger.com]

Loss of function mutations lead to congenital insensitivity to pain. [ncbi.nlm.nih.gov]

pain Sweat reduced Aδ & C Insensitivity to pain ZFHX2 14q11 Dominant Childhood Absent pain Sweat reduced None Absent pain, Congenital CLTCL1 22q11 Recessive Congenital Absent [neuromuscular.wustl.edu]

Isolated Congenital Anosmia

Congenital insensitivity to pain. Genetics Home Reference. November 2012; http://ghr.nlm.nih.gov/condition/congenital-insensitivity-to-pain. [rarediseases.info.nih.gov]

[…] to pain ). [3] Last updated: 10/14/2016 Source: GARD (NIH) 1 • • • Back to: « Congenital anosmia References Source: GARD (NIH): rarediseases.info.nih.gov/ diseases/ 9486/ [familydiagnosis.com]

pain). [malacards.org]

X-Linked Mental Retardation Type Lubs

insensitivity Poor eye contact Progressive spasticity Repetitive compulsive behavior Seizure Severe global developmental delay Sleep disturbance Status epilepticus Tonic [ncbi.nlm.nih.gov]

[…] regression Generalized non-motor (absence) seizure Global developmental delay Hostility Inability to walk Intellectual disability, severe Lower limb spasticity Motor stereotypy Pain [ncbi.nlm.nih.gov]

Congenital Disorder of Glycosylation Type 1G

see Congenital insensitivity to pain Congenital insensitivity to pain Congenital insensitivity to pain, see Hereditary sensory and autonomic neuropathy type V Congenital [medlineplus.gov]

[…] to pain, congenital, with anhidrosis (CIPA) Insensitivity to pain, congenital, with anhidrosis (CIPA) Isovaleric academia Jalili syndrome Joubert syndrome Joubert syndrome [zerlaboratories.com]

[…] to pain, see Congenital insensitivity to pain Char syndrome Charcot disease, see Amyotrophic lateral sclerosis Charcot-Marie-Tooth disease Charcot-Marie-Tooth hereditary [medlineplus.gov]

Spondyloepimetaphyseal Dysplasia-Hypotrichosis Syndrome

insensitivity to pain. [radiologykey.com]

[…] to pain Congenital insensitivity to pain (CIP) is condition affecting pain sensation and olfaction. [kegg.jp]

[…] to Pain Syndrome Congenital Lipoid Adrenal Hyperplasia Congenital Merosin Deficient Muscular Dystrophy Congenital Muscular Dystrophy, Type 1C, with Neurologic Abnormalities [sequencing.com]