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117 Possible Causes for Insulin C-Peptide Increased, Some Patients Develop Diabetes Mellitus as Adolescents

  • Lipodystrophy

    Hyperinsulinemia leads to development of widespread acanthosis nigricans, followed by onset of diabetes mellitus during adolescence 7, 8.[ncbi.nlm.nih.gov] Some patients develop extreme hypertriglyceridemia especially after the onset of insulin-resistant diabetes mellitus and are prone to recurrent attacks of acute pancreatitis[ncbi.nlm.nih.gov] Diabetes is generally ketosis-resistant.[ncbi.nlm.nih.gov]

  • Malignant Neoplasm of Pancreas

    Pancreatic cancer is a type of cancer that starts in the pancreas. (Cancer starts when cells in the body begin to grow out of control. To learn more about how cancers start and spread, see What Is Cancer? ) Pancreatic adenocarcinoma is the most common type of pancreatic cancer. Pancreatic neuroendocrine[…][cancer.org]

    Missing: Some Patients Develop Diabetes Mellitus as Adolescents
  • Islet Cell Tumor

    C-peptide elevated serum insulin level increased gastrin level positive secretin stimulation test for pancreas elevated fasting glucose level elevated serum glucagon level[medicine.georgetown.edu] Laboratory medicine investigations showed reduced levels of insulin, C-peptide, insulin-like growth factor binding protein (IGFBP)-3, and insulin-like growth factor (IGF)-[ncbi.nlm.nih.gov] […] abdomen to show pancreatic tumor (MRI can sometimes see smaller tumors than those seen with a CT scan) abnormal glucose tolerance test low fasting glucose level elevated serum insulin[medicine.georgetown.edu]

    Missing: Some Patients Develop Diabetes Mellitus as Adolescents
  • Insulinoma

    […] high C-peptide Insulin glucose ratio 0.4 Increase in C-peptide Urine/serum sulfonylureas (factitious disorder) Please rate topic.[medbullets.com] Blood sugar, insulin and c-peptide levels are taken in regular intervals.[flexikon.doccheck.com] A fasting blood test found inappropriately elevated insulin levels during hypoglycemia, undetectable β-hydroxybutyrate, and increased C-peptide levels in line with insulin[ncbi.nlm.nih.gov]

    Missing: Some Patients Develop Diabetes Mellitus as Adolescents
  • Generalized Lipodystrophy

    We present an individual with a generalized and infantile onset lipodystrophy who later developed hypertriglyceridemia, pancreatitis, refractory diabetes, irregular menses and renal failure. She showed the hallmark features of a congenital, generalized lipodystrophy (CGL). Sequencing PPARG identified two pathogenic[…][ncbi.nlm.nih.gov]

    Missing: Some Patients Develop Diabetes Mellitus as Adolescents
  • Familial Partial Lipodystrophy

    Intern Med. 2018 Aug 15;57(16):2301-2313. doi: 10.2169/internalmedicine.0225-17. Epub 2018 Mar 30. Author information 1 Department of Diabetes and Endocrinology, Kusatsu General Hospital, Japan. 2 Department of Endocrinology, Metabolism and Hypertension, Clinical Research Institute, National Hospital Organization Kyoto[…][ncbi.nlm.nih.gov]

    Missing: Some Patients Develop Diabetes Mellitus as Adolescents
  • Beckwith-Wiedemann Syndrome

    An elevated risk of hepatoblastoma for children with Beckwith-Wiedemann syndrome or isolated hemihyperplasia is well established. We describe five children with Beckwith-Wiedemann syndrome or isolated hemihyperplasia for whom serial serum alpha-fetoprotein screening, usually in combination with abdominal ultrasound, led[…][ncbi.nlm.nih.gov]

    Missing: Some Patients Develop Diabetes Mellitus as Adolescents
  • Cystic Fibrosis

    Individuals with cystic fibrosis may be at risk for developing cystic fibrosis-related diabetes mellitus (CFRD).[rarediseases.org] Two years after the first IT, arginine-stimulated C-peptide secretion increased to 2,956 pmol/L and insulin doses could be reduced to 0.82 units/kg/day.[ncbi.nlm.nih.gov] CFRD may occur in some adolescents with cystic fibrosis, although the prevalence increases during adulthood, as the longer patients live with cystic fibrosis, the more likely[rarediseases.org]

  • Hypoglycemia

    A fasting blood test found inappropriately elevated insulin levels during hypoglycemia, undetectable β-hydroxybutyrate, and increased C-peptide levels in line with insulin[ncbi.nlm.nih.gov]

    Missing: Some Patients Develop Diabetes Mellitus as Adolescents
  • Insulin Resistance

    Homa-B, AUCs of insulin, and C-peptide of the twin brothers increased in response to the increment of Homa-IR as they entered middle and late puberty.[ncbi.nlm.nih.gov] Using a standard meal test, insulin secretory rate was calculated by C-peptide deconvolution.[ncbi.nlm.nih.gov] The proband's Homa-IR decreased into adulthood, while her Homa-B, insulinogenic index, AIR, AUCs of insulin, and C-peptide decreased accordingly.[ncbi.nlm.nih.gov]

    Missing: Some Patients Develop Diabetes Mellitus as Adolescents

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