Insulin Decreased: Causes & Reasons

Possible Causes for Insulin Decreased

The mechanisms involved in weight loss and improved blood glucose control appear to involve increased insulin sensitivity, decreased lipotoxicity/inflammation, and changes [doi.org]

Biguanides Decrease hepatic gluoneogenesis Obesity+ insulin resistance Decrease peripheral insulin resistance Thiazolidenediones Decrease peripheral insulin resistance Insulin [academic.oup.com]

Answer Type I no endogenous insulin Type II insulin resistance decreased insulin Secondary gestational chronic pancreatitis hemochromatosis Cushing's Syndrome pacreatectomy [meddean.luc.edu]

Acute Alcohol Intoxication

(IGF-I) or insulin-like growth factor binding protein-3 (IGFBP3); an increase in plasma glucose and a decrease in insulin in the female adolescents but not in the males. [ncbi.nlm.nih.gov]

AAI produced in the adolescents of both sexes in our series: a decrease in growth hormone (GH) levels, without significant alteration of either insulin-like growth factor-I [ncbi.nlm.nih.gov]

Preeclampsia

These factors may act both individually and synergistically to decrease breast cancer risk. [doi.org]

They postulated that genetically determined insulin resistance will lead to decreased insulin-mediated growth in the fetus and that it will also lead to insulin resistance [doi.org]

Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons. [journals.lww.com]

Conn Syndrome

Glucose- hyperglycaemia sometimes seen secondary to decreased pancreatic insulin due to the hypokalaemia. ECG – changes associated with hypokalaemia. [myvmc.com]

Cystic Fibrosis

It improves C-peptide secretion, decreases insulin needs, and lowers HbA1c. [ncbi.nlm.nih.gov]

Pancreatic insufficiency also leads to decreased levels of insulin. As a result, insulin dependent diabetes mellitus can occur. [symptoma.com]

The implication of both relative decrease in pancreatic insulin release, and an increase in insulin resistance to glucose metabolism by the body suggests potential roles for [dx.doi.org]

Pheochromocytoma

[…] in the pancreas, decreased glucose uptake in the peripheral tissues, and increased insulin resistance. [ncbi.nlm.nih.gov]

insulin secretion. [wikilectures.eu]

Alpha2 receptors mediate the presynaptic feedback inhibition of norepinephrine release and decrease insulin secretion. [emedicine.com]

Kwashiorkor

This decrease was negatively correlated with insulin-like growth factor I but not with insulin. [ncbi.nlm.nih.gov]

Endocrinopathies where insulin levels are decreased; growth hormone is increased, but insulin-like growth factor levels are reduced. [physio-pedia.com]

[…] weight gain, serum SHBG concentrations were significantly higher (0.10 +/- 0.04 micromol/L) than in the age-matched control subjects (0.06 +/- 0.03 micromol/L, P < 0.001) and decreased [ncbi.nlm.nih.gov]

Doege-Potter Syndrome

Decreased hepatic glucose production may also be related to the insulin effect of large IGF-II, and glucagon secretion may also be low in NICTH. [biomedgrid.com]

The first response to falling serum glucose concentration is a decrease in the secretion of endogenous insulin. [hindawi.com]

For all cases, when hypoglycemia manifests, the levels of C peptide and insulin were found to have decreased somewhat. [journals.lww.com]

Insulin Resistance

There is a direct correlation between insulin resistance and chronic kidney disease pathology [ R ]. 1) Weight Loss Decreases Insulin Resistance Weight loss has been shown [selfhacked.com]

Prednisone ingestion caused significant insulin resistance with an insignificant decrease in insulin binding. [ncbi.nlm.nih.gov]

Fasting insulin decreased from 647.27 to 12.95 uIU/mL 6 weeks later. [ncbi.nlm.nih.gov]

Aerobic Exercise

[…] total cholesterol Improves glucose tolerance and reduces insulin resistance Decreases clinical symptoms of anxiety, tension and depression Increases maximal oxygen consumption [sparkpeople.com]

Insulin adjustments and glucose supplementation Participants reduced their insulin doses on exercise days by making either a 10% decrease in intermediate or long-acting insulin [care.diabetesjournals.org]

[…] abdominal fat and improves insulin sensitivity in older men with type 2 diabetes. [doi.org]

Hyperinsulinemia

Genetic background, consumption of the “modern” Western diet and over‐nutrition may increase insulin secretion, decrease insulin pulses and/or reduce hepatic insulin clearance [repub.eur.nl]

[…] in insulin-resistant conditions) can produce insulin resistance (decreased insulin receptor sensitivity), and this decrease in insulin action may occur at the receptor and [encyclopedia.pub]

[…] response and decreased insulin sensitivity. [blog.designsforhealth.com]

Insulin-Resistance Syndrome Type B

Fasting insulin decreased from 647.27 to 12.95 uIU/mL 6 weeks later. [ingentaconnect.com]

Two different types of insulin resistance are identified and explained; Type A insulin resistance results from a decrease in the number of insulin receptors, whereas Type [diabetesincontrol.com]

When prednisone 60 mg/day was administered, her daily insulin requirements decreased to near her pre-admission doses. [professional.diabetes.org]

Glycogen Storage Disease Type 1

Glycogen storage disease type 1 (GSD1) is an inborn error of metabolism caused by deficiency of glucose-6-phosphatase, the enzyme catalysing the conversion of glucose-6-phosphate (G6P) to glucose. GSD1 is associated with severe hyperlipidaemia and hepatic steatosis. The underlying mechanisms responsible for these[…] [ncbi.nlm.nih.gov]

Alcoholic Ketoacidosis

Decreased insulin and elevated glucagon, cortisol, catecholamine, and growth hormone levels can increase the rate of ketogenesis. [emedicine.com]

The following are the 3 main predisposing events: Delay and decrease in insulin secretion and excess glucagon secretion, induced by starvation and counter-regulatory hormones [emedicine.com]

The decreased insulin-to-glucagon ratio that occurs in starvation indirectly reduces the inhibition on CAT activity, thereby allowing more free fatty acids to undergo oxidation [emedicine.com]

Acanthosis Nigricans with Insulin Resistance

We studied two patients with acanthosis nigricans and insulin resistance caused by a decrease in the number of cell surface insulin receptors. [ncbi.nlm.nih.gov]

[…] cultured fibroblasts compatible with a primary or genetic decrease in cell-surface insulin receptors. [ncbi.nlm.nih.gov]

The patient's Epstein-Barr virus-transformed lymphocytes revealed slightly decreased insulin binding and markedly decreased insulin-stimulated autophosphorylation of the insulin [ncbi.nlm.nih.gov]

Diabetic Hypoglycemia

Reduction in insulin resistance via modification of glucose metabolic pathways Inhibits mitochondrial glycerophosphate dehydrogenase (mGPD) Decreases hepatic gluconeogenesis [amboss.com]

Muscle cells have more insulin receptors than fat cells, so a person can decrease insulin resistance by exercising. [verywellhealth.com]

[…] delivery fasting glucose at 6 week postnatal check Clinical Manifestations of Type I Diabetes decrease in insulin at meals and fasting increase in glucagon increase glucose [chegg.com]

Polycystic Ovary Syndrome

Insulin decreased the expression levels of miR‑19b and stimulated cell proliferation. [ncbi.nlm.nih.gov]

RESULTS: In the 10 women given D-chiro-inositol, the mean (+/- standard error) area under the plasma insulin curve after oral administration of glucose decreased significantly [ncbi.nlm.nih.gov]

[…] a medication used in the treatment of type 2 diabetes, is often used to decrease insulin resistance in PCOS. [stanfordchildrens.org]

Diabetic Ketoacidosis

As levels of insulin decrease, fuel stores are mobilized during fasting, resulting in hyperglycemia. When pancreatic β-cell reserve is present, ... [accessmedicine.mhmedical.com]

insulin-dependent patients are initiated on an SGLT2 inhibitor, the insulin dose should be decreased to avoid the risk of hypoglycemia. [pharmacytimes.com]

[…] infusion and had a lower total dose of intravenous insulin and significantly decreased hyperglycemia after discontinuation of the intravenous insulin. [ncbi.nlm.nih.gov]

Factitious Hypoglycemia

Serum insulin concentration steadily decreased over the hospital course. [ncbi.nlm.nih.gov]

Distinguishes type 1 from type 2 diabetes mellitus - Decreased C-peptide and insulin levels associated with islet cell antibodies suggest type 1 diabetes. [ebmconsult.com]

When available, demonstration of anti-insulin antibodies was the most helpful diagnostic test. Decreased plasma C-peptide levels corroborated the diagnosis. [ncbi.nlm.nih.gov]

Donohue Syndrome

The post-binding defect of the insulin receptor signaling in cultured fibroblasts demonstrated decreased insulin receptor autophosphorylation. [ncbi.nlm.nih.gov]

In the experiments conducted using COS7 cells homozygously transfected with the INSR mutation, T910M INSR failed to process the proreceptor and decreased insulin-stimulated [ncbi.nlm.nih.gov]

A novel homozygous missense mutation p.Leu795Pro was found, located in the extracellular portion of the β subunit of the insulin receptor. [ncbi.nlm.nih.gov]

Hyperglycemia

It is caused by a decrease in the production of insulin, a decrease in the action of insulin, or a combination of the two abnormalities. [britannica.com]

Whether this decreased insulin activity is due to a decreased amount of insulin produced ( type 1 diabetes ), or from the insensitivity of the cells to a normal amount of [endocrineweb.com]

The basic defect in all patients with diabetes is the decreased ability of insulin to induce cells of the body to remove glucose (sugar) molecules from the blood. [endocrineweb.com]

Insulin Overdose

#20 Insulin decreases gluconeogenesis / increases glcose utilization. Glucagon does the opposite. Just think: Glucose stimulates insulin release (in healthy beta cells). [forums.studentdoctor.net]

The serum phosphorus and magnesium concentrations decreased to nadirs of 1.6 mg/dl and 1.6 mg/dl respectively 7 hours after insulin injection. [ncbi.nlm.nih.gov]

#24 Insulin decreases gluconeogenesis / increases glcose utilization. Glucagon does the opposite. Just think: Glucose stimulates insulin release (in healthy beta cells). [forums.studentdoctor.net]

Diabetic Ketotic Coma

Between meals, insulin secretion decreases, as does the insulin-mediated glucagon inhibition in the pancreatic islets. The glucagon levels rise in the plasma. [emedicine.medscape.com]

In patients with a pre-existing lack of or resistance to insulin, a physiological stress such as an acute illness can cause further net reduction in circulating insulin. [diabetesincontrol.com]

If glucose levels do not decrease by 50-75 mg/dL during the first hour of insulin therapy, the insulin infusion should be increased every hour until a steady decline in glucose [endocrinologyadvisor.com]

Drug-Induced Hypoglycemia

The test sensitivity limit listed for each drug is lower than the concentration that will cause increased insulin and decreased glucose. [mayomedicallaboratories.com]

Pancreatic beta cell failure: L-asparaginase decreases insulin synthesis by depletion of asparagine and decreasing insulin secretion from beta cells. [clinicaladvisor.com]

4) Increased insulin sensitivity (eg, after a decrease in body weight, as a delayed effect of exercise, or due to improved diabetes control). [empendium.com]

Mauriac Syndrome

The actual cause is unknown, but it is probably a combination of factors including inadequate glucose uptake and utilization in the tissues, decreased insulin-like growth [omicsonline.org]

The growth retardation and delayed puberty are possibly due to an inadequate glucose delivery to tissues, decreased insulin-like growth factor-1 (IGF-1) and growth hormone [accessanesthesiology.mhmedical.com]

The incidence of this syndrome had decreased significantly with introduction of long-acting insulin and better control of blood sugar.[1] Recently, there has been re-emergence [journals.lww.com]

Metolazone

decreases effects of insulin degludec/insulin aspart by Other (see comment). [reference.medscape.com]

Insulin Degludec; Liraglutide: (Moderate) Thiazide diuretics can decrease insulin sensitivity thereby leading to glucose intolerance and hyperglycemia. [pdr.net]

Use Caution/Monitor. insulin degludec metolazone decreases effects of insulin degludec by Other (see comment). Use Caution/Monitor. [reference.medscape.com]

Rabson-Mendenhall Syndrome

Similarly, [125I]insulin binding to cultured lymphocytes and cultured fibroblasts was markedly decreased. [ncbi.nlm.nih.gov]

However, the slope of the regression and the predicted insulin level at zero glucose decreased with increasing age. [ncbi.nlm.nih.gov]

Abstract In some patients with genetic forms of extreme insulin resistance, there is a marked decrease in the number of insulin receptors on the cell surface. [ncbi.nlm.nih.gov]

Insulin Administration

Blood samples were taken at -15, 0, 15, 30, 60, 90, and 120 min after insulin administration. 15 min after insulin administration, vaspin serum concentrations decreased by [ncbi.nlm.nih.gov]

The maximal plasma K decrease occurred after two hours of dialysis or glucose-insulin infusion; administration of glucose-insulin after dialysis resulted in no further plasma [circres.ahajournals.org]

This represented a decrease in omission of coverage insulin by 54% compared with preprocess improvement. [ncbi.nlm.nih.gov]

Insulin Antibody

The amount of antibody-bound insulin decreased in a biphasic pattern over 13 mo of observation with an initial half-life of 35 days and a more gradual decrease with a half-life [ncbi.nlm.nih.gov]

Introduction Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. [prospecbio.com]

However, FITC-insulin (lacking anti CYP1A1 conjugates) or insulin alone also decreased BaP metabolism by 50%. [ncbi.nlm.nih.gov]

Insulin-Resistance Syndrome Type A

When prednisone 60 mg/day was administered, her daily insulin requirements decreased to near her pre-admission doses. [professional.diabetes.org]

insulin resistance ( antibodies against insulin receptors) Decreased adiponectin and leptin associated with lipodystrophies. [dermnetnz.org]

These drugs primarily act to decrease insulin resistance through improved sensitivity to insulin in muscle and adipose tissue. [podiatrytoday.com]