Possible Causes for insulin increased Polycystic Ovary Syndrome In addition, with FAI increase, glycosylated hemoglobin (HbA1c), plasma glucose concentrations, and serum insulin levels increased, while insulin sensitivity and β -cell function [ncbi.nlm.nih.gov] […] and chronic vascular damage, especially in situations where insulin levels are increased. [ncbi.nlm.nih.gov] PCOS is seriously underdiagnosed Emma Kapotes/Rd.com About 7 million U.S. women have polycystic ovary syndrome (PCOS), which results when excess insulin increases the production [rd.com] Obesity RESULTS: Results: Due to increased insulin resistance and reduced glucose absorption by tissues of pregnant women with obesity, there are prerequisites for the development [ncbi.nlm.nih.gov] Dysregulation of these hormones is associated with overeating (or hyperphagy) and with tissue resistance to insulin, increasing the risk of type II diabetes. [britannica.com] The insulin-resistant state that is so common in obesity probably reflects the effects of increased release of fatty acids from fat cells that are then stored in the liver [ncbi.nlm.nih.gov] Diabetes Mellitus […] frequency of insulin-dependent diabetes in several countries is best explained today by the decline of infections. [dx.doi.org] The earliest abnormality in an individual who develops type 2 diabetes mellitus is insulin resistance, which initially is compensated for with an increase in insulin secretion [doi.org] […] the β-cells in the pancreas, decreased glucose uptake in the peripheral tissues, and increased insulin resistance. [ncbi.nlm.nih.gov] Insulin Resistance (Reuters Health) - Insulin resistance may increase the risk for Alzheimer’s disease by depriving the brain of sugar needed for normal cognition, a small study suggests. [reuters.com] High glucose and insulin increased the secretion of Shh-positive ADEs. [ncbi.nlm.nih.gov] Insulin resistance in fat cells reduces the effects of insulin and results in elevated hydrolysis of stored triglycerides in the absence of measures which either increase [phys.org] Hyperkalemia Because the risk of hypoglycemia is increased with using large insulin doses, sufficient glucose (60 grams with the administration of 20 units of insulin and 50 grams with [ncbi.nlm.nih.gov] […] deficiency can cause hyperkalemia as the hormone insulin increases the uptake of potassium into the cells. [en.wikipedia.org] […] age dehydration hypoaldosteronism metabolic acidosis diabetes mellitus, insulin deficiency increased potassium intake References 1. [emedexpert.com] Third Trimester Pregnancy The concomitant phenomenon of a third trimester pregnancy with a significant degree of pelvic organ prolapse is extremely rare. We report on a patient with pelvic organ prolapse complicating third trimester pregnancy treated by concomitant cesarean hysterectomy and abdominal sacrocolpopexy. A 30-year-old woman,[…] [ncbi.nlm.nih.gov] Chronic Kidney Insufficiency Thiazolidinediones Thiazolidinediones (pioglitazone, rosiglitazone) increase insulin sensitivity by acting as PPARγ agonists. [clindiabetesendo.biomedcentral.com] […] risk seen with insulin therapy. 30, 31 Exogenous insulin is normally metabolized by the kidney. [clinical.diabetesjournals.org] (observed in diabetic patients) – both are hypothesized to cause a rise in the GFR increasing renal flow Hyperfiltration of glucose leads to augmented sodium-glucose transport [pathophys.org] Portal Cirrhosis Even if it seems clear that obesity and insulin resistance increase the risk of decompensation in patients with compensated cirrhosis, several issues need to be clarified [elsevier.es] […] resistance and obesity, progresses to NASH due to increased inflammation, oxidative stress, apoptosis, and adipokine dysfunction Insulin resistance Insulin resistance enhances [pathophys.org] […] resistance as a consequence of increased porto-systemic shunting,41 and (c) insulin resistance is largely corrected or reversed by abolishing porto-systemic shunting by liver [elsevier.es] Graves Disease Increased insulin action and clearance in hyperthyroid newly diagnosed IDDM patient: restoration to normal with anti-thyroid treatment. Diabetes Care 1989;12:319-24. 13. [cmaj.ca] They express potentially pathogenic autoantigens, such as thyrotropin receptor and insulin-like growth factor-1 receptor. [doi.org] Congenital rubella syndrome as a model for type 1 (insulin-dependent) diabetes mellitus: increased prevalence of islet cell surface antibodies. [doi.org] Septicemia Furthermore it was also pointed out that intensive insulin therapy increased the labor requirement of nursing staff in the ICU[ 26 ]. [doi.org] Doctors use a number of medications to treat sepsis, including: antibiotics via IV to fight infection vasoactive medications to increase blood pressure insulin to stabilize [healthline.com] Vincent J-L, Preiser J-C, Sprung CL, Moreno R, Sakr Y (2010) Insulin-treated diabetes is not associated with increased mortality in critically ill patients. [dx.doi.org] Hypoglycemia Insulin levels were not different among sessions, whereas glucagon increased with MDG administration ( P 0.001). [ncbi.nlm.nih.gov] pills that increase insulin production, or both—increases the risk of hypoglycemia. [web.archive.org] pills that increase insulin production, or both-increases the risk of hypoglycemia. [web.archive.org] Maternal Diabetes Syndrome This causes the baby's body to secrete increased amounts of insulin, which results in increased tissue and fat deposits. [stanfordchildrens.org] In the second trimester the insulin requirement increases, which is sometimes associated with ketoacidosis and resultant high fetal mortality. [utmb.edu] Type II is non-insulin-dependent, similar to the adult onset diabetes in humans due to pancreatic damage—there is a high or normal initial blood insulin level and no increase [medical-dictionary.thefreedictionary.com] Metabolic Syndrome High insulin itself does not cause obesity. On the contrary, obesity leads to increased insulin resistance. [drlam.com] […] together increase the risk of stroke, heart disease and type 2 diabetes. [healthdirect.gov.au] […] resistance (increased blood sugar after fasting). [healthdirect.gov.au] Malignant Neoplasm of the Pancreas […] in the strength or number of oral hypoglycemics (i.e., diabetes pills) needed to control diabetes increase in required insulin needed to control diabetes transition from [pancyst.org] In both men and women, central obesity is associated with increased levels of insulin and with disruption of normal endocrine and metabolic functions. [britannica.com] Insulin resistance and accompanying compensatory hyperinsulinemia might increase local blood flow and cell division in the pancreas ( 11 ). [care.diabetesjournals.org] Prolactinoma Hyperprolactinemia may be involved in the preclinical increase in carotid IMT, directly or by promoting atherogenic factors, including insulin resistance, low-grade inflammation [ncbi.nlm.nih.gov] CONCLUSIONS: Our study did not show an association between anabolic hormones and increased thyroid volume in women with prolactinoma. Copyright 2015 Elsevier Masson SAS. [ncbi.nlm.nih.gov] Prolactin secretion increases steadily during pregnancy and peaks at parturition. During the postpartum period, plasma prolactin rapidly declines to normal levels. [pituitaryadenomas.com] Primary Hyperparathyroidism Although primary hyperparathyroidism is frequently asymptomatic, it has been associated with an increased prevalence of hypertension, insulin resistance, dyslipidemia, cardiovascular [ncbi.nlm.nih.gov] Página 309 - Increased insulin-like growth factor II production and consequent suppression of growth hormone secretion: a dual mechanism for tumorinduced hypoglycemia, J. [books.google.es] Patients with PHPT may have an increased risk of hypertension, insulin resistance, and cardiovascular morbidity and mortality, although this remains controversial. [orthopaedicsone.com] Panhypopituitarism Therefore, absence of or reduction in IGF-1 secretion would lead to increased hepatic glucose production and favour peripheral insulin resistance [21]. [hindawi.com] His plasma cortisol was below the detection level, and insulin induced hypoglycaemia failed to increase the plasma cortisol concentration. [adc.bmj.com] The peak serum cortisol level could increase to 19.08 μg/dL by insulin-induced hypoglycemia. [ncbi.nlm.nih.gov] Islet Cell Tumor It is considered to cause hypoglycemia by increasing the insulin-like bioactivity of the circulating insulin-like growth factor (IGF) system, however, the precise mechanism [ncbi.nlm.nih.gov] C-peptide elevated serum insulin level increased gastrin level positive secretin stimulation test for pancreas elevated fasting glucose level elevated serum glucagon level [medicine.georgetown.edu] […] be considered to play a major pathogenic role in enhanced hypoglycemic insulin-like activity. [ncbi.nlm.nih.gov] Insulinoma Insulin sensitivity was greatly reduced in patients with insulinoma (38.9% 22.3%), while beta cells function was increased (359.0 171.5%), but to a variable extent (range: [ncbi.nlm.nih.gov] Patients with insulinoma also show increased c-peptide and proinsulin levels. Insulin release of a diagnosed insulinoma can be inhibited by giving octreotide. [flexikon.doccheck.com] They include a decrease in insulin production and/or an increase in peripheral insulin resistance. [edmcasereports.com] Pancreatic Adenoma Symptoms - Pancreatic adenoma * Abdominal pain * Nausea * Vomiting * Biliary obstruction * Low blood sugar * Increased insulin secretion * Increased gastrin secretion * Sweating [checkorphan.org] Insulin overdose sudden massive hypoglycemia collapse/death. Pituitary tumor increased serum cortisol hyperglycemia feedback to pancreas increased insulin secretion. [vetstream.com] Blood tests look for increased levels of hormones such as insulin, glucagon, and gastrin, as well as glucose levels in the bloodstream. [healthline.com] Insulin Overdose Doctors call this pathology - absolute insulin deficiency. The main sign of it is hyperglycemia - an increase in glucose (sugar) in the blood. [en.intoxication-stop.com] Even in a CCB poisoned animal model insulin increases myocardial glucose uptake resulting in improved contractility. [coreem.net] Owing to an increasing dextrose requirement and a dependence on hourly intramuscular glucagon injections, a continuous intravenous infusion of glucagon was commenced which [ncbi.nlm.nih.gov] Familial Partial Lipodystrophy CONCLUSION/INTERPRETATION: The combination of BMI 27 kg/m(2) and the use of 100 U insulin/day increases the chance of identifying lipodystrophy. [ncbi.nlm.nih.gov] Her body weight increased from 62.0 to 71.0 kg after 12 months of treatment, suggesting that weight gain may result from synergism between thiazolidinediones and insulin-promoting [ncbi.nlm.nih.gov] The presence of lamin A/C nuclear aggregates was restricted to actively transcribing cells, and it was increased in insulin-treated fibroblasts. [ncbi.nlm.nih.gov] Lipodystrophy The higher levels of insulin may increase fat accumulation. [thewellproject.org] […] resistance has increased from 50 percent to 60 percent; and diabetes is developing in 10 percent to 14 percent. [hopkinsmedicine.org] Another theory is that insulin resistance and increased lipid levels play a role in fat gain. [thewellproject.org] Pituitary Cushing Syndrome […] hormone/insulin-like growth factor 1 values, hypogonadotropic hypogonadism and central hypothyroidism. [ncbi.nlm.nih.gov] Cushing's disease (CD), a state of chronic glucocorticoid (GC) excess characterized by visceral obesity and insulin resistance, may be associated with increased systemic inflammation [ncbi.nlm.nih.gov] However, if the adrenal glands overproduce testosterone and other hormones too, this may increase libido. [medicalnewstoday.com] Acquired Partial Lipodystrophy Although uncommon, insulin resistance increases cardiovascular risk. [en.wikipedia.org] Whilst there is an increased risk of insulin resistance and metabolic complications (including menstrual irregularities, hirsutism, diabetes mellitus, dyslipidemia, hypertension [orpha.net] CONCLUSIONS: Our results show that APL is associated with increased risk for developing metabolic abnormalities. [ncbi.nlm.nih.gov] Congenital Generalized Lipodystrophy Her levels returned to near normal only with extremely high doses of insulin (up to 1,700 units/d) and increased doses of leptin and metformin. [ncbi.nlm.nih.gov] We investigated whether insulin resistance in CGL patients is associated with abnormal muscle morphology and whether increased muscularity imparts increased muscle strength [ncbi.nlm.nih.gov] Exercise is also helpful in increasing peripheral insulin sensitivity and HDL cholesterol levels. [symptoma.com] Myotonia Congenita Growth hormone: Reduced release Insulin resistance Pregnancy: Frequent fetal loss & major complications Insulin-like growth factor-1 (IGF-1): Reduced Hypertriglyceridemia [neuromuscular.wustl.edu] […] debility, though strength benefits may not be dramatic and care should be taken not to increase fatigue in individuals who are already active. [now.aapmr.org] […] fetal isoforms (Absent exon 10) APP protein: Fetal splice isoforms (Exon 7 exclusion products) Other abnormal splicing Insulin receptor: Insulin resistance MTM1 SERCA Longer [neuromuscular.wustl.edu] Fetal Erythroblastosis To present intensive intrauterine treatment of recurrent early onset fetal erythroblastosis due to anti-M alloimmunization. A 33-year-old woman, gravid 3, para 1, had anti-M IgG antibody, which caused alloimmunization of her previous pregnancies. This time she visited our hospital for intensive intervention. No evidence[…] [ncbi.nlm.nih.gov] Launois Syndrome Abnormal growth is mediated by increased secretion of insulin-like growth factor I (IGF-I). [symptoma.com] Insulin Increased Insulin increases PAI-1 production in several experimental systems, but the mechanism of insulin-activated PAI-1 transcription remains to be determined. [ncbi.nlm.nih.gov] Insulin increases hCAT-1 activity and expression in HUVECs, and A(2A)AR stimulation increases insulin sensitivity in subjects with insulin resistance. [ncbi.nlm.nih.gov] […] effect of fasting insulin on BMI, with a 0.01 (-0.39, 0.38) SD decrease in BMI per log pmol/L increase in fasting insulin (P 0.98). [biorxiv.org]
