Insulin Increased: Causes & Reasons

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Possible Causes for Insulin Increased

Polycystic Ovary Syndrome

In addition, with FAI increase, glycosylated hemoglobin (HbA1c), plasma glucose concentrations, and serum insulin levels increased, while insulin sensitivity and β -cell function [ncbi.nlm.nih.gov]

[…] and chronic vascular damage, especially in situations where insulin levels are increased. [ncbi.nlm.nih.gov]

[…] resistance, increased testosterone levels, and other reproductive abnormalities. [ncbi.nlm.nih.gov]

Diabetes Mellitus

[…] frequency of insulin-dependent diabetes in several countries is best explained today by the decline of infections. [dx.doi.org]

The earliest abnormality in an individual who develops type 2 diabetes mellitus is insulin resistance, which initially is compensated for with an increase in insulin secretion [doi.org]

[…] the β-cells in the pancreas, decreased glucose uptake in the peripheral tissues, and increased insulin resistance. [ncbi.nlm.nih.gov]

Maternal Diabetes Syndrome

Type II is non-insulin-dependent, similar to the adult onset diabetes in humans due to pancreatic damage—there is a high or normal initial blood insulin level and no increase [medical-dictionary.thefreedictionary.com]

Insulin levels significantly increase in the second and third trimesters of pregnancy as a normal part of pregnancy; the majority of women with PCOS already have high insulin [pcosnutrition.com]

This condition is called "insulin resistance." As the placenta grows larger during pregnancy, it produces more hormones and increases this insulin resistance. [my.clevelandclinic.org]

Acanthosis Nigricans with Insulin Resistance

[…] with insulinaemia. 1-3 IGF receptors are also present in the ovarian stroma and, when bound by insulin, increased androgen production occurs, causing hirsutism and virilism [pmj.bmj.com]

Increased insulin levels can lead to the discoloration or changes in texture in a person’s skin, but the causes of these increased insulin levels vary. [theprettypimple.com]

Insulin resistance increases your risk for progressing to diabetes. You could be insulin resistant for years without knowing it. [healthline.com]

Insulinoma

Insulin sensitivity was greatly reduced in patients with insulinoma (38.9%±22.3%), while beta cells function was increased (359.0±171.5%), but to a variable extent (range: [ncbi.nlm.nih.gov]

Patients with insulinoma also show increased c-peptide and proinsulin levels. Insulin release of a diagnosed insulinoma can be inhibited by giving octreotide. [flexikon.doccheck.com]

They include a decrease in insulin production and/or an increase in peripheral insulin resistance. [edmcasereports.com]

Insulin Overdose

Even in a CCB poisoned animal model insulin increases myocardial glucose uptake resulting in improved contractility. [coreem.net]

Doctors call this pathology - absolute insulin deficiency. The main sign of it is hyperglycemia - an increase in glucose (sugar) in the blood. [en.intoxication-stop.com]

Owing to an increasing dextrose requirement and a dependence on hourly intramuscular glucagon injections, a continuous intravenous infusion of glucagon was commenced which [ncbi.nlm.nih.gov]

Familial Partial Lipodystrophy

CONCLUSION/INTERPRETATION: The combination of BMI ≤ 27 kg/m(2) and the use of >100 U insulin/day increases the chance of identifying lipodystrophy. [ncbi.nlm.nih.gov]

Her body weight increased from 62.0 to 71.0 kg after 12 months of treatment, suggesting that weight gain may result from synergism between thiazolidinediones and insulin-promoting [ncbi.nlm.nih.gov]

The presence of lamin A/C nuclear aggregates was restricted to actively transcribing cells, and it was increased in insulin-treated fibroblasts. [ncbi.nlm.nih.gov]

Lipodystrophy

The higher levels of insulin may increase fat accumulation. [thewellproject.org]

[…] resistance has increased from 50 percent to 60 percent; and diabetes is developing in 10 percent to 14 percent. [hopkinsmedicine.org]

Another theory is that insulin resistance and increased lipid levels play a role in fat gain. [thewellproject.org]

Hyperkalemia

Because the risk of hypoglycemia is increased with using large insulin doses, sufficient glucose (60 grams with the administration of 20 units of insulin and 50 grams with [ncbi.nlm.nih.gov]

[…] age dehydration hypoaldosteronism metabolic acidosis diabetes mellitus, insulin deficiency increased potassium intake References 1. [emedexpert.com]

[…] deficiency can cause hyperkalemia as the hormone insulin increases the uptake of potassium into the cells. [en.wikipedia.org]

Acquired Partial Lipodystrophy

Although uncommon, insulin resistance increases cardiovascular risk. [en.wikipedia.org]

With a goal of increasing insulin sensitivity, pioglitazone has been shown to be more efficacious than metformin in this patient population. [statpearls.com]

Whilst there is an increased risk of insulin resistance and metabolic complications (including menstrual irregularities, hirsutism, diabetes mellitus, dyslipidemia, hypertension [orpha.net]

Obesity

RESULTS: Results: Due to increased insulin resistance and reduced glucose absorption by tissues of pregnant women with obesity, there are prerequisites for the development [ncbi.nlm.nih.gov]

The insulin-resistant state that is so common in obesity probably reflects the effects of increased release of fatty acids from fat cells that are then stored in the liver [ncbi.nlm.nih.gov]

Dysregulation of these hormones is associated with overeating (or hyperphagy) and with tissue resistance to insulin, increasing the risk of type II diabetes. [britannica.com]

Pancreatic Adenoma

Symptoms - Pancreatic adenoma * Abdominal pain * Nausea * Vomiting * Biliary obstruction * Low blood sugar * Increased insulin secretion * Increased gastrin secretion * Sweating [checkorphan.org]

Peripheral insulin resistance → hyperglycemia → feedback to pancreas → increased insulin secretion. [vetstream.com]

Blood tests look for increased levels of hormones such as insulin, glucagon, and gastrin, as well as glucose levels in the bloodstream. [healthline.com]

Congenital Generalized Lipodystrophy

Her levels returned to near normal only with extremely high doses of insulin (up to 1,700 units/d) and increased doses of leptin and metformin. [ncbi.nlm.nih.gov]

DISCUSSION Various etiologies for the syndrome include excess of hypothalamic releasing factors, an inherited or acquired anomaly in the peripheral insulin response, increased [jpma.org.pk]

We investigated whether insulin resistance in CGL patients is associated with abnormal muscle morphology and whether increased muscularity imparts increased muscle strength [ncbi.nlm.nih.gov]

Glucose Intake

Growth hormone increases blood glucose level and in response insulin goes up but insulin can't work. [forums.studentdoctor.net]

insulin mediated increases in sympathetic activity. [ncbi.nlm.nih.gov]

Review Topic QID: 100308 1 Increased levels of circulating insulin 2 Decreased levels of circulating insulin 3 Increased plasma glucose concentration 4 Decreased plasma glucose [medbullets.com]

Hyperlipoproteinemia Type 4

With increasing insulin deficiency, liver steatosis and the more common type 4 hyperlipoproteinemia pattern may progress to fatty liver hepatitis and type 5 hyperlipoproteinemia [journals.lww.com]

This may increase your risk of a severe case of hypertriglyceridemia. [healthline.com]

Obesity Abdominal obesity (more common in men) is associated with insulin resistance, hypertriglyceridaemia and elevated Apo B. [diapedia.org]

Malignant Neoplasm of the Pancreas

[…] in the strength or number of oral hypoglycemics (i.e., diabetes pills) needed to control diabetes increase in required insulin needed to control diabetes transition from [pancyst.org]

In both men and women, central obesity is associated with increased levels of insulin and with disruption of normal endocrine and metabolic functions. [britannica.com]

Blood tests look for increased levels of hormones such as insulin, glucagon, and gastrin, as well as glucose levels in the bloodstream. [healthline.com]

Lipoatrophic Diabetes Mellitus

Definitely, the endogenous insulin secretion is increased. In other words, insulin resistance is documented. [ncbi.nlm.nih.gov]

Her serum insulin level gradually decreased, her glycemic control worsened, and her HbA1c level increased above 12% even with 1000 U of insulin per day. [endocrine-abstracts.org]

which is characterized by the presence of insulin resistance with an inadequate compensatory increase in insulin secretion. [diabetesmanager.pbworks.com]

Chronic Kidney Insufficiency

Thiazolidinediones Thiazolidinediones (pioglitazone, rosiglitazone) increase insulin sensitivity by acting as PPARγ agonists. [clindiabetesendo.biomedcentral.com]

[…] risk seen with insulin therapy. 30, 31 Exogenous insulin is normally metabolized by the kidney. [clinical.diabetesjournals.org]

(observed in diabetic patients) – both are hypothesized to cause a rise in the GFR increasing renal flow Hyperfiltration of glucose leads to augmented sodium-glucose transport [pathophys.org]

Portal Cirrhosis

Even if it seems clear that obesity and insulin resistance increase the risk of decompensation in patients with compensated cirrhosis, several issues need to be clarified [elsevier.es]

[…] resistance and obesity, progresses to NASH due to increased inflammation, oxidative stress, apoptosis, and adipokine dysfunction Insulin resistance Insulin resistance enhances [pathophys.org]

[…] resistance as a consequence of increased porto-systemic shunting,41 and (c) insulin resistance is largely corrected or reversed by abolishing porto-systemic shunting by liver [elsevier.es]

Islet Cell Tumor

C-peptide elevated serum insulin level increased gastrin level positive secretin stimulation test for pancreas elevated fasting glucose level elevated serum glucagon level [medicine.georgetown.edu]

In the case of insulinomas, they increase insulin levels in the body, which in turn causes low blood sugar. [symptoma.com]

[…] abdomen to show pancreatic tumor (MRI can sometimes see smaller tumors than those seen with a CT scan) abnormal glucose tolerance test low fasting glucose level elevated serum insulin [medicine.georgetown.edu]

Septicemia

Furthermore it was also pointed out that intensive insulin therapy increased the labor requirement of nursing staff in the ICU[ 26 ]. [doi.org]

Doctors use a number of medications to treat sepsis, including: antibiotics via IV to fight infection vasoactive medications to increase blood pressure insulin to stabilize [healthline.com]

Vincent J-L, Preiser J-C, Sprung CL, Moreno R, Sakr Y (2010) Insulin-treated diabetes is not associated with increased mortality in critically ill patients. [doi.org]

Panhypopituitarism

Therefore, absence of or reduction in IGF-1 secretion would lead to increased hepatic glucose production and favour peripheral insulin resistance [21]. [hindawi.com]

His plasma cortisol was below the detection level, and insulin induced hypoglycaemia failed to increase the plasma cortisol concentration. [adc.bmj.com]

The peak serum cortisol level could increase to 19.08 μg/dL by insulin-induced hypoglycemia. [ncbi.nlm.nih.gov]

Primary Hyperparathyroidism

Página 309 - Increased insulin-like growth factor II production and consequent suppression of growth hormone secretion: a dual mechanism for tumorinduced hypoglycemia, J. ‎ [books.google.es]

Although primary hyperparathyroidism is frequently asymptomatic, it has been associated with an increased prevalence of hypertension, insulin resistance, dyslipidemia, cardiovascular [ncbi.nlm.nih.gov]

Patients with PHPT may have an increased risk of hypertension, insulin resistance, and cardiovascular morbidity and mortality, although this remains controversial. [orthopaedicsone.com]

Graves Disease

They express potentially pathogenic autoantigens, such as thyrotropin receptor and insulin-like growth factor-1 receptor. [doi.org]

Increased insulin action and clearance in hyperthyroid newly diagnosed IDDM patient: restoration to normal with anti-thyroid treatment. [cmaj.ca]

An intricate interplay between these autoantigens and the autoantibodies found in Graves disease may lead to the activation of OFs, which then leads to increased hyaluronan [doi.org]

Pituitary Cushing Syndrome

[…] hormone/insulin-like growth factor 1 values, hypogonadotropic hypogonadism and central hypothyroidism. [ncbi.nlm.nih.gov]

Cushing's disease (CD), a state of chronic glucocorticoid (GC) excess characterized by visceral obesity and insulin resistance, may be associated with increased systemic inflammation [ncbi.nlm.nih.gov]

However, if the adrenal glands overproduce testosterone and other hormones too, this may increase libido. [medicalnewstoday.com]

Launois Syndrome

Abnormal growth is mediated by increased secretion of insulin-like growth factor I (IGF-I). [symptoma.com]

Prolactinoma

Hyperprolactinemia may be involved in the preclinical increase in carotid IMT, directly or by promoting atherogenic factors, including insulin resistance, low-grade inflammation [ncbi.nlm.nih.gov]

CONCLUSIONS: Our study did not show an association between anabolic hormones and increased thyroid volume in women with prolactinoma. [ncbi.nlm.nih.gov]

Prolactin secretion increases steadily during pregnancy and peaks at parturition. During the postpartum period, plasma prolactin rapidly declines to normal levels. [pituitaryadenomas.com]

Pheochromocytoma-Islet Cell Tumor Syndrome

In general, the risk of insulin-dependent diabetes mellitus in relatives of probands increases with titre of ICA, is greater in multiplex families, and is increased in those [kmle.co.kr]

[…] suppression of counterregulatory hormones for insulin or insulin-like factors secreted by the tumor. [hindawi.com]

In two randomised, prospective, placebo-controlled studies of recent-onset insulin-dependent diabetes mellitus, cyclosporine immunosuppression increased the rate of non-insulin-requiring [kmle.co.kr]

Non-Dystrophic Myotonia

Sometimes a simple ingestion of simple carbohydrates (e.g., fruit juices, glucose-containing candies) decreases the serum potassium level by increasing insulin secretion and [neupsykey.com]

Beta-adrenergic agonists (e.g., metaproterenol, albuterol, salbutamol) also may increase strength but one needs to take care in regard to associated cardiac arrhythmias. [neupsykey.com]

Myotonia Congenita

[…] debility, though strength benefits may not be dramatic and care should be taken not to increase fatigue in individuals who are already active. [now.aapmr.org]

Recommendations for moderate active exercise, both resistance and cardiovascular, would appear to be safe and may improve insulin sensitivity and reduce risks of frailty and [now.aapmr.org]