Hyperinsulinemia: Causes & Reasons

Possible Causes for Hyperinsulinemia

Most of the PCOS women with normal gonadotropin ratio belong to a group of patients suffering from hyperinsulinemia and obesity. [ncbi.nlm.nih.gov]

Cross-sectional study examining the relationships between hyperinsulinemia, composite cardiovascular risk scores, and prevalence of individual risk factors among lean and [ncbi.nlm.nih.gov]

KEYWORDS: body mass index; hyperinsulinemia; irisin; meta-analysis; polycystic ovary syndrome [ncbi.nlm.nih.gov]

Insulinoma

After resection of the insulinoma, the levels of these parameters all were mostly restored, which suggests that hyperinsulinemia and subsequent hyperphagia played a role in [ncbi.nlm.nih.gov]

Insulinoma response to glucagon A 72-hour fast is performed to establish a diagnosis of endogenous hyperinsulinemia. [healio.com]

The fasting test was performed and the laboratory results showed endogenous hyperinsulinemia compatible with insulinoma. [ncbi.nlm.nih.gov]

Familial Partial Lipodystrophy

FPLD recapitulates the main metabolic attributes of the insulin resistance syndrome, including central obesity, hyperinsulinemia, glucose intolerance and diabetes, dyslipidemia [ncbi.nlm.nih.gov]

All of the patients had normal glucose tolerance but had fasting and postprandial hyperinsulinemia suggestive of insulin resistance. [ncbi.nlm.nih.gov]

Does hyperinsulinemia and insulin resistance, respectively, precede dyslipidemia and diabetes mellitus in this selected cohort of patients? [circ.ahajournals.org]

Congenital Generalized Lipodystrophy

Improvement in the hyperglycemia, hyperinsulinemia and acanthosis nigricans was also observed. [ncbi.nlm.nih.gov]

Several studies have demonstrated a correlation between neoplasms and hyperinsulinemia and insulin resistance, which are often associated with a higher risk for and/or aggressiveness [ncbi.nlm.nih.gov]

Congenital Lipodystrophy (BSCL) is a rare autosomal recessive syndrome characterized by a difficulty in storing lipids in adipocytes, low body fat mass, hypoleptinemia, and hyperinsulinemia [ncbi.nlm.nih.gov]

Maternal Diabetes Syndrome

It correlates with poor maternal control resulting in fetal hyperinsulinemia. [utmb.edu]

Hypoglycemia is caused by hyperinsulinemia due to hyperplasia of fetal pancreatic beta cells consequent to maternal-fetal hyperglycemia. [emedicine.medscape.com]

Chronic hyperinsulinemia can lead to an increased erythropoiesis and also to an accelerated hemolysis due to glycation processes, that associated to prematurity, modified [dmsjournal.biomedcentral.com]

Acanthosis Nigricans with Insulin Resistance

Therapy with thyroxine resulted in weight loss, reversal of hyperinsulinemia, and resolution of the acanthosis nigricans. [ncbi.nlm.nih.gov]

[…] hypothyroidism does not resolve the hyperinsulinemia or the acanthosis nigricans. [ncbi.nlm.nih.gov]

Abstract Acanthosis nigricans in obese adolescents is frequently associated with hyperinsulinemia and insulin resistance. We report three cases of this condition. [ncbi.nlm.nih.gov]

Lipodystrophy

Does hyperinsulinemia and insulin resistance, respectively, precede dyslipidemia and diabetes mellitus in this selected cohort of patients? [circ.ahajournals.org]

Low-dose metformin treatment decreased body mass index and abdominal fat, improved hyperinsulinemia, and lowered diastolic blood pressure. [the-scientist.com]

In addition to the changes in fat distribution described above, patients have hyperinsulinemia and occasionally autoimmune disorders such as rheumatoid arthritis, hypothyroidism [healio.com]

Pancreatic Adenoma

That such a state, so-called hyperinsulinemia, might arise spontaneously within the human body as a result of the overproduction of insulin by the cells of the islands of [jamanetwork.com]

Prognosis : grave for primary hyperinsulinemia; fair for secondary hyperinsulinemia. [vetstream.com]

Since none of the foregoing cases has come to autopsy or been surgically explored, the hypoglycemia cannot be irrefutably ascribed to hyperinsulinemia resulting from hyperplasia [jamanetwork.com]

Acquired Partial Lipodystrophy

In addition to the changes in fat distribution described above, patients have hyperinsulinemia and occasionally autoimmune disorders such as rheumatoid arthritis, hypothyroidism [healio.com]

As is common to many lipodystrophies, metabolic anomalies including hyperinsulinemia, insulin resistance, and hypertriglyceridemia often occur. [statpearls.com]

A 75 g oral glucose tolerance test (OGTT) revealed IGT and hyperinsulinemia. [edmcasereports.com]

Malignant Neoplasm of the Pancreas

Insulin resistance and accompanying compensatory hyperinsulinemia might increase local blood flow and cell division in the pancreas ( 11 ). [care.diabetesjournals.org]

Diabetes Mellitus

Iatrogenic hypoglycemia, typically the result of the interplay of therapeutic hyperinsulinemia and compromised defenses resulting in hypoglycemia-associated autonomic failure [ncbi.nlm.nih.gov]

If chronic peripheral hyperinsulinemia exists, insulin transport across the blood-brain barrier will decrease. [elsevier.es]

Hyperinsulinemia as an independent risk factor for ischemic heart disease. [academic.oup.com]

Obesity

He had hyperinsulinemia, dyslipidemia and grade 2 hepatosteatosis. He had a 7-year-old, healthy brother with a normal body weight. [ncbi.nlm.nih.gov]

Google Scholar 12 : Hyperinsulinemia, hyperglycemia, and impaired hemostasis: the Framingham Offspring Study. JAMA 2000 ; 283 : 221. [dx.doi.org]

Google Scholar 36 : Sex hormone-binding globulin as a marker for hyperinsulinemia and/or insulin resistance in obese children. Eur J Endocrinol 2000 ; 143 : 85. [dx.doi.org]

Beckwith-Wiedemann Syndrome

The cause of hypoglycemia is unclear, but direct and indirect evidence supports a hyperinsulinemia as the major factor. [ncbi.nlm.nih.gov]

The similar extent of the pUPD suggests a similar mechanism driving hyperinsulinemia in both conditions. [ncbi.nlm.nih.gov]

Beckwith-wiedemann syndrome mnemonic "Big body" Macrosomia "Big tongue" Macroglossia "Big abdomen" Omphalocele "Big pancreas" Hyperinsulinemia -> Hypoglycemia "Big organs" [medicowesome.com]

Insulin Overdose

Using Hyperinsulinemia Euglycemia Therapy (Lugassy 2015) Hyperinsulinemia Euglycemia Therapy (HIET) Initiation: Intravenous bolus of regular insulin at a dose of 1 unit/kg [coreem.net]

Islet Cell Tumor

An insulinoma is characterized by endogenous hyperinsulinemia and hypoglycemia. [ncbi.nlm.nih.gov]

The patient, a 64-year-old woman showed severe hypoglycemia as the initial symptom, and hyperinsulinemia was demonstrated by laboratory examinations. [ncbi.nlm.nih.gov]

The laboratory findings showed hypoglycemia and hyperinsulinemia. Abdominal ultrasonography revealed a tumor in the body of the pancreas. [ncbi.nlm.nih.gov]

Estrogen Resistance Syndrome

Hyperinsulinemia Causes Hyperandrogenism More support in the literature may be found for the premise that hyperinsulinemia causes ovarian hyperandrogenism. [glowm.com]

PCOS is characterized by hyperandrogenism, irregular ovulatory cycles, and a metabolic derangement including glucose intolerance and hyperinsulinemia. [pathophys.org]

Glucose intolerance, hyperinsulinemia and lipid abnormalities may also be present. [uniprot.org]

Fetal Erythroblastosis

Raivio KO, Osterlung K: Hypoglycemia and hyperinsulinemia associated with erythroblastosis fetalis. Pediatrics 1969;43:217-225. [karger.com]

However, IVT has many advantages, including immediate correction of anemia and resolution of fetal hydrops, reduced rate of hemolysis and subsequent hyperinsulinemia, and [emedicine.medscape.com]

Hyperlipoproteinemia Type 4

Hypertriglyceridemic waist: a marker of the atherogenic metabolic triad (hyperinsulinemia; hyperapolipoprotein B; small, dense LDL) in men? [cmaj.ca]

Endogenous HTG is usually related to hyperinsulinemia and insulin resistance and is most often caused by obesity, excess calorie intake, alcohol use, or the use of estrogens [kjpbt.org]

In patients with uncontrolled type 2 diabetes mellitus and hyperinsulinemia, triglycerides are elevated for several reasons, including the following: Lipoprotein lipase is [emedicine.medscape.com]

Portal Cirrhosis

Insulin resistance in cirrhosis: prolonged reduction of hyperinsulinemia normalizes insulin sensitivity. Hepatology, 28 (1998), pp. 141-149 [35] A.S. Petrides, R.A. [elsevier.es]

[…] and inhibits FFA oxidation These increased levels of serum free fatty acids are then taken up by the liver and drive triglyceride production and hepatic steatosis Chronic hyperinsulinemia [pathophys.org]

[…] esophageal varices independent of liver function and non-invasive markers of portal hypertension (platelet count and spleen size).46 This association was expected, since hyperinsulinemia [elsevier.es]

Glucose Intake

In patients with intact β-cell function these changes are counterbalanced by hyperinsulinemia – such hyperinsulinemia may in the long term induce increased cardiovascular [karger.com]

More rarely, hyperinsulinemia results from an insulin-secreting tumor (insulinoma) in the pancreas. [vivo.colostate.edu]

[…] and adipose cells no longer inhibiting free fatty acid release. 1 This then results in higher levels of insulin being produced, and chronically high insulin is known as hyperinsulinemia [thatsugarfilm.com]

Pheochromocytoma-Islet Cell Tumor Syndrome

Insulinoma in MEN1 Syndrome Characterized by Normoglycemia/Normoinsulinemia but Abnormal C-Peptide and Abnormal Proinsulin Levels Introduction: Insulinoma associated w/ hyperinsulinemia [enets.org]

[…] homeostasisホメオスタシス、恒常性 hormoneホルモン hyperalimentation栄養過剰 hypercalcemia高カルシウム血［症］ hypercholesterolemia高コレステロール血［症］ hyperglycemia高血糖［症］ hyperglycemic hyperosmolarsyndrome高血糖高浸透圧症候群 hyperinsulinemia [tokyo-med.ac.jp]

Hyperkalemia

BLOEDGLUCOSESPIEGEL HYPOGLYKEMIE HYPOGLYCEMIA DokterDokter: Hyperinsulinisme Hyperinsulinisme Hyperinsulinemie/Onverklaarbaar overgewicht Wikipedia (Eng): Hyperinsulinism Hyperinsulinemia [catsclem.nl]

Hyperinsulinemia/euglycemia therapy for calcium channel blocker poisoning. Pediatr Emerg Care. 2002 ; 18 :36–37. Crossref Medline Google Scholar 285. [doi.org]

Aminozuurstofwisselingsziekten Homocystunirie Homocystinuria Hyperhomocysteinemia Transfusion Medicine Update: Hyperhomocysteinemia HYPERINSULINISME HYPERINSULINISM HYPERINSULINEMIE HYPERINSULINEMIA [catsclem.nl]

Launois Syndrome

These are associated not inconstant factors: ethylism, tabagism, hyperinsulinemia, hyperlipoproteinemia and hyperuricemia. [rbcp.org.br]

Septicemia

Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia. [ncbi.nlm.nih.gov]

Stegenga ME, van der Crabben SN, Levi M, de Vos AF, Tanck MW, Sauerwein HP, van der Poll T (2006) Hyperglycemia stimulates coagulation, whereas hyperinsulinemia impairs fibrinolysis [dx.doi.org]

Hyperglycemia stimulates coagulation, whereas hyperinsulinemia impairs fibrinolysis in healthy humans. Diabetes. 2006; 55 :1807–1812. [ PubMed ] [ Google Scholar ] 52. [ncbi.nlm.nih.gov]

Panhypopituitarism

Serum insulin was 0.91, which ruled out hyperinsulinemia. Growth hormone (GH) was 0.519, suggesting GH deficiency. ACTH stimulation test was normal. [hindawi.com]

Myotonia Congenita

Hyperinsulinemia, a carbohydrate load, and exercise are important in precipitating paralytic attacks. [emedicine.medscape.com]

Lipoatrophic Diabetes Mellitus

Most AGL patients have had fasting and/or postprandial hyperinsulinemia, diabetes mellitus, hypertriglyceridemia, and fatty liver. [soc-bdr.org]

Type A insulin resistance refers to the clinical syndrome of acanthosis nigricans, virilization in women, polycystic ovaries, and hyperinsulinemia. [diabetesmanager.pbworks.com]

Patients also frequently present with severe insulin resistance (and diabetes), hyperinsulinemia, hypertriglyceridemia, dyslipidemia (in particular low serum high-density [dovepress.com]

Insulin Resistance

DBH-deficient mice exhibit hyperinsulinemia, lower plasma glucose levels, and insulin resistance due to loss of tonic sympathetic inhibition of insulin secretion. [ncbi.nlm.nih.gov]

Obesity is associated with both insulin resistance and hyperinsulinemia. [ncbi.nlm.nih.gov]

The proband's mother had hyperinsulinemia and diabetes mellitus but did not show any common clinical features of type A insulin resistance. [ncbi.nlm.nih.gov]

Metabolic Syndrome

Plasma glucose levels after an oral glucose challenge were significantly higher (P We conclude that healthy persons with hyperinsulinemia and normal glucose tolerance have [dx.doi.org]

Hyperinsulinemia is a condition where large amounts of insulin are pumped into the bloodstream. [texasheart.org]

One group of 32 subjects was defined as having hyperinsulinemia (serum insulin, >2 SD above the mean) and then compared with 32 normoinsulinemic subjects (serum insulin within [dx.doi.org]

Third Trimester Pregnancy

OBJECTIVE: To perform a prospective, observational study in a tertiary center to determine whether anemia (hemoglobin level < 10 g/dL) developing in the third trimester was associated with an increased placental weight/birth weight ratio (placental ratio) and whether the placental ratio correlated with the[…] [ncbi.nlm.nih.gov]