Insulin Increased: Causes & Reasons

Warning: Do not use in emergencies, if pregnant, if under 18, or as a substitute for a doctor’s advice or diagnosis. Learn more

Possible Causes for Insulin Increased

Polycystic Ovary Syndrome

In addition, with FAI increase, glycosylated hemoglobin (HbA1c), plasma glucose concentrations, and serum insulin levels increased, while insulin sensitivity and β -cell function [ncbi.nlm.nih.gov]

[…] and chronic vascular damage, especially in situations where insulin levels are increased. [ncbi.nlm.nih.gov]

[…] resistance, increased testosterone levels, and other reproductive abnormalities. [ncbi.nlm.nih.gov]

Diabetes Mellitus

The earliest abnormality in an individual who develops type 2 diabetes mellitus is insulin resistance, which initially is compensated for with an increase in insulin secretion [doi.org]

[…] the β-cells in the pancreas, decreased glucose uptake in the peripheral tissues, and increased insulin resistance. [ncbi.nlm.nih.gov]

[…] pump If patient is on epinephrine, glucocorticoids, or growth hormone, there may be an increase in blood glucose levels, thus an increased level of insulin may be needed. [physio-pedia.com]

Maternal Diabetes Syndrome

Type II is non-insulin-dependent, similar to the adult onset diabetes in humans due to pancreatic damage—there is a high or normal initial blood insulin level and no increase [medical-dictionary.thefreedictionary.com]

Insulin levels significantly increase in the second and third trimesters of pregnancy as a normal part of pregnancy; the majority of women with PCOS already have high insulin [pcosnutrition.com]

This condition is called "insulin resistance." As the placenta grows larger during pregnancy, it produces more hormones and increases this insulin resistance. [my.clevelandclinic.org]

Insulinoma

Insulin sensitivity was greatly reduced in patients with insulinoma (38.9%±22.3%), while beta cells function was increased (359.0±171.5%), but to a variable extent (range: [ncbi.nlm.nih.gov]

Patients with insulinoma also show increased c-peptide and proinsulin levels. Insulin release of a diagnosed insulinoma can be inhibited by giving octreotide. [flexikon.doccheck.com]

They include a decrease in insulin production and/or an increase in peripheral insulin resistance. [edmcasereports.com]

Acanthosis Nigricans with Insulin Resistance

[…] with insulinaemia. 1-3 IGF receptors are also present in the ovarian stroma and, when bound by insulin, increased androgen production occurs, causing hirsutism and virilism [pmj.bmj.com]

Increased insulin levels can lead to the discoloration or changes in texture in a person’s skin, but the causes of these increased insulin levels vary. [theprettypimple.com]

Insulin resistance increases your risk for progressing to diabetes. You could be insulin resistant for years without knowing it. [healthline.com]

Insulin Overdose

Even in a CCB poisoned animal model insulin increases myocardial glucose uptake resulting in improved contractility. [coreem.net]

Doctors call this pathology - absolute insulin deficiency. The main sign of it is hyperglycemia - an increase in glucose (sugar) in the blood. [en.intoxication-stop.com]

Owing to an increasing dextrose requirement and a dependence on hourly intramuscular glucagon injections, a continuous intravenous infusion of glucagon was commenced which [ncbi.nlm.nih.gov]

Familial Partial Lipodystrophy

CONCLUSION/INTERPRETATION: The combination of BMI ≤ 27 kg/m(2) and the use of >100 U insulin/day increases the chance of identifying lipodystrophy. [ncbi.nlm.nih.gov]

Her body weight increased from 62.0 to 71.0 kg after 12 months of treatment, suggesting that weight gain may result from synergism between thiazolidinediones and insulin-promoting [ncbi.nlm.nih.gov]

The presence of lamin A/C nuclear aggregates was restricted to actively transcribing cells, and it was increased in insulin-treated fibroblasts. [ncbi.nlm.nih.gov]

Lipodystrophy

The higher levels of insulin may increase fat accumulation. [thewellproject.org]

[…] resistance has increased from 50 percent to 60 percent; and diabetes is developing in 10 percent to 14 percent. [hopkinsmedicine.org]

Another theory is that insulin resistance and increased lipid levels play a role in fat gain. [thewellproject.org]

Hyperkalemia

Because the risk of hypoglycemia is increased with using large insulin doses, sufficient glucose (60 grams with the administration of 20 units of insulin and 50 grams with [ncbi.nlm.nih.gov]

[…] age dehydration hypoaldosteronism metabolic acidosis diabetes mellitus, insulin deficiency increased potassium intake References 1. [emedexpert.com]

[…] deficiency can cause hyperkalemia as the hormone insulin increases the uptake of potassium into the cells. [en.wikipedia.org]

Acquired Partial Lipodystrophy

Although uncommon, insulin resistance increases cardiovascular risk. [en.wikipedia.org]

With a goal of increasing insulin sensitivity, pioglitazone has been shown to be more efficacious than metformin in this patient population. [statpearls.com]

Whilst there is an increased risk of insulin resistance and metabolic complications (including menstrual irregularities, hirsutism, diabetes mellitus, dyslipidemia, hypertension [orpha.net]

Glucose Intake

Growth hormone increases blood glucose level and in response insulin goes up but insulin can't work. [forums.studentdoctor.net]

insulin mediated increases in sympathetic activity. [ncbi.nlm.nih.gov]

Review Topic QID: 100308 1 Increased levels of circulating insulin 2 Decreased levels of circulating insulin 3 Increased plasma glucose concentration 4 Decreased plasma glucose [medbullets.com]

Obesity

RESULTS: Results: Due to increased insulin resistance and reduced glucose absorption by tissues of pregnant women with obesity, there are prerequisites for the development [ncbi.nlm.nih.gov]

The insulin-resistant state that is so common in obesity probably reflects the effects of increased release of fatty acids from fat cells that are then stored in the liver [ncbi.nlm.nih.gov]

Dysregulation of these hormones is associated with overeating (or hyperphagy) and with tissue resistance to insulin, increasing the risk of type II diabetes. [britannica.com]

Lipoatrophic Diabetes Mellitus

Definitely, the endogenous insulin secretion is increased. In other words, insulin resistance is documented. [ncbi.nlm.nih.gov]

Her serum insulin level gradually decreased, her glycemic control worsened, and her HbA1c level increased above 12% even with 1000 U of insulin per day. [endocrine-abstracts.org]

which is characterized by the presence of insulin resistance with an inadequate compensatory increase in insulin secretion. [diabetesmanager.pbworks.com]

Congenital Generalized Lipodystrophy

Her levels returned to near normal only with extremely high doses of insulin (up to 1,700 units/d) and increased doses of leptin and metformin. [ncbi.nlm.nih.gov]

DISCUSSION Various etiologies for the syndrome include excess of hypothalamic releasing factors, an inherited or acquired anomaly in the peripheral insulin response, increased [jpma.org.pk]

We investigated whether insulin resistance in CGL patients is associated with abnormal muscle morphology and whether increased muscularity imparts increased muscle strength [ncbi.nlm.nih.gov]

Pancreatic Adenoma

Symptoms - Pancreatic adenoma * Abdominal pain * Nausea * Vomiting * Biliary obstruction * Low blood sugar * Increased insulin secretion * Increased gastrin secretion * Sweating [checkorphan.org]

Peripheral insulin resistance → hyperglycemia → feedback to pancreas → increased insulin secretion. [vetstream.com]

Blood tests look for increased levels of hormones such as insulin, glucagon, and gastrin, as well as glucose levels in the bloodstream. [healthline.com]

Hyperlipoproteinemia Type 4

With increasing insulin deficiency, liver steatosis and the more common type 4 hyperlipoproteinemia pattern may progress to fatty liver hepatitis and type 5 hyperlipoproteinemia [journals.lww.com]

This may increase your risk of a severe case of hypertriglyceridemia. [healthline.com]

Obesity Abdominal obesity (more common in men) is associated with insulin resistance, hypertriglyceridaemia and elevated Apo B. [diapedia.org]

Malignant Neoplasm of the Pancreas

[…] in the strength or number of oral hypoglycemics (i.e., diabetes pills) needed to control diabetes increase in required insulin needed to control diabetes transition from [pancyst.org]

In both men and women, central obesity is associated with increased levels of insulin and with disruption of normal endocrine and metabolic functions. [britannica.com]

Blood tests look for increased levels of hormones such as insulin, glucagon, and gastrin, as well as glucose levels in the bloodstream. [healthline.com]

Chronic Kidney Insufficiency

Thiazolidinediones Thiazolidinediones (pioglitazone, rosiglitazone) increase insulin sensitivity by acting as PPARγ agonists. [clindiabetesendo.biomedcentral.com]

[…] risk seen with insulin therapy. 30, 31 Exogenous insulin is normally metabolized by the kidney. [clinical.diabetesjournals.org]

(observed in diabetic patients) – both are hypothesized to cause a rise in the GFR increasing renal flow Hyperfiltration of glucose leads to augmented sodium-glucose transport [pathophys.org]

Islet Cell Tumor

C-peptide elevated serum insulin level increased gastrin level positive secretin stimulation test for pancreas elevated fasting glucose level elevated serum glucagon level [medicine.georgetown.edu]

In the case of insulinomas, they increase insulin levels in the body, which in turn causes low blood sugar. [symptoma.com]

[…] abdomen to show pancreatic tumor (MRI can sometimes see smaller tumors than those seen with a CT scan) abnormal glucose tolerance test low fasting glucose level elevated serum insulin [medicine.georgetown.edu]

Panhypopituitarism

Therefore, absence of or reduction in IGF-1 secretion would lead to increased hepatic glucose production and favour peripheral insulin resistance [21]. [hindawi.com]

His plasma cortisol was below the detection level, and insulin induced hypoglycaemia failed to increase the plasma cortisol concentration. [adc.bmj.com]

The peak serum cortisol level could increase to 19.08 μg/dL by insulin-induced hypoglycemia. [ncbi.nlm.nih.gov]

Portal Cirrhosis

Even if it seems clear that obesity and insulin resistance increase the risk of decompensation in patients with compensated cirrhosis, several issues need to be clarified [elsevier.es]

[…] resistance and obesity, progresses to NASH due to increased inflammation, oxidative stress, apoptosis, and adipokine dysfunction Insulin resistance Insulin resistance enhances [pathophys.org]

[…] resistance as a consequence of increased porto-systemic shunting,41 and (c) insulin resistance is largely corrected or reversed by abolishing porto-systemic shunting by liver [elsevier.es]

Primary Hyperparathyroidism

Página 309 - Increased insulin-like growth factor II production and consequent suppression of growth hormone secretion: a dual mechanism for tumorinduced hypoglycemia, J. ‎ [books.google.es]

Although primary hyperparathyroidism is frequently asymptomatic, it has been associated with an increased prevalence of hypertension, insulin resistance, dyslipidemia, cardiovascular [ncbi.nlm.nih.gov]

Patients with PHPT may have an increased risk of hypertension, insulin resistance, and cardiovascular morbidity and mortality, although this remains controversial. [orthopaedicsone.com]

Launois Syndrome

Abnormal growth is mediated by increased secretion of insulin-like growth factor I (IGF-I). [symptoma.com]

Septicemia

Furthermore it was also pointed out that intensive insulin therapy increased the labor requirement of nursing staff in the ICU[ 26 ]. [doi.org]

Doctors use a number of medications to treat sepsis, including: antibiotics via IV to fight infection vasoactive medications to increase blood pressure insulin to stabilize [healthline.com]

Vincent J-L, Preiser J-C, Sprung CL, Moreno R, Sakr Y (2010) Insulin-treated diabetes is not associated with increased mortality in critically ill patients. [doi.org]

Pituitary Cushing Syndrome

[…] hormone/insulin-like growth factor 1 values, hypogonadotropic hypogonadism and central hypothyroidism. [ncbi.nlm.nih.gov]

Cushing's disease (CD), a state of chronic glucocorticoid (GC) excess characterized by visceral obesity and insulin resistance, may be associated with increased systemic inflammation [ncbi.nlm.nih.gov]

However, if the adrenal glands overproduce testosterone and other hormones too, this may increase libido. [medicalnewstoday.com]

Pheochromocytoma-Islet Cell Tumor Syndrome

In general, the risk of insulin-dependent diabetes mellitus in relatives of probands increases with titre of ICA, is greater in multiplex families, and is increased in those [kmle.co.kr]

[…] suppression of counterregulatory hormones for insulin or insulin-like factors secreted by the tumor. [hindawi.com]

In two randomised, prospective, placebo-controlled studies of recent-onset insulin-dependent diabetes mellitus, cyclosporine immunosuppression increased the rate of non-insulin-requiring [kmle.co.kr]

Graves Disease

They express potentially pathogenic autoantigens, such as thyrotropin receptor and insulin-like growth factor-1 receptor. [doi.org]

Increased insulin action and clearance in hyperthyroid newly diagnosed IDDM patient: restoration to normal with anti-thyroid treatment. [cmaj.ca]

An intricate interplay between these autoantigens and the autoantibodies found in Graves disease may lead to the activation of OFs, which then leads to increased hyaluronan [doi.org]

Prolactinoma

Hyperprolactinemia may be involved in the preclinical increase in carotid IMT, directly or by promoting atherogenic factors, including insulin resistance, low-grade inflammation [ncbi.nlm.nih.gov]

CONCLUSIONS: Our study did not show an association between anabolic hormones and increased thyroid volume in women with prolactinoma. [ncbi.nlm.nih.gov]

Prolactin secretion increases steadily during pregnancy and peaks at parturition. During the postpartum period, plasma prolactin rapidly declines to normal levels. [pituitaryadenomas.com]

Myotonia Congenita

[…] debility, though strength benefits may not be dramatic and care should be taken not to increase fatigue in individuals who are already active. [now.aapmr.org]

Recommendations for moderate active exercise, both resistance and cardiovascular, would appear to be safe and may improve insulin sensitivity and reduce risks of frailty and [now.aapmr.org]

Beckwith-Wiedemann Syndrome

When an individual eats a meal high in glucose or carbohydrates, this leads to a rise in blood sugar, which is then a signal for the increased insulin secretion by the islet [encyclopedia.com]