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19 Possible Causes for Interictal Downbeat Nystagmus, Myokymia

  • Episodic Ataxia

    According to Baloh and others (1997), EA2 is characterized by a progressive ataxia with interictal rebound nystagmus evoked by gaze, as well as downbeating nystagmus.[dizziness-and-balance.com] In addition, myokymia (rippling of muscles, diagnosable by electromyography) is evident during and between attacks.[ncbi.nlm.nih.gov] Initial examination disclosed a central type of positional nystagmus (conjugate downbeat nystagmus that did not fatigue with repeated positioning).[jnnp.bmj.com]

  • Autosomal Recessive Spinocerebellar Ataxia 8

    According to Baloh and others (1997), EA2 is characterized by a progressive ataxia with interictal rebound nystagmus evoked by gaze, as well as downbeating nystagmus.[tchain.com] 1 MYOKYMIA 1 WITH HYPOMAGNESEMIA Kv1.5 (K7/45) ATRIAL FIBRILLATION, FAMILIAL, TYPE 7 Laforin (N84/1) PROGRESSIVE MYOCLONIC EPILEPSY, TYPE 2A MMACHC (N230/21) METHYLMALONIC[neuromab.ucdavis.edu] EPISODIC ATAXIA, TYPE 1; EA1 PAROXYSMAL ATAXIA WITH NEUROMYOTONIA, HEREDITARY EPISODIC ATAXIA WITH MYOKYMIA; EAM ATAXIA, EPISODIC, WITH MYOKYMIA; AEM; AEMK MYOKYMIA WITH PERIODIC[slideshare.net]

  • Spinocerebellar Ataxia Type 6

    Initial examination disclosed a central type of positional nystagmus (conjugate downbeat nystagmus that did not fatigue with repeated positioning).[jnnp.bmj.com] Litt MKramer PBrowne D et al A gene for episodic ataxia/myokymia maps to chromosome 12p13. Am J Hum Genet. 1994;55:702-709. Google Scholar 9.[doi.org] Neurol., 1992 , vol. 31 (pg. 147 - 154 ) 4 A gene for episodic ataxia/myokymia maps to chromosome 12pl3, Am. J. Hum.[academic.oup.com]

  • Adult-Onset Autosomal Recessive Cerebellar Ataxia

    . ; EA2 with interictal nystagmus , is long-lasting (hours) associated with attacks of vertigo, diffuse weakness, slurred speech, dystonia, seizures, truncal and limb ataxia[neuroweb.us] Myokymia, vertigo, or hearing loss may occur in some of the subtypes.[blueprintgenetics.com] Purkinje cells, dorsal root sensory ganglion neurons, and ascending posterior columns Spinocerebellar ataxia 5 See the list below: Clinical features Cerebellar ataxia, facial myokymia[emedicine.medscape.com]

  • Cerebellar Ataxia with Peripheral Neuropathy Type 2

    . ; EA2 with interictal nystagmus , is long-lasting (hours) associated with attacks of vertigo, diffuse weakness, slurred speech, dystonia, seizures, truncal and limb ataxia[neuroweb.us] EPISODIC ATAXIA, TYPE 1; EA1 PAROXYSMAL ATAXIA WITH NEUROMYOTONIA, HEREDITARY EPISODIC ATAXIA WITH MYOKYMIA; EAM ATAXIA, EPISODIC, WITH MYOKYMIA; AEM; AEMK MYOKYMIA WITH PERIODIC[slideshare.net] Purkinje cells, dorsal root sensory ganglion neurons, and ascending posterior columns Spinocerebellar ataxia 5 See the list below: Clinical features Cerebellar ataxia, facial myokymia[emedicine.medscape.com]

  • Spastic Ataxia with Congenital Miosis

    Interictal examination showed spontaneous downbeat and gaze-evoked nystagmus and mild dysarthria and truncal ataxia.[findzebra.com] May respond to periodic relaxation of accommodation or reading glasses, or may require cycloplegia Superior oblique myokymia Repetitive firing of superior oblique muscle.[pedseyes.org] […] type 4 Episodic ataxia type 5 Episodic ataxia type 6 Episodic ataxia type 7 Familial congenital mirror movements Familial cortical myoclonus Familial dyskinesia and facial myokymia[se-atlas.de]

  • Early-Onset Cerebellar Ataxia

    . ; EA2 with interictal nystagmus , is long-lasting (hours) associated with attacks of vertigo, diffuse weakness, slurred speech, dystonia, seizures, truncal and limb ataxia[neuroweb.us] Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K channel. Proc Natl Acad Sci U S A. 2001;98:12272–7.[bmcmedgenet.biomedcentral.com] There is no interictal myokymia but gaze-evoked nystagmus is seen.[jpgmonline.com]

  • Acute Cerebellar Ataxia

    . ; EA2 with interictal nystagmus , is long-lasting (hours) associated with attacks of vertigo, diffuse weakness, slurred speech, dystonia, seizures, truncal and limb ataxia[neuroweb.us] Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1.[ajnr.org] […] and downbeat nystagmus , often associated with nausea, vomiting and headache (migraine, often hemiplegic migraine).[neuroweb.us]

  • Alcoholic Cerebellar Degeneration

    . ; EA2 with interictal nystagmus , is long-lasting (hours) associated with attacks of vertigo, diffuse weakness, slurred speech, dystonia, seizures, truncal and limb ataxia[neuroweb.us] Continuous myokymia between attacks are charateristic. Kinesigenic provocation (movement, startle or emotion) is common.[neuroweb.us] […] and downbeat nystagmus, often associated with nausea, vomiting and headache (migraine, often hemiplegic migraine).[neuroweb.us]

  • Spinocerebellar Ataxia Type 4

    Initial examination disclosed a central type of positional nystagmus (conjugate downbeat nystagmus that did not fatigue with repeated positioning).[jnnp.bmj.com] Purkinje cells, dorsal root sensory ganglion neurons, and ascending posterior columns Spinocerebellar ataxia 5 See the list below: Clinical features Cerebellar ataxia, facial myokymia[emedicine.medscape.com] SCA2 is subdivided in Episodic Ataxia Type 1 or EA1 (also named Paroxysmal and Myokymia syndrome) and Episodic Ataxia Type 2 or EA2.[encyclopedia.com]

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