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28 Possible Causes for Interictal Downbeat Nystagmus, Selective Loss of Cerebellar Purkinje Cells

  • Spinocerebellar Ataxia Type 6

    Initial examination disclosed a central type of positional nystagmus (conjugate downbeat nystagmus that did not fatigue with repeated positioning).[jnnp.bmj.com] About a year later, she noticed mild interictal imbalance.[jnnp.bmj.com]

  • Alcoholic Cerebellar Degeneration

    . ; EA2 with interictal nystagmus , is long-lasting (hours) associated with attacks of vertigo, diffuse weakness, slurred speech, dystonia, seizures, truncal and limb ataxia[neuroweb.us] […] the cerebellar hemispheres less extensive Loss of neurons in the cerebellum involves all types but Purkinje’s cells are the most seriously affected 8 MRI Figure 1: Sagittal[slideplayer.com] […] atrophy and loss of purkinje cells at post mortem - Progressive ataxia and myoclonus, Anti-endomysial IgA, Anti transglutaminase IgA, Exclude nutritional deficiency Selective[medexam.net]

  • Cerebellar Ataxia with Peripheral Neuropathy Type 2

    . ; EA2 with interictal nystagmus , is long-lasting (hours) associated with attacks of vertigo, diffuse weakness, slurred speech, dystonia, seizures, truncal and limb ataxia[neuroweb.us] […] atrophy and loss of purkinje cells at post mortem - Progressive ataxia and myoclonus, Anti-endomysial IgA, Anti transglutaminase IgA, Exclude nutritional deficiency Selective[medexam.net] […] and downbeat nystagmus, often associated with nausea, vomiting and headache (migraine, often hemiplegic migraine).[neuroweb.us]

  • Benign Adult Familial Myoclonic Epilepsy

    Pathologically, in SCA6 patients neuronal loss is confined to Purkinje cells of the cerebellar cortex and selective atrophy of the cerebellum with the brain stem and the cerebral[academic.oup.com]

    Missing: Interictal Downbeat Nystagmus
  • Leigh's Disease

    […] of Purkinje cells in the cerebellar cortex.[ncbi.nlm.nih.gov] It is suggested that this association may be explained on the basis of the selective loss of climbing fibres causing increased firing activity of Purkinje cells with consequent[ncbi.nlm.nih.gov] […] series of 17 cases of Leigh's disease it has been observed that there is a close correlation between damage to the inferior olivary nuclei by vasculo-necrotic change and loss[ncbi.nlm.nih.gov]

    Missing: Interictal Downbeat Nystagmus
  • Cerebral Palsy

    Selective loss of Purkinje cells in a patient with anti-glutamic acid decarboxylase antibody-associated cerebellar ataxia. J Neurol Neurosurg Psychiatry. 2007;78:190–2.[dx.doi.org]

    Missing: Interictal Downbeat Nystagmus
  • Ataxia

    Selective loss of Purkinje cells in a patient with anti-glutamic acid decarboxylase antibody-associated cerebellar ataxia. J Neurol Neurosurg Psychiatry. 2007;78:190–2.[dx.doi.org]

    Missing: Interictal Downbeat Nystagmus
  • Acute Cerebellar Ataxia

    . ; EA2 with interictal nystagmus , is long-lasting (hours) associated with attacks of vertigo, diffuse weakness, slurred speech, dystonia, seizures, truncal and limb ataxia[neuroweb.us] […] and downbeat nystagmus , often associated with nausea, vomiting and headache (migraine, often hemiplegic migraine).[neuroweb.us]

    Missing: Selective Loss of Cerebellar Purkinje Cells
  • Episodic Ataxia

    According to Baloh and others (1997), EA2 is characterized by a progressive ataxia with interictal rebound nystagmus evoked by gaze, as well as downbeating nystagmus.[dizziness-and-balance.com] Initial examination disclosed a central type of positional nystagmus (conjugate downbeat nystagmus that did not fatigue with repeated positioning).[jnnp.bmj.com] About a year later, she noticed mild interictal imbalance.[jnnp.bmj.com]

    Missing: Selective Loss of Cerebellar Purkinje Cells
  • Cerebellar Ataxia

    GRID2 encodes the glutamate receptor subunit delta-2, selectively expressed in cerebellar Purkinje cells.[ncbi.nlm.nih.gov] Selective loss of Purkinje cells in a patient with anti-glutamic acid decarboxylase antibody-associated cerebellar ataxia. J Neurol Neurosurg Psychiatry. 2007;78:190–2.[doi.org] The phenotype associated with loss of GRID2 function was described only in mice until now, characterized by different degrees of cerebellar ataxia and usually relatively mild[ncbi.nlm.nih.gov]

    Missing: Interictal Downbeat Nystagmus

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