Intermediate: Causes & Reasons

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Possible Causes for Intermediate

Maple Syrup Urine Disease

Three children were diagnosed with the intermediate form of maple syrup urine disease during routine evaluation of mental retardation. [ncbi.nlm.nih.gov]

We describe two patients with an intermediate form of MSUD who presented later in childhood. [ncbi.nlm.nih.gov]

An 8-year-old boy with the intermediate variant of maple syrup urine disease is reported. [ncbi.nlm.nih.gov]

Toxoplasmosis

PCR was useful in the case of intermediate avidity. [ncbi.nlm.nih.gov]

Intermediate hosts in nature (including birds and rodents) become infected after ingesting soil, water or plant material contaminated with oocysts. [cdc.gov]

IgG avidity was low in 9 women suggesting an acute infection; 3 women presented an intermediate avidity. [ncbi.nlm.nih.gov]

Uveitis

Keywords: Intermediate uveitis, pars planitis How to cite this article: Babu B M, Rathinam S R. Intermediate uveitis. [doi.org]

Intermediate uveitis Anterior vitreous cells in Intermediate uveitis Specialty Ophthalmology Intermediate uveitis is a form of uveitis localized to the vitreous and peripheral [en.wikipedia.org]

INTERMEDIATE UVEITIS • Intermediate uveitis (IU) is described as inflammation in the anterior vitreous, pars plana and the peripheral retina • The diagnostic term pars planitis [slideshare.net]

Anterior Uveitis

Intermediate uveitis is a form of uveitis localized to the vitreous and peripheral retina. [en.wikipedia.org]

Histology Granulomatous Nongranulomatous Anatomy Anterior uveitis Intermediate uveitis Posterior uveitis Panuveitis 17. • In a large community-based study, the vast majority [slideshare.net]

What are the treatments for intermediate and posterior uveitis? [rnib.org.uk]

Tumor Lysis Syndrome

The median S-UA on day 5 after chemotherapy was 3.3 mg/dl (range=1.1-5.8 mg/dl) (p CONCLUSION: Febuxostat is promising for the management of TLS of an intermediate-risk patient [ncbi.nlm.nih.gov]

RESULTS: A total of 346 patients (82.1% intermediate TLS risk; 82.7% assigned to standard dose) were randomized. [ncbi.nlm.nih.gov]

GCT is classified as intermediate risk for TLS, and the patients who have other TLS risks factors are classified to be at high risk for TLS. [ci.nii.ac.jp]

Refractory Anemia with Excess Blasts in Transformation

1, intermediate- 2, and high-risk International Prognostic Scoring System groups. [medical-dictionary.thefreedictionary.com]

If your IPSS score is 0.5 to 1, you are in the intermediate-1 risk group. Low and Intermediate-1 risk categories are together considered lower-risk MDS. [aamds.org]

Most people with RAEB will fall into the intermediate-1, intermediate-2 or high risk categories. [leukaemia.org.au]

Pituicytoma

Ultrastructurally, the lesion was composed of elongated cells containing in the Golgi area aggregates of intermediate filaments in a concentric pathway (fibrous body), and [ncbi.nlm.nih.gov]

These features intermediate between a pituicytoma and a pituitary adenoma suggest that ¤ ¤ pituicytomas´´ may also arise from the specialized stromal folliculo-stellate cells [doi.org]

Electron microscopy identified intermediate filaments, numerous broad cell junctions, no secretory granules, and two cellular populations with either an electron-dense or [ncbi.nlm.nih.gov]

Distal Spinal Muscular Atrophy Type 5

Dominant Intermediate CMT (DI-CMT) is so named owing to their “intermediate” conduction velocities and thus an uncertainty regarding whether the neuropathy is primarily axonal [rarediseases.org]

Their nerve conduction studies tend to be in the intermediate range of between 35 and 45 m/s. [cmtausa.org]

A dominant-intermediate classification (DI-CMT) may also be encountered. [now.aapmr.org]

Idiopathic Anterior Uveitis

Findings of intermediate and posterior uveitis are most easily seen after dilating the pupil. [merckmanuals.com]

Intermediate Uveitis : Intermediate uveitis refers to inflammation just behind the iris, sometimes known as pars planitis. [improveyourvision.com]

What is Intermediate Uveitis? Intermediate uveitis is commonly seen in young adults. The center of the inflammation often appears in the vitreous (see diagram). [nei.nih.gov]

Myelodysplasia

Eighty-three of 159 patients aged < 61 years, classified as intermediate 1, intermediate 2 and high risk according to the IPSS, received intensive treatment consisting of [ncbi.nlm.nih.gov]

For low- and intermediate-1-risk MDS, delayed BMT is associated with maximal life expectancy, whereas immediate transplantation for intermediate-2- and high-risk disease is [ncbi.nlm.nih.gov]

Among patients with intermediate-risk cytogenetics, median overall survival with azacitidine was 16.4 months, and with CCR was 8.9 months (hazard ratio 0.73 [95%CI 0.48, 1.10 [ncbi.nlm.nih.gov]

Alexander Disease

[…] mice in which the corresponding intermediate filament gene has been inactivated. [ncbi.nlm.nih.gov]

We describe three patients with unique characteristics, and whose mutations have implications for AxD diagnosis and studies of intermediate filaments. [ncbi.nlm.nih.gov]

AxD is caused by mutations in GFAP, the main astrocyte intermediate filament protein. [ncbi.nlm.nih.gov]

Myelofibrosis

KEYWORDS: IPSS; MF; intermediate-1 risk; myelofibrosis; ruxolitinib [ncbi.nlm.nih.gov]

The IPSS and DIPSS-plus were the best models to discriminate between the intermediate-1 and intermediate-2 risk categories, which is a critical cut-off point for patient selection [ncbi.nlm.nih.gov]

2, 21% intermediate-1 and 3% low. [ncbi.nlm.nih.gov]

Acute Hepatic Porphyria

This increase in ALAS1 results in the buildup of neurotoxic intermediates – aminolevulinic acid (ALA) and porphobilinogen (PBG) – throughout the body. [alnylam.com]

Red or brownish urine results from marked increases in urinary excretion of heme pathway intermediates. [bestpractice.bmj.com]

This increase in ALAS1 results in the buildup of neurotoxic acid intermediates – aminolevulinic acid (ALA) and porphobilinogen (PBG) – throughout the body. [alnylam.com]

Panuveitis

Results: One hundred and fifty-nine intermediate uveitis, posterior uveitis, and panuveitis patients (237 eyes) were identified. [dovepress.com]

The FDA has approved AbbVie ’s Humira (adalimumab) for the treatment of non-infectious intermediate, posterior and panuveitis. [centerwatch.com]

A Duke study reported sarcoidosis uveitis in 2% of intermediate uveitis patients, and a Boston study reported intermediate uveitis secondary to sarcoidosis in 22% of patients [dovepress.com]

Ganglioneuroblastoma

Grading / Staging Clinical staging classifies patients into low, intermediate and high risk groups based on: Patient age (most important) International Neuroblastoma Pathology [surgpathcriteria.stanford.edu]

Ganglioneuroblastoma is an intermediate tumor arising from nerve tissue. [haveyroo.blogspot.com]

It is contained within the neuroblastic tumors group, which includes: Ganglioneuroma (benign) Ganglioneuroblastoma (intermediate). [en.wikipedia.org]

Congenital Bile Acid Synthesis Defect Type 2

The resultant intermediates cannot be secreted into the bile and thus appear in blood and urine. [symptoma.com]

[…] stimulates bile flow and facilitates fat soluble vitamin absorption and suppresses atypical bile acid synthesis thereby reducing the production of toxic bile acid metabolic intermediates [rarediseases.info.nih.gov]

The abnormal intermediates accumulating in CBAS2 patients have been postulated to exert hepatotoxic effects. [symptoma.com]

Post-Polycythemia Vera Myelofibrosis

The purpose of this study is to assess the effectiveness of fedratinib in successive 28-day cycles to treat subjects with intermediate or high-risk primary myelofibrosis, [rush.edu]

Methods: Eligibility criteria include age of at least 18 years, platelets >50,000/µl, ECOG PS 0–2, and a diagnosis of high- or intermediate-risk 2 primary MF, post-PV MF, [ascopubs.org]

HR (95% CI) using IPSS were 2.3 (1.4–3.7) for high vs intermediate-2, 4.3 (2.2–8.5) for high vs intermediate-1, 6.6 (2.9–15.3) for high vs low, 2.9 (1.3–6.7) for intermediate [nature.com]

Low Anorectal Malformation

Constipation is a major functional complication after internal sphincter-saving posterior sagittal anorectoplasty for high and intermediate anorectal malformations. [thieme-connect.com]

Fistulous communications between the blind rectum and the urinary tract are common in boys with high/intermediate anomalies, but it is uncommon in children with low anorectal [ncbi.nlm.nih.gov]

Of these, seven had high/intermediate malformations. Patients with high/intermediate malformations were more likely to have co-morbidity. [intechopen.com]

Diffuse Lymphoma

The International prognostic index (IPI) is the standard method of assessing prognosis at presentation. 0 – 1 Low 2 Low-intermediate 3 High-intermediate 4 High Age (years) [hmds.info]

[…] risk; 3, high-intermediate risk; and 4 to 5, high risk. [jhoonline.biomedcentral.com]

In patients with high-intermediate–risk/high-risk DLBCL, a phase II study of brentuximab vedotin (Adcetris) with R-CHOP is yielding positive results, especially in patients [ascopost.com]

Epidermolysis Bullosa Simplex

We therefore suggest that an imbalance of cytoplasmic K14 monomers and K14 incorporated into the intermediate filament (IF) network leads to elevated stress signalling, potentially [ncbi.nlm.nih.gov]

Basal keratinocytes in skin and in culture completely lacked keratin 14 and intermediate filaments. [ncbi.nlm.nih.gov]

Ultrastructurally, hemidesmosomes were fairly normal, but the attachment of intermediate filaments with the hemidesmosomal plaques appeared to be impaired. [ncbi.nlm.nih.gov]

Sertoli Leydig Cell Tumor

Microscopically, the tumor was composed of intermediately differentiated Sertoli-Leydig cell tumor and well-differentiated mucinous adenocarcinoma. [ncbi.nlm.nih.gov]

We present the fourth case of an ovarian SLCT of intermediate differentiation with rhabdomyosarcoma and a review of the literature. [ncbi.nlm.nih.gov]

Here, we report a SLCT with intermediate differentiation in a 23-year-old woman investigated by light microscopy, immunohistochemistry for intermediate filaments, and sex [ncbi.nlm.nih.gov]

Primary Myelofibrosis

Investigational drug therapy is reasonable for symptomatic intermediate-1 or intermediate-2 risk disease. Splenectomy is considered for drug-refractory splenomegaly. [ncbi.nlm.nih.gov]

The presence of 0, 1, "2 or 3" and ≥4 adverse factors defines low, intermediate-1, intermediate-2 and high-risk disease with median survivals of approximately 15.4, 6.5, 2.9 [ncbi.nlm.nih.gov]

The corresponding figures for intermediate-2/high risk patients were 30 and 64 months (P < 0.01). Documented causes of death did not include iron overload. [ncbi.nlm.nih.gov]

Secondary Myelofibrosis

Determine DIPSS risk category and prognosis DIPSS score DIPSS risk category Median OS (y) 0 Low Not reached 1 - 2 Intermediate-1 14.2 3 - 4 Intermediate-2 4 5 - 6 High 1.5 [bloodref.com]

DESIGN, SETTING, AND PARTICIPANTS: Double-blind, randomized, placebo-controlled phase 3 study in 94 sites in 24 countries in which 289 adult patients (≥18 years of age) with intermediate [ncbi.nlm.nih.gov]

1 7.9 14.2 6.5 Intermediate-2 4.0 4.0 2.9 High 2.25 1.5 1.3 Risk Category b Median Survival (Yr) IPSS DIPSS DIPSS Plus Low 11.25 NR 15.4 Intermediate-1 7.9 14.2 6.5 Intermediate [ajhp.org]

Echinococcosis

Natural intermediate hosts depend on genotype. [cdc.gov]

E. oligarthrus (up to 2.9 mm long) has a life cycle that involves wild felids as definitive hosts and rodents as intermediate hosts. [cdc.gov]

Humans are aberrant intermediate hosts, and become infected by ingesting eggs. [cdc.gov]

Echinococcus Infection of Lung

The definitive host becomes infected by ingesting the cyst-containing organs of the infected intermediate host. [web.archive.org]

E. oligarthrus (up to 2.9 mm long) has a life cycle that involves wild felids as definitive hosts and rodents as intermediate hosts. [web.archive.org]

After ingestion by a suitable intermediate host (under natural conditions: sheep, goat, swine, cattle, horses, camel), the egg hatches in the small bowel and releases an oncosphere [web.archive.org]

Rhabdomyosarcoma

[…] histologic, immunohistochemical, and molecular findings documented for the first time a chronological progression from an invasive MM to a pleomorphic rhabdomyosarcoma through an intermediate [ncbi.nlm.nih.gov]

Patients at intermediate risk of treatment failure also require three-drug chemotherapy. [ncbi.nlm.nih.gov]

The overall survival rate for this group is more than 90%. [19] Patients with intermediate risk and an intermediate prognosis include those with embryonal rhabdomyosarcoma [emedicine.com]

Echinococcus Infection of Liver

The definitive host becomes infected by ingesting the cyst-containing organs of the infected intermediate host. [cdc.gov]

Intermediate hosts are small mammals (rodents and lagomorphs). [web.archive.org]

E. oligarthrus (up to 2.9 mm long) has a life cycle that involves wild felids as definitive hosts and rodents as intermediate hosts. [cdc.gov]

Benign Hemangioendothelioma

An epithelioid hemangioendothelioma is an extremely rare tumor classified as an intermediate grade vascular tumor. [synapse.koreamed.org]

Hemangioendotheliomas are relatively rare and are of intermediate malignancy (between benign hemangiomas and conventional angiosarcomas). [mesh.kib.ki.se]

The lesion shows high signal intensity with focal intermediate to low signal intensity foci and numerous septae (arrowheads). [synapse.koreamed.org]

Posterior Uveitis

[…] prior authorization, pregnancy considerations, and subspecialty practice lead to changes in therapeutic decisions among uveitis and retina specialists in the treatment of intermediate [ncbi.nlm.nih.gov]

Application to Clinical Practice Dexamethasone intravitreal implant may be used safely and effectively for treatment of intermediate and posterior uveitis. [ncbi.nlm.nih.gov]

Abstract Sight-threatening intraocular inflammation affecting the posterior segment of the eye may be predominantly located in the peripheral retina and vitreous (intermediate [ncbi.nlm.nih.gov]

X-linked Distal Spinal Muscular Atrophy Type 3

[…] children resemble type 1 with inability to sit and significantly impaired respiratory system What is intermediate type 2 SMA? [quizlet.com]

[…] bacterial infection and amylopectinosis Autosomal dominant Charcot-Marie-Tooth disease type 2D Autosomal dominant Charcot-Marie-Tooth disease type 2N Autosomal recessive intermediate [csbg.cnb.csic.es]

[…] tone “Frog-leg” posture when lying Severe muscle weakness on both sides of body Progressive weakness of muscles that help in breathing (intercostal muscles) 7-18 months (intermediate [togetherinsma.com]