Intermediate: Causes & Reasons

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Possible Causes for Intermediate

Maple Syrup Urine Disease

A mutation in the PPM1K gene (4q22.1) has been reported in a single case of mild intermediate MSUD. [orpha.net]

Three children were diagnosed with the intermediate form of maple syrup urine disease during routine evaluation of mental retardation. [ncbi.nlm.nih.gov]

Presentation is very similar to intermediate MSUD but with accompanying lactic acidosis. [patient.info]

Toxoplasmosis

PCR was useful in the case of intermediate avidity. [ncbi.nlm.nih.gov]

Intermediate hosts in nature (including birds and rodents) become infected after ingesting soil, water or plant material contaminated with oocysts. [cdc.gov]

IgG avidity was low in 9 women suggesting an acute infection; 3 women presented an intermediate avidity. [ncbi.nlm.nih.gov]

Tumor Lysis Syndrome

The median S-UA on day 5 after chemotherapy was 3.3 mg/dl (range=1.1-5.8 mg/dl) (p CONCLUSION: Febuxostat is promising for the management of TLS of an intermediate-risk patient [ncbi.nlm.nih.gov]

RESULTS: A total of 346 patients (82.1% intermediate TLS risk; 82.7% assigned to standard dose) were randomized. [ncbi.nlm.nih.gov]

GCT is classified as intermediate risk for TLS, and the patients who have other TLS risks factors are classified to be at high risk for TLS. [ci.nii.ac.jp]

Uveitis

Intermediate uveitis is mostly idiopathic. Secondary causes such as sarcoidosis, Lyme’s disease and multiple sclerosis may also cause intermediate uveitis. [symptoma.com]

Depending on your symptoms, any of these treatments might be used for intermediate uveitis. [web.archive.org]

Intermediate uveitis Anterior vitreous cells in Intermediate uveitis Specialty Ophthalmology Intermediate uveitis is a form of uveitis localized to the vitreous and peripheral [en.wikipedia.org]

Pulmonary Embolism

A total of 5,622 patients with low/intermediate or unlikely PTP were assessed using the VIDAS D-dimer. [ncbi.nlm.nih.gov]

In intermediate-risk PE, clinical success for CDT and usCDT was 95.0% (95% CI, 88.5%-99.2%) and 97.5% (95% CI, 95.0%-99.4%), respectively. [ncbi.nlm.nih.gov]

Differently, the prevalence of T- wave inversion was similar in high and intermediate-risk patients. [ncbi.nlm.nih.gov]

Anterior Uveitis

Histology Granulomatous Nongranulomatous Anatomy Anterior uveitis Intermediate uveitis Posterior uveitis Panuveitis 17. • In a large community-based study, the vast majority [slideshare.net]

What are the treatments for intermediate and posterior uveitis? [rnib.org.uk]

Abstract Anterior uveitis is far more common than intermediate, posterior or panuveitis. About 50% of patients with acute anterior uveitis are HLA B27+. [ncbi.nlm.nih.gov]

Refractory Anemia with Excess Blasts in Transformation

1, intermediate- 2, and high-risk International Prognostic Scoring System groups. [medical-dictionary.thefreedictionary.com]

If your IPSS score is 0.5 to 1, you are in the intermediate-1 risk group. Low and Intermediate-1 risk categories are together considered lower-risk MDS. [aamds.org]

Most people with RAEB will fall into the intermediate-1, intermediate-2 or high risk categories. [leukaemia.org.au]

Rhabdomyosarcoma

Patients at intermediate risk of treatment failure also require three-drug chemotherapy. [ncbi.nlm.nih.gov]

The overall survival rate for this group is more than 90%. [19] Patients with intermediate risk and an intermediate prognosis include those with embryonal rhabdomyosarcoma [emedicine.com]

Most children and adolescents with favorable and intermediate risk RMS will be cured with presently available multidisciplinary therapeutic approaches. [ncbi.nlm.nih.gov]

Macular Degeneration

PHP is useful for detecting CNV in regularly monitored eyes with intermediate AMD while maintaining a low false-positive rate. [ncbi.nlm.nih.gov]

LLQ is a useful patient-centered functional measure of visual impairment in early and intermediate AMD. [ncbi.nlm.nih.gov]

Methods: Participants included 33 older drivers with AMD (mean age [M] = 76.6 ± 6.1 years; better eye Age-Related Eye Disease Study grades: early [61%] and intermediate [39% [ncbi.nlm.nih.gov]

Diffuse Lymphoma

The International prognostic index (IPI) is the standard method of assessing prognosis at presentation. 0 – 1 Low 2 Low-intermediate 3 High-intermediate 4 High Age (years) [hmds.info]

[…] risk; 3, high-intermediate risk; and 4 to 5, high risk. [jhoonline.biomedcentral.com]

In patients with high-intermediate–risk/high-risk DLBCL, a phase II study of brentuximab vedotin (Adcetris) with R-CHOP is yielding positive results, especially in patients [ascopost.com]

Pituicytoma

Ultrastructurally, the lesion was composed of elongated cells containing in the Golgi area aggregates of intermediate filaments in a concentric pathway (fibrous body), and [ncbi.nlm.nih.gov]

These features intermediate between a pituicytoma and a pituitary adenoma suggest that ¤ ¤ pituicytomas´´ may also arise from the specialized stromal folliculo-stellate cells [doi.org]

Electron microscopy identified intermediate filaments, numerous broad cell junctions, no secretory granules, and two cellular populations with either an electron-dense or [ncbi.nlm.nih.gov]

Myelodysplasia

Eighty-three of 159 patients aged < 61 years, classified as intermediate 1, intermediate 2 and high risk according to the IPSS, received intensive treatment consisting of [ncbi.nlm.nih.gov]

For low- and intermediate-1-risk MDS, delayed BMT is associated with maximal life expectancy, whereas immediate transplantation for intermediate-2- and high-risk disease is [ncbi.nlm.nih.gov]

Among patients with intermediate-risk cytogenetics, median overall survival with azacitidine was 16.4 months, and with CCR was 8.9 months (hazard ratio 0.73 [95%CI 0.48, 1.10 [ncbi.nlm.nih.gov]

Distal Spinal Muscular Atrophy Type 5

Dominant Intermediate CMT (DI-CMT) is so named owing to their “intermediate” conduction velocities and thus an uncertainty regarding whether the neuropathy is primarily axonal [rarediseases.org]

Their nerve conduction studies tend to be in the intermediate range of between 35 and 45 m/s. [cmtausa.org]

A dominant-intermediate classification (DI-CMT) may also be encountered. [now.aapmr.org]

Primary Mediastinal Large B-Cell Lymphoma

[…] patients (43%) an intermediate-high/high (2 to 3) International Prognostic Index (IPI) score. [ncbi.nlm.nih.gov]

Intermediate to large sized cytologically atypical lymphoid cells Diffuse distribution of intermediate to large sized lymphoma cells CD19 CD20 CD23 CD30 Endobronchial [pathologyoutlines.com]

RESULTS: Principal component analysis demonstrated that mediastinal gray zone lymphoma has a distinct epigenetic profile intermediate between classical Hodgkin's lymphoma [ncbi.nlm.nih.gov]

Gynandroblastoma

Histological study revealed, the tumour was composed of mixed sex cord elements with predominantly intermediate differentiated Sertoli-Leydig cell component and a second adult [ncbi.nlm.nih.gov]

The testicular-type elements accounted for 20% of the tumor and resembled intermediate-grade SLCT. [ncbi.nlm.nih.gov]

Following surgical excision, the ovarian mass was diagnosed as gynandroblastoma, which consisted of 45% juvenile granulosa cell tumor and 55% intermediately differentiated [wwww.unboundmedicine.com]

X-linked Distal Spinal Muscular Atrophy Type 3

[…] children resemble type 1 with inability to sit and significantly impaired respiratory system What is intermediate type 2 SMA? [quizlet.com]

[…] bacterial infection and amylopectinosis Autosomal dominant Charcot-Marie-Tooth disease type 2D Autosomal dominant Charcot-Marie-Tooth disease type 2N Autosomal recessive intermediate [csbg.cnb.csic.es]

[…] tone “Frog-leg” posture when lying Severe muscle weakness on both sides of body Progressive weakness of muscles that help in breathing (intercostal muscles) 7-18 months (intermediate [togetherinsma.com]

Hilar Cell Tumor of the Ovary

[…] differentiation Sertoli-Leydig tumor (androblastoma),of intermediate differentiation, variant with heterologous elements Sertoli-Leydig tumor (androblastoma), poorly differentiated [pathpedia.com]

Such tumors may contain an intermediate quantity of cytoplasmic lipid and be unaccompanied by clear-cut evidence of steroid hormone production. [glowm.com]

Sertoli–Leydig cell tumour is a group of tumours composed of variable proportions of Sertoli cells, Leydig cells, and in the case of intermediate and poorly differentiated [en.wikipedia.org]

Primary Myelofibrosis

Investigational drug therapy is reasonable for symptomatic intermediate-1 or intermediate-2 risk disease. Splenectomy is considered for drug-refractory splenomegaly. [ncbi.nlm.nih.gov]

The presence of 0, 1, "2 or 3" and ≥4 adverse factors defines low, intermediate-1, intermediate-2 and high-risk disease with median survivals of approximately 15.4, 6.5, 2.9 [ncbi.nlm.nih.gov]

The corresponding figures for intermediate-2/high risk patients were 30 and 64 months (P < 0.01). Documented causes of death did not include iron overload. [ncbi.nlm.nih.gov]

Chondrosarcoma

Biopsy revealed intermediate-grade conventional chondrosarcoma. [ncbi.nlm.nih.gov]

low, intermediate or high grade clear cell chondrosarcoma myxoid chondrosarcoma : usually intermediate grade mesenchymal chondrosarcoma : usually high grade extraskeletal [radiopaedia.org]

Subsequent femoral resection was remarkable for an intermediate-grade chondrosarcomatous component juxtaposed to an area composed of anastomosing nests and cords of malignant [ncbi.nlm.nih.gov]

Congenital Bile Acid Synthesis Defect Type 2

The resultant intermediates cannot be secreted into the bile and thus appear in blood and urine. [symptoma.com]

[…] stimulates bile flow and facilitates fat soluble vitamin absorption and suppresses atypical bile acid synthesis thereby reducing the production of toxic bile acid metabolic intermediates [rarediseases.info.nih.gov]

The abnormal intermediates accumulating in CBAS2 patients have been postulated to exert hepatotoxic effects. [symptoma.com]

Pilomyxoid Astrocytoma

Spectrum of pilomyxoid astrocytomas: intermediate pilomyxoid tumors. Am J Surg Pathol. 2010;34(12):1783-91. [ Links ] 10. [scielo.br]

[…] enhancement Occasional CSF dissemination Gross images Images hosted on other servers : Coronal sections through hypothalamus Microscopic (histologic) description Monomorphous intermediate [pathologyoutlines.com]

CASE REPORT Intermediate pilomyxoid astrocytoma and diencephalic syndrome: imaging findings Olavo Kyosen Nakamura I ; Marco da Cunha Pinho I ; Vicente Odone Filho II ; Sergio [scielo.br]

Acute Hepatic Porphyria

The accumulation of pathway intermediates that occur most notably when these diseases are active is the basis for screening and establishing a biochemical diagnosis of these [researchexperts.utmb.edu]

This increase in ALAS1 results in the buildup of neurotoxic intermediates – aminolevulinic acid (ALA) and porphobilinogen (PBG) – throughout the body. [alnylam.com]

Red or brownish urine results from marked increases in urinary excretion of heme pathway intermediates. [bestpractice.bmj.com]

Synovial Hemangioma

Intraarticular hemangiomas may be operated at once, but in case of hemangiomas of intermediate type an angiography is recommended. [ncbi.nlm.nih.gov]

If the synovial hemangioma is an intermediate type then arthrotomy should be performed. [jmedicalcasereports.biomedcentral.com]

MRI was consistently effective in allowing the correct diagnosis to be made preoperatively, showing an intra-articular or juxta-articular mass of intermediate signal intensity [ncbi.nlm.nih.gov]

Idiopathic Anterior Uveitis

Findings of intermediate and posterior uveitis are most easily seen after dilating the pupil. [merckmanuals.com]

Intermediate Uveitis : Intermediate uveitis refers to inflammation just behind the iris, sometimes known as pars planitis. [improveyourvision.com]

What is Intermediate Uveitis? Intermediate uveitis is commonly seen in young adults. The center of the inflammation often appears in the vitreous (see diagram). [nei.nih.gov]

Testicular Choriocarcinoma

Definition / general Malignant germ cell tumor composed of syncytiotrophoblast, cytotrophoblast and intermediate trophoblast cells Identical tumors arise in placenta, ovary [pathologyoutlines.com]

Placental site trophoblastic tumor Very rare, composed of intermediated trophoblasts. [auanet.org]

It consisted of a pure proliferation of intermediate trophoblast cells and was identical to the placental site trophoblastic tumor of the uterus. [thedoctorsdoctor.com]

Alexander Disease

[…] mice in which the corresponding intermediate filament gene has been inactivated. [ncbi.nlm.nih.gov]

We describe three patients with unique characteristics, and whose mutations have implications for AxD diagnosis and studies of intermediate filaments. [ncbi.nlm.nih.gov]

AxD is caused by mutations in GFAP, the main astrocyte intermediate filament protein. [ncbi.nlm.nih.gov]

B-Cell Lymphoma

This B-cell lymphoma is usually aggressive with an intermediate prognosis between DLBCL and cHL. Figure 1. [atlasgeneticsoncology.org]

[…] between BL and DLBCL Diagnose BL or DLBCL with features intermediate between BL and DLBCL in conjunction with clinical, morphologic, and flow cytometric data Detects all [arupconsult.com]

Back to Triple Hit B-cell Lymphoma with MYC, BCL2 and BCL6 Rearrangements Clinical presentation and case summary of a B-cell lymphoma, unclassifiable, with features intermediate [ascp.org]

Ganglioneuroblastoma

Grading / Staging Clinical staging classifies patients into low, intermediate and high risk groups based on: Patient age (most important) International Neuroblastoma Pathology [surgpathcriteria.stanford.edu]

Ganglioneuroblastoma is an intermediate tumor arising from nerve tissue. [haveyroo.blogspot.com]

It is contained within the neuroblastic tumors group, which includes: Ganglioneuroma (benign) Ganglioneuroblastoma (intermediate). [en.wikipedia.org]

Myelofibrosis

KEYWORDS: IPSS; MF; intermediate-1 risk; myelofibrosis; ruxolitinib [ncbi.nlm.nih.gov]

The IPSS and DIPSS-plus were the best models to discriminate between the intermediate-1 and intermediate-2 risk categories, which is a critical cut-off point for patient selection [ncbi.nlm.nih.gov]

2, 21% intermediate-1 and 3% low. [ncbi.nlm.nih.gov]

Differentiated Thyroid Gland Carcinoma

Essential features Intermediate grade follicular cell carcinoma with limited evidence of follicular cell differentiation Terminology Insular / trabecular carcinoma Primordial [pathologyoutlines.com]

Neck dissection is usually done for intermediate-risk and high-risk differentiated thyroid cancers. [cancer.ca]

In patient with ATA intermediate risk disease, the goal TSH level can be around 0.1 to 0.5 mU/L. [endocrinologyadvisor.com]