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21 Possible Causes for Intermittent Jaundice, Pruritus, Uric Acid Increased

  • Hereditary Spherocytosis

    Abstract Hereditary spherocytosis is an autosomal dominant congenital hemolytic anemia due to defect in RBC membrane protein that commonly presents with intermittent jaundice[ncbi.nlm.nih.gov] A 18 year old Turkish patient with hereditary spherocytosis was admitted to hospital with pruritus and severe jaundice.[ncbi.nlm.nih.gov] Dubin-Johnson syndrome is a chronic, benign, intermittent jaundice, mostly of conjugated hyperbilirubinemia.[ncbi.nlm.nih.gov]

  • Primary Biliary Cirrhosis

    Twenty four hour urine demonstrated a low renal fractional tubular reabsorption of phosphate, increased fractional excretion of uric acid and generalized aminoaciduria.[ncbi.nlm.nih.gov] Jaundice (30 -70 %) -Acute cholangitis - relatively rare (5-25%) symptoms secondary to biliary cirrhosis: -portal HTN -liver failure Advanced liver disease -ascites, variceal[quizlet.com] Intense pruritus can be itself an indication to liver transplantation, in extreme cases leading to suicide.[ncbi.nlm.nih.gov]

  • Hepatorenal Syndrome

    Wui-Chiang Lee, Han-Chieh Lin, Ming-Chih Hou, Hsiao-Yi Lin, Fa-Yauh Lee, Sun-Sang Wang, Full-Young Chang and Shou-Dong Lee , Serum Uric Acid Levels in Patients With Cirrhosis[doi.org] Severe circulatory dysfunction (mean arterial pressure usually is 70 mm Hg) and very low systemic vascular resistance. • Severe liver disease, with jaundice, coagulopathy,[scielo.mec.pt] Signs of liver failure in HRS Liver enlargement (hepatomegaly) Ascites Jaundice Itching or pruritus Features of portal hypertension (e.g. dilated blood vessels at the base[medindia.net]

  • Sickle Cell Disease

    Jaundice Fatigue Swollen hands and feet The severity of these symptoms can vary significantly for each individual with the disease, according to the specific characteristics[news-medical.net] These include nausea, vomiting, pruritus, constipation, mental changes, tolerance, dependence, hyperalgesia, and addiction.[doi.org] Each individual with SCD is unique, but the most common features are: Anemia (may cause fatigue and decreased endurance), reticulocytosis, and jaundice Intermittent acute[clinicaladvisor.com]

  • Renal Impairment

    […] in uric acid excretion, serum creatinine, or BUN.[hyper.ahajournals.org] Abstract Benign recurrent intrahepatic cholestasis (BRIC) is a rare autosomal recessive condition characterized by intermittent episodes of pruritus and jaundice that may[ncbi.nlm.nih.gov] Adverse events that were reported in at least 10% of the patients were pruritus, fatigue, and nausea. Serious adverse events were reported in 24% of the patients.[ncbi.nlm.nih.gov]

  • Hypercholesterolemia

    Gout or increased uric acid.[circ.ahajournals.org] We report the case of a male infant who had developed failure to thrive, jaundice, intermittent pruritus, and multiple diffuse symmetrical skin xanthomas at 1 year of age.[ncbi.nlm.nih.gov] This is a case of severe hypercholesterolemia and liver disease in a 3- year old male that presented with pruritus, pale stool, scleral ictus, and abdominal distention.[ncbi.nlm.nih.gov]

  • Diabetic Enteropathy

    […] risk of acute coronary ischaemia Autonomic dysfunction: Increased sympathetic nervous system activity Type 2 diabetes Uric acid levels 50% higher with neuropathy than without[neuromuscular.wustl.edu] Typical symptoms of biliary colic include intermittent right upper abdominal pain, jaundice, or pancreatitis.[journal.diabetes.org] Peripheral Autonomic Dysfunction Contributes to the following symptoms/signs: Neuropathic arthropathy (Charcot foot) Aching, pulsation, tightness, cramping, dry skin, pruritus[slideshare.net]

  • Pericholangitis

    acid stones Migratory arthritis Sacroiliitis and ankylosing spondylitis Erythema nodosum and uveitis Complications Toxic megacolon Adenocarcinoma of the colon (1-16%) Increased[learningradiology.com] Clinically, this condition usually manifests with chronic intermittent obstructive jaundice. Abdominal pain, pruritus, fatiguability and fever are variably present.[sonoworld.com] Both had only mild pruritus; neither had ever been icteric.[docslide.com.br]

  • Congenital Liver Cirrhosis

    acid level elevated Maternal mortality, 1%; prematurity and fetal death, 5%-30% Beta blocker, methyldopa, magnesium sulfate; early delivery HELLP syndrome Beyond 22 wk and[clevelandclinicmeded.com] He had intermittent high grade fever with dry cough and respiratory distress for 4 days duration.[indianpediatrics.net] […] splenomegaly due to portal hypertension or the direct effects of alcohol on bone marrow Coagulopathy due to impaired liver synthetic function, vitamin K deficiency, or both Pruritus[merckmanuals.com]

  • Progressive Retinal Dystrophy due to Retinol Transport Defect

    […] serum uric acid levels. ( 27151312 ) Solak B....Solak Y. 2016 15 Relationship between acne vulgaris and attention-deficit/hyperactivity disorder symptoms in a clinical sample[malacards.org] […] gland Prostatitis Macular atrophy Intermittent jaundice Vitiligo Type I diabetes mellitus Abnormality of the gastrointestinal tract X-linked recessive inheritance Chronic[mendelian.co] Development and Severity of Acne Vulgaris in a Nigerian Population. ( 27600928 ) Ikaraoha C.I....Amah H.C. 2016 14 Isotretinoin use for acne vulgaris is associated with increased[malacards.org]

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