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3,481 Possible Causes for intracellular, of, sterol, transport, upregulation

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  • Bile Salt

    We aimed to determine whether BE-specific miRNAs are upregulated in an esophageal SQ cell line (Het-1A) in an environment with acid and/or bile salts and whether this is nuclear[ncbi.nlm.nih.gov] Solutes other than bile salts are also transported by NTCP. However, ASBT has not been shown to be a transporter for non-bile salt substrates.[ncbi.nlm.nih.gov] Increases in BA were largely maintained post-week 1 and were generally correlated with FGF-19 and inversely correlated with plant sterols.[ncbi.nlm.nih.gov] Finally, BSIA in H69 cholangiocytes was inhibited by intracellular Ca(2 ) chelation, aggravated by thapsigargin, and unaffected by removal of extracellular calcium.[ncbi.nlm.nih.gov] In addition, three bile salt hydrolases were significantly upregulated by bile exposure.[ncbi.nlm.nih.gov]

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  • Tangier Disease

    A striking feature of ABCA1 gene expression is its marked upregulation in foam cells ( 28 ), which was recently shown to be mediated by binding of the oxysterol-activated[jci.org] ATP-binding cassette transporter A1 (ABCA1) A second important mechanism for reverse cholesterol transport involves the ATP-binding cassette transporter A1 (ABCA1).[usmle.biochemistryformedics.com] Under these conditions, specific HDL3-mediated efflux of sterols was almost absent in Tangier fibroblasts.[ncbi.nlm.nih.gov] It is postulated that Tangier disease may be a disorder of intracellular membrane traffic in which HDL is diverted into the lysosomal compartment and degraded instead of being[ncbi.nlm.nih.gov] Recently, Langmann and coworkers ( 27 ) reported that ABC1 expression is upregulated in cultured macrophages by acetylated LDL.[jci.org]

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  • Niemann-Pick Disease Type C

    Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes.[ncbi.nlm.nih.gov] Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport.[doi.org] Here, we review progress in mouse-model-based studies of NPC disease, specifically focusing on the subtype that is caused by a deficiency in NPC1, a sterol-binding late endosomal[ncbi.nlm.nih.gov] The rapid pace of research in this area has vastly improved our overall understanding of intracellular cholesterol homeostasis.[ncbi.nlm.nih.gov] ., 2005 ), and upregulated during differentiation of oligodendrocytes from human ES cells ( Letzen et al., 2010 ), suggesting conserved roles in myelination between mice and[doi.org]

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  • Niemann-Pick Disease

    Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes.[ncbi.nlm.nih.gov] HOPS) multisubunit tethering complex, which is involved in the fusion of endosomes to lysosomes, and 39 independent mutations that disrupt the endo/lysosomal cholesterol transporter[ncbi.nlm.nih.gov] These vesicles transiently interact with cholesterol-laden lysosomes to facilitate sterol relocation.[emedicine.medscape.com] Abstract Drugs often use endocytosis to achieve intracellular delivery, either by passive uptake from the extracellular fluid or by active targeting of cell surface features[ncbi.nlm.nih.gov] In contrast, NPC2 was upregulated and accumulated in cholesterol storing late endocytic organelles [13] .[wikigenes.org]

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  • Ezetimibe

    […] of hepatic HMG-CoA reductase activity. 10,11,18 The upregulation of hepatic cholesterol synthesis resulted in a normalization of circulating cholesterol levels.[atvb.ahajournals.org] KEYWORDS: bile salt; biliary cholesterol; reverse cholesterol transport; transintestinal cholesterol transport [Indexed for MEDLINE] Free full text[ncbi.nlm.nih.gov] Ezetimibe also reduces the gastrointestinal absorption of plant sterols, thereby also lowering the serum concentrations of plant sterols.[ncbi.nlm.nih.gov] Intracellular reactive oxygen species (ROS) generation was evaluated by measuring dichlorofluorescein (DCF) fluorescence.[ncbi.nlm.nih.gov] Annexin 2-caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transport.[ncbi.nlm.nih.gov]

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  • Idiopathic Pulmonary Fibrosis

    These results indicate that a significant increase in the number of primary cilia in IPF contributes to the upregulation of SHH signals.[ncbi.nlm.nih.gov] This ultimately leads to lesser amount of oxygen that can be transported into the body and less carbon dioxide that can be expelled out.[stemcellthailand.org] […] levels in IPF patients, a total of 62 unique lipids were identified by statistical analysis including 24 kinds of glycerophoslipids, 30 kinds of glycerolipids, 3 kinds of sterol[ncbi.nlm.nih.gov] These lung fibrocytes have increased surface expression of HLA-DR, increased intracellular collagen-1 expression, and also altered forward and side scatter characteristics[ncbi.nlm.nih.gov] […] via increased steroid binding and cholesterol transporter activity.[nature.com]

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  • Coxiella Burnetii

    Upregulated SCV genes included those involved in oxidative stress responses, arginine acquisition, and cell wall remodeling.[ncbi.nlm.nih.gov] Transport and Metabolism. The transporter content of C. burnetii seems to largely reflect its intracellular lifestyle within the hostile environment of the PL.[pnas.org] The PV membrane is rich in sterols, and drugs perturbing host cell cholesterol homeostasis inhibit PV formation and bacterial growth.[ncbi.nlm.nih.gov] This hardy, obligate intracellular pathogen has evolved to not only survive, but to thrive, in the harshest of intracellular compartments: the phagolysosome.[ncbi.nlm.nih.gov] MDM responded to inoculation with a general upregulation of Th1-related cytokines such as interleukin-1β (IL-1β), IL-12, and tumor necrosis factor alpha (TNF-α) early on ([ncbi.nlm.nih.gov]

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  • Niemann-Pick Disease Type B

    Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes.[ncbi.nlm.nih.gov] Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport.[doi.org] ) of SCAP (SREBP cleavage-activating protein; SREBP sterol regulated element binding protein ) and HMG-CoA reductase (HMGR).[themedicalbiochemistrypage.org] We have previously shown that expression of PTB-GULP in Chinese hamster ovary cells promotes intracellular cholesterol trafficking and ABCA1-mediated cholesterol efflux.[ncbi.nlm.nih.gov] ., 2005 ), and upregulated during differentiation of oligodendrocytes from human ES cells ( Letzen et al., 2010 ), suggesting conserved roles in myelination between mice and[doi.org]

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  • Smith Lemli Opitz Syndrome

    HMG-CoA synthase and squalene synthase activities in the patient were upregulated to 149% and 532%, respectively, while the activity of HMG-CoA reductase, the rate-limiting[ncbi.nlm.nih.gov] The cholesterol transporters Abca1, Abcg1, and Sr-b1 are present in placenta; however, their potential role in placental transport remains undetermined.[ncbi.nlm.nih.gov] RSH/SLOS, possibly one affecting intracellular transport of sterols.[ncbi.nlm.nih.gov] The aim of this study was to analyse plasma and intracellular CoQ10 levels in SLOS patients and to determine the influence of HMG-CoA reductase inhibitors.[ncbi.nlm.nih.gov] Increased Dhcr7 expression is likely due to a coordinated upregulation of SREBP2-regulated cholesterol biosynthetic genes in response to simvastatin treatment.[doi.org]

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  • Sterol 27-Hydroxylase Deficiency

    The disease can be treated successfully with chenodeoxycholic acid, which reduces the upregulation of cholesterol 7 alpha-hydroxylase and, therefore, the formation of cholestanol[ncbi.nlm.nih.gov] However, almost 95% are reclaimed by the ileal BA transporter (IBAT), also known as apical sodium-dependent BA transporter, abundantly expressed in the terminal ileum[ 8 ,[wjgnet.com] […] alteration in the sterol 27-hydroxylase gene.[symptoma.com] However, the RXR (retinoid X receptor) ligand, 9- cis -retinoic acid, upregulates CYP27A1 expression.[biochemj.org] Synthesis of a full complement of bile acids requires 17 individual enzymes and occurs in multiple intracellular compartments that include the cytosol, endoplasmic reticulum[themedicalbiochemistrypage.org]

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