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2,922 Possible Causes for intracellular, of, transport, upregulation

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  • Influenza

    No significant upregulation was observed in either group of guinea pigs for TNFα, TBK1, IRF5, or IFNγ ( Figure 5 ).[doi.org] Dynein-Directed Transport on Microtubules in Stage II.[doi.org] However, it is not so clear how RNA viruses, such as influenza viruses cope with intracellular signaling.[horizonpress.com] Secretion of IFNα/β results in the induction of a cellular antiviral response involving the transcriptional upregulation of 100 genes ( 1 ).[doi.org]

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  • Urinary Tract Infection

    We report here that UPEC upregulates the expression of ethanolamine utilization genes during uncomplicated UTIs in humans.[ncbi.nlm.nih.gov] […] the body, includes the kidneys (where the urine is made), the bladder (where it is stored before urination), the ureters (tubes that connect the kidney to the bladder and transport[urology.ucla.edu] Thus, it is important to develop novel therapeutics to eliminate these intracellular pathogens.[ncbi.nlm.nih.gov] That's because the urethra -- the tube that transports urine from the bladder to the outside of the body -- is located close to the anus .[webmd.com]

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  • Ehrlichia Chaffeensis

    […] glutamine transporter inhibitor (histidine), or proline analogs inhibited E. chaffeensis infection, whereas pretreatment with proline or glutamine enhanced infection and upregulated[ncbi.nlm.nih.gov] Abstract Obligatory intracellular, human ehrlichiosis agents Ehrlichia chaffeensis and Anaplasma phagocytophilum create unique replicative compartments devoid of lysosomal[ncbi.nlm.nih.gov] TRP120 targeted inflammatory chemokine genes, CCL2, CCL20, and CXCL11, which were strongly upregulated during E. chaffeensis infection and were also upregulated by direct[ncbi.nlm.nih.gov] Host proteins that interact with TRPs are involved in cellular processes, including cell signaling, vesicle trafficking and intracellular transport, transcriptional regulation[ncbi.nlm.nih.gov]

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  • Sunburn

    Together the data may have broad implications for the immunotherapeutic properties of vitamin D in skin homeostasis, and implicate arginase-1 upregulation as a previously[ncbi.nlm.nih.gov] DeLouise , In vivo quantification of quantum dot systemic transport in C57BL/6 hairless mice following skin application post-ultraviolet radiation , Particle and Fibre Toxicology[doi.org] In vitro analysis showed that UV irradiation of human dermal fibroblasts caused production of intracellular reactive oxygen species (ROS) without cellular toxicity.[ncbi.nlm.nih.gov] UVR activates release of membrane fatty acids and upregulates their metabolism by cyclooxygenases (COX) and lipoxygenases (LOX) to different eicosanoids.[ncbi.nlm.nih.gov]

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  • Dementia

    […] gmail.com Search for more papers by this author First published: 28 April 2016 Cited by: 15 Abstract Objective Rosacea is a common chronic inflammatory skin disorder where upregulation[doi.org] […] symptoms, and mildly impaired cognitive function. 131 I-metaiodobenzylguanidine myocardial scintigraphy showed decreased cardiac sympathetic nerve function, and dopamine transporter[ncbi.nlm.nih.gov] […] cholesterol (HDL‐C) levels, perhaps as a result of the stability of cholesterol in myelin; however, it has not been established whether intramembranous lipid domains or intracellular[doi.org] Employment Energy Environment Finance and Investment Governance Industry and Services Nuclear Energy Science and Technology Social Issues/Migration/Health Taxation Trade Transport[doi.org]

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  • Endocrine Dysfunction

    […] were associated with human omental-AT expression of ATG5 mRNA, associations that remained significant (β -0.197, P 0.011; β 0.267, P 30%, including the obesity-associated upregulation[ncbi.nlm.nih.gov] Still other EDCs can directly interfere with the production, storage, release, transport, or elimination of natural hormones in the body.[hormone.org] Endocrine dysfunction is often observed in genetic mitochondrial diseases and reflects decreased intracellular production or extracellular secretion of hormones.[ncbi.nlm.nih.gov] Altered zinc transport disrupts mitochondrial protein processing/import in fragile X-associated tremor/ataxia syndrome. Hum. Mol.[mdpi.com]

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  • Osteoporosis

    The results showed that miR-133a was significantly upregulated and negatively correlated with lumbar spine BMD in serum of postmenopausal osteoporotic women.[ncbi.nlm.nih.gov] New antiresorptive approaches are being investigated, including selective inhibitors of osteoclastic hydrogen ion transport and cathepsin K as well as antagonists to the α[doi.org] […] state targeted for ubiquination and subsequent degradation within intracellular lysosomes.[emedicine.medscape.com] […] of male mice in high-fat diet Antioxidant lipoic acid 17 upregulated, 19 downregulated Upregulated: COL1A1, ALP1, IGF-1 , and IL12 ; downregulated: MMP9, CTSK, P53, TGFBR1[doi.org]

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  • Tangier Disease

    A striking feature of ABCA1 gene expression is its marked upregulation in foam cells ( 28 ), which was recently shown to be mediated by binding of the oxysterol-activated[jci.org] ATP-binding cassette transporter A1 (ABCA1) A second important mechanism for reverse cholesterol transport involves the ATP-binding cassette transporter A1 (ABCA1).[usmle.biochemistryformedics.com] It is postulated that Tangier disease may be a disorder of intracellular membrane traffic in which HDL is diverted into the lysosomal compartment and degraded instead of being[ncbi.nlm.nih.gov] Recently, Langmann and coworkers ( 27 ) reported that ABC1 expression is upregulated in cultured macrophages by acetylated LDL.[jci.org]

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  • Bile Salt

    We aimed to determine whether BE-specific miRNAs are upregulated in an esophageal SQ cell line (Het-1A) in an environment with acid and/or bile salts and whether this is nuclear[ncbi.nlm.nih.gov] Solutes other than bile salts are also transported by NTCP. However, ASBT has not been shown to be a transporter for non-bile salt substrates.[ncbi.nlm.nih.gov] Finally, BSIA in H69 cholangiocytes was inhibited by intracellular Ca(2 ) chelation, aggravated by thapsigargin, and unaffected by removal of extracellular calcium.[ncbi.nlm.nih.gov] In addition, three bile salt hydrolases were significantly upregulated by bile exposure.[ncbi.nlm.nih.gov]

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  • Malignant Neoplasm

    Received: 28 October 2014 / Revised: 5 February 2015 / Accepted: 11 February 2015 / Published: 27 February 2015 Background: Intestinal exposure to gliadin leads to zonulin upregulation[dx.doi.org] transporter-4.[ncbi.nlm.nih.gov] […] more potent ones are relatively inert chemically and become damaging only after they have been changed to a more reactive form by metabolic processes—notably by a set of intracellular[ncbi.nlm.nih.gov] HMGA1b protein interferes with estrogen-induced upregulation of BRCA1 .[doi.org]

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