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3 Possible Causes for Intracytoplasmic Vacuoles in Basal Keratinocytes

  • NISCH Syndrome

    Abstract Claudin-1 (CLDN1) is a structural tight junction (TJ) protein and is expressed in differentiating keratinocytes and Langerhans cells in the epidermis. Our objective was to identify immunoreactive CLDN1 in human epidermal Langerhans cells and to examine the pattern of epidermal Langerhans cells in genetic[…][ncbi.nlm.nih.gov]

  • Erythema Annulare Centrifugum

    Histopathologic examination showed lobulated, endophytic epidermal hyperplasia, with a very large eosinophilic intracytoplasmic inclusion in each keratinocyte ( Figure 2 A[jamanetwork.com] Heavy superficial perivascular lymphohistiocytic infiltrates, focal basal vacuolization, mild spongiosis, and mounts of parakeratosis were also observed around the main lesion[jamanetwork.com]

  • Tyrosine Transaminase Deficiency

    Intracytoplasmic vacuoles which include or lead to pseudomyelinic formations extend progressively from the mitochondrial alterations in the epidemial basal layers.[ncbi.nlm.nih.gov] The keratinocytes show 2 types of anomaly ranged in strates in the epiderm.[ncbi.nlm.nih.gov] Bulky polyhedral electron dense particles are found in the cytoplasm of the superficial keratinocytes.[ncbi.nlm.nih.gov]

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