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62 Possible Causes for Intraneuronal Inclusions

  • Alzheimer Disease

    inclusions.[jneurosci.org] […] fibrils described here when injected into mutant α-synuclein Tg mice (M83), implicating shared pathogenic mechanisms underlying neurodegenerative diseases with proteinaceous intraneuronal[jneurosci.org]

  • Traumatic Brain Injury

    TDP-43 inclusions.[ncbi.nlm.nih.gov] […] additionally showed NFT predominance in the superficial layers of the cortex, hypothalamus and brainstem, diffuse Lewy bodies in the cortex, amygdala and brainstem, and intraneuronal[ncbi.nlm.nih.gov]

  • Moderate and Severe Traumatic Brain Injury

    TDP-43 inclusions.[ncbi.nlm.nih.gov] […] additionally showed NFT predominance in the superficial layers of the cortex, hypothalamus and brainstem, diffuse Lewy bodies in the cortex, amygdala and brainstem, and intraneuronal[ncbi.nlm.nih.gov]

  • Progressive Myoclonic Epilepsy Type 7

    Lafora’s disease, characterized by intraneuronal inclusions, is a form of myoclonus epilepsy not linked to EPM1 and chromosome 21.[pediatricneurologybriefs.com]

  • Parkinson's Disease

    The nigral dopamine neurons of MitoPark mice show respiratory chain dysfunction, accompanied by the development of intraneuronal inclusions and eventual cell death.[ncbi.nlm.nih.gov] The knockout mice exhibited a Parkinsonian phenotype with adult onset of slowly progressive impairment of motor function accompanied by formation of intraneuronal inclusions[ncbi.nlm.nih.gov] inclusion (possibly a Lewy body equivalent), 4) preferential death of dopaminergic neurons in the SN compared to the VTA and 5) responsiveness to leva-dopa.[ncbi.nlm.nih.gov]

  • Dementia

    TDP-43 inclusions.[ncbi.nlm.nih.gov] […] additionally showed NFT predominance in the superficial layers of the cortex, hypothalamus and brainstem, diffuse Lewy bodies in the cortex, amygdala and brainstem, and intraneuronal[ncbi.nlm.nih.gov]

  • Unverricht-Lundborg Syndrome

    The intraneuronal inclusions of Lafora 3A,3B have been the dramatic neuropathologic finding.[jamanetwork.com]

  • Neuronal Intranuclear Inclusion Disease

    These fibrillary and granular Cowdry type A and B intraneuronal inclusions were consistent with the diagnosis of NIHID associated with severe coronary atherosclerosis.[journals.lww.com] These ubiquitinated intranuclear inclusions are morphologically similar to the intraneuronal aggregates that have been identified in the CAG/polyglutamine expansion diseases[ncbi.nlm.nih.gov] At autopsy, neuronal intranuclear hyaline inclusions and neuronal loss were seen in his brain, brainstem, cerebellum, spinal cord, bowel, bladder, and esophagus.[journals.lww.com]

  • Lafora Disease

    There are characteristic intraneuronal inclusion bodies of different morphological forms with Nissl granules. Periodic acid Schiff; originally 1000.[jnnp.bmj.com] An axillary biopsy proved negative, but the cerebral cortex showed inclusion bodies characteristic of Lafora’s disease, most of which were intraneuronal.[jnnp.bmj.com] A patient with dementia and Lafora inclusion bodies but without epilepsy has only previously been described by Suzuki et al . 7 This was a patient aged 59 with dementia who[jnnp.bmj.com]

  • Parkinson's Disease Type 3

    Unique pathological findings, such as neuronal loss, astrogliosis, and the presence of intraneuronal Lewy-body–like synuclein inclusions specifically targeting the hippocampal[nejm.org] Lewy-body–like synuclein inclusions in patients with both type 1 and neuronopathic Gaucher's disease points to a selective vulnerability and cytotoxicity, specifically targeting[nejm.org] […] in rare familial cases, and the aggregated protein is a major component of Lewy bodies, the pathological hallmark of sporadic Parkinson's disease. 5 Thus, the presence of intraneuronal[nejm.org]

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