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62 Possible Causes for Intraneuronal Inclusions

  • Dementia

    TDP-43 inclusions.[ncbi.nlm.nih.gov] […] additionally showed NFT predominance in the superficial layers of the cortex, hypothalamus and brainstem, diffuse Lewy bodies in the cortex, amygdala and brainstem, and intraneuronal[ncbi.nlm.nih.gov]

  • Amyotrophic Lateral Sclerosis 17

    inclusions and neuronal loss extending beyond the motor system in patients with ALS with or without cognitive impairment. 35 VBM studies in patients with ALS have provided[ajnr.org] […] ubiquitin-immunoreactive inclusions Frequency ALS-Dementia: 100% Non-demented ALS patients: 20% to 50% Frontotemporal dementia lacking motor symptoms: Some patients Locations[neuromuscular.wustl.edu] […] and limbic regions compared with those with no evidence of cognitive deficits. 88 These findings are consistent with pathologic studies demonstrating ubiquitin-positive intraneuronal[ajnr.org]

  • Hypertelorism and Tetralogy of Fallot

    Autopsy showed prominent intraneuronal inclusions with vacuolar degeneration mainly in thalamic nuclei, dentate nuclei, cerebellar cortex and inferior olivery nuclei.[ojhas.org] Severe neurological impairment associated with intraneuronal inclusions and vacuolar degeneration has been taken as evidence for a lysosomal storage disorder.(7) Dworzak et[ojhas.org]

  • Methylphenyltetrahydropyridine

    Firstly, according to most published reports, pigmented nuclei such as locus coeruleus have been spared, except in the SNpc, Secondly, the eosinophilic intraneuronal inclusions[neurodegeneration.uni-goettingen.de]

  • Prion Disease

    inclusions, low apolipoprotein E-4 (APOE-4), and no significant nerve cell loss.[ncbi.nlm.nih.gov] […] next examined the CA1 region of the hippocampus from 14 patients with PrionD and found that 5 patients had low levels of scrapie-associated prion protein (PrP), many Aβ42 intraneuronal[ncbi.nlm.nih.gov]

  • Primary Torsion Dystonia 6

    The midbrain and pons were stained with antibodies to ubiquitin and p62 to assess the presence of intraneuronal inclusions in the periaqueductal gray matter, pedunculopontine[karger.com] Perhaps the most interesting finding in isolated dystonia has been a neuropathological study of genetically confirmed DYT1 cases in which intraneuronal inclusions immunoreactive[karger.com]

  • Lafora Disease

    There are characteristic intraneuronal inclusion bodies of different morphological forms with Nissl granules. Periodic acid Schiff; originally 1000.[jnnp.bmj.com] An axillary biopsy proved negative, but the cerebral cortex showed inclusion bodies characteristic of Lafora’s disease, most of which were intraneuronal.[jnnp.bmj.com] A patient with dementia and Lafora inclusion bodies but without epilepsy has only previously been described by Suzuki et al . 7 This was a patient aged 59 with dementia who[jnnp.bmj.com]

  • Hallervorden-Spatz Syndrome

    A rare neuroaxonal dystrophy, histologically characterized by axonal spheroids, iron deposition, lewy body (lb)-like intraneuronal inclusions and neurofibrillary tangles.[icd10data.com]

  • Tauopathy

    However, intracerebral injections of either T40PL preformed fibrils (PFFs) or AD-tau seeds into T40PL-GFP mice induced abundant intraneuronal pathological inclusions of hyperphosphorylated[ncbi.nlm.nih.gov]

  • Infantile Neuroaxonal Dystrophy 1

    A rare neuroaxonal dystrophy, histologically characterized by axonal spheroids, iron deposition, lewy body (lb)-like intraneuronal inclusions and neurofibrillary tangles.[icd10data.com]

Further symptoms