Intranuclear Inclusion Bodies: Causes & Reasons

Possible Causes for Intranuclear Inclusion Bodies

Generalized Herpes Simplex Infection of the Newborn

The diagnosis of generalized viral infection was established from virologic studies of liver and brain tissue and from the demonstration of intranuclear inclusion bodies in [onlinelibrary.wiley.com]

Hepato-adrenal necrosis with intranuclear inclusion bodies: report of a case. Am J Pathol 1935; 11 :127–147. 2 Kimberlin DW, Lin CY, Jacobs RF, et al. [nature.com]

The intranuclear inclusion is the characteristic cellular lesion, and it consists of a single, eosinophilic, well-demarcated inclusion body surrounded by a halo and marginated [histopathology-india.net]

Herpes Simplex Infection

bodies in the nucleus, known as Cowdry type A acidophilic intranuclear inclusion bodies. [symptoma.com]

Tzanck smear, i.e.Papanicolaou staining of corneal smears, show multinucleated giant cells and intranuclear inclusion bodies, however, the test is low in sensitivity and specificity [en.wikipedia.org]

A Tzanck smear can reveal multinucleated giant cells and intranuclear eosinophilic inclusion bodies. [eyewiki.aao.org]

Generalized Herpes Simplex

Groups of hepatocytes surrounding these areas contain intranuclear eosinophilic viral bodies (Cowdry type A inclusions). Inflammatory response is minimal. [meddean.luc.edu]

Light Microscopy - cells from the base of the lesion, or wiped from a mucous surface, or biopsy material, may reveal intranuclear inclusions (Lipschutz inclusion bodies). [virology-online.com]

Infected cell may become cytomegalic but since the infection may not produce morphological changes, the absence of large cells and of intranuclear inclusions do not exclude [meddean.luc.edu]

Laryngotracheitis

Suggestive lesions of ILT, such as epithelial necrosis, sero-fibrinous and sero-hemorrhagic exudates, syncytia and intranuclear inclusion bodies were observed in layers of [scopemed.org]

inclusion bodies in the tracheal epithelium in the early stage of infection Virus isolation Molecular biology methods to detect viral DNA such as PCR Serology Other diagnostic [vectormune.com]

The diagnosis is confirmed with the detection of intranuclear inclusion bodies in the trachea throughout the histological study in the early stages of the disease, serological [thepoultrysite.com]

Hydropericardium

Histological examination revealed multifocal necrotic areas and two types of intranuclear inclusion bodies adjacent to necrotic areas in the liver. [hungary.pure.elsevier.com]

The liver of infected birds shows necrotic foci and basophilic intranuclear inclusion bodies in the hepatocytes. [ncbi.nlm.nih.gov]

inclusion bodies in the hepatocytes. [ncbi.nlm.nih.gov]

Neuronal Intranuclear Inclusion Disease

Intranuclear; Inclusion, Nuclear; Inclusion, Intranuclear; Inclusion Body, Nuclear; Inclusion Body, Intranuclear; Inclusion Bodies, Nuclear; Nuclear Inclusions; Nuclear [reference.md]

Abstract Neuronal intranuclear inclusion disease, a progressive ataxia that may be familial or sporadic, is characterized by numerous neuronal intranuclear inclusion bodies [ncbi.nlm.nih.gov]

Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder with eosinophilic intranuclear inclusion bodies. [ncbi.nlm.nih.gov]

Genital Herpes

Am Fam Physician. 2016 Jun 1;93(11):928-934. Patient information : See related handout on genital herpes, written by the author of this article. Author disclosure: No relevant financial affiliations. Genital herpes is a common sexually transmitted disease, affecting more than 400 million persons worldwide. It is caused[…] [aafp.org]

Genital Herpes in Women

Genital herpes affects many women. Which symptoms does female herpes cause and what are the risks? Find out how to spot herpes and how to deal with the condition. Female Herpes Genital herpes is caused by the herpes simplex virus 2. Many women carry this virus without ever developing genital herpes symptoms.[…] [onlinedoctor.superdrug.com]

Herpes Simplex Esophagitis

Fig. 2 High-power photomicrograph showing multinucleated giant cells with intranuclear inclusion bodies, typical of herpes esophagitis. [doi.org]

Histological examination of biopsy specimens showed Cowdry type A intranuclear inclusion bodies in epithelial cells. [ncbi.nlm.nih.gov]

Esophageal biopsy showed multinucleated giant cells with Cowdry type A intranuclear inclusion bodies in epithelial cells, characteristic of herpes esophagitis ([ Fig. 2 ]) [doi.org]

Cytomegalovirus Colitis

Colonic mucosal intranuclear inclusion bodies were found in 12 patients. [ncbi.nlm.nih.gov]

Repeated sigmoidoscopic examination with re-biopsy showed intranuclear inclusion bodies suggestive of CMV infection. [ekjm.org]

A biopsy specimen revealed intranuclear inclusion bodies, so we diagnosed that this case was UC associated with CMV infection. [ci.nii.ac.jp]

Disseminated Cytomegalovirus Infection

Cytomegalovirus (CMV) Inclusions resemble owl’s eyes Classic owl’s eye inclusions Characteristic owl’s eye intranuclear inclusion bodies in the kidney of a pateint with disseminated [medical-labs.net]

The fully developed change shows basophilic intranuclear and intracytoplasmic inclusion bodies. [symbiosisonlinepublishing.com]

Morphologically, it is characterized by the presence of intranuclear inclusion bodies. Cytomegalovirus (cmv) is a virus found around the world. [icd10data.com]

Cytomegalovirus Mononucleosis

The demonstration of intranuclear inclusion bodies in a few gastric glandular epithelial cells contributed to the diagnosis of CMV gastritis. [ncbi.nlm.nih.gov]

inclusion bodies that have an owl-eye appearance Monospot (heterophile antibody ) test : negative Serological tests Direct evidence of viremia : especially useful in immunosuppressed [amboss.com]

The biopsy showed stratified squamous epithelium with plenty of inflammatory cells with large cells showing typical intranuclear inclusion bodies suggestive of CMV esophagitis [caijournal.com]

Cytomegalovirus Esophagitis

inclusion bodies that have an owl-eye appearance Monospot (heterophile antibody ) test : negative Serological tests Direct evidence of viremia : especially useful in immunosuppressed [amboss.com]

Endoscopy will reveal ulcers in the distal esophagus and diagnosis is confirmed by the demonstration of characteristic intranuclear inclusion bodies in the endothelial cells [wikidoc.org]

Morphologically, it is characterized by the presence of intranuclear inclusion bodies. Cytomegalovirus (cmv) is a virus found around the world. [icd10data.com]

Keratitis Disciformis

[…] eosinophilic inclusion bodies Viral culture Immunohistochemistry looking for herpes simplex viral antigens Polymerase chain reaction (PCR) assay [3] See Workup for more detail [emedicine.medscape.com]

Tzanck Smear Papanicolaou or Giemsa stains of corneal smears are examined for the presence of multinucleated giant cells and intranuclear eosinophilic inclusion bodies (Cowdry [aao.org]

Measles Pneumonia

Multinucleated giant cells with intranuclear inclusion bodies were revealed in the transbronchial lung biopsy (TBLB) specimen of patient 2. [ncbi.nlm.nih.gov]

Synopsis Warthin-Finkedley cells Multinucleated giant cells with intranuclear inclusion bodies were revealed in the transbronchial lung biopsy (TBLB) Variants familial cases [humpath.com]

Giant cells contain both intracytoplasmic and intranuclear, eosinophilic inclusion bodies. [histopathology-india.net]

Desquamative Interstitial Pneumonia

In 9 of 11 cases there were intranuclear inclusion bodies histologically. [annals.org]

In 4 of 12 control cases there were intranuclear inclusion bodies similar to those found in desquamative interstitial pneumonia. [annals.org]

Stomach Perforation

The biopsy specimen of the ulcer showed cytomegalic cells with intranuclear inclusion bodies and blood test was positive for human immunodeficiency virus (HIV) antibody. [jstage.jst.go.jp]

Histologic examination of a gastric biopsy showed inflammatory infiltrate and immunostaining typical intranuclear CMV inclusion bodies. [bmcinfectdis.biomedcentral.com]

Histopathologic analysis of a gastric biopsy showed edema, inflammatory infiltrate and typical intranuclear cytomegalic inclusion bodies in endothelial cells in mucosa. [bmcinfectdis.biomedcentral.com]

Laryngeal Herpes

The skin biopsy showed an intraepidermal vesicle with multinucleated giant cells containing intranuclear inclusion bodies [Figure - 1]. [ijdvl.com]

Histopathological examination revealed areas of focal necrosis with ballooning degeneration, mononuclear giant cells, and eosinophillic intranuclear inclusion bodies; which [laryngologyandvoice.org]

Necrotizing Alveolitis

bodies). [vetbook.org]

Pathology is often seen in immunodeficient monkeys, including necrotizing alveolitis and bronchiolitis, pneumonia, necrotizing pancreatitis, and enteritis (intranuclear inclusion [vetbook.org]

Intranuclear Rod Myopathy

inclusion bodies predominantly within glial cells. [tr-ex.me]

Lesions are found in the brains of dogs with neurological complications include neuronal degeneration, gliosis, demyelination, nonsuppurative leptomeningitis and intranuclear [tr-ex.me]

Aún más, demostraron que en el ratón tratado con trehalosa se había reducido la atrofia cerebral y había disminuido el número de agregados intranucleares en un 55% en relación [tr-ex.me]

Pelizaeus-Merzbacher Disease Type Löwenberg-Hill

Harford: Intranuclear inclusion bodies in the tissue reactions produced by injection of certain foreign substances. Amer. J. Path.13, 729–748 (1937). [link.springer.com]

Google Scholar ——: Further observations on intranuclear inclusions produced by non-virus materials. Proc. Soc. exp. Biol. (N.Y.)38, 92–94 (1938). [link.springer.com]

Herpes Simplex Keratitis

General Pathology Corneal scrapings of HSV keratitis prepared with Giemsa stain may reveal the presence of intranuclear viral inclusion bodies. [eyewiki.org]

[…] laboratory diagnosis can be made using the following [2] : Giemsa stain - Scrapings of the corneal or skin lesions show multinucleated giant cells Papanicolaou stain - This shows intranuclear [emedicine.medscape.com]

Bwamba Fever Virus

[…] acidophilic bodies resembling inclusions. [ajtmh.org]

[…] the virus in mice are essentially limited to the nervous system and are characterized by damage to cortical cells in various areas of the brain, and by the appearance of intranuclear [ajtmh.org]

Endotheliitis

In vivo confocal microscopy findings have revealed the presence of cells that resemble the characteristic owl's eye (acidophilic intranuclear inclusion bodies) related to [scielo.br]

inclusion body seen on confocal microscopy is characteristic of CMV infection.13 In this case, anterior chamber paracentesis and viral culture from the aqueous humor with [docksci.com]

[…] is easy to perform, reasonably sensitive, and highly speciﬁc for the diagnosis of viral infection.3,5,12 Confocal microscopy is useful in some cases.13,14 For example, an intranuclear [docksci.com]

Dentatorubral-Pallidoluysian Atrophy

The relationship of pathological intranuclear inclusions to functional intranuclear bodies will also be discussed. [doi.org]

inclusions in intranuclear inclusion body disease, Pathology International, 62, 6, (407-411), (2012). [doi.org]

Optineurin immunoreactivity in neuronal nuclear inclusions of polyglutamine diseases (Huntington's, DRPLA, SCA2, SCA3) and intranuclear inclusion body disease. [ncbi.nlm.nih.gov]

Cytomegalovirus Infection

Morphologically, it is characterized by the presence of intranuclear inclusion bodies. [ NCIT:C53649 ] Synonyms: INFECT CYTOMEGALOVIRUS, HCMV, Cytomegaloviral disease, unspecified [ebi.ac.uk]

The fully developed change shows basophilic intranuclear and intracytoplasmic inclusion bodies. [symbiosisonlinepublishing.com]

Histological examination of the ulcer margin showed intranuclear inclusion bodies. [ginmu.naramed-u.ac.jp]

Gingivostomatitis

Lipschutz intranuclear acidophilic inclusion bodies have been demonstrated in the cells of the injected cornea and the brains of animals inoculated with the virus of herpes [ajodo.org]

The characteristic intranuclear inclusion bodies known as Cowdry type A are found on light microscopy showing arrays of viral capsids and electron dense glycoproteins.[6] [ncbi.nlm.nih.gov]

[…] are intranuclear inclusion bodies visible under light microscopy. [en.wikipedia.org]

Herpes Simplex Dendritic Keratitis

General Pathology Corneal scrapings of HSV keratitis prepared with Giemsa stain may reveal the presence of intranuclear viral inclusion bodies. [eyewiki.aao.org]

Herpes Simplex Gingivostomatitis

[…] are intranuclear inclusion bodies visible under light microscopy. [en.wikipedia.org]

The characteristic intranuclear inclusion bodies known as Cowdry type A are found on light microscopy showing arrays of viral capsids and electron dense glycoproteins. [6] [ncbi.nlm.nih.gov]

Cowdry A inclusion bodies (non-specific) Results available within 1 hour Unable to differentiate between HSV-1 and HSV-2 Viral culture: gold standard for definitive diagnosis [amboss.com]

Machado-Joseph Disease

Atrophy of the basis pontis is common, and polyglutamine-positive neuronal intranuclear inclusion bodies are most readily found in the pontine gray. [ncbi.nlm.nih.gov]

inclusion bodies. [en.wikipedia.org]

[…] main motor problems cause by MJD: the tightening and twisting of the limb and the abrupt, irregular movements. [16] In affected cells, this protein builds up and assembles intranuclear [en.wikipedia.org]