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4,244 Possible Causes for ion, iron, of, transport, upregulation

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  • Chelating Agent

    We demonstrated that deferasirox increased expression of the metastasis suppressor protein N -myc downstream-regulated gene 1 and upregulated the cyclin-dependent kinase inhibitor[molpharm.aspetjournals.org] A calcium ion electrode was used to measure the equilibrium calcium ion concentrations from which stability constants were calculated.[link.springer.com] Abstract ICL670 is an orally active representative of a new class of tridentate iron chelator developed for the treatment of blood transfusion-dependent iron overload in chronic[ncbi.nlm.nih.gov] A facilitated transport of DMPS mediated by the anion carrier protein was concluded on the basis of the following similarities with the anion transport: inhibition of [14C[ncbi.nlm.nih.gov] Calcium ion was shown to play an essential role in regulating sperm molitility in semen, and EDTA was demonstrated to exert spermicidal activity by modulating calcium ion[ncbi.nlm.nih.gov]

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  • Influenza

    No significant upregulation was observed in either group of guinea pigs for TNFα, TBK1, IRF5, or IFNγ ( Figure 5 ).[doi.org] […] of the wt ion channel protein.[doi.org] What perverted staff away-day came up with this ‘ironic’ disaster?[dailymail.co.uk] Dynein-Directed Transport on Microtubules in Stage II.[doi.org] Pneumonia isolates carried higher proportions of virulence genes sfa/foc , papGIII , hlyC , cnf1 , and iroN compared with bacteremia isolates.[cdc.gov]

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  • Disorder of Manganese Transport

    […] neurodegeneration in response to MeHg exposure. (2) Under conditions of MeHg-induced oxidative stress, Nrf2 (a master regulator of antioxidant responses) coordinates the upregulation[einstein.yu.edu] Thus, metal ions play a pivotal role in neurodegenerative phenomena.[books.google.com] Mov Disord 24:441–445 PubMed CrossRef Google Scholar [42] Finberg KE, Heeney MM, Campagna DR et al. (2008) Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia[link.springer.com] SLC39A8 deficiency: a disorder of manganese transport and glycosylation.[uniprot.org] […] by admin on September 16, 2017 Slc39a8 deficiency a disorder of manganese transport and glycosylation stamps.[hiame.novolt.ru]

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  • Mucolipidosis Type 4

    Among the four types identified to date, we previously demonstrated that plasma membrane-associated ganglioside sialidase (NEU3) is markedly upregulated in various human cancers[ncbi.nlm.nih.gov] TRPML1 (mucolipin 1, also known as MCOLN1) is predicted to be an intracellular late endosomal and lysosomal ion channel protein that belongs to the mucolipin subfamily of[ncbi.nlm.nih.gov] Lipid Transport to the Golgi Complex.[doi.org] Importantly, these events induce an upregulation of NC Ca-ATP ( 403 ).[doi.org] Researchers dispute the physiological role of the protein product and which ion it transports.[en.wikipedia.org]

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  • Deficiency of Ceruloplasmin

    When exposed to excess dietary zinc, the absorptive duodenal cells upregulate metallothionein, an intracellular metal-binding ligand.[nutramed.com] The effects of lithium ion and other agents on the activity of myo-inositol- 1-phosphatase from bovine brain, J. ‎ Página 673 - A. (1992).[books.google.es] […] for Assessing Transport 602 23 Regulation of Intestinal Iron Transport 626 24 Regulation of Systemic Iron Transport 665 25 Regulation of Liver Iron Metabolism 681 26 Iron[books.google.ro] Free Radic Biol Med 2007 ; 42 : 1534 – 42 . 15 Mechanisms of copper ion mediated Huntington's disease progression .[ajcn.nutrition.org] […] the iron disorder to aceruloplasminemia.[bloodjournal.org]

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  • Microcytic Anemia

    […] parenteral iron complexes, which must be processed and exported by macrophages before utilization. 107 Because overexpression of TMPRSS6 blocks activation of diverse pathways for upregulation[dx.doi.org] The main function of the DMT1 protein is to transport iron ions into the cells. This protein can also carry other metal ions.[ivami.com] […] with oral iron.[ncbi.nlm.nih.gov] […] targeting, and recycling through endosomes, concomitant with retention of the transporter in the endoplasmic reticulum.[ncbi.nlm.nih.gov] Polymorphism, Single Nucleotide/genetics RNA, Messenger/genetics Rats Substances Cation Transport Proteins RNA, Messenger solute carrier family 11- (proton-coupled divalent metal ion[ncbi.nlm.nih.gov]

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  • Urinary Tract Infection

    We report here that UPEC upregulates the expression of ethanolamine utilization genes during uncomplicated UTIs in humans.[ncbi.nlm.nih.gov] Drug interaction Cipro is not recommended to take with medications decreasing acidity in your stomach and any alkaline mineral waters and also medications which contain ions[corpohs.com] An iron-trafficking protein that binds to iron through its interaction with siderophores.[doi.org] That's because the urethra -- the tube that transports urine from the bladder to the outside of the body -- is located close to the anus .[webmd.com] The metal ion-dependent adhesion site motif of the Enterococcus faecalis EbpA pilin mediates pilus function in catheter-associated urinary tract infection . mBio 3 , e00177[doi.org]

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  • Sideroblastic Anemia

    Quantitative reverse transcription polymerase chain reaction (RT-PCR) analysis confirmed significant upregulation of heme-regulated genes, such as the globin genes [hemoglobin[ncbi.nlm.nih.gov] Among these genes, the COX3 gene product participates in iron ion oxidoreduction reactions as one of the cytochrome C oxidase subunits.[jhoonline.biomedcentral.com] Ring sideroblasts can develop as a result of a heme synthesis defect in erythroblasts (ALAS2 mutations), a defect in iron-sulfur cluster assembly, iron-sulfur protein precursor[ncbi.nlm.nih.gov] Srivastava S, Barrett JN, Moraes CT (2007) PGC-1alpha/beta upregulation is associated with improved oxidative phosphorylation in cells harboring nonsense mtDNA mutations.[doi.org] In this review article, we will focus on the iron metabolism in erythroid cells as well as in patients with congenital sideroblastic anemia.[ncbi.nlm.nih.gov]

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  • Iron Deficiency

    Secondly, the nonspecific upregulation of intestinal metal ion absorption is reverted to normal, thus limiting the hyperabsorption of potentially toxic lead and cadmium even[ncbi.nlm.nih.gov] Antigens were extracted from sera of CKD patients using functionalized iron-oxide nanoparticles (fAb-IONs) followed by magnetic separation.[ncbi.nlm.nih.gov] A reduction in the total iron content in the human body is called iron deficiency. Iron is essential for several metabolic processes as well as erythropoiesis.[symptoma.com] Abstract The role of iron transport proteins in the pathogenesis of anemia in patients with diabetes mellitus (T2DM) is still unclear.[ncbi.nlm.nih.gov] Excessive uptake of other nutrient ions such as ammonium, phosphate, manganese, zinc, copper, and other heavy metals often results in Fe deficiency symptoms being expressed[edis.ifas.ufl.edu]

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  • Congenital Chloride Diarrhea

    Dudeja , CDX2 upregulates SLC26A3 gene expression in intestinal epithelial cells , American Journal of Physiology-Gastrointestinal and Liver Physiology , 313 , 3 , (G256)[doi.org] Being a chaotropic ion, HCO(3)(-) is essential for solubilization of ions and macromolecules such as mucins and digestive enzymes in secreted fluids.[ncbi.nlm.nih.gov] […] protein absorption Infant formula intolerance Intestinal malabsorption of carbohydrate Intestinal malabsorption of fat Intestinal malabsorption of protein Malabsorption - iron[icd9data.com] To determine whether DRA is an intestinal chloride transporter and how mutations affect transport, Xenopus oocytes were injected with wild-type and mutagenized DRA cRNA and[ncbi.nlm.nih.gov] Expression of Slc26a9 appears to be dynamic and is upregulated in the gastric mucosa of H. pylori -infected mice ( 39 ).[doi.org]

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