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72 Possible Causes for Irinotecan, Malignant Ascites, Peripheral Neuropathy

  • Malignant Gastric Neoplasm

    Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Patient or[] A 71-year-old man diagnosed with advanced gastric cancer with malignant ascites was treated with nab-paclitaxel as a second-line chemotherapy.[] Side effects may include: tiredness nausea and vomiting nerve damage ( peripheral neuropathy ) hair loss diarrhoea anaemia (a lack of red blood cells) weight loss skin changes[]

  • Adenocarcinoma of the Ovary

    The 50% growth inhibitory concentrations (IC50) (nM) of various anticancer drugs were: cisplatin 10,000, paclitaxel 80, SN-38 (irinotecan metabolite) 460, and gemcitabine[] Normal cells purified from the malignant ascites did not show such amplification.[] She had recurrent tumors after primary cytoreductive surgery, which were unresectable and also resistant to paclitaxel, carboplatin, irinotecan, and oral etoposide.[]

  • Gastric Adenocarcinoma

    ., 5-FU (5 μ M); cisplatin (0.5 μ M); irinotecan (2.5 μ M); carboplatin (5 μ M); paclitaxel (2-4 n M); and X rays (1.8 Gy)] also potentiated gastric cancer clonogenic cell[] Direct peritoneal seeding can produce malignant ascites (fluid accumulation in the abdomen).[] neuropathy grade 2 Inability to tolerate intravenous hydration e.g due to cardiac disease Co-morbidities (based on clinical judgement by the investigator) that in the view[]

  • Metastatic Ovarian Carcinoma

    Research output : Article 2000 Irinotecan--második vonalbeli kezeléssel szerzett tapasztalatok elórehaladott colorectalis daganatokban.[] Cytology specimens were taken from the portio, endocervix and endometrium of the uterus, ascites and vaginal surgical stump.[] A specific chemotherapy regimen for rare clear-cell cancers is also under investigation: irinotecan combined with cisplatin. [62] PARP inhibitors have also shown promise in[]

  • Adenocarcinoma of the Colon

    Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal .N Engl J Med 2004;351:337-45. 13. T. Delaunoit1, S.R. Alberts, D.J.[] Several studies have shown that routine cytopathology using ascitic fluid smears is positive for malignant cells in two out of 10 patients with ascites [ 12 ].[] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[]

  • Malignant Neoplasm of Pancreas

    If you’re in fairly good health you may receive FOLFIRINOX (5-FU/ leucovorin / oxaliplatin / irinotecan ).[] The liver may be tender and enlarged with advanced disease, and patients may present with ascites, palmar erythema, and spider angioma.[] […] may occur in either the central nervous system (CNS) or the peripheral nervous system (PNS).[]

  • Esophageal Carcinoma

    Enzinger PC, Clark J, Bryan D et al. (2004) Phase II study of docetaxel, cisplatin, and irinotecan in advanced esophageal and gastric cancer.[] Other findings may include superior vena cava syndrome, malignant ascites, and bone pain.[] Physicians' Choice of Single Agent Docetaxel, Paclitaxel, or Irinotecan in Subjects with Advanced/Metastatic Adenocarcinoma...[]

  • Pleural Mesothelioma

    Efficacy and safety of first- or second-line irinotecan, cisplatin, and mitomycin in mesothelioma. Cancer 2007;109:93-9. Kwak EL, Bang YJ, Camidge DR, et al.[] We report the case of malignant ascites in a patient with malignant pleural mesothelioma (MPM) whose symptoms were relieved by CART.[] Further, such chemotherapeutic agents as cisplatin can cause painful peripheral neuropathies. 69 Patients who receive radiation therapy may experience radiation pneumonitis[]

  • Peritoneal Metastasis

    Twenty patients received oxaliplatin-based (OX) and twelve patients received irinotecan-based HIPEC (IRI).[] The image intensity with increasing malignant ascites was significantly increased at days 7, 16, and 21.[] Leukopenia, fatigue and peripheral neuropathy were higher on the triplet regimen than the doublet regimens.[]

  • Endometrial Adenocarcinoma

    […] first-line bevacizumab, oxaliplatin, and a fluoropyrimidine would exhibit improved survival when ramucirumab was added to second-line FOLFIRI (folinic acid, 5-fluorouracil, and irinotecan[] Intraoperative cytology detected malignant cells in the ascites.[] Side effects of treatment with carboplatin and paclitaxel include bone marrow suppression, allergic reactions, peripheral neuropathy, and renal failure.[]

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