Create issue ticket

72 Possible Causes for Irinotecan, Malignant Ascites, Peripheral Neuropathy

  • Malignant Gastric Neoplasm

    Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Patient or[doi.org] A 71-year-old man diagnosed with advanced gastric cancer with malignant ascites was treated with nab-paclitaxel as a second-line chemotherapy.[ncbi.nlm.nih.gov] Side effects may include: tiredness nausea and vomiting nerve damage ( peripheral neuropathy ) hair loss diarrhoea anaemia (a lack of red blood cells) weight loss skin changes[nhs.uk]

  • Adenocarcinoma of the Ovary

    The 50% growth inhibitory concentrations (IC50) (nM) of various anticancer drugs were: cisplatin 10,000, paclitaxel 80, SN-38 (irinotecan metabolite) 460, and gemcitabine[ncbi.nlm.nih.gov] Normal cells purified from the malignant ascites did not show such amplification.[ncbi.nlm.nih.gov] She had recurrent tumors after primary cytoreductive surgery, which were unresectable and also resistant to paclitaxel, carboplatin, irinotecan, and oral etoposide.[ncbi.nlm.nih.gov]

  • Gastric Adenocarcinoma

    ., 5-FU (5 μ M); cisplatin (0.5 μ M); irinotecan (2.5 μ M); carboplatin (5 μ M); paclitaxel (2-4 n M); and X rays (1.8 Gy)] also potentiated gastric cancer clonogenic cell[ncbi.nlm.nih.gov] Direct peritoneal seeding can produce malignant ascites (fluid accumulation in the abdomen).[gastrointestinalatlas.com] neuropathy grade 2 Inability to tolerate intravenous hydration e.g due to cardiac disease Co-morbidities (based on clinical judgement by the investigator) that in the view[clinicaltrials.gov]

  • Metastatic Ovarian Carcinoma

    Research output : Article 2000 Irinotecan--második vonalbeli kezeléssel szerzett tapasztalatok elórehaladott colorectalis daganatokban.[hungary.pure.elsevier.com] Cytology specimens were taken from the portio, endocervix and endometrium of the uterus, ascites and vaginal surgical stump.[ncbi.nlm.nih.gov] A specific chemotherapy regimen for rare clear-cell cancers is also under investigation: irinotecan combined with cisplatin. [62] PARP inhibitors have also shown promise in[en.wikipedia.org]

  • Adenocarcinoma of the Colon

    Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal .N Engl J Med 2004;351:337-45. 13. T. Delaunoit1, S.R. Alberts, D.J.[scielo.mec.pt] Several studies have shown that routine cytopathology using ascitic fluid smears is positive for malignant cells in two out of 10 patients with ascites [ 12 ].[jmedicalcasereports.biomedcentral.com] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[cancer.gov]

  • Malignant Neoplasm of Pancreas

    If you’re in fairly good health you may receive FOLFIRINOX (5-FU/ leucovorin / oxaliplatin / irinotecan ).[webmd.com] The liver may be tender and enlarged with advanced disease, and patients may present with ascites, palmar erythema, and spider angioma.[aafp.org] […] may occur in either the central nervous system (CNS) or the peripheral nervous system (PNS).[en.wikipedia.org]

  • Esophageal Carcinoma

    Enzinger PC, Clark J, Bryan D et al. (2004) Phase II study of docetaxel, cisplatin, and irinotecan in advanced esophageal and gastric cancer.[springermedizin.de] Other findings may include superior vena cava syndrome, malignant ascites, and bone pain.[msdmanuals.com] Physicians' Choice of Single Agent Docetaxel, Paclitaxel, or Irinotecan in Subjects with Advanced/Metastatic Adenocarcinoma...[clinicaltrialsregister.eu]

  • Pleural Mesothelioma

    Efficacy and safety of first- or second-line irinotecan, cisplatin, and mitomycin in mesothelioma. Cancer 2007;109:93-9. Kwak EL, Bang YJ, Camidge DR, et al.[annalscts.com] We report the case of malignant ascites in a patient with malignant pleural mesothelioma (MPM) whose symptoms were relieved by CART.[ncbi.nlm.nih.gov] Further, such chemotherapeutic agents as cisplatin can cause painful peripheral neuropathies. 69 Patients who receive radiation therapy may experience radiation pneumonitis[dovepress.com]

  • Peritoneal Metastasis

    Twenty patients received oxaliplatin-based (OX) and twelve patients received irinotecan-based HIPEC (IRI).[ncbi.nlm.nih.gov] The image intensity with increasing malignant ascites was significantly increased at days 7, 16, and 21.[ncbi.nlm.nih.gov] Leukopenia, fatigue and peripheral neuropathy were higher on the triplet regimen than the doublet regimens.[ncbi.nlm.nih.gov]

  • Endometrial Adenocarcinoma

    […] first-line bevacizumab, oxaliplatin, and a fluoropyrimidine would exhibit improved survival when ramucirumab was added to second-line FOLFIRI (folinic acid, 5-fluorouracil, and irinotecan[annonc.oxfordjournals.org] Intraoperative cytology detected malignant cells in the ascites.[ncbi.nlm.nih.gov] Side effects of treatment with carboplatin and paclitaxel include bone marrow suppression, allergic reactions, peripheral neuropathy, and renal failure.[clinicaladvisor.com]

Similar symptoms