Create issue ticket

181 Possible Causes for Irinotecan, Malnutrition, Peripheral Neuropathy

  • Pancreatic Adenocarcinoma

    Six patients suffered from significant morbidities including recurrent cholangitis, second malignancy, malnutrition and bowel perforation.[ncbi.nlm.nih.gov] Options for front-line therapy include both infusional 5-fluorouracil, leucovorin, irinotecan, oxaliplatin (FOLFIRINOX) and the combination of gemcitabine plus nab-paclitaxel[ncbi.nlm.nih.gov] The main adverse effects are peripheral neuropathy, neutropenia, thrombocytopenia and fatigue.[nature.com]

  • Malignant Gastric Neoplasm

    BACKGROUND/AIM: Recent evidence suggests that preoperative malnutrition may lead to poor survival in cancer patients.[ncbi.nlm.nih.gov] Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Patient or[doi.org] Side effects may include: tiredness nausea and vomiting nerve damage ( peripheral neuropathy ) hair loss diarrhoea anaemia (a lack of red blood cells) weight loss skin changes[nhs.uk]

  • Gastric Adenocarcinoma

    According to MS-score, 92% of the patients had malnutrition and it could predict malnutrition with 96.8% sensitivity, 50% specificity and accuracy of 91.4%.[ncbi.nlm.nih.gov] ., 5-FU (5 μ M); cisplatin (0.5 μ M); irinotecan (2.5 μ M); carboplatin (5 μ M); paclitaxel (2-4 n M); and X rays (1.8 Gy)] also potentiated gastric cancer clonogenic cell[ncbi.nlm.nih.gov] neuropathy grade 2 Inability to tolerate intravenous hydration e.g due to cardiac disease Co-morbidities (based on clinical judgement by the investigator) that in the view[clinicaltrials.gov]

  • Malignant Neoplasm of Pancreas

    ., frequent bowel motions which appear oily, greasy and often float on the top of toilet bowel) weight loss (unintentional) malnutrition, muscle wasting diabetes (endocrine[pancyst.org] If you’re in fairly good health you may receive FOLFIRINOX (5-FU/ leucovorin / oxaliplatin / irinotecan ).[webmd.com] […] may occur in either the central nervous system (CNS) or the peripheral nervous system (PNS).[en.wikipedia.org]

  • Esophageal Carcinoma

    It can lead to regurgitation of food, weight loss, physical wasting, and malnutrition.[medical-dictionary.thefreedictionary.com] Enzinger PC, Clark J, Bryan D et al. (2004) Phase II study of docetaxel, cisplatin, and irinotecan in advanced esophageal and gastric cancer.[springermedizin.de] Physicians' Choice of Single Agent Docetaxel, Paclitaxel, or Irinotecan in Subjects with Advanced/Metastatic Adenocarcinoma...[clinicaltrialsregister.eu]

  • Thiamine Deficiency

    High Calorie Malnutrition and Its Impact on Health 7. The Three Circles of Health 8.[elsevier.com] A 67-year-old woman with colon cancer receiving ramucirumab in combination with second-line fluorouracil with folinic acid and irinotecan. Her PS was 1.[ncbi.nlm.nih.gov] […] degeneration and peripheral neuropathy.[ncbi.nlm.nih.gov]

  • Adenocarcinoma of the Ovary

    Complications of advanced disease: malnutrition, electrolyte imbalance, small and large bowel obstruction, infection, ascites, pleural effusion.[patient.info] The 50% growth inhibitory concentrations (IC50) (nM) of various anticancer drugs were: cisplatin 10,000, paclitaxel 80, SN-38 (irinotecan metabolite) 460, and gemcitabine[ncbi.nlm.nih.gov] Combination chemotherapy with irinotecan hydrochloride plus cisplatin has been reported to be effective for primary and recurrent or resistant CCC.[ncbi.nlm.nih.gov]

  • Cecal Adenocarcinoma

    Growth deficiency and malnutrition in Bloom syndrome. J Pediatr. 1999 Apr. 134 (4):472-9. [Medline]. Passarge E. Bloom’s syndrome. German J, ed.[medscape.com] Irinotecan 24,25 Days 1 and 8: Irinotecan 125mg/m 2 IV over 30–90 minutes. Repeat cycle every 3 weeks. OR Day 1: Irinotecan 300–350mg/m 2 IV over 30–90 minutes.[cancertherapyadvisor.com] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[cancer.gov]

  • Peripheral Sensory Neuropathy

    Overt malnutrition was not present, but a deficit of micronutrients, in particular thiamine, cobalamine, folate and sulfur amino acids appears to have been a primary determinant[ncbi.nlm.nih.gov] N9741: a phase III study comparing irinotecan to oxaliplatin-containing regimens in advanced colorectal cancer , Clin Colorectal Cancer , 2002 , vol. 2 pg. 81 8.[academic.oup.com] Features of Textbook of Peripheral Neuropathy Include : ̈ Practical yet comprehensiveóan accessible ìgo-toî reference for clinicians ̈ Covers all clinically relevant peripheral[books.google.com]

  • Drug-induced Peripheral Neuropathy

    […] especially in patients with a risk for development of neuropathy or with already existing neuropathy, e.g. patients with hepatic or renal failure, diabetes mellitus, or malnutrition[ncbi.nlm.nih.gov] , prednisone/vincristine/methotrexate, platinum/capecitabine, platinum/fluorouracil/irinotecan/leucovorin and rituximab/cyclophosphamide/doxorubicin/vincristine/prednisone[biodatamining.biomedcentral.com] Peripheral neuropathy can be caused by medication, and various descriptions have been applied for this condition.[ncbi.nlm.nih.gov]

Similar symptoms