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31 Possible Causes for Irinotecan, Microangiopathic Anemia, Peripheral Neuropathy

  • Adenocarcinoma of the Colon

    Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal .N Engl J Med 2004;351:337-45. 13. T. Delaunoit1, S.R. Alberts, D.J.[scielo.mec.pt] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[cancer.gov] Irinotecan 24,25 Days 1 and 8: Irinotecan 125mg/m 2 IV over 30–90 minutes. Repeat cycle every 3 weeks. OR Day 1: Irinotecan 300–350mg/m 2 IV over 30–90 minutes.[cancertherapyadvisor.com]

  • Adenocarcinoma of the Ovary

    The 50% growth inhibitory concentrations (IC50) (nM) of various anticancer drugs were: cisplatin 10,000, paclitaxel 80, SN-38 (irinotecan metabolite) 460, and gemcitabine[ncbi.nlm.nih.gov] Combination chemotherapy with irinotecan hydrochloride plus cisplatin has been reported to be effective for primary and recurrent or resistant CCC.[ncbi.nlm.nih.gov] She had recurrent tumors after primary cytoreductive surgery, which were unresectable and also resistant to paclitaxel, carboplatin, irinotecan, and oral etoposide.[ncbi.nlm.nih.gov]

  • Cecal Adenocarcinoma

    Irinotecan 24,25 Days 1 and 8: Irinotecan 125mg/m 2 IV over 30–90 minutes. Repeat cycle every 3 weeks. OR Day 1: Irinotecan 300–350mg/m 2 IV over 30–90 minutes.[cancertherapyadvisor.com] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[cancer.gov] Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med. 2004 Jul 22. 351(4):337-45. [Medline].[emedicine.medscape.com]

  • Gastric Adenocarcinoma

    ., 5-FU (5 μ M); cisplatin (0.5 μ M); irinotecan (2.5 μ M); carboplatin (5 μ M); paclitaxel (2-4 n M); and X rays (1.8 Gy)] also potentiated gastric cancer clonogenic cell[ncbi.nlm.nih.gov] neuropathy grade 2 Inability to tolerate intravenous hydration e.g due to cardiac disease Co-morbidities (based on clinical judgement by the investigator) that in the view[clinicaltrials.gov] One of them was by Enzinger et al who reported that bevacizumab (Avastin, Genentech), cisplatin, docetaxel and irinotecan in a three-week cycle produced a response rate of[healio.com]

  • Bronchogenic Carcinoma

    Etoposide, carboplatin, cislatin or irinotecan are recommended chemotherapeutic agents.[symptoma.com] neuropathy, acanthosis nigricans, and hypertrophic osteoarthropathy (Example: clubbing of fingers).[histopathology-india.net] In an effort to identify biomarkers that better predict response to camptothecin, we investigated the association of CPT-11 (irinotecan)-induced cytotoxicity (IC50) with apoptosis[ncbi.nlm.nih.gov]

  • Bronchial Adenocarcinoma

    Targeted therapy with drugs such as paclitaxel, carboplatin, irinotecan, and erlotinib has also shown results.[medical-dictionary.thefreedictionary.com] neuropathy, acanthosis nigricans, and hypertrophic osteoarthropathy (Example: clubbing of fingers).[histopathology-india.net] Paraneoplastic syndrome• Lambert-Eaton syndrome• Peripheral neuropathy• Acanthosis nigricans• Leukemoid reaction• Hypertrophic pulmonary osteoarthropathy• Horner syndrome•[slideshare.net]

  • Malignant Gastric Neoplasm

    Other associated abnormalities include peripheral thrombophlebitis and microangiopathic hemolytic anemia.[emedicine.medscape.com] Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Patient or[doi.org] Side effects may include: tiredness nausea and vomiting nerve damage ( peripheral neuropathy ) hair loss diarrhoea anaemia (a lack of red blood cells) weight loss skin changes[nhs.uk]

  • Small-Cell Carcinoma of the Lung

    We investigated 45 patients with advanced small cell lung cancer who received chemotherapy with irinotecan combined with cisplatin or carboplatin.[ncbi.nlm.nih.gov] The most common (in 1% of patients) treatment-related events leading to discontinuation were pneumonitis in the nivolumab group (in 2%) and peripheral neuropathy and fatigue[nejm.org] However, another regimen that may be used is carboplatin (Paraplatin) plus irinotecan (Camptosar) Radiation therapy of the brain may be used before or after chemotherapy for[lungcancer.org]

  • Paraneoplastic Syndrome

    , and poor iron availability Microangiopathic hemolytic anemia resulting from diffuse intravascular coagulation (DIC), with formation of fibrin filaments in capillary vessels[emedicine.medscape.com] He was then switched to cisplatin and irinotecan with good response and completed five cycles.[healio.com] Abstract POEMS (peripheral neuropathy, organomegaly, endocrinopathy, M protein, skin changes) syndrome is a rare multisystem paraneoplastic disorder.[ncbi.nlm.nih.gov]

  • Metastatic Liver Carcinoma

    The 1- and 2-year survivals of 82% and 51% compare favorably with modern systemic combinations, e.g., irinotecan/FU/LV/bevacizumab ( 6 ), Oxaliplatin/5FU/LV ( 7 ), and irinotecan[mct.aacrjournals.org] […] may occur in either the central nervous system (CNS) or the peripheral nervous system (PNS).[en.wikipedia.org] The advantage of intermittent treatment with irinotecan-based regimens is not clear.[esmoopen.bmj.com]

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