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72 Possible Causes for Irinotecan, Occult Malignancy, Peripheral Neuropathy

  • Pancreatic Adenocarcinoma

    Options for front-line therapy include both infusional 5-fluorouracil, leucovorin, irinotecan, oxaliplatin (FOLFIRINOX) and the combination of gemcitabine plus nab-paclitaxel[ncbi.nlm.nih.gov] The main adverse effects are peripheral neuropathy, neutropenia, thrombocytopenia and fatigue.[nature.com] […] in patients in a very good health condition, two recent intensive chemotherapies can be proposed with modified doses and a close follow-up: the 5-fluoroucil, leucovorin, irinotecan[ncbi.nlm.nih.gov]

  • Cecal Adenocarcinoma

    Irinotecan 24,25 Days 1 and 8: Irinotecan 125mg/m 2 IV over 30–90 minutes. Repeat cycle every 3 weeks. OR Day 1: Irinotecan 300–350mg/m 2 IV over 30–90 minutes.[cancertherapyadvisor.com] Most importantly, for patients with blood cultures that grow C. septicum , a comprehensive search for occult malignancy is imperative, especially for adenocarcinomas in the[acgcasereports.gi.org] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[cancer.gov]

  • Adenocarcinoma of the Ovary

    The 50% growth inhibitory concentrations (IC50) (nM) of various anticancer drugs were: cisplatin 10,000, paclitaxel 80, SN-38 (irinotecan metabolite) 460, and gemcitabine[ncbi.nlm.nih.gov] […] invasion in the primary tumor. 11 Malignant Serous Tumors Micropapillary Serous Carcinoma In 1978, Russell and Merkur described a noninvasive serous tumor, the morphology[glowm.com] She had recurrent tumors after primary cytoreductive surgery, which were unresectable and also resistant to paclitaxel, carboplatin, irinotecan, and oral etoposide.[ncbi.nlm.nih.gov]

  • Bronchogenic Carcinoma

    Etoposide, carboplatin, cislatin or irinotecan are recommended chemotherapeutic agents.[symptoma.com] […] metastases from lung cancer may present clinically or as a finding at autopsy. [3] Clinically they present with symptoms of colonic obstruction, lower gastrointestinal bleed (occult[jpgmonline.com] neuropathy, acanthosis nigricans, and hypertrophic osteoarthropathy (Example: clubbing of fingers).[histopathology-india.net]

  • Adenocarcinoma of the Colon

    Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal .N Engl J Med 2004;351:337-45. 13. T. Delaunoit1, S.R. Alberts, D.J.[scielo.mec.pt] C septicum infections are most often nontraumatic in nature and associated with either an occult colonic or hematologic malignancy.[ncbi.nlm.nih.gov] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[cancer.gov]

  • Small-Cell Carcinoma of the Lung

    We investigated 45 patients with advanced small cell lung cancer who received chemotherapy with irinotecan combined with cisplatin or carboplatin.[ncbi.nlm.nih.gov] Small cell carcinoma is a highly malignant neoplasm with often extrathoracic metastases at the time of diagnosis, and a very low 5-years survival.[ncbi.nlm.nih.gov] The most common (in 1% of patients) treatment-related events leading to discontinuation were pneumonitis in the nivolumab group (in 2%) and peripheral neuropathy and fatigue[nejm.org]

  • Malignant Gastric Neoplasm

    Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Patient or[doi.org] Patients presenting with this set of dermatoses should be suspected to harbor an occult malignancy, or have persistence of a known malignancy.[doi.org] Side effects may include: tiredness nausea and vomiting nerve damage ( peripheral neuropathy ) hair loss diarrhoea anaemia (a lack of red blood cells) weight loss skin changes[nhs.uk]

  • Peritoneal Metastasis

    Twenty patients received oxaliplatin-based (OX) and twelve patients received irinotecan-based HIPEC (IRI).[ncbi.nlm.nih.gov] In cases of unknown primary, FBC may show iron deficiency suggestive of gastrointestinal malignancy, microscopic haematuria may reveal occult genitourinary malignancy and[patient.info] Leukopenia, fatigue and peripheral neuropathy were higher on the triplet regimen than the doublet regimens.[ncbi.nlm.nih.gov]

  • Paraneoplastic Syndrome

    He was then switched to cisplatin and irinotecan with good response and completed five cycles.[healio.com] CONCLUSIONS: Patients presenting with memory impairment, seizures, and hyponatremia should undergo a thorough workup for occult malignancy.[ncbi.nlm.nih.gov] Abstract POEMS (peripheral neuropathy, organomegaly, endocrinopathy, M protein, skin changes) syndrome is a rare multisystem paraneoplastic disorder.[ncbi.nlm.nih.gov]

  • Bone Metastasis

    Irinotecan Study Group. N Engl J Med. 2000, 343: 905-914. 10.1056/NEJM200009283431302.[doi.org] The most frequent malignant lesion involving the hyoid bone metastasized from the larynx, followed by the vallecula and pyriform sinus.[ncbi.nlm.nih.gov] Cancer-induced Peripheral Neuropathy When it comes to cancer-induced peripheral neuropathy, so peripheral being the ends of your limbs, peripheral being fingers and toes,[melioguide.com]

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