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266 Possible Causes for Irinotecan, Peripheral Neuropathy

  • Adenocarcinoma of the Colon

    Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal .N Engl J Med 2004;351:337-45. 13. T. Delaunoit1, S.R. Alberts, D.J.[scielo.mec.pt] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[cancer.gov] Irinotecan 24,25 Days 1 and 8: Irinotecan 125mg/m 2 IV over 30–90 minutes. Repeat cycle every 3 weeks. OR Day 1: Irinotecan 300–350mg/m 2 IV over 30–90 minutes.[cancertherapyadvisor.com]

  • Gastric Cancer

    Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Patient or[doi.org] Side effects may include: tiredness nausea and vomiting nerve damage ( peripheral neuropathy ) hair loss diarrhoea anaemia (a lack of red blood cells) weight loss skin changes[nhs.uk] neuropathy and diarrhea.[doi.org]

  • Pancreatic Adenocarcinoma

    Options for front-line therapy include both infusional 5-fluorouracil, leucovorin, irinotecan, oxaliplatin (FOLFIRINOX) and the combination of gemcitabine plus nab-paclitaxel[ncbi.nlm.nih.gov] The main adverse effects are peripheral neuropathy, neutropenia, thrombocytopenia and fatigue.[nature.com] […] in patients in a very good health condition, two recent intensive chemotherapies can be proposed with modified doses and a close follow-up: the 5-fluoroucil, leucovorin, irinotecan[ncbi.nlm.nih.gov]

  • Adenocarcinoma of the Ovary

    The 50% growth inhibitory concentrations (IC50) (nM) of various anticancer drugs were: cisplatin 10,000, paclitaxel 80, SN-38 (irinotecan metabolite) 460, and gemcitabine[ncbi.nlm.nih.gov] She had recurrent tumors after primary cytoreductive surgery, which were unresectable and also resistant to paclitaxel, carboplatin, irinotecan, and oral etoposide.[ncbi.nlm.nih.gov] Combination chemotherapy with irinotecan hydrochloride plus cisplatin has been reported to be effective for primary and recurrent or resistant CCC.[ncbi.nlm.nih.gov]

  • Bronchogenic Carcinoma

    Etoposide, carboplatin, cislatin or irinotecan are recommended chemotherapeutic agents.[symptoma.com] neuropathy, acanthosis nigricans, and hypertrophic osteoarthropathy (Example: clubbing of fingers).[histopathology-india.net] In an effort to identify biomarkers that better predict response to camptothecin, we investigated the association of CPT-11 (irinotecan)-induced cytotoxicity (IC50) with apoptosis[ncbi.nlm.nih.gov]

  • Cecal Adenocarcinoma

    Irinotecan 24,25 Days 1 and 8: Irinotecan 125mg/m 2 IV over 30–90 minutes. Repeat cycle every 3 weeks. OR Day 1: Irinotecan 300–350mg/m 2 IV over 30–90 minutes.[cancertherapyadvisor.com] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[cancer.gov] Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med. 2004 Jul 22. 351(4):337-45. [Medline].[emedicine.medscape.com]

  • Gastric Adenocarcinoma

    ., 5-FU (5 μ M); cisplatin (0.5 μ M); irinotecan (2.5 μ M); carboplatin (5 μ M); paclitaxel (2-4 n M); and X rays (1.8 Gy)] also potentiated gastric cancer clonogenic cell[ncbi.nlm.nih.gov] neuropathy grade 2 Inability to tolerate intravenous hydration e.g due to cardiac disease Co-morbidities (based on clinical judgement by the investigator) that in the view[clinicaltrials.gov] One of them was by Enzinger et al who reported that bevacizumab (Avastin, Genentech), cisplatin, docetaxel and irinotecan in a three-week cycle produced a response rate of[healio.com]

  • Paraneoplastic Syndrome

    He was then switched to cisplatin and irinotecan with good response and completed five cycles.[healio.com] Abstract POEMS (peripheral neuropathy, organomegaly, endocrinopathy, M protein, skin changes) syndrome is a rare multisystem paraneoplastic disorder.[ncbi.nlm.nih.gov] Subacute sensory neuropathy is a more specific but rare peripheral neuropathy.[merckmanuals.com]

  • Malignant Neoplasm of Pancreas

    If you’re in fairly good health you may receive FOLFIRINOX (5-FU/ leucovorin / oxaliplatin / irinotecan ).[webmd.com] […] may occur in either the central nervous system (CNS) or the peripheral nervous system (PNS).[en.wikipedia.org] National Library of Medicine Drug Information Portal Medline Plus Health Information Liposomal irinotecan (Brand name: Onivyde ) - Manufactured by Merrimack Pharmaceuticals[rarediseases.info.nih.gov]

  • Metastatic Ovarian Carcinoma

    Research output : Article 2000 Irinotecan--második vonalbeli kezeléssel szerzett tapasztalatok elórehaladott colorectalis daganatokban.[hungary.pure.elsevier.com] Research output : Article Irinotecan in combination with 5-fluorouracil and folinic acid or with cisplatin in patients with advanced gastric or esophageal-gastric junction[hungary.pure.elsevier.com]

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