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43 Possible Causes for Irinotecan, Peripheral Neuropathy, Pleural Effusion on Chest X-Ray

  • Adenocarcinoma of the Colon

    Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal .N Engl J Med 2004;351:337-45. 13. T. Delaunoit1, S.R. Alberts, D.J.[scielo.mec.pt] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[cancer.gov] Irinotecan 24,25 Days 1 and 8: Irinotecan 125mg/m 2 IV over 30–90 minutes. Repeat cycle every 3 weeks. OR Day 1: Irinotecan 300–350mg/m 2 IV over 30–90 minutes.[cancertherapyadvisor.com]

  • Adenocarcinoma of the Ovary

    Sometimes, a chest x-ray is used to detect metastases in the chest or pleural effusion.[en.wikipedia.org] The 50% growth inhibitory concentrations (IC50) (nM) of various anticancer drugs were: cisplatin 10,000, paclitaxel 80, SN-38 (irinotecan metabolite) 460, and gemcitabine[ncbi.nlm.nih.gov] Combination chemotherapy with irinotecan hydrochloride plus cisplatin has been reported to be effective for primary and recurrent or resistant CCC.[ncbi.nlm.nih.gov]

  • Cecal Adenocarcinoma

    Irinotecan 24,25 Days 1 and 8: Irinotecan 125mg/m 2 IV over 30–90 minutes. Repeat cycle every 3 weeks. OR Day 1: Irinotecan 300–350mg/m 2 IV over 30–90 minutes.[cancertherapyadvisor.com] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[cancer.gov] Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med. 2004 Jul 22. 351(4):337-45. [Medline].[emedicine.medscape.com]

  • Gastric Adenocarcinoma

    ., 5-FU (5 μ M); cisplatin (0.5 μ M); irinotecan (2.5 μ M); carboplatin (5 μ M); paclitaxel (2-4 n M); and X rays (1.8 Gy)] also potentiated gastric cancer clonogenic cell[ncbi.nlm.nih.gov] neuropathy grade 2 Inability to tolerate intravenous hydration e.g due to cardiac disease Co-morbidities (based on clinical judgement by the investigator) that in the view[clinicaltrials.gov] One of them was by Enzinger et al who reported that bevacizumab (Avastin, Genentech), cisplatin, docetaxel and irinotecan in a three-week cycle produced a response rate of[healio.com]

  • Bronchogenic Carcinoma

    Etoposide, carboplatin, cislatin or irinotecan are recommended chemotherapeutic agents.[symptoma.com] Chest X-ray lateral view showed a soft tissue swelling arising from the sternum.[ccij-online.org] neuropathy, acanthosis nigricans, and hypertrophic osteoarthropathy (Example: clubbing of fingers).[histopathology-india.net]

  • Bronchial Adenocarcinoma

    Diagnosis Testing After physical examination and CBC, chest x-ray is often the first test performed.[emedicine.medscape.com] Targeted therapy with drugs such as paclitaxel, carboplatin, irinotecan, and erlotinib has also shown results.[medical-dictionary.thefreedictionary.com] neuropathy, acanthosis nigricans, and hypertrophic osteoarthropathy (Example: clubbing of fingers).[histopathology-india.net]

  • Multiple Myeloma

    Ishida, Hirokazu Komatsu, Hiroshi Inagaki, Atsushi Suzuki and Ryuzo Ueda, Overexpression of carboxylesterase‐2 results in enhanced efficacy of topoisomerase I inhibitor, irinotecan[doi.org] The mechanism of the development of the peripheral neuropathy is poorly understood.[ncbi.nlm.nih.gov] BACKGROUND: Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) for different drugs, we aimed to aggregate results of all previously[ncbi.nlm.nih.gov]

  • Small-Cell Carcinoma of the Lung

    We investigated 45 patients with advanced small cell lung cancer who received chemotherapy with irinotecan combined with cisplatin or carboplatin.[ncbi.nlm.nih.gov] The most common (in 1% of patients) treatment-related events leading to discontinuation were pneumonitis in the nivolumab group (in 2%) and peripheral neuropathy and fatigue[nejm.org] However, another regimen that may be used is carboplatin (Paraplatin) plus irinotecan (Camptosar) Radiation therapy of the brain may be used before or after chemotherapy for[lungcancer.org]

  • Metastatic Ovarian Carcinoma

    Chest X-ray revealed persistent massive pleural effusion (Figure 1B) without any improvement in clinical symptoms.[jpmsonline.com] Research output : Article 2000 Irinotecan--második vonalbeli kezeléssel szerzett tapasztalatok elórehaladott colorectalis daganatokban.[hungary.pure.elsevier.com] A specific chemotherapy regimen for rare clear-cell cancers is also under investigation: irinotecan combined with cisplatin. [62] PARP inhibitors have also shown promise in[en.wikipedia.org]

  • Carcinoma of the Lung

    Diagnosis Testing After physical examination and CBC, chest x-ray is often the first test performed.[emedicine.medscape.com] Alternating chemotherapy with amrubicin plus cisplatin and weekly administration of irinotecan plus cisplatin for extensive-stage small cell lung cancer.[www2.nms.ac.jp] Paraneoplastic syndrome• Lambert-Eaton syndrome• Peripheral neuropathy• Acanthosis nigricans• Leukemoid reaction• Hypertrophic pulmonary osteoarthropathy• Horner syndrome•[slideshare.net]

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