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82 Possible Causes for Irinotecan, Peripheral Neuropathy, Recurrent Abdominal Pain

  • Adenocarcinoma of the Colon

    Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal .N Engl J Med 2004;351:337-45. 13. T. Delaunoit1, S.R. Alberts, D.J.[] abdominal pain or discomfort associated with 2 or more of: improvement in abdominal pain with defecation, change in frequency of stool, change in form (appearance) of stool[] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[]

  • Pancreatic Adenocarcinoma

    Options for front-line therapy include both infusional 5-fluorouracil, leucovorin, irinotecan, oxaliplatin (FOLFIRINOX) and the combination of gemcitabine plus nab-paclitaxel[] One year after the second procedure, the patient enjoys good health and has been free of fever and abdominal pain and has not received any antibiotic therapy.[] The main adverse effects are peripheral neuropathy, neutropenia, thrombocytopenia and fatigue.[]

  • Malignant Gastric Neoplasm

    Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Patient or[] Side effects may include: tiredness nausea and vomiting nerve damage ( peripheral neuropathy ) hair loss diarrhoea anaemia (a lack of red blood cells) weight loss skin changes[] neuropathy and diarrhea.[]

  • Gastric Adenocarcinoma

    ., 5-FU (5 μ M); cisplatin (0.5 μ M); irinotecan (2.5 μ M); carboplatin (5 μ M); paclitaxel (2-4 n M); and X rays (1.8 Gy)] also potentiated gastric cancer clonogenic cell[] neuropathy grade 2 Inability to tolerate intravenous hydration e.g due to cardiac disease Co-morbidities (based on clinical judgement by the investigator) that in the view[] One of them was by Enzinger et al who reported that bevacizumab (Avastin, Genentech), cisplatin, docetaxel and irinotecan in a three-week cycle produced a response rate of[]

  • Malignant Neoplasm of Pancreas

    If you’re in fairly good health you may receive FOLFIRINOX (5-FU/ leucovorin / oxaliplatin / irinotecan ).[] Patients are usually in their seventh to eighth decade of life and present with abdominal pain, or recurrent pancreatitis, thought to be caused by obstruction of the pancreatic[] […] may occur in either the central nervous system (CNS) or the peripheral nervous system (PNS).[]

  • Peritoneal Metastasis

    Twenty patients received oxaliplatin-based (OX) and twelve patients received irinotecan-based HIPEC (IRI).[] Presents with recurrent bouts of abdominal pain and tenderness along with pleuritic or joint pain. Fever and leukocytosis are common.[] Leukopenia, fatigue and peripheral neuropathy were higher on the triplet regimen than the doublet regimens.[]

  • Adenocarcinoma of the Ovary

    The 50% growth inhibitory concentrations (IC50) (nM) of various anticancer drugs were: cisplatin 10,000, paclitaxel 80, SN-38 (irinotecan metabolite) 460, and gemcitabine[] pain or swelling Elevated levels of the protein CA-125 According to the Ovarian Cancer National Alliance, most patients diagnosed with ovarian cancer develop a recurrence[] Combination chemotherapy with irinotecan hydrochloride plus cisplatin has been reported to be effective for primary and recurrent or resistant CCC.[]

  • Abdominal Radiation

    [PUBMED Abstract] Gupta E, Lestingi TM, Mick R, et al.: Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea.[] But we've all seen many patients who come to the ED for recurrent abdominal pain, some of whom carry known diagnoses, some of whom have repeatedly defied diagnosis.[] The major acute toxicities encountered were myelosuppression and peripheral neuropathy.[]

  • Irritable Bowel Syndrome

    Prevention of irinotecan induced diarrhea by probiotics: A randomized double blind, placebo controlled pilot study.[] Sixty two (62.5%) of the students with recurrent abdominal pain had IBS. IBS was more prevalent in the females compared to the males (p 0.000).[] neuropathy, ataxia, attention deficit hyperactivity disorder) or autoimmune diseases.[]

  • Paraneoplastic Syndrome

    He was then switched to cisplatin and irinotecan with good response and completed five cycles.[] A female patient presented with recurrent attacks of chills, fever and abdominal pain was found to have simultaneous cyclic oscillation in leukocyte counts and C-reactive[] Abstract POEMS (peripheral neuropathy, organomegaly, endocrinopathy, M protein, skin changes) syndrome is a rare multisystem paraneoplastic disorder.[]

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