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21 Possible Causes for Irinotecan, Peripheral Neuropathy, Sister Mary Joseph's Nodule

  • Adenocarcinoma of the Colon

    A Sister Marie Joseph nodule may develop at the umbilicus from tumour infiltration. Liver metastases are quite asymptomatic in the early stages.[surgwiki.com] Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal .N Engl J Med 2004;351:337-45. 13. T. Delaunoit1, S.R. Alberts, D.J.[scielo.mec.pt] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[cancer.gov]

  • Pancreatic Adenocarcinoma

    If cutaneous metastases do indeed occur, it is often near the umbilicus, known as the Sister Mary Joseph's nodule.[ncbi.nlm.nih.gov] Options for front-line therapy include both infusional 5-fluorouracil, leucovorin, irinotecan, oxaliplatin (FOLFIRINOX) and the combination of gemcitabine plus nab-paclitaxel[ncbi.nlm.nih.gov] The main adverse effects are peripheral neuropathy, neutropenia, thrombocytopenia and fatigue.[nature.com]

  • Malignant Gastric Neoplasm

    Other possible signs of metastatic disease include left supraclavicular adenopathy (Virchow's node), periumbilical node (Sister Mary Joseph nodule), and an anterior axillary[symptoma.com] Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Patient or[doi.org] Side effects may include: tiredness nausea and vomiting nerve damage ( peripheral neuropathy ) hair loss diarrhoea anaemia (a lack of red blood cells) weight loss skin changes[nhs.uk]

  • Adenocarcinoma of the Ovary

    Mary Joseph nodule* Table 6 History and Examination Findings Associated with Ovarian Cancer Family history Bilateral breast cancer Early-onset breast cancer (younger than[aafp.org] The 50% growth inhibitory concentrations (IC50) (nM) of various anticancer drugs were: cisplatin 10,000, paclitaxel 80, SN-38 (irinotecan metabolite) 460, and gemcitabine[ncbi.nlm.nih.gov] Combination chemotherapy with irinotecan hydrochloride plus cisplatin has been reported to be effective for primary and recurrent or resistant CCC.[ncbi.nlm.nih.gov]

  • Gastric Adenocarcinoma

    ., left supraclavicular), Sister Mary Joseph’s nodule (periumbilical), or Blumer’s shelf (metastatic tumor felt on rectal examination, with growth in the rectouterine/rectovesical[aafp.org] ., 5-FU (5 μ M); cisplatin (0.5 μ M); irinotecan (2.5 μ M); carboplatin (5 μ M); paclitaxel (2-4 n M); and X rays (1.8 Gy)] also potentiated gastric cancer clonogenic cell[ncbi.nlm.nih.gov] neuropathy grade 2 Inability to tolerate intravenous hydration e.g due to cardiac disease Co-morbidities (based on clinical judgement by the investigator) that in the view[clinicaltrials.gov]

  • Malignant Neoplasm of Pancreas

    Mary Joseph nodule or nodules) Possible presence of palpable metastatic mass in the rectal pouch (Blumer shelf) Possible presence of palpable metastatic cervical nodes: Nodes[emedicine.medscape.com] If you’re in fairly good health you may receive FOLFIRINOX (5-FU/ leucovorin / oxaliplatin / irinotecan ).[webmd.com] […] may occur in either the central nervous system (CNS) or the peripheral nervous system (PNS).[en.wikipedia.org]

  • Cecal Adenocarcinoma

    Umbilical metastasis (Sister Mary Joseph's nodule) is a rare occurrence and indicates, in most of the patients, an advanced intraabdominal malignancy.[ncbi.nlm.nih.gov] Irinotecan 24,25 Days 1 and 8: Irinotecan 125mg/m 2 IV over 30–90 minutes. Repeat cycle every 3 weeks. OR Day 1: Irinotecan 300–350mg/m 2 IV over 30–90 minutes.[cancertherapyadvisor.com] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[cancer.gov]

  • Metastatic Ovarian Carcinoma

    Our patient had a Sister Mary Joseph’s nodule and other nodules around the previous incision and periumbilical area.[jmedicalcasereports.biomedcentral.com] Research output : Article 2000 Irinotecan--második vonalbeli kezeléssel szerzett tapasztalatok elórehaladott colorectalis daganatokban.[hungary.pure.elsevier.com] A specific chemotherapy regimen for rare clear-cell cancers is also under investigation: irinotecan combined with cisplatin. [62] PARP inhibitors have also shown promise in[en.wikipedia.org]

  • Adenocarcinoma of the Rectum

    A Sister Marie Joseph nodule may develop at the umbilicus from tumour infiltration. Liver metastases are quite asymptomatic in the early stages.[surgwiki.com] He received intravenous chemotherapy 3 weeks after surgery, with standard doses of irinotecan and cisplatin.[academic.oup.com] Neuropathy A research study is evaluating an investigational treatment for chemotherapy induced peripheral neuropathy in patients with colorectal cancer (CRC).[centerwatch.com]

  • Gastric Cancer

    Abstract Sister Mary Joseph nodule is a metastatic lesion of the umbilicus, which is an uncommon phenomenon that carries an ominous prognosis.[ncbi.nlm.nih.gov] KEYWORDS: 5-fluorouracil; gastric carcinoma; hyaluronic acid; irinotecan; layer-by-layer nanoparticles[ncbi.nlm.nih.gov] Side effects may include: tiredness nausea and vomiting nerve damage ( peripheral neuropathy ) hair loss diarrhoea anaemia (a lack of red blood cells) weight loss skin changes[nhs.uk]

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