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11 Possible Causes for Irinotecan, Peripheral Neuropathy, Umbilical Plaque

  • Pancreatic Adenocarcinoma

    Options for front-line therapy include both infusional 5-fluorouracil, leucovorin, irinotecan, oxaliplatin (FOLFIRINOX) and the combination of gemcitabine plus nab-paclitaxel[ncbi.nlm.nih.gov] The main adverse effects are peripheral neuropathy, neutropenia, thrombocytopenia and fatigue.[nature.com] […] in patients in a very good health condition, two recent intensive chemotherapies can be proposed with modified doses and a close follow-up: the 5-fluoroucil, leucovorin, irinotecan[ncbi.nlm.nih.gov]

  • Malignant Gastric Neoplasm

    Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Patient or[doi.org] Side effects may include: tiredness nausea and vomiting nerve damage ( peripheral neuropathy ) hair loss diarrhoea anaemia (a lack of red blood cells) weight loss skin changes[nhs.uk] neuropathy and diarrhea.[dx.doi.org]

  • Adenocarcinoma of the Colon

    Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal .N Engl J Med 2004;351:337-45. 13. T. Delaunoit1, S.R. Alberts, D.J.[scielo.mec.pt] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[cancer.gov] Irinotecan 24,25 Days 1 and 8: Irinotecan 125mg/m 2 IV over 30–90 minutes. Repeat cycle every 3 weeks. OR Day 1: Irinotecan 300–350mg/m 2 IV over 30–90 minutes.[cancertherapyadvisor.com]

  • Adenocarcinoma of the Ovary

    The 50% growth inhibitory concentrations (IC50) (nM) of various anticancer drugs were: cisplatin 10,000, paclitaxel 80, SN-38 (irinotecan metabolite) 460, and gemcitabine[ncbi.nlm.nih.gov] Combination chemotherapy with irinotecan hydrochloride plus cisplatin has been reported to be effective for primary and recurrent or resistant CCC.[ncbi.nlm.nih.gov] She had recurrent tumors after primary cytoreductive surgery, which were unresectable and also resistant to paclitaxel, carboplatin, irinotecan, and oral etoposide.[ncbi.nlm.nih.gov]

  • Gastric Adenocarcinoma

    ., 5-FU (5 μ M); cisplatin (0.5 μ M); irinotecan (2.5 μ M); carboplatin (5 μ M); paclitaxel (2-4 n M); and X rays (1.8 Gy)] also potentiated gastric cancer clonogenic cell[ncbi.nlm.nih.gov] neuropathy grade 2 Inability to tolerate intravenous hydration e.g due to cardiac disease Co-morbidities (based on clinical judgement by the investigator) that in the view[clinicaltrials.gov] One of them was by Enzinger et al who reported that bevacizumab (Avastin, Genentech), cisplatin, docetaxel and irinotecan in a three-week cycle produced a response rate of[healio.com]

  • Malignant Neoplasm of Pancreas

    If you’re in fairly good health you may receive FOLFIRINOX (5-FU/ leucovorin / oxaliplatin / irinotecan ).[webmd.com] […] may occur in either the central nervous system (CNS) or the peripheral nervous system (PNS).[en.wikipedia.org] National Library of Medicine Drug Information Portal Medline Plus Health Information Liposomal irinotecan (Brand name: Onivyde ) - Manufactured by Merrimack Pharmaceuticals[rarediseases.info.nih.gov]

  • Fluorouracil

    We suggest fluorouracil, leucovorin, oxaliplatin, and irinotecan is an effective therapy for patients with advanced urothelial cancer.[ncbi.nlm.nih.gov] CASES REPORTS 5-Fluorouracil induced late peripheral neuropathy.[scielo.br] The antiangiogenic monoclonal antibody aflibercept in association with fluorouracil and irinotecan improves the survival of patients with metastatic colorectal cancer (mCRC[ncbi.nlm.nih.gov]

  • Hypertrichotic Osteochondrodysplasia

    , anthracyclines, taxanes, vinca alkaloids, statins Pseudoxanthoma elasticum ABCC2 10q24.2 69,979 MRP2 1545 PM bilirubin, bile salts irinotecan, anthracyclines, taxanes, vinca[mdpi.com] Neuropathies download Inherited Peripheral Neuropathies.pdf CMT Dominant Demyelinating CMT1A (Disease MIM 118200 ) Blood 3-5ml in EDTA PMP22 601097 CMT Dominant Demyelinating[nbt.nhs.uk] neuropathy Abnormality of the hand Flexion contracture Overgrowth Metatarsus adductus Hyperextensibility of the finger joints Muscle weakness Hemangioma Webbed neck Cleft[mendelian.co]

  • Megacystis - Microcolon - Intestinal Hypoperistalsis Syndrome

    A phase II trial of gemcitabine, irinotecan and panitumumab in advanced cholangiocarcinoma. Ann Oncol. (12):3061-5, 2013. PMID: 24146220.[cancer.columbia.edu] neuropathy manifesting as paresthesias (tingling, numbness, and pain) and symmetric and distal weakness more prominently affecting the lower extremities.[ncbi.nlm.nih.gov] […] gastroesophageal reflux, postprandial emesis, episodic abdominal pain and/or distention, and diarrhea; ptosis/ophthalmoplegia or ophthalmoparesis; hearing loss; and demyelinating peripheral[ncbi.nlm.nih.gov]

  • Orofaciodigital Syndrome Type 7

    The clinical and cost effectiveness of aflibercept in combination with irinotecan and fluorouracil-based therapy (FOLFIRI) for the treatment of metastatic colorectal cancer[york.ac.uk] Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, And Hirschsprung Disease 4 Periventricular Nodular Heterotopia 7 1 Perlman Syndrome 1 Permanent Neonatal[preventiongenetics.com] Syndrome 1 Patterned Dystrophy Of Retinal Pigment Epithelium 4 Peeling Skin Syndrome, Acral Type 1 Pelger-Huet Anomaly 2 Pelizaeus-Merzbacher Disease 2 Pendred Syndrome 3 Peripheral[preventiongenetics.com]

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